ENSBTAP00000049813-D5 (Bos grunniens)
Homeodomain

TF Information

Pfam ID Interpro ID Gene ID CIS-BP ID Sequence source
PF00046 (Homeobox) IPR001356 ENSBTAP00000049813-D5 T225897_2.00 GigaDB (2015-Oct-22)
NCBI Gene Info:
This gene encodes a cell surface receptor and transmembrane precursor protein that is cleaved by secretases to form a number of peptides. Some of these peptides are secreted and can bind to the acetyltransferase complex APBB1/TIP60 to promote transcriptional activation, while others form the protein basis of the amyloid plaques found in the brains of patients with Alzheimer disease. In addition, two of the peptides are antimicrobial peptides, having been shown to have bacteriocidal and antifungal activities. Mutations in this gene have been implicated in autosomal dominant Alzheimer disease and cerebroarterial amyloidosis (cerebral amyloid angiopathy). Multiple transcript variants encoding several different isoforms have been found for this gene. [provided by RefSeq, Aug 2014]

Directly determined binding motifs

Name/Motif ID Species Forward Reverse Type/Study/Study ID SR
Score		 DBD
Identity
No direct experiments

Motifs from related TFs

Name/Motif ID Species Forward Reverse Type/Study/Study ID SR
Score		 DBD
Identity
HESX1
M03187_2.00 		Homo sapiens
NHTAATTRVH
DBYAATTADN		 SELEX
Jolma et al.(2013)
HESX1_1 		0.632 0.148
HESX1
M03188_2.00 		Homo sapiens
NTAATTRGYAATTAD
HTAATTRCYAATTAN		 SELEX
Jolma et al.(2013)
HESX1_2 		0.632 0.148
HESX1
M05227_2.00 		Homo sapiens
DYAATTRV
BYAATTRH		 SELEX
Yin et al.(2017)
HESX1_FL_HT-SELEX 		0.632 0.148
HESX1
M05228_2.00 		Homo sapiens
NYAATTRD
HYAATTRN		 SELEX
Yin et al.(2017)
HESX1_FL_Methyl-HT-SELEX 		0.632 0.148
NOBOX
M09135_2.00 		Homo sapiens
HTAATTRVB
VBYAATTAD		 Misc
Kulakovskiy et al.(2013)
NOBOX_HUMAN.H11MO.0.C 		0.618 0.261
For this family, TFs with SR scores > 0.599 will likely have a similar motif

DNA Binding Domains

Protein ID Domain From To Sequence
ENSBTAP00000049813-D5 Homeodomain 23 68
ENSBTAP00000049813-D5 Homeodomain 101 142

