Grhl1 (Mus musculus)
Grainyhead

TF Information

Pfam ID Interpro ID Gene ID CIS-BP ID Sequence source Animal TF db
PF04516 (CP2) IPR007604 ENSMUSG00000020656 T199108_2.00 Ensembl (2018-Dec-8) Link out
NCBI Gene Info:
Enables transcription cis-regulatory region binding activity. Involved in epidermis development. Acts upstream of or within desmosome organization; establishment of skin barrier; and regulation of keratinocyte differentiation. Located in nucleus. Is expressed in several structures, including alimentary system; central nervous system; genitourinary system; heart; and sensory organ. Orthologous to human GRHL1 (grainyhead like transcription factor 1). [provided by Alliance of Genome Resources, Apr 2022]

Directly determined binding motifs

Name/Motif ID Species Forward Reverse Type/Study/Study ID SR
Score		 DBD
Identity
No direct experiments

Motifs from related TFs

Name/Motif ID Species Forward Reverse Type/Study/Study ID SR
Score		 DBD
Identity
GRHL1
M03071_2.00 		Homo sapiens
RACYKGWHNDWCMGGTT
AACCKGWHNDWCMRGTY		 SELEX
Jolma et al.(2013)
GRHL1_1 		0.963 0.963
GRHL1
M03072_2.00 		Homo sapiens
DAACCGGTTH
DAACCGGTTH		 SELEX
Jolma et al.(2013)
GRHL1_2 		0.963 0.963
GRHL1
M03073_2.00 		Homo sapiens
HWAACCGGTTTD
HAAACCGGTTWD		 SELEX
Jolma et al.(2013)
GRHL1_3 		0.963 0.963
GRHL1
M04887_2.00 		Homo sapiens
DAACCGGTTH
DAACCGGTTH		 SELEX
Yin et al.(2017)
GRHL1_eDBD_HT-SELEX 		0.963 0.963
GRHL1
M04888_2.00 		Homo sapiens
DAACMKGTTH
DAACMKGTTH		 SELEX
Yin et al.(2017)
GRHL1_eDBD_Methyl-HT-SELEX 		0.963 0.963
GRHL2
M08129_2.00 		Homo sapiens
NNNAACTGGTTTNNN
NNNAAACCAGTTNNN		 ChIP-seq
Mathelier et al.(2014)
MA1105.1 		0.726 0.726
GRHL2
M09125_2.00 		Homo sapiens
AACYDGYYBDDC
GHHVRRCHRGTT		 Misc
Kulakovskiy et al.(2013)
GRHL2_HUMAN.H11MO.0.A 		0.726 0.726
Grhl2
M09126_2.00 		Mus musculus
RDCCDGTYYKDC
GHMRRACHGGHY		 Misc
Kulakovskiy et al.(2013)
GRHL2_MOUSE.H11MO.0.A 		0.726 0.726
GRHL2
M09558_2.00 		Homo sapiens
NRAACHDGHHDDDCHDGTTY
RAACHDGHHHDDCHDGTTYN		 Misc
Heinz et al.(2010)
HBE-GRHL2_GSE46194 		0.726 0.726
For this family, TFs with SR scores > 0.700 will likely have a similar motif

DNA Binding Domains

Protein ID Domain From To Sequence
ENSMUSP00000020985 Grainyhead 146 360
ENSMUSP00000082689 Grainyhead 228 442

