ENSP00000251808-D1 (Bos grunniens)
Grainyhead

TF Information

Pfam ID Interpro ID Gene ID CIS-BP ID Sequence source
PF04516 (CP2) IPR007604 ENSP00000251808-D1 T199523_2.00 GigaDB (2015-Oct-22)
NCBI Gene Info:
This gene encodes a tumor suppressor protein containing transcriptional activation, DNA binding, and oligomerization domains. The encoded protein responds to diverse cellular stresses to regulate expression of target genes, thereby inducing cell cycle arrest, apoptosis, senescence, DNA repair, or changes in metabolism. Mutations in this gene are associated with a variety of human cancers, including hereditary cancers such as Li-Fraumeni syndrome. Alternative splicing of this gene and the use of alternate promoters result in multiple transcript variants and isoforms. Additional isoforms have also been shown to result from the use of alternate translation initiation codons from identical transcript variants (PMIDs: 12032546, 20937277). [provided by RefSeq, Dec 2016]

Directly determined binding motifs

Name/Motif ID Species Forward Reverse Type/Study/Study ID SR
Score
DBD
Identity
No direct experiments

Motifs from related TFs

Name/Motif ID Species Forward Reverse Type/Study/Study ID SR
Score
DBD
Identity
GRHL2
M08129_2.00
Homo sapiens
NNNAACTGGTTTNNN

NNNAAACCAGTTNNN
ChIP-seq
Mathelier et al.(2014)
MA1105.1
0.884 0.884
GRHL2
M09125_2.00
Homo sapiens
AACYDGYYBDDC

GHHVRRCHRGTT
Misc
Kulakovskiy et al.(2013)
GRHL2_HUMAN.H11MO.0.A
0.884 0.884
GRHL2
M09558_2.00
Homo sapiens
NRAACHDGHHDDDCHDGTTY

RAACHDGHHHDDCHDGTTYN
Misc
Heinz et al.(2010)
HBE-GRHL2_GSE46194
0.884 0.884
Grhl2
M09126_2.00
Mus musculus
RDCCDGTYYKDC

GHMRRACHGGHY
Misc
Kulakovskiy et al.(2013)
GRHL2_MOUSE.H11MO.0.A
0.880 0.880
For this family, TFs with SR scores > 0.700 will likely have a similar motif

