grhl2b (Danio rerio)
Grainyhead

TF Information

Pfam ID Interpro ID Gene ID CIS-BP ID Sequence source Animal TF db
PF04516 (CP2) IPR007604 ENSDARG00000061974 T198956_2.00 Ensembl (2018-Dec-8) Link out
NCBI Gene Info:
Enables transcription cis-regulatory region binding activity. Acts upstream of or within apoptotic process involved in morphogenesis; inner ear development; and midbrain-hindbrain boundary morphogenesis. Predicted to be active in nucleus. Is expressed in several structures, including anterior axial hypoblast; midbrain hindbrain boundary neural rod; neurogenic placode; optic vesicle; and posterior lateral line system. Used to study autosomal dominant nonsyndromic deafness. Human ortholog(s) of this gene implicated in autosomal dominant nonsyndromic deafness 28 and posterior polymorphous corneal dystrophy 4. Orthologous to human GRHL2 (grainyhead like transcription factor 2). [provided by Alliance of Genome Resources, Apr 2022]

Directly determined binding motifs

Name/Motif ID Species Forward Reverse Type/Study/Study ID SR
Score		 DBD
Identity
No direct experiments

Motifs from related TFs

Name/Motif ID Species Forward Reverse Type/Study/Study ID SR
Score		 DBD
Identity
Grhl2
M09126_2.00 		Mus musculus
RDCCDGTYYKDC
GHMRRACHGGHY		 Misc
Kulakovskiy et al.(2013)
GRHL2_MOUSE.H11MO.0.A 		0.852 0.852
GRHL2
M08129_2.00 		Homo sapiens
NNNAACTGGTTTNNN
NNNAAACCAGTTNNN		 ChIP-seq
Mathelier et al.(2014)
MA1105.1 		0.848 0.848
GRHL2
M09125_2.00 		Homo sapiens
AACYDGYYBDDC
GHHVRRCHRGTT		 Misc
Kulakovskiy et al.(2013)
GRHL2_HUMAN.H11MO.0.A 		0.848 0.848
GRHL2
M09558_2.00 		Homo sapiens
NRAACHDGHHDDDCHDGTTY
RAACHDGHHHDDCHDGTTYN		 Misc
Heinz et al.(2010)
HBE-GRHL2_GSE46194 		0.848 0.848
For this family, TFs with SR scores > 0.700 will likely have a similar motif

