CIS-BP Database: Catalog of Inferred Sequence Binding Preferences
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klu-1
(
Caenorhabditis elegans
)
C2H2 ZF
TF Information
Pfam ID
Interpro ID
Gene ID
CIS-BP ID
Sequence source
Animal TF db
PF00096 (zf-C2H2)
IPR007087
WBGene00013970
T131613_2.00
Ensembl (2018-Dec-8)
Link out
NCBI Gene Info:
Predicted to enable DNA-binding transcription factor activity and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Predicted to be involved in regulation of transcription by RNA polymerase II. Is expressed in anal depressor muscle; body wall musculature; and reproductive system. Human ortholog(s) of this gene implicated in B-lymphoblastic leukemia/lymphoma and common variable immunodeficiency. Orthologous to human GLI4 (GLI family zinc finger 4) and IKZF1 (IKAROS family zinc finger 1). [provided by Alliance of Genome Resources, Apr 2022]
Directly determined binding motifs
Name/Motif ID
Species
Forward
Reverse
Type/Study/Study ID
SR
Score
DBD
Identity
klu-1
M00637_2.00
Caenorhabditis elegans
CDCCCMCV
BGKGGGHG
PBM
Narasimhan et al.(2015)
pTH9355
(Direct)
(Direct)
Motifs from related TFs
Name/Motif ID
Species
Forward
Reverse
Type/Study/Study ID
SR
Score
DBD
Identity
For this family, TFs with SR scores >
0.755
will likely have a similar motif
Experimental Constructs
Motif ID
Domain
From
To
Sequence
M00637_2.00
C2H2 ZF
51
74
YPCTLCGQAFAVHDRLAKHIASRH
M00637_2.00
C2H2 ZF
88
110
HKCNMCSKSFSRSDMLTRHMRLH
M00637_2.00
C2H2 ZF
116
138
YSCPTCNQVFSRSDHLSTHLRTH
M00637_2.00
C2H2 ZF
144
166
YACPMCNYSASRRDMISRHMRTH
DNA Binding Domains
Protein ID
Domain
From
To
Sequence
ZK337.2
C2H2 ZF
332
355
YPCTLCGQAFAVHDRLAKHIASRH
ZK337.2
C2H2 ZF
369
391
HKCNMCSKSFSRSDMLTRHMRLH
ZK337.2
C2H2 ZF
397
419
YSCPTCNQVFSRSDHLSTHLRTH
ZK337.2
C2H2 ZF
425
447
YACPMCNYSASRRDMISRHMRTH
Links
Other
C2H2 ZF
family TFs
Other
Caenorhabditis elegans
TFs
24 Related TFs
Name
Species
Gene ID
Motif Evidence
SR
Score
Action
Invalid Input OrderBy