DNA Binding Domains

Protein ID Domain From To Sequence
ENSP00000251808-D1 Grainyhead 208 432

Links

Other Grainyhead family TFs
Other Bos grunniens TFs

120 Related TFs

Name Species Gene ID Motif Evidence SR
Score
Action
GRHL2 Tursiops truncatus ENSTTRG00000005794 I 1.000
GRHL2 Bos taurus ENSBTAG00000004518 I 1.000
ENSMPUG00000015153 Mustela putorius furo ENSMPUG00000015153 I 0.996
ENSAMEG00000000278 Ailuropoda melanoleuca ENSAMEG00000000278 I 0.996
ENSOARG00000018325 Ovis aries ENSOARG00000018325 I 0.996
GRHL2 Equus caballus ENSECAG00000013681 I 0.991
GRHL2 Oryctolagus cuniculus ENSOCUG00000004750 I 0.991
GRHL2 Dasypus novemcinctus ENSDNOG00000048641 I 0.991
ENSTGUG00000012086 Taeniopygia guttata ENSTGUG00000012086 I 0.990
GRHL2 Felis catus ENSFCAG00000004963 I 0.987
ENSP00000379261 Macaca fascicularis ENSP00000379261 I 0.942
GRHL2 Macaca mulatta ENSMMUG00000020995 I 0.942
GRHL2 Ornithorhynchus anatinus ENSOANG00000004305 I 0.923
GRHL2 Loxodonta africana ENSLAFG00000010356 I 0.916
GRHL2 Canis familiaris ENSCAFG00000000587 I 0.911
GRHL2 Cavia porcellus ENSCPOG00000005630 I 0.905
ENSPPYG00000018794 Pongo abelii ENSPPYG00000018794 I 0.902
grhl1 Danio rerio ENSDARG00000061391 I 0.901
ENSSTOG00000001498 Ictidomys tridecemlineatus ENSSTOG00000001498 I 0.900
GRHL2 Otolemur garnettii ENSOGAG00000004751 I 0.896
GRHL2 Sus scrofa ENSSSCG00000006060 I 0.896
Grhl2 Rattus norvegicus ENSRNOG00000007000 I 0.892
Grhl2 Mus musculus ENSMUSG00000022286 D 0.892
GRHL2 Gorilla gorilla ENSGGOG00000004401 I 0.892
ENSSHAG00000015849 Sarcophilus harrisii ENSSHAG00000015849 I 0.887
GRHL2 Monodelphis domestica ENSMODG00000006048 I 0.887
Gfo_R006019 Geospiza fortis Gfo_R006019 I 0.885
GRHL2 Pan troglodytes ENSPTRG00000020479 I 0.884
ENSCSAG00000011989 Chlorocebus sabaeus ENSCSAG00000011989 I 0.884
Myotis_brandtii_GRHL2_10032153 Myotis brandtii Myotis_brandtii_GRHL2_10032153 I 0.884
ENSNLEG00000003271 Nomascus leucogenys ENSNLEG00000003271 I 0.884
GRHL2 Homo sapiens ENSG00000083307 D 0.884
ENSPANG00000017807 Papio anubis ENSPANG00000017807 I 0.884
GRHL2 Callithrix jacchus ENSCJAG00000015886 I 0.884
GRHL2 Myotis lucifugus ENSMLUG00000010961 I 0.884
GRHL2 Erinaceus europaeus ENSEEUG00000015263 I 0.881
ENSPMAG00000005876 Petromyzon marinus ENSPMAG00000005876 I 0.878
ENSSTOG00000019842 Ictidomys tridecemlineatus ENSSTOG00000019842 I 0.878
ENSGALG00000014208 Gallus gallus ENSGALG00000014208 I 0.877
Afo_R002230 Aptenodytes forsteri Afo_R002230 I 0.874
Brh_R013325 Buceros rhinoceros Brh_R013325 I 0.874
grhl2 Xenopus tropicalis XB-GENE-485995 I 0.874
Aan_R003923 Calypte anna Aan_R003923 I 0.874
ENSFALG00000005879 Ficedula albicollis ENSFALG00000005879 I 0.874
ENSAPLG00000002882 Anas platyrhynchos ENSAPLG00000002882 I 0.871
GRHL2 Microcebus murinus ENSMICG00000014771 I 0.867
ENSPSIG00000003669 Pelodiscus sinensis ENSPSIG00000003669 I 0.853
GRHL2 Meleagris gallopavo ENSMGAG00000012259 I 0.853
Pvit_03833 Pogona vitticeps Pvit_03833 I 0.849
GRHL2 Anolis carolinensis ENSACAG00000008759 I 0.847
ENSLACG00000006172 Latimeria chalumnae ENSLACG00000006172 I 0.844
grhl2b Danio rerio ENSDARG00000061974 I 0.839
ENSLOCG00000009655 Lepisosteus oculatus ENSLOCG00000009655 I 0.834
ENSPFOG00000006095 Poecilia formosa ENSPFOG00000006095 I 0.806
ENSXMAG00000003725 Xiphophorus maculatus ENSXMAG00000003725 I 0.806
grhl2b Gasterosteus aculeatus ENSGACG00000003695 I 0.802
ENSPMAG00000005869 Petromyzon marinus ENSPMAG00000005869 I 0.797
ENSONIG00000002710 Oreochromis niloticus ENSONIG00000002710 I 0.778
