GRHL1 (Homo sapiens)
Grainyhead

TF Information

Pfam ID Interpro ID Gene ID CIS-BP ID Sequence source Animal TF db
PF04516 (CP2) IPR007604 ENSG00000134317 T199007_2.00 Ensembl (2018-Dec-8) Link out
NCBI Gene Info:
This gene encodes a member of the grainyhead family of transcription factors. The encoded protein can exist as a homodimer or can form heterodimers with sister-of-mammalian grainyhead or brother-of-mammalian grainyhead. This protein functions as a transcription factor during development. [provided by RefSeq, Jun 2009]

Directly determined binding motifs

Name/Motif ID Species Forward Reverse Type/Study/Study ID SR
Score
DBD
Identity
GRHL1
M03071_2.00
Homo sapiens
RACYKGWHNDWCMGGTT

AACCKGWHNDWCMRGTY
SELEX
Jolma et al.(2013)
GRHL1_1
(Direct) (Direct)
GRHL1
M03072_2.00
Homo sapiens
DAACCGGTTH

DAACCGGTTH
SELEX
Jolma et al.(2013)
GRHL1_2
(Direct) (Direct)
GRHL1
M03073_2.00
Homo sapiens
HWAACCGGTTTD

HAAACCGGTTWD
SELEX
Jolma et al.(2013)
GRHL1_3
(Direct) (Direct)
GRHL1
M04887_2.00
Homo sapiens
DAACCGGTTH

DAACCGGTTH
SELEX
Yin et al.(2017)
GRHL1_eDBD_HT-SELEX
(Direct) (Direct)
GRHL1
M04888_2.00
Homo sapiens
DAACMKGTTH

DAACMKGTTH
SELEX
Yin et al.(2017)
GRHL1_eDBD_Methyl-HT-SELEX
(Direct) (Direct)

Motifs from related TFs

Name/Motif ID Species Forward Reverse Type/Study/Study ID SR
Score
DBD
Identity
GRHL2
M08129_2.00
Homo sapiens
NNNAACTGGTTTNNN

NNNAAACCAGTTNNN
ChIP-seq
Mathelier et al.(2014)
MA1105.1
0.732 0.732
GRHL2
M09125_2.00
Homo sapiens
AACYDGYYBDDC

GHHVRRCHRGTT
Misc
Kulakovskiy et al.(2013)
GRHL2_HUMAN.H11MO.0.A
0.732 0.732
Grhl2
M09126_2.00
Mus musculus
RDCCDGTYYKDC

GHMRRACHGGHY
Misc
Kulakovskiy et al.(2013)
GRHL2_MOUSE.H11MO.0.A
0.723 0.723
GRHL2
M09558_2.00
Homo sapiens
NRAACHDGHHDDDCHDGTTY

RAACHDGHHHDDCHDGTTYN
Misc
Heinz et al.(2010)
HBE-GRHL2_GSE46194
0.723 0.723
For this family, TFs with SR scores > 0.700 will likely have a similar motif

DNA Binding Domains

Protein ID Domain From To Sequence
ENSP00000324693 Grainyhead 230 442
ENSP00000384209 Grainyhead 34 253
ENSP00000418275 Grainyhead 230 442

