grhl1 (Danio rerio)
Grainyhead

TF Information

Pfam ID Interpro ID Gene ID CIS-BP ID Sequence source Animal TF db
PF04516 (CP2) IPR007604 ENSDARG00000061391 T198955_2.00 Ensembl (2018-Dec-8) Link out
NCBI Gene Info:
Predicted to enable DNA-binding transcription activator activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Acts upstream of or within several processes, including desmosome organization; epiboly; and inner ear development. Located in cytoplasm. Is expressed in several structures, including epidermal cell; head; integument; pronephric duct; and sensory system. Orthologous to human GRHL1 (grainyhead like transcription factor 1). [provided by Alliance of Genome Resources, Apr 2022]

Directly determined binding motifs

Name/Motif ID Species Forward Reverse Type/Study/Study ID SR
Score		 DBD
Identity
No direct experiments

Motifs from related TFs

Name/Motif ID Species Forward Reverse Type/Study/Study ID SR
Score		 DBD
Identity
GRHL1
M03071_2.00 		Homo sapiens
RACYKGWHNDWCMGGTT
AACCKGWHNDWCMRGTY		 SELEX
Jolma et al.(2013)
GRHL1_1 		0.923 0.923
GRHL1
M03072_2.00 		Homo sapiens
DAACCGGTTH
DAACCGGTTH		 SELEX
Jolma et al.(2013)
GRHL1_2 		0.923 0.923
GRHL1
M03073_2.00 		Homo sapiens
HWAACCGGTTTD
HAAACCGGTTWD		 SELEX
Jolma et al.(2013)
GRHL1_3 		0.803 0.803
GRHL1
M04887_2.00 		Homo sapiens
DAACCGGTTH
DAACCGGTTH		 SELEX
Yin et al.(2017)
GRHL1_eDBD_HT-SELEX 		0.923 0.923
GRHL1
M04888_2.00 		Homo sapiens
DAACMKGTTH
DAACMKGTTH		 SELEX
Yin et al.(2017)
GRHL1_eDBD_Methyl-HT-SELEX 		0.923 0.923
GRHL2
M08129_2.00 		Homo sapiens
NNNAACTGGTTTNNN
NNNAAACCAGTTNNN		 ChIP-seq
Mathelier et al.(2014)
MA1105.1 		0.901 0.901
GRHL2
M09125_2.00 		Homo sapiens
AACYDGYYBDDC
GHHVRRCHRGTT		 Misc
Kulakovskiy et al.(2013)
GRHL2_HUMAN.H11MO.0.A 		0.901 0.901
Grhl2
M09126_2.00 		Mus musculus
RDCCDGTYYKDC
GHMRRACHGGHY		 Misc
Kulakovskiy et al.(2013)
GRHL2_MOUSE.H11MO.0.A 		0.901 0.901
GRHL2
M09558_2.00 		Homo sapiens
NRAACHDGHHDDDCHDGTTY
RAACHDGHHHDDCHDGTTYN		 Misc
Heinz et al.(2010)
HBE-GRHL2_GSE46194 		0.901 0.901
For this family, TFs with SR scores > 0.700 will likely have a similar motif

DNA Binding Domains

Protein ID Domain From To Sequence
ENSDARP00000123737 Grainyhead 1 91
ENSDARP00000124180 Grainyhead 220 432
ENSDARP00000124914 Grainyhead 220 432