Links

Other Grainyhead family TFs
Other Mus musculus TFs

107 Related TFs

Name Species Gene ID Motif Evidence SR
Score		 Action
ENSPANG00000020814 Papio anubis ENSPANG00000020814 I 0.981
GRHL1 Otolemur garnettii ENSOGAG00000014342 I 0.981
ENSPPYG00000012661 Pongo abelii ENSPPYG00000012661 I 0.981
GRHL1 Pteropus vampyrus ENSPVAG00000002002 I 0.981
GRHL1 Pan troglodytes ENSPTRG00000011643 I 0.977
Myotis_brandtii_GRHL1_10020834 Myotis brandtii Myotis_brandtii_GRHL1_10020834 I 0.977
ENSSHAG00000002291 Sarcophilus harrisii ENSSHAG00000002291 I 0.972
GRHL1 Cavia porcellus ENSCPOG00000010783 I 0.972
GRHL1 Loxodonta africana ENSLAFG00000009330 I 0.967
ENSOARG00000015298 Ovis aries ENSOARG00000015298 I 0.967
GRHL1 Equus caballus ENSECAG00000015969 I 0.967
GRHL1 Callithrix jacchus ENSCJAG00000006431 I 0.967
GRHL1 Dasypus novemcinctus ENSDNOG00000014493 I 0.963
GRHL1 Homo sapiens ENSG00000134317 D 0.963
ENSNLEG00000013634 Nomascus leucogenys ENSNLEG00000013634 I 0.963
GRHL1 Macaca mulatta ENSMMUG00000001535 I 0.963
GRHL1 Monodelphis domestica ENSMODG00000014753 I 0.963
GRHL1 Myotis lucifugus ENSMLUG00000002290 I 0.963
ENSMMUP00000002046 Macaca fascicularis ENSMMUP00000002046 I 0.963
ENSCSAG00000007158 Chlorocebus sabaeus ENSCSAG00000007158 I 0.963
ENSMPUG00000013263 Mustela putorius furo ENSMPUG00000013263 I 0.962
GRHL1 Canis familiaris ENSCAFG00000003394 I 0.962
GRHL1 Felis catus ENSFCAG00000007856 I 0.958
ENSAMEG00000011320 Ailuropoda melanoleuca ENSAMEG00000011320 I 0.958
GRHL1 Gorilla gorilla ENSGGOG00000002692 I 0.958
GRHL1 Vicugna pacos ENSVPAG00000010842 I 0.958
GRHL1 Ornithorhynchus anatinus ENSOANG00000007788 I 0.949
GRHL1 Bos taurus ENSBTAG00000007485 I 0.944
ENSP00000384209-D1 Bos grunniens ENSP00000384209-D1 I 0.944
GRHL1 Meleagris gallopavo ENSMGAG00000014007 I 0.930
Tal_R012680 Tyto alba Tal_R012680 I 0.930
ENSFALG00000006639 Ficedula albicollis ENSFALG00000006639 I 0.930
Afo_R015753 Aptenodytes forsteri Afo_R015753 I 0.930
GRHL1 Taeniopygia guttata ENSTGUG00000013038 I 0.930
Gfo_R015266 Geospiza fortis Gfo_R015266 I 0.930
ENSAPLG00000008667 Anas platyrhynchos ENSAPLG00000008667 I 0.930
ENSGALG00000016439 Gallus gallus ENSGALG00000016439 I 0.930
GRHL1 Oryctolagus cuniculus ENSOCUG00000017717 I 0.926
grhl1.L Xenopus laevis XB-GENE-486580 I 0.925
XP_002938935 Xenopus tropicalis XP_002938935 I 0.920
XP_002938936 Xenopus tropicalis XP_002938936 I 0.912
Ogr04284 Ophisaurus gracilis Ogr04284 I 0.902
GRHL1 Anolis carolinensis ENSACAG00000000132 I 0.902
Grhl1 Rattus norvegicus ENSRNOG00000054989 I 0.865
Brh_R003016 Buceros rhinoceros Brh_R003016 I 0.860
Aan_R015393 Calypte anna Aan_R015393 I 0.860
ENSPSIG00000010930 Pelodiscus sinensis ENSPSIG00000010930 I 0.847
ENSTSYG00000004124 Tarsius syrichta ENSTSYG00000004124 I 0.841
Alligator_sinensis_CCG017490.1 Alligator sinensis Alligator_sinensis_CCG017490.1 I 0.823
ENSLOCG00000016835 Lepisosteus oculatus ENSLOCG00000016835 I 0.809
grhl1 Danio rerio ENSDARG00000061391 I 0.795
grhl1 Takifugu rubripes ENSTRUG00000013628 I 0.791
