CIS-BP Database: Catalog of Inferred Sequence Binding Preferences
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grhl2b
(
Danio rerio
)
Grainyhead
TF Information
Pfam ID
Interpro ID
Gene ID
CIS-BP ID
Sequence source
Animal TF db
PF04516 (CP2)
IPR007604
ENSDARG00000061974
T198956_2.00
Ensembl (2018-Dec-8)
Link out
NCBI Gene Info:
Enables transcription cis-regulatory region binding activity. Acts upstream of or within apoptotic process involved in morphogenesis; inner ear development; and midbrain-hindbrain boundary morphogenesis. Predicted to be active in nucleus. Is expressed in several structures, including anterior axial hypoblast; midbrain hindbrain boundary neural rod; neurogenic placode; optic vesicle; and posterior lateral line system. Used to study autosomal dominant nonsyndromic deafness. Human ortholog(s) of this gene implicated in autosomal dominant nonsyndromic deafness 28 and posterior polymorphous corneal dystrophy 4. Orthologous to human GRHL2 (grainyhead like transcription factor 2). [provided by Alliance of Genome Resources, Apr 2022]
Directly determined binding motifs
Name/Motif ID
Species
Forward
Reverse
Type/Study/Study ID
SR
Score
DBD
Identity
No direct experiments
Motifs from related TFs
Name/Motif ID
Species
Forward
Reverse
Type/Study/Study ID
SR
Score
DBD
Identity
Grhl2
M09126_2.00
Mus musculus
RDCCDGTYYKDC
GHMRRACHGGHY
Misc
Kulakovskiy et al.(2013)
GRHL2_MOUSE.H11MO.0.A
0.852
0.852
GRHL2
M08129_2.00
Homo sapiens
NNNAACTGGTTTNNN
NNNAAACCAGTTNNN
ChIP-seq
Mathelier et al.(2014)
MA1105.1
0.848
0.848
GRHL2
M09125_2.00
Homo sapiens
AACYDGYYBDDC
GHHVRRCHRGTT
Misc
Kulakovskiy et al.(2013)
GRHL2_HUMAN.H11MO.0.A
0.848
0.848
GRHL2
M09558_2.00
Homo sapiens
NRAACHDGHHDDDCHDGTTY
RAACHDGHHHDDCHDGTTYN
Misc
Heinz et al.(2010)
HBE-GRHL2_GSE46194
0.848
0.848
For this family, TFs with SR scores >
0.700
will likely have a similar motif
DNA Binding Domains
Protein ID
Domain
From
To
Sequence
ENSDARP00000124302
Grainyhead
200
423
PESTYEDDSNEKYRSSSIGPDDFIFDQSHMLDTFQYTLEASKSLRQKQGEGPMTYLNKGQFYAITLSETSANKRLRHPISKVRSVVMVVFSEDKNRDEQLKYWKYWHSRQHTAKQRVLDIADYKESFNTIGNIEEIAYNAVSFTWDLNEEAKIFITVNCLSTDFSSQKGVKGLPLMIQIDTYSYNNRSNKPLHRAYCQIKVFCDKGAERKIRDEERKQNRKKTK
Links
Other
Grainyhead
family TFs
Other
Danio rerio
TFs
112 Related TFs
Name
Species
Gene ID
Motif Evidence
SR
Score
Action
Invalid Input OrderBy