Links

Other Grainyhead family TFs
Other Danio rerio TFs

156 Related TFs

Name Species Gene ID Motif Evidence SR
Score		 Action
grhl1 Takifugu rubripes ENSTRUG00000013628 I 0.967
grhl1 Tetraodon nigroviridis ENSTNIG00000017317 I 0.956
ENSONIG00000003707 Oreochromis niloticus ENSONIG00000003707 I 0.956
grhl1 Oryzias latipes ENSORLG00000015232 I 0.956
ENSXMAG00000013267 Xiphophorus maculatus ENSXMAG00000013267 I 0.945
GRHL1 Ornithorhynchus anatinus ENSOANG00000007788 I 0.945
ENSLOCG00000016835 Lepisosteus oculatus ENSLOCG00000016835 I 0.945
GRHL1 Callithrix jacchus ENSCJAG00000006431 I 0.934
GRHL1 Otolemur garnettii ENSOGAG00000014342 I 0.934
GRHL1 Loxodonta africana ENSLAFG00000009330 I 0.934
grhl1 Gasterosteus aculeatus ENSGACG00000008845 I 0.934
GRHL1 Pteropus vampyrus ENSPVAG00000002002 I 0.934
GRHL1 Felis catus ENSFCAG00000007856 I 0.934
Myotis_brandtii_GRHL1_10020834 Myotis brandtii Myotis_brandtii_GRHL1_10020834 I 0.934
ENSSTOG00000019842 Ictidomys tridecemlineatus ENSSTOG00000019842 I 0.932
GRHL1 Homo sapiens ENSG00000134317 D 0.923
Brh_R003016 Buceros rhinoceros Brh_R003016 I 0.923
ENSGALG00000016439 Gallus gallus ENSGALG00000016439 I 0.923
Gfo_R015266 Geospiza fortis Gfo_R015266 I 0.923
GRHL1 Monodelphis domestica ENSMODG00000014753 I 0.923
ENSP00000384209-D1 Bos grunniens ENSP00000384209-D1 I 0.923
ENSNLEG00000013634 Nomascus leucogenys ENSNLEG00000013634 I 0.923
GRHL1 Macaca mulatta ENSMMUG00000001535 I 0.923
GRHL1 Myotis lucifugus ENSMLUG00000002290 I 0.923
ENSSHAG00000002291 Sarcophilus harrisii ENSSHAG00000002291 I 0.923
GRHL1 Taeniopygia guttata ENSTGUG00000013038 I 0.923
GRHL1 Meleagris gallopavo ENSMGAG00000014007 I 0.923
GRHL1 Gorilla gorilla ENSGGOG00000002692 I 0.923
ENSFALG00000006639 Ficedula albicollis ENSFALG00000006639 I 0.923
ENSCSAG00000007158 Chlorocebus sabaeus ENSCSAG00000007158 I 0.923
ENSMMUP00000002046 Macaca fascicularis ENSMMUP00000002046 I 0.923
Tal_R012680 Tyto alba Tal_R012680 I 0.923
ENSAPLG00000008667 Anas platyrhynchos ENSAPLG00000008667 I 0.923
GRHL1 Bos taurus ENSBTAG00000007485 I 0.923
GRHL1 Dasypus novemcinctus ENSDNOG00000014493 I 0.923
Aan_R015393 Calypte anna Aan_R015393 I 0.923
Afo_R015753 Aptenodytes forsteri Afo_R015753 I 0.923
XP_002938936 Xenopus tropicalis XP_002938936 I 0.901
GRHL2 Bos taurus ENSBTAG00000004518 I 0.901
ENSP00000251808-D1 Bos grunniens ENSP00000251808-D1 I 0.901
GRHL2 Loxodonta africana ENSLAFG00000010356 I 0.901
Grhl2 Mus musculus ENSMUSG00000022286 D 0.901
ENSMPUG00000015153 Mustela putorius furo ENSMPUG00000015153 I 0.901
GRHL2 Microcebus murinus ENSMICG00000014771 I 0.901
GRHL2 Pan troglodytes ENSPTRG00000020479 I 0.901
ENSAMEG00000000278 Ailuropoda melanoleuca ENSAMEG00000000278 I 0.901
grhl2 Xenopus tropicalis XB-GENE-485995 I 0.901
GRHL2 Myotis lucifugus ENSMLUG00000010961 I 0.901
GRHL2 Ornithorhynchus anatinus ENSOANG00000004305 I 0.901
grhl1.L Xenopus laevis XB-GENE-486580 I 0.901
GRHL2 Tursiops truncatus ENSTTRG00000005794 I 0.901
