CIS-BP Database: Catalog of Inferred Sequence Binding Preferences
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Lhx4
(
Rattus norvegicus
)
Homeodomain
TF Information
Pfam ID
Interpro ID
Gene ID
CIS-BP ID
Sequence source
Animal TF db
PF00046 (Homeobox)
IPR001356
ENSRNOG00000003595
T215337_2.00
Ensembl (2018-Dec-8)
Link out
NCBI Gene Info:
Predicted to enable DNA-binding transcription activator activity, RNA polymerase II-specific; RNA polymerase II transcription regulatory region sequence-specific DNA binding activity; and methyl-CpG binding activity. Predicted to be involved in neuron differentiation and positive regulation of transcription by RNA polymerase II. Predicted to act upstream of or within several processes, including negative regulation of apoptotic process; neuron differentiation; and placenta development. Predicted to be active in nucleus. Human ortholog(s) of this gene implicated in panhypopituitarism. Orthologous to human LHX4 (LIM homeobox 4). [provided by Alliance of Genome Resources, Apr 2022]
Directly determined binding motifs
Name/Motif ID
Species
Forward
Reverse
Type/Study/Study ID
SR
Score
DBD
Identity
No direct experiments
Motifs from related TFs
Name/Motif ID
Species
Forward
Reverse
Type/Study/Study ID
SR
Score
DBD
Identity
Lhx4
M00430_2.00
Mus musculus
NYAATHN
NDATTRN
PBM
Berger et al.(2008)
Lhx4_1719
0.656
0.930
Lhx4
M03257_2.00
Mus musculus
BTAATTRN
NYAATTAV
SELEX
Jolma et al.(2013)
Lhx4_1
0.656
0.930
LHX4
M05063_2.00
Homo sapiens
BYAATYRV
BYRATTRV
SELEX
Yin et al.(2017)
LHX4_eDBD_HT-SELEX
0.656
0.930
LHX4
M05066_2.00
Homo sapiens
BTAATTAN
NTAATTAV
SELEX
Yin et al.(2017)
LHX4_FL_HT-SELEX
0.656
0.930
LHX4
M05064_2.00
Homo sapiens
BYAATTRV
BYAATTRV
SELEX
Yin et al.(2017)
LHX4_eDBD_Methyl-HT-SELEX_1
0.656
0.930
LHX4
M05065_2.00
Homo sapiens
NTWAYGHN
NDCRTWAN
SELEX
Yin et al.(2017)
LHX4_eDBD_Methyl-HT-SELEX_2
0.656
0.930
LHX4
M05067_2.00
Homo sapiens
NYAATTRN
NYAATTRN
SELEX
Yin et al.(2017)
LHX4_FL_Methyl-HT-SELEX_1
0.656
0.930
LHX4
M05068_2.00
Homo sapiens
NTAAYGHN
NDCRTTAN
SELEX
Yin et al.(2017)
LHX4_FL_Methyl-HT-SELEX_2
0.656
0.930
Lhx3
M00435_2.00
Mus musculus
NNNYAATHW
WDATTRNNN
PBM
Berger et al.(2008)
Lhx3_3431
0.651
0.877
Lhx3
M02687_2.00
Mus musculus
VRWTAATTAATTW
WAATTAATTAWYB
SELEX
Mathelier et al.(2014)
MA0135.1
0.651
0.877
LHX3
M09137_2.00
Homo sapiens
NYTAATTAAWTHH
DDAWTTAATTARN
Misc
Kulakovskiy et al.(2013)
LHX3_HUMAN.H11MO.0.C
0.651
0.877
Lhx3
M09188_2.00
Mus musculus
NYTRATKRV
BYMATYARN
Misc
Kulakovskiy et al.(2013)
LHX3_MOUSE.H11MO.0.C
0.651
0.877
Lhx3
M09570_2.00
Mus musculus
NNBTAATTAV
BTAATTAVNN
Misc
Heinz et al.(2010)
Neuron-Lhx3_GSE31456
0.651
0.877
LHX3
M10657_2.00
Homo sapiens
Transfac license required
Transfac license required
Transfac
Matys et al.(2006)
V$LHX3A_01
0.651
0.877
LHX3
M10658_2.00
Homo sapiens
Transfac license required
Transfac license required
Transfac
Matys et al.(2006)
V$LHX3b_01
0.651
0.877
LHX3
M10659_2.00
Homo sapiens
Transfac license required
Transfac license required
Transfac
Matys et al.(2006)
V$LHX3_Q3
0.651
0.877
Lim3
M02116_2.00
Drosophila melanogaster
NNNNNATBRN
NYVATNNNNN
PBM
Weirauch et al.(2014)
pTH6478
0.643
0.860
Lim3
M03796_2.00
Drosophila melanogaster
BTAATTAV
BTAATTAV
SELEX
Nitta et al.(2015)
Lim3_1
0.643
0.860
Lim3
M06492_2.00
Drosophila melanogaster
HTAATKA
TMATTAD
B1H
Mathelier et al.(2014)
MA0195.1
0.643
0.860
Lim3
M06258_2.00
Drosophila melanogaster
HHTAATKA
TMATTADD
B1H
Zhu et al.(2011)
Lim3_Cell_FBgn0002023
0.643
0.860
Lim3
M06259_2.00
Drosophila melanogaster
HTRATTR
YAATYAD
B1H
Zhu et al.(2011)
Lim3_SOLEXA_FBgn0002023
0.643
0.860
C4B866_NEMVE
M02052_2.00
Nematostella vectensis
NNTTAATTARNN
NNYTAATTAANN
PBM
Weirauch et al.(2014)
pTH6176
0.600
0.596
For this family, TFs with SR scores >
0.599
will likely have a similar motif
DNA Binding Domains
Protein ID
Domain
From
To
Sequence
ENSRNOP00000060479
Homeodomain
157
213
RSGRDTITAKQLETLKNAYKNSPKPARHVREQLSSETGLDMRVVQVWFQNRRAKEKR
Links
Other
Homeodomain
family TFs
Other
Rattus norvegicus
TFs
242 Related TFs
Name
Species
Gene ID
Motif Evidence
SR
Score
Action
Invalid Input OrderBy