ENSBTAP00000049813-D5 (Bos grunniens)
Homeodomain

TF Information

Pfam ID Interpro ID Gene ID CIS-BP ID Sequence source
PF00046 (Homeobox) IPR001356 ENSBTAP00000049813-D5 T225897_2.00 GigaDB (2015-Oct-22)
NCBI Gene Info:
This gene encodes a cell surface receptor and transmembrane precursor protein that is cleaved by secretases to form a number of peptides. Some of these peptides are secreted and can bind to the acetyltransferase complex APBB1/TIP60 to promote transcriptional activation, while others form the protein basis of the amyloid plaques found in the brains of patients with Alzheimer disease. In addition, two of the peptides are antimicrobial peptides, having been shown to have bacteriocidal and antifungal activities. Mutations in this gene have been implicated in autosomal dominant Alzheimer disease and cerebroarterial amyloidosis (cerebral amyloid angiopathy). Multiple transcript variants encoding several different isoforms have been found for this gene. [provided by RefSeq, Aug 2014]

Directly determined binding motifs

Name/Motif ID Species Forward Reverse Type/Study/Study ID SR
Score		 DBD
Identity
No direct experiments

Motifs from related TFs

Name/Motif ID Species Forward Reverse Type/Study/Study ID SR
Score		 DBD
Identity
HESX1
M03187_2.00 		Homo sapiens
NHTAATTRVH
DBYAATTADN		 SELEX
Jolma et al.(2013)
HESX1_1 		0.632 0.148
HESX1
M03188_2.00 		Homo sapiens
NTAATTRGYAATTAD
HTAATTRCYAATTAN		 SELEX
Jolma et al.(2013)
HESX1_2 		0.632 0.148
HESX1
M05227_2.00 		Homo sapiens
DYAATTRV
BYAATTRH		 SELEX
Yin et al.(2017)
HESX1_FL_HT-SELEX 		0.632 0.148
HESX1
M05228_2.00 		Homo sapiens
NYAATTRD
HYAATTRN		 SELEX
Yin et al.(2017)
HESX1_FL_Methyl-HT-SELEX 		0.632 0.148
NOBOX
M09135_2.00 		Homo sapiens
HTAATTRVB
VBYAATTAD		 Misc
Kulakovskiy et al.(2013)
NOBOX_HUMAN.H11MO.0.C 		0.618 0.261
For this family, TFs with SR scores > 0.599 will likely have a similar motif

DNA Binding Domains

Protein ID Domain From To Sequence
ENSBTAP00000049813-D5 Homeodomain 23 68
ENSBTAP00000049813-D5 Homeodomain 101 142

Links

Other Homeodomain family TFs
Other Bos grunniens TFs

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64 Related TFs

Name Species Gene ID Motif Evidence SR
Score		 Action