GRHL2 Dasypus novemcinctus ENSDNOG00000048641 I 0.901
GRHL2 Homo sapiens ENSG00000083307 D 0.901
Myotis_brandtii_GRHL2_10032153 Myotis brandtii Myotis_brandtii_GRHL2_10032153 I 0.901
GRHL2 Felis catus ENSFCAG00000004963 I 0.901
ENSNLEG00000003271 Nomascus leucogenys ENSNLEG00000003271 I 0.901
Pvit_03833 Pogona vitticeps Pvit_03833 I 0.901
GRHL2 Sus scrofa ENSSSCG00000006060 I 0.901
Grhl2 Rattus norvegicus ENSRNOG00000007000 I 0.901
GRHL2 Otolemur garnettii ENSOGAG00000004751 I 0.901
ENSOARG00000018325 Ovis aries ENSOARG00000018325 I 0.901
Ogr04284 Ophisaurus gracilis Ogr04284 I 0.901
GRHL2 Callithrix jacchus ENSCJAG00000015886 I 0.901
ENSSHAG00000015849 Sarcophilus harrisii ENSSHAG00000015849 I 0.901
ENSPANG00000017807 Papio anubis ENSPANG00000017807 I 0.901
ENSCSAG00000011989 Chlorocebus sabaeus ENSCSAG00000011989 I 0.901
Cmyd_10003336 Chelonia mydas Cmyd_10003336 I 0.890
GRHL1 Oryctolagus cuniculus ENSOCUG00000017717 I 0.890
ENSGALG00000014208 Gallus gallus ENSGALG00000014208 I 0.890
grhl2b Danio rerio ENSDARG00000061974 I 0.890
ENSAPLG00000002882 Anas platyrhynchos ENSAPLG00000002882 I 0.890
ENSAMXG00000000221 Astyanax mexicanus ENSAMXG00000000221 I 0.890
ENSLACG00000006172 Latimeria chalumnae ENSLACG00000006172 I 0.890
ENSTGUG00000012086 Taeniopygia guttata ENSTGUG00000012086 I 0.890
ENSPSIG00000010930 Pelodiscus sinensis ENSPSIG00000010930 I 0.890
GRHL2 Meleagris gallopavo ENSMGAG00000012259 I 0.890
ENSPSIG00000003669 Pelodiscus sinensis ENSPSIG00000003669 I 0.890
grhl2b Takifugu rubripes ENSTRUG00000002119 I 0.879
ENSPFOG00000006095 Poecilia formosa ENSPFOG00000006095 I 0.879
ENSONIG00000002710 Oreochromis niloticus ENSONIG00000002710 I 0.868
grhl2a Danio rerio ENSDARG00000058342 I 0.868
ENSPMAG00000005876 Petromyzon marinus ENSPMAG00000005876 I 0.865
ENSPFOG00000004774 Poecilia formosa ENSPFOG00000004774 I 0.857
GRHL1 Vicugna pacos ENSVPAG00000010842 I 0.813
ENSMPUG00000013263 Mustela putorius furo ENSMPUG00000013263 I 0.812
GRHL1 Canis familiaris ENSCAFG00000003394 I 0.812
ENSOARG00000015298 Ovis aries ENSOARG00000015298 I 0.812
ENSAMEG00000011320 Ailuropoda melanoleuca ENSAMEG00000011320 I 0.812
GRHL1 Equus caballus ENSECAG00000015969 I 0.812
ENSPANG00000020814 Papio anubis ENSPANG00000020814 I 0.808
GRHL1 Pan troglodytes ENSPTRG00000011643 I 0.808
ENSPPYG00000012661 Pongo abelii ENSPPYG00000012661 I 0.808
Alligator_sinensis_CCG017490.1 Alligator sinensis Alligator_sinensis_CCG017490.1 I 0.806
grhl2a Oryzias latipes ENSORLG00000002613 N 0.802
GRHL1 Cavia porcellus ENSCPOG00000010783 I 0.802
Grhl1 Mus musculus ENSMUSG00000020656 I 0.795
XP_002938935 Xenopus tropicalis XP_002938935 I 0.792
grhl2a Tetraodon nigroviridis ENSTNIG00000013309 I 0.791
ENSPFOG00000010589 Poecilia formosa ENSPFOG00000010589 N 0.791
grhl2a Takifugu rubripes ENSTRUG00000011936 N 0.780
Grhl1 Rattus norvegicus ENSRNOG00000054989 I 0.769
GRHL1 Anolis carolinensis ENSACAG00000000132 I 0.767
ENSAMXG00000017898 Astyanax mexicanus ENSAMXG00000017898 N 0.762