DNA Binding Domains

Protein ID Domain From To Sequence
ENSDARP00000124302 Grainyhead 200 423

Links

Other Grainyhead family TFs
Other Danio rerio TFs

112 Related TFs

Name Species Gene ID Motif Evidence SR
Score		 Action
grhl1 Danio rerio ENSDARG00000061391 I 0.890
GRHL2 Canis familiaris ENSCAFG00000000587 I 0.869
ENSSTOG00000019842 Ictidomys tridecemlineatus ENSSTOG00000019842 I 0.865
ENSLOCG00000009655 Lepisosteus oculatus ENSLOCG00000009655 I 0.861
GRHL2 Cavia porcellus ENSCPOG00000005630 I 0.859
Grhl2 Mus musculus ENSMUSG00000022286 D 0.856
Grhl2 Rattus norvegicus ENSRNOG00000007000 I 0.856
ENSSTOG00000001498 Ictidomys tridecemlineatus ENSSTOG00000001498 I 0.855
GRHL2 Ornithorhynchus anatinus ENSOANG00000004305 I 0.852
GRHL2 Loxodonta africana ENSLAFG00000010356 I 0.852
ENSLACG00000006172 Latimeria chalumnae ENSLACG00000006172 I 0.852
ENSFALG00000005879 Ficedula albicollis ENSFALG00000005879 I 0.851
Afo_R002230 Aptenodytes forsteri Afo_R002230 I 0.851
Aan_R003923 Calypte anna Aan_R003923 I 0.851
Brh_R013325 Buceros rhinoceros Brh_R013325 I 0.851
GRHL2 Sus scrofa ENSSSCG00000006060 I 0.851
GRHL2 Monodelphis domestica ENSMODG00000006048 I 0.851
GRHL2 Callithrix jacchus ENSCJAG00000015886 I 0.848
GRHL2 Gorilla gorilla ENSGGOG00000004401 I 0.848
ENSGALG00000014208 Gallus gallus ENSGALG00000014208 I 0.848
Myotis_brandtii_GRHL2_10032153 Myotis brandtii Myotis_brandtii_GRHL2_10032153 I 0.848
GRHL2 Myotis lucifugus ENSMLUG00000010961 I 0.848
ENSNLEG00000003271 Nomascus leucogenys ENSNLEG00000003271 I 0.848
ENSPANG00000017807 Papio anubis ENSPANG00000017807 I 0.848
GRHL2 Homo sapiens ENSG00000083307 D 0.848
ENSPPYG00000018794 Pongo abelii ENSPPYG00000018794 I 0.848
ENSAPLG00000002882 Anas platyrhynchos ENSAPLG00000002882 I 0.848
ENSSHAG00000015849 Sarcophilus harrisii ENSSHAG00000015849 I 0.848
ENSCSAG00000011989 Chlorocebus sabaeus ENSCSAG00000011989 I 0.848
GRHL2 Pan troglodytes ENSPTRG00000020479 I 0.848
Gfo_R006019 Geospiza fortis Gfo_R006019 I 0.844
grhl2 Xenopus tropicalis XB-GENE-485995 I 0.843
ENSPFOG00000006095 Poecilia formosa ENSPFOG00000006095 I 0.843
ENSPSIG00000003669 Pelodiscus sinensis ENSPSIG00000003669 I 0.843
GRHL2 Otolemur garnettii ENSOGAG00000004751 I 0.843
GRHL2 Meleagris gallopavo ENSMGAG00000012259 I 0.843
ENSP00000251808-D1 Bos grunniens ENSP00000251808-D1 I 0.839
GRHL2 Bos taurus ENSBTAG00000004518 I 0.839
ENSOARG00000018325 Ovis aries ENSOARG00000018325 I 0.839
Pvit_03833 Pogona vitticeps Pvit_03833 I 0.839
GRHL2 Tursiops truncatus ENSTTRG00000005794 I 0.839
GRHL2 Dasypus novemcinctus ENSDNOG00000048641 I 0.834
ENSAMEG00000000278 Ailuropoda melanoleuca ENSAMEG00000000278 I 0.834
GRHL2 Microcebus murinus ENSMICG00000014771 I 0.834
ENSMPUG00000015153 Mustela putorius furo ENSMPUG00000015153 I 0.834
ENSXMAG00000003725 Xiphophorus maculatus ENSXMAG00000003725 I 0.833
GRHL2 Anolis carolinensis ENSACAG00000008759 I 0.829
GRHL2 Oryctolagus cuniculus ENSOCUG00000004750 I 0.827
GRHL2 Equus caballus ENSECAG00000013681 I 0.827
GRHL2 Felis catus ENSFCAG00000004963 I 0.827
ENSP00000379261 Macaca fascicularis ENSP00000379261 I 0.826
GRHL2 Macaca mulatta ENSMMUG00000020995 I 0.826
ENSTGUG00000012086 Taeniopygia guttata ENSTGUG00000012086 I 0.821
grhl2b Gasterosteus aculeatus ENSGACG00000003695 I 0.820
