ENSP00000278780 (Macaca fascicularis)
C2H2 ZF

TF Information

Pfam ID Interpro ID Gene ID CIS-BP ID Sequence source
PF00096 (zf-C2H2) IPR007087 ENSP00000278780 T134970_2.00 GigaDB (2015-Oct-22)
NCBI Gene Info:
This gene encodes a member of the evolutionarily conserved ovo-like protein family. Mammalian members of this family contain a single zinc finger domain composed of a tetrad of C2H2 zinc fingers with variable N- and C-terminal extensions that contain intrinsically disordered domains. Members of this family are involved in epithelial development and differentiation. Knockout of this gene in mouse results in early embryonic lethality with phenotypes that include neurectoderm expansion, impaired vascularization, and heart anomalies. In humans, allelic variants of this gene have been associated with posterior polymorphous corneal dystrophy. [provided by RefSeq, Apr 2016]

Directly determined binding motifs

Name/Motif ID Species Forward Reverse Type/Study/Study ID SR
Score		 DBD
Identity
No direct experiments

Motifs from related TFs

Name/Motif ID Species Forward Reverse Type/Study/Study ID SR
Score		 DBD
Identity
OVOL2
M00235_2.00 		Homo sapiens
NCCGYTANNN
NNNTARCGGN		 PBM
Barrera et al.(2016)
OVOL2_REF 		0.827 1.000
OVOL2
M04445_2.00 		Homo sapiens
NNHCCGYTANNHN
NDNNTARCGGDNN		 SELEX
Yin et al.(2017)
OVOL2_eDBD_HT-SELEX 		0.827 1.000
OVOL2
M04447_2.00 		Homo sapiens
DDWCCGTTABNHN
NDNVTAACGGWHH		 SELEX
Yin et al.(2017)
OVOL2_FL_HT-SELEX 		0.827 1.000
OVOL2
M10207_2.00 		Homo sapiens Transfac license required
 Transfac license required
 Transfac
Matys et al.(2006)
V$MOVOB_01 		0.827 1.000
OVOL2
M04446_2.00 		Homo sapiens
NNWCCGTTANNHN
NDNNTAACGGWNN		 SELEX
Yin et al.(2017)
OVOL2_eDBD_Methyl-HT-SELEX 		0.827 1.000
OVOL2
M04448_2.00 		Homo sapiens
DDWCCGTTABNHN
NDNVTAACGGWHH		 SELEX
Yin et al.(2017)
OVOL2_FL_Methyl-HT-SELEX 		0.827 1.000
Ovol2
M08993_2.00 		Mus musculus
HCCGTTAN
NTAACGGD		 Misc
Kulakovskiy et al.(2013)
OVOL2_MOUSE.H11MO.0.C 		0.813 0.967
OVOL2
M00234_2.00 		Homo sapiens
NCCGYTANNN
NNNTARCGGN		 PBM
Barrera et al.(2016)
OVOL2_D228E 		0.772 0.989
For this family, TFs with SR scores > 0.755 will likely have a similar motif

DNA Binding Domains

Protein ID Domain From To Sequence
ENSP00000278780 C2H2 ZF 13 35
ENSP00000278780 C2H2 ZF 41 63
ENSP00000278780 C2H2 ZF 69 92
ENSP00000278780 C2H2 ZF 108 131

Links

Other C2H2 ZF family TFs
Other Macaca fascicularis TFs

Invalid Input OrderBy

54 Related TFs

Name Species Gene ID Motif Evidence SR
Score		 Action