Alligator_sinensis_CCG017490.1 Alligator sinensis Alligator_sinensis_CCG017490.1 I 0.774
Ogr11913 Ophisaurus gracilis Ogr11913 I 0.774
ENSAMXG00000000221 Astyanax mexicanus ENSAMXG00000000221 I 0.773
grhl2b Tetraodon nigroviridis ENSTNIG00000009151 I 0.772
grhl2b Takifugu rubripes ENSTRUG00000002119 I 0.764
grhl2a Danio rerio ENSDARG00000058342 I 0.758
ENSMMUP00000002046 Macaca fascicularis ENSMMUP00000002046 I 0.756
ENSNLEG00000013634 Nomascus leucogenys ENSNLEG00000013634 I 0.756
GRHL1 Macaca mulatta ENSMMUG00000001535 I 0.756
GRHL1 Dasypus novemcinctus ENSDNOG00000014493 I 0.756
ENSCSAG00000007158 Chlorocebus sabaeus ENSCSAG00000007158 I 0.756
Tal_R005229 Tyto alba Tal_R005229 I 0.754
GRHL1 Gorilla gorilla ENSGGOG00000002692 I 0.751
GRHL1 Vicugna pacos ENSVPAG00000010842 I 0.751
GRHL1 Loxodonta africana ENSLAFG00000009330 I 0.751
ENSOARG00000015298 Ovis aries ENSOARG00000015298 I 0.751
grhl1.L Xenopus laevis XB-GENE-486580 I 0.750
XP_002938935 Xenopus tropicalis XP_002938935 I 0.750
grhl1 Tetraodon nigroviridis ENSTNIG00000017317 I 0.748
GRHL1 Homo sapiens ENSG00000134317 D 0.746
ENSPANG00000020814 Papio anubis ENSPANG00000020814 I 0.746
GRHL1 Callithrix jacchus ENSCJAG00000006431 I 0.746
ENSPPYG00000012661 Pongo abelii ENSPPYG00000012661 I 0.746
GRHL1 Equus caballus ENSECAG00000015969 I 0.746
ENSSHAG00000002291 Sarcophilus harrisii ENSSHAG00000002291 I 0.746
grhl2a Tetraodon nigroviridis ENSTNIG00000013309 I 0.744
ENSMPUG00000013263 Mustela putorius furo ENSMPUG00000013263 I 0.742
ENSP00000384209-D1 Bos grunniens ENSP00000384209-D1 I 0.742
ENSFALG00000006639 Ficedula albicollis ENSFALG00000006639 I 0.742
Afo_R015753 Aptenodytes forsteri Afo_R015753 I 0.742
GRHL1 Canis familiaris ENSCAFG00000003394 I 0.742
Gfo_R015266 Geospiza fortis Gfo_R015266 I 0.742
grhl1 Takifugu rubripes ENSTRUG00000013628 I 0.742
GRHL1 Pan troglodytes ENSPTRG00000011643 I 0.742
ENSAMEG00000011320 Ailuropoda melanoleuca ENSAMEG00000011320 I 0.742
ENSPFOG00000004774 Poecilia formosa ENSPFOG00000004774 I 0.742
Tal_R012680 Tyto alba Tal_R012680 I 0.742
GRHL1 Bos taurus ENSBTAG00000007485 I 0.742
GRHL1 Cavia porcellus ENSCPOG00000010783 I 0.741
Grhl1 Mus musculus ENSMUSG00000020656 I 0.740
ENSAPLG00000008667 Anas platyrhynchos ENSAPLG00000008667 I 0.737
GRHL1 Taeniopygia guttata ENSTGUG00000013038 I 0.737
grhl1 Oryzias latipes ENSORLG00000015232 I 0.736
GRHL1 Felis catus ENSFCAG00000007856 I 0.732
GRHL1 Otolemur garnettii ENSOGAG00000014342 I 0.731
ENSONIG00000003707 Oreochromis niloticus ENSONIG00000003707 I 0.729
grhl1 Gasterosteus aculeatus ENSGACG00000008845 I 0.727
ENSLOCG00000016835 Lepisosteus oculatus ENSLOCG00000016835 I 0.724
ENSAMXG00000016712 Astyanax mexicanus ENSAMXG00000016712 I 0.719
Ogr04284 Ophisaurus gracilis Ogr04284 I 0.719
ENSGALG00000016439 Gallus gallus ENSGALG00000016439 I 0.716
GRHL1 Meleagris gallopavo ENSMGAG00000014007 I 0.716
GRHL1 Anolis carolinensis ENSACAG00000000132 I 0.716
ENSGMOG00000003256 Gadus morhua ENSGMOG00000003256 I 0.712
ENSXMAG00000013267 Xiphophorus maculatus ENSXMAG00000013267 I 0.711
GRHL1 Myotis lucifugus ENSMLUG00000002290 I 0.711
GRHL1 Monodelphis domestica ENSMODG00000014753 I 0.711
nDi.2.2.2.g12300 Dirofilaria immitis nDi.2.2.2.g12300 I 0.709
GRHL1 Ornithorhynchus anatinus ENSOANG00000007788 I 0.707
Brh_R003016 Buceros rhinoceros Brh_R003016 I 0.707
Myotis_brandtii_GRHL1_10020834 Myotis brandtii Myotis_brandtii_GRHL1_10020834 I 0.702
SNAPOd2T00016626001 Oikopleura dioica SNAPOd2T00016626001 I 0.700