Links

Other Grainyhead family TFs
Other Homo sapiens TFs

109 Related TFs

Name Species Gene ID Motif Evidence SR
Score
Action
GRHL1 Pan troglodytes ENSPTRG00000011643 I 0.995
GRHL1 Gorilla gorilla ENSGGOG00000002692 I 0.995
ENSSTOG00000002434 Ictidomys tridecemlineatus ENSSTOG00000002434 I 0.993
ENSMMUP00000002046 Macaca fascicularis ENSMMUP00000002046 I 0.991
GRHL1 Macaca mulatta ENSMMUG00000001535 I 0.991
ENSNLEG00000013634 Nomascus leucogenys ENSNLEG00000013634 I 0.991
GRHL1 Dasypus novemcinctus ENSDNOG00000014493 I 0.991
ENSCSAG00000007158 Chlorocebus sabaeus ENSCSAG00000007158 I 0.991
ENSPANG00000020814 Papio anubis ENSPANG00000020814 I 0.991
ENSPPYG00000012661 Pongo abelii ENSPPYG00000012661 I 0.991
GRHL1 Loxodonta africana ENSLAFG00000009330 I 0.986
GRHL1 Vicugna pacos ENSVPAG00000010842 I 0.986
GRHL1 Callithrix jacchus ENSCJAG00000006431 I 0.986
GRHL1 Equus caballus ENSECAG00000015969 I 0.986
Myotis_brandtii_GRHL1_10020834 Myotis brandtii Myotis_brandtii_GRHL1_10020834 I 0.986
ENSSHAG00000002291 Sarcophilus harrisii ENSSHAG00000002291 I 0.981
GRHL1 Pteropus vampyrus ENSPVAG00000002002 I 0.981
ENSMPUG00000013263 Mustela putorius furo ENSMPUG00000013263 I 0.981
GRHL1 Myotis lucifugus ENSMLUG00000002290 I 0.981
GRHL1 Canis familiaris ENSCAFG00000003394 I 0.981
ENSOARG00000015298 Ovis aries ENSOARG00000015298 I 0.977
ENSAMEG00000011320 Ailuropoda melanoleuca ENSAMEG00000011320 I 0.977
GRHL1 Otolemur garnettii ENSOGAG00000014342 I 0.977
GRHL1 Felis catus ENSFCAG00000007856 I 0.977
GRHL1 Cavia porcellus ENSCPOG00000010783 I 0.972
ENSP00000384209-D1 Bos grunniens ENSP00000384209-D1 I 0.972
GRHL1 Monodelphis domestica ENSMODG00000014753 I 0.972
GRHL1 Bos taurus ENSBTAG00000007485 I 0.972
GRHL1 Ornithorhynchus anatinus ENSOANG00000007788 I 0.972
Grhl1 Mus musculus ENSMUSG00000020656 I 0.963
GRHL1 Oryctolagus cuniculus ENSOCUG00000017717 I 0.962
GRHL1 Meleagris gallopavo ENSMGAG00000014007 I 0.962
ENSGALG00000016439 Gallus gallus ENSGALG00000016439 I 0.962
ENSSTOG00000019842 Ictidomys tridecemlineatus ENSSTOG00000019842 I 0.959
GRHL1 Tupaia belangeri ENSTBEG00000007777 I 0.958
Tal_R012680 Tyto alba Tal_R012680 I 0.945
ENSAPLG00000008667 Anas platyrhynchos ENSAPLG00000008667 I 0.945
Afo_R015753 Aptenodytes forsteri Afo_R015753 I 0.945
Gfo_R015266 Geospiza fortis Gfo_R015266 I 0.940
ENSFALG00000006639 Ficedula albicollis ENSFALG00000006639 I 0.940
grhl1.L Xenopus laevis XB-GENE-486580 I 0.939
GRHL1 Taeniopygia guttata ENSTGUG00000013038 I 0.935
XP_002938935 Xenopus tropicalis XP_002938935 I 0.934
XP_002938936 Xenopus tropicalis XP_002938936 I 0.929
grhl1 Danio rerio ENSDARG00000061391 I 0.923
Ogr04284 Ophisaurus gracilis Ogr04284 I 0.908
GRHL1 Anolis carolinensis ENSACAG00000000132 I 0.907
Brh_R003016 Buceros rhinoceros Brh_R003016 I 0.892
Aan_R015393 Calypte anna Aan_R015393 I 0.892
ENSPSIG00000010930 Pelodiscus sinensis ENSPSIG00000010930 I 0.873
ENSTSYG00000004124 Tarsius syrichta ENSTSYG00000004124 I 0.848
Grhl1 Rattus norvegicus ENSRNOG00000054989 I 0.847
Tal_R009556 Tyto alba Tal_R009556 I 0.837
ENSTGUG00000014574 Taeniopygia guttata ENSTGUG00000014574 I 0.837