grhl1 Tetraodon nigroviridis ENSTNIG00000017317 I 0.791
ENSONIG00000003707 Oreochromis niloticus ENSONIG00000003707 I 0.781
grhl1 Oryzias latipes ENSORLG00000015232 I 0.777
grhl1 Gasterosteus aculeatus ENSGACG00000008845 I 0.772
Pvit_14440 Pogona vitticeps Pvit_14440 I 0.765
ENSXMAG00000013267 Xiphophorus maculatus ENSXMAG00000013267 I 0.758
ENSPFOG00000004774 Poecilia formosa ENSPFOG00000004774 I 0.756
ENSPMAG00000005869 Petromyzon marinus ENSPMAG00000005869 I 0.754
ENSMPUG00000015153 Mustela putorius furo ENSMPUG00000015153 I 0.740
ENSONIG00000002710 Oreochromis niloticus ENSONIG00000002710 I 0.740
ENSOARG00000018325 Ovis aries ENSOARG00000018325 I 0.740
ENSAMEG00000000278 Ailuropoda melanoleuca ENSAMEG00000000278 I 0.740
ENSP00000251808-D1 Bos grunniens ENSP00000251808-D1 I 0.740
GRHL2 Dasypus novemcinctus ENSDNOG00000048641 I 0.740
GRHL2 Tursiops truncatus ENSTTRG00000005794 I 0.740
GRHL2 Bos taurus ENSBTAG00000004518 I 0.740
GRHL2 Felis catus ENSFCAG00000004963 I 0.740
GRHL2 Canis familiaris ENSCAFG00000000587 I 0.738
GRHL2 Otolemur garnettii ENSOGAG00000004751 I 0.730
Myotis_brandtii_GRHL2_10032153 Myotis brandtii Myotis_brandtii_GRHL2_10032153 I 0.730
ENSLACG00000006172 Latimeria chalumnae ENSLACG00000006172 I 0.730
grhl2b Danio rerio ENSDARG00000061974 I 0.730
ENSPSIG00000003669 Pelodiscus sinensis ENSPSIG00000003669 I 0.730
Pvit_03833 Pogona vitticeps Pvit_03833 I 0.730
GRHL2 Loxodonta africana ENSLAFG00000010356 I 0.730
GRHL2 Myotis lucifugus ENSMLUG00000010961 I 0.730
GRHL2 Meleagris gallopavo ENSMGAG00000012259 I 0.726
GRHL2 Callithrix jacchus ENSCJAG00000015886 I 0.726
grhl2 Xenopus tropicalis XB-GENE-485995 I 0.726
ENSCSAG00000011989 Chlorocebus sabaeus ENSCSAG00000011989 I 0.726
GRHL2 Sus scrofa ENSSSCG00000006060 I 0.726
Grhl2 Mus musculus ENSMUSG00000022286 D 0.726
GRHL2 Pan troglodytes ENSPTRG00000020479 I 0.726
ENSPANG00000017807 Papio anubis ENSPANG00000017807 I 0.726
ENSNLEG00000003271 Nomascus leucogenys ENSNLEG00000003271 I 0.726
ENSPPYG00000018794 Pongo abelii ENSPPYG00000018794 I 0.726
GRHL2 Homo sapiens ENSG00000083307 D 0.726
Grhl2 Rattus norvegicus ENSRNOG00000007000 I 0.721
ENSSHAG00000015849 Sarcophilus harrisii ENSSHAG00000015849 I 0.721
GRHL2 Microcebus murinus ENSMICG00000014771 I 0.721
GRHL2 Ornithorhynchus anatinus ENSOANG00000004305 I 0.721
ENSAPLG00000002882 Anas platyrhynchos ENSAPLG00000002882 I 0.716
ENSXMAG00000003725 Xiphophorus maculatus ENSXMAG00000003725 I 0.716
ENSGALG00000014208 Gallus gallus ENSGALG00000014208 I 0.716
ENSPFOG00000006095 Poecilia formosa ENSPFOG00000006095 I 0.716
Gfo_R006019 Geospiza fortis Gfo_R006019 I 0.712
grhl2b Takifugu rubripes ENSTRUG00000002119 I 0.712
ENSTGUG00000012086 Taeniopygia guttata ENSTGUG00000012086 I 0.712
GRHL2 Macaca mulatta ENSMMUG00000020995 I 0.710
ENSP00000379261 Macaca fascicularis ENSP00000379261 I 0.710
GRHL2 Cavia porcellus ENSCPOG00000005630 I 0.709
GRHL2 Oryctolagus cuniculus ENSOCUG00000004750 I 0.707
ENSSTOG00000001498 Ictidomys tridecemlineatus ENSSTOG00000001498 I 0.706
GRHL2 Equus caballus ENSECAG00000013681 I 0.702