CIS-BP Database: Catalog of Inferred Sequence Binding Preferences
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MYB12
(
Arabidopsis thaliana
)
Myb/SANT
TF Information
Pfam ID
Interpro ID
Gene ID
CIS-BP ID
Sequence source
Animal TF db
PF00249 (Myb_DNA-binding)
IPR014778
AT2G47460
T266417_2.00
Ensembl (2018-Dec-8)
Link out
NCBI Gene Info:
''MYB12 belongs to subgroup 7 of the R2R3-MYB family. It strongly activates the promoters of chalcone synthase (CHS), flavanone 3-hydroxylase (F3H), flavonol synthase (FLS) and - to a lesser extent - chalcone flavanone isomerase (CHI), but cannot activate the promoters of flavonoid-3'hydroxylase (F3'H) and dihydroflavonol 4-reductase (DF). The activation requires a functional MYB recognition element (MRE). Results from the myb12-1f allele indicate that an activation domain might be present in the C-terminus. Overexpression or knock-out plants do not show any obvious phenotype under greenhouse conditions. Young myb12-ko seedlings contain reduced amounts of flavonoids (quercetin and kaempferol), while seedlings as well as leaves of MYB12-OX plants displayed an increased flavonoid content. They did not show any significant difference in anthocyanin content. Expression of CHS and FLS shows a clear correlation to MYB12 expression levels. CHI and F3H show increased transcript levels in the MYB12-OX lines, but no differences in the knock-out. Even in the absence of functional MYB12, flavonol biosynthesis is not completely absent, suggesting functional redundancy. '' The redundant factors are MYB11 and MYB111 although MYB12 is primarily required for flavonol biosynthesis in roots. Mutations in MYB12 block both auxin and ethylene stimulation of flavonoid synthesis.
Directly determined binding motifs
Name/Motif ID
Species
Forward
Reverse
Type/Study/Study ID
SR
Score
DBD
Identity
No direct experiments
Motifs from related TFs
Name/Motif ID
Species
Forward
Reverse
Type/Study/Study ID
SR
Score
DBD
Identity
PK06182.1
M02349_2.00
Cannabis sativa
WTACCTACCN
NGGTAGGTAW
PBM
Weirauch et al.(2014)
pTH9581
0.802
0.849
MYB111
M00882_2.00
Arabidopsis thaliana
NNNAMCDAMY
RKTHGKTNNN
PBM
Franco-Zorrilla et al.(2014)
MYB111
0.773
0.871
Q2TCH0_PETHY
M11072_2.00
Petunia x hybrida
Transfac license required
Transfac license required
Transfac
Matys et al.(2006)
P$PH4_01
0.672
0.742
For this family, TFs with SR scores >
0.661
will likely have a similar motif
DNA Binding Domains
Protein ID
Domain
From
To
Sequence
AT2G47460.1
Myb
14
61
RGRWTAEEDQILSNYIQSNGEGSWRSLPKNAGLKRCGKSCRLRWINYL
AT2G47460.1
Myb
67
112
RGNITPEEEELVVKLHSTLGNRWSLIAGHLPGRTDNEIKNYWNSHL
Links
Other
Myb/SANT
family TFs
Other
Arabidopsis thaliana
TFs
358 Related TFs
Name
Species
Gene ID
Motif Evidence
SR
Score
Action
Invalid Input OrderBy