Links

Other Homeodomain family TFs
Other Bos grunniens TFs

64 Related TFs

Name Species Gene ID Motif Evidence SR
Score		 Action
EFV55592 Trichinella spiralis EFV55592 I 0.669
SVUK_0001056001 Strongylus vulgaris SVUK_0001056001 I 0.656
PPAI007004 Phlebotomus papatasi PPAI007004 I 0.656
SPU_004366 Strongylocentrotus purpuratus SPU_004366 I 0.652
MCOS_0000004601 Mesocestoides corti MCOS_0000004601 I 0.651
TTRE_0000072001 Trichuris trichiura TTRE_0000072001 I 0.651
LHX6 Gorilla gorilla ENSGGOG00000008310 I 0.650
GK22877 Drosophila willistoni FBgn0224839 I 0.649
Cflo_02794--XP_001120105.1_APIME Camponotus floridanus Cflo_02794--XP_001120105.1_APIME I 0.648
L892_g24303 Steinernema scapterisci L892_g24303 I 0.644
SNAPOd2T00016706001 Oikopleura dioica SNAPOd2T00016706001 I 0.640
ADAC001468 Anopheles darlingi ADAC001468 I 0.640
nRc.2.0.1.g34428 Romanomermis culicivorax nRc.2.0.1.g34428 I 0.640
NEMVEDRAFT_v1g198584 Nematostella vectensis NEMVEDRAFT_v1g198584 I 0.639
ADAC008104 Anopheles darlingi ADAC008104 I 0.638
ENSMODG00000001675 Monodelphis domestica ENSMODG00000001675 I 0.636
Ogr09065 Ophisaurus gracilis Ogr09065 I 0.635
GF12207 Drosophila ananassae FBgn0089246 I 0.635
OESDEN_01216 Oesophagostomum dentatum OESDEN_01216 I 0.635
DICVIV_02647 Dictyocaulus viviparus DICVIV_02647 I 0.635
HCOI01026600 Haemonchus contortus HCOI01026600 I 0.633
TELCIR_10796 Teladorsagia circumcincta TELCIR_10796 I 0.633
ANCCAN_10593 Ancylostoma caninum ANCCAN_10593 I 0.632
HESX1 Homo sapiens ENSG00000163666 D 0.632
ENSCSAVG00000000940 Ciona savignyi ENSCSAVG00000000940 I 0.631
drgx Takifugu rubripes ENSTRUG00000013446 I 0.628
ENSP00000419457-D1 Bos grunniens ENSP00000419457-D1 I 0.626
NOBOX Canis familiaris ENSCAFG00000003500 I 0.626
ENSP00000360811-D1 Bos grunniens ENSP00000360811-D1 I 0.626
fgenesh2_pg.scaffold_23000163 Branchiostoma floridae fgenesh2_pg.scaffold_23000163 I 0.626
Aan_R011917 Calypte anna Aan_R011917 I 0.624
PRRX2 Cavia porcellus ENSCPOG00000021821 I 0.624
HMEL006244 Heliconius melpomene HMEL006244 I 0.621
HPBE_0000873701 Heligmosomoides bakeri HPBE_0000873701 I 0.618
NOBOX Homo sapiens ENSG00000106410 D 0.618
NOBOX Pan troglodytes ENSPTRG00000019828 I 0.618
tetur14g02510 Tetranychus urticae tetur14g02510 I 0.617
CGI_10009720 Crassostrea gigas CGI_10009720 I 0.616
ALUE_0000848601 Ascaris lumbricoides ALUE_0000848601 I 0.614
lhx8b Takifugu rubripes ENSTRUG00000017607 I 0.614
Cflo_04174--XP_001120833.1_APIME Camponotus floridanus Cflo_04174--XP_001120833.1_APIME I 0.614
MCINX008871 Melitaea cinxia MCINX008871 I 0.613
YQE_10100 Dendroctonus ponderosae YQE_10100 I 0.612
NBR_0000705501 Nippostrongylus brasiliensis NBR_0000705501 I 0.611
ENSACAG00000002147 Anolis carolinensis ENSACAG00000002147 I 0.611
NOBOX Myotis lucifugus ENSMLUG00000004209 I 0.609
NOBOX Macaca mulatta ENSMMUG00000020609 I 0.609
NOBOX Felis catus ENSFCAG00000004352 I 0.609
NOBOX Gorilla gorilla ENSGGOG00000022185 I 0.609
ENSCSAG00000007090 Chlorocebus sabaeus ENSCSAG00000007090 I 0.609
NOBOX Equus caballus ENSECAG00000003123 I 0.609
NOBOX Oryctolagus cuniculus ENSOCUG00000001027 I 0.609
ENSMMUP00000027138 Macaca fascicularis ENSMMUP00000027138 I 0.609
ENSSTOG00000026570 Ictidomys tridecemlineatus ENSSTOG00000026570 I 0.609
ENSPANG00000018829 Papio anubis ENSPANG00000018829 I 0.609
NOBOX Otolemur garnettii ENSOGAG00000010413 I 0.609
ENSNLEG00000003406 Nomascus leucogenys ENSNLEG00000003406 I 0.609
NOBOX Callithrix jacchus ENSCJAG00000009917 I 0.609
ENSMPUG00000007079 Mustela putorius furo ENSMPUG00000007079 I 0.609
HelroG173001 Helobdella robusta HelroG173001 I 0.605
BGLB004491 Biomphalaria glabrata BGLB004491 I 0.604
TCNE_0000653501 Toxocara canis TCNE_0000653501 I 0.601
Myotis_brandtii_NOBOX_10026198 Myotis brandtii Myotis_brandtii_NOBOX_10026198 I 0.600
Pvit_13361 Pogona vitticeps Pvit_13361 I 0.600