GRHL2 Canis familiaris ENSCAFG00000000587 I 0.757
ENSGMOG00000003256 Gadus morhua ENSGMOG00000003256 I 0.750
grhl2a Gasterosteus aculeatus ENSGACG00000003655 I 0.747
ENSPMAG00000005869 Petromyzon marinus ENSPMAG00000005869 I 0.746
GRHL2 Cavia porcellus ENSCPOG00000005630 I 0.736
Afo_R008962 Aptenodytes forsteri Afo_R008962 N 0.736
Brh_R012570 Buceros rhinoceros Brh_R012570 N 0.736
Tal_R005479 Tyto alba Tal_R005479 N 0.736
ENSSTOG00000001498 Ictidomys tridecemlineatus ENSSTOG00000001498 I 0.733
ENSSTOG00000002434 Ictidomys tridecemlineatus ENSSTOG00000002434 I 0.732
GRHL2 Gorilla gorilla ENSGGOG00000004401 I 0.726
ENSSTOG00000023529 Ictidomys tridecemlineatus ENSSTOG00000023529 N 0.725
GRHL2 Erinaceus europaeus ENSEEUG00000015263 I 0.725
GRHL3 Taeniopygia guttata ENSTGUG00000001153 N 0.725
ENSFALG00000000490 Ficedula albicollis ENSFALG00000000490 N 0.725
GRHL2 Monodelphis domestica ENSMODG00000006048 I 0.725
Gfo_R006019 Geospiza fortis Gfo_R006019 I 0.725
Gfo_R011603 Geospiza fortis Gfo_R011603 N 0.725
ENSPPYG00000018794 Pongo abelii ENSPPYG00000018794 I 0.723
Afo_R002230 Aptenodytes forsteri Afo_R002230 I 0.721
ENSFALG00000005879 Ficedula albicollis ENSFALG00000005879 I 0.721
Aan_R003923 Calypte anna Aan_R003923 I 0.721
Brh_R013325 Buceros rhinoceros Brh_R013325 I 0.721
ENSP00000379261 Macaca fascicularis ENSP00000379261 I 0.719
GRHL2 Macaca mulatta ENSMMUG00000020995 I 0.719
GRHL2 Oryctolagus cuniculus ENSOCUG00000004750 I 0.716
GRHL3 Gorilla gorilla ENSGGOG00000001792 N 0.714
Alligator_sinensis_CCG010998.1 Alligator sinensis Alligator_sinensis_CCG010998.1 N 0.714
GRHL3 Microcebus murinus ENSMICG00000000542 N 0.714
GRHL3 Homo sapiens ENSG00000158055 N 0.714
Myotis_brandtii_Grhl3_10029711 Myotis brandtii Myotis_brandtii_Grhl3_10029711 N 0.714
ENSCSAG00000000939 Chlorocebus sabaeus ENSCSAG00000000939 N 0.714
Grhl3 Dipodomys ordii ENSDORG00000001381 N 0.714
GRHL3 Equus caballus ENSECAG00000009866 N 0.714
ENSMPUG00000015840 Mustela putorius furo ENSMPUG00000015840 N 0.714
GRHL3 Loxodonta africana ENSLAFG00000001618 N 0.714
GRHL3 Pan troglodytes ENSPTRG00000000344 N 0.714
GRHL3 Procavia capensis ENSPCAG00000011355 N 0.714
ENSPANG00000024748 Papio anubis ENSPANG00000024748 N 0.714
ENSPPYG00000001721 Pongo abelii ENSPPYG00000001721 N 0.714
ENSP00000288955 Macaca fascicularis ENSP00000288955 N 0.714
ENSOARG00000006636 Ovis aries ENSOARG00000006636 N 0.714
Grhl3 Mus musculus ENSMUSG00000037188 N 0.714
GRHL2 Anolis carolinensis ENSACAG00000008759 I 0.712
GRHL2 Equus caballus ENSECAG00000013681 I 0.711
nDi.2.2.2.g12300 Dirofilaria immitis nDi.2.2.2.g12300 I 0.709
ENSLACG00000015480 Latimeria chalumnae ENSLACG00000015480 N 0.703
GRHL3 Anolis carolinensis ENSACAG00000017262 N 0.703
ENSAMEG00000009982 Ailuropoda melanoleuca ENSAMEG00000009982 N 0.703
GRHL3 Sus scrofa ENSSSCG00000003539 N 0.703
GRHL3 Bos taurus ENSBTAG00000019791 N 0.703
ENSBTAP00000026370-D1 Bos grunniens ENSBTAP00000026370-D1 N 0.703