Alligator_sinensis_CCG017490.1 Alligator sinensis Alligator_sinensis_CCG017490.1 I 0.831
ENSLOCG00000016835 Lepisosteus oculatus ENSLOCG00000016835 I 0.822
ENSPMAG00000005876 Petromyzon marinus ENSPMAG00000005876 I 0.811
grhl1 Takifugu rubripes ENSTRUG00000013628 I 0.798
ENSONIG00000003707 Oreochromis niloticus ENSONIG00000003707 I 0.793
ENSTGUG00000012086 Taeniopygia guttata ENSTGUG00000012086 I 0.793
Pvit_14440 Pogona vitticeps Pvit_14440 I 0.779
Cmyd_10003336 Chelonia mydas Cmyd_10003336 I 0.777
ENSXMAG00000013267 Xiphophorus maculatus ENSXMAG00000013267 I 0.775
grhl1 Gasterosteus aculeatus ENSGACG00000008845 I 0.775
grhl1 Tetraodon nigroviridis ENSTNIG00000017317 I 0.775
ENSPFOG00000004774 Poecilia formosa ENSPFOG00000004774 I 0.765
grhl1 Oryzias latipes ENSORLG00000015232 I 0.764
ENSPMAG00000005869 Petromyzon marinus ENSPMAG00000005869 I 0.763
ENSGMOG00000003256 Gadus morhua ENSGMOG00000003256 I 0.760
ENSOARG00000018325 Ovis aries ENSOARG00000018325 I 0.746
GRHL2 Tursiops truncatus ENSTTRG00000005794 I 0.746
GRHL2 Bos taurus ENSBTAG00000004518 I 0.746
ENSP00000251808-D1 Bos grunniens ENSP00000251808-D1 I 0.746
grhl2b Takifugu rubripes ENSTRUG00000002119 I 0.745
GRHL2 Myotis lucifugus ENSMLUG00000010961 I 0.737
Myotis_brandtii_GRHL2_10032153 Myotis brandtii Myotis_brandtii_GRHL2_10032153 I 0.737
ENSPSIG00000003669 Pelodiscus sinensis ENSPSIG00000003669 I 0.737
ENSNLEG00000003271 Nomascus leucogenys ENSNLEG00000003271 I 0.732
ENSCSAG00000011989 Chlorocebus sabaeus ENSCSAG00000011989 I 0.732
GRHL2 Callithrix jacchus ENSCJAG00000015886 I 0.732
GRHL2 Homo sapiens ENSG00000083307 D 0.732
GRHL2 Meleagris gallopavo ENSMGAG00000012259 I 0.732
ENSPANG00000017807 Papio anubis ENSPANG00000017807 I 0.732
GRHL2 Pan troglodytes ENSPTRG00000020479 I 0.732
GRHL2 Canis familiaris ENSCAFG00000000587 I 0.729
ENSONIG00000002710 Oreochromis niloticus ENSONIG00000002710 I 0.728
ENSLACG00000006172 Latimeria chalumnae ENSLACG00000006172 I 0.728
GRHL2 Microcebus murinus ENSMICG00000014771 I 0.728
Pvit_03833 Pogona vitticeps Pvit_03833 I 0.728
ENSAPLG00000002882 Anas platyrhynchos ENSAPLG00000002882 I 0.723
GRHL2 Loxodonta africana ENSLAFG00000010356 I 0.721
ENSP00000379261 Macaca fascicularis ENSP00000379261 I 0.710
GRHL2 Otolemur garnettii ENSOGAG00000004751 I 0.710
GRHL2 Macaca mulatta ENSMMUG00000020995 I 0.710
GRHL2 Cavia porcellus ENSCPOG00000005630 I 0.709
ENSPFOG00000006095 Poecilia formosa ENSPFOG00000006095 I 0.709
GRHL2 Felis catus ENSFCAG00000004963 I 0.707
GRHL2 Dasypus novemcinctus ENSDNOG00000048641 I 0.707
ENSAMEG00000000278 Ailuropoda melanoleuca ENSAMEG00000000278 I 0.707
ENSMPUG00000015153 Mustela putorius furo ENSMPUG00000015153 I 0.707
GRHL2 Oryctolagus cuniculus ENSOCUG00000004750 I 0.707
ENSSTOG00000001498 Ictidomys tridecemlineatus ENSSTOG00000001498 I 0.706
GRHL2 Ornithorhynchus anatinus ENSOANG00000004305 I 0.705
GRHL2 Sus scrofa ENSSSCG00000006060 I 0.703
Grhl2 Mus musculus ENSMUSG00000022286 D 0.703
GRHL2 Equus caballus ENSECAG00000013681 I 0.702
Gfo_R006019 Geospiza fortis Gfo_R006019 I 0.702
ENSGALG00000014208 Gallus gallus ENSGALG00000014208 I 0.700