ztf-16 (Caenorhabditis elegans)
C2H2 ZF

TF Information

Pfam ID Interpro ID Gene ID CIS-BP ID Sequence source Animal TF db
PF00096 (zf-C2H2) IPR007087 WBGene00019960 T131635_2.00 Ensembl (2018-Dec-8) Link out
NCBI Gene Info:
Predicted to enable metal ion binding activity. Involved in gonad development and positive regulation of gene expression. Located in nucleus. Is expressed in several structures, including accessory cell; gonad; hypodermis; intestine; and pharynx. Human ortholog(s) of this gene implicated in B-lymphoblastic leukemia/lymphoma; common variable immunodeficiency; and primary immunodeficiency disease. Orthologous to several human genes including IKZF1 (IKAROS family zinc finger 1); IKZF2 (IKAROS family zinc finger 2); and IKZF3 (IKAROS family zinc finger 3). [provided by Alliance of Genome Resources, Apr 2022]

Directly determined binding motifs

Name/Motif ID Species Forward Reverse Type/Study/Study ID SR
Score		 DBD
Identity
ztf-16
M00644_2.00		 Caenorhabditis elegans
NNYNHGGAWN
NWTCCDNRNN		 PBM
Narasimhan et al.(2015)
pTH10805		 (Direct) (Direct)

Motifs from related TFs

Name/Motif ID Species Forward Reverse Type/Study/Study ID SR
Score		 DBD
Identity
For this family, TFs with SR scores > 0.755 will likely have a similar motif

Experimental Constructs

Motif ID Domain From To Sequence
M00644_2.00 C2H2 ZF 51 73
M00644_2.00 C2H2 ZF 79 101
M00644_2.00 C2H2 ZF 108 133
M00644_2.00 C2H2 ZF 142 164

DNA Binding Domains

Protein ID Domain From To Sequence
R08E3.4a C2H2 ZF 133 155
R08E3.4a C2H2 ZF 161 183
R08E3.4a C2H2 ZF 190 215
R08E3.4a C2H2 ZF 224 246
R08E3.4b C2H2 ZF 133 155
R08E3.4b C2H2 ZF 161 183
R08E3.4b C2H2 ZF 190 215
R08E3.4b C2H2 ZF 224 246

Links

Other C2H2 ZF family TFs
Other Caenorhabditis elegans TFs

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1 Related TFs

Name Species Gene ID Motif Evidence SR
Score		 Action