ENSPMAG00000005869 Petromyzon marinus ENSPMAG00000005869 I 0.805
grhl2b Tetraodon nigroviridis ENSTNIG00000009151 I 0.799
ENSONIG00000002710 Oreochromis niloticus ENSONIG00000002710 I 0.798
grhl2b Takifugu rubripes ENSTRUG00000002119 I 0.785
ENSAMXG00000000221 Astyanax mexicanus ENSAMXG00000000221 I 0.771
Alligator_sinensis_CCG017490.1 Alligator sinensis Alligator_sinensis_CCG017490.1 I 0.766
GRHL2 Erinaceus europaeus ENSEEUG00000015263 I 0.762
Ogr11913 Ophisaurus gracilis Ogr11913 I 0.761
ENSPFOG00000004774 Poecilia formosa ENSPFOG00000004774 I 0.751
grhl2a Tetraodon nigroviridis ENSTNIG00000013309 I 0.749
ENSLOCG00000016835 Lepisosteus oculatus ENSLOCG00000016835 I 0.749
grhl1 Tetraodon nigroviridis ENSTNIG00000017317 I 0.748
ENSAMXG00000016712 Astyanax mexicanus ENSAMXG00000016712 I 0.746
grhl1 Takifugu rubripes ENSTRUG00000013628 I 0.742
GRHL1 Vicugna pacos ENSVPAG00000010842 I 0.742
grhl2a Danio rerio ENSDARG00000058342 I 0.740
ENSONIG00000003707 Oreochromis niloticus ENSONIG00000003707 I 0.740
ENSOARG00000015298 Ovis aries ENSOARG00000015298 I 0.737
ENSPANG00000020814 Papio anubis ENSPANG00000020814 I 0.737
ENSPPYG00000012661 Pongo abelii ENSPPYG00000012661 I 0.737
ENSSHAG00000002291 Sarcophilus harrisii ENSSHAG00000002291 I 0.732
GRHL1 Equus caballus ENSECAG00000015969 I 0.732
GRHL1 Pan troglodytes ENSPTRG00000011643 I 0.732
grhl1 Oryzias latipes ENSORLG00000015232 I 0.731
grhl1.L Xenopus laevis XB-GENE-486580 I 0.731
XP_002938935 Xenopus tropicalis XP_002938935 I 0.731
Grhl1 Mus musculus ENSMUSG00000020656 I 0.730
ENSAPLG00000008667 Anas platyrhynchos ENSAPLG00000008667 I 0.728
ENSMPUG00000013263 Mustela putorius furo ENSMPUG00000013263 I 0.728
GRHL1 Cavia porcellus ENSCPOG00000010783 I 0.726
ENSXMAG00000013267 Xiphophorus maculatus ENSXMAG00000013267 I 0.726
GRHL1 Canis familiaris ENSCAFG00000003394 I 0.723
ENSAMEG00000011320 Ailuropoda melanoleuca ENSAMEG00000011320 I 0.723
GRHL1 Anolis carolinensis ENSACAG00000000132 I 0.721
GRHL1 Felis catus ENSFCAG00000007856 I 0.718
grhl1 Gasterosteus aculeatus ENSGACG00000008845 I 0.717
Tal_R012680 Tyto alba Tal_R012680 I 0.709
nDi.2.2.2.g12300 Dirofilaria immitis nDi.2.2.2.g12300 I 0.709
Afo_R015753 Aptenodytes forsteri Afo_R015753 I 0.709
Gfo_R015266 Geospiza fortis Gfo_R015266 I 0.709
ENSMMUP00000002046 Macaca fascicularis ENSMMUP00000002046 I 0.709
GRHL1 Ornithorhynchus anatinus ENSOANG00000007788 I 0.709
GRHL1 Macaca mulatta ENSMMUG00000001535 I 0.709
Aan_R015393 Calypte anna Aan_R015393 I 0.709
GRHL1 Meleagris gallopavo ENSMGAG00000014007 I 0.709
GRHL1 Loxodonta africana ENSLAFG00000009330 I 0.709
ENSNLEG00000013634 Nomascus leucogenys ENSNLEG00000013634 I 0.709
ENSFALG00000006639 Ficedula albicollis ENSFALG00000006639 I 0.709
ENSCSAG00000007158 Chlorocebus sabaeus ENSCSAG00000007158 I 0.709
GRHL1 Dasypus novemcinctus ENSDNOG00000014493 I 0.709
ENSGALG00000016439 Gallus gallus ENSGALG00000016439 I 0.709
GRHL1 Callithrix jacchus ENSCJAG00000006431 I 0.704
GRHL1 Myotis lucifugus ENSMLUG00000002290 I 0.704
Brh_R003016 Buceros rhinoceros Brh_R003016 I 0.704
GRHL1 Taeniopygia guttata ENSTGUG00000013038 I 0.704
ENSPSIG00000010930 Pelodiscus sinensis ENSPSIG00000010930 I 0.704
GRHL1 Otolemur garnettii ENSOGAG00000014342 I 0.704
GRHL1 Gorilla gorilla ENSGGOG00000002692 I 0.704