CIS-BP Database: Catalog of Inferred Sequence Binding Preferences
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tp53
(
Danio rerio
)
p53
TF Information
Pfam ID
Interpro ID
Gene ID
CIS-BP ID
Sequence source
Animal TF db
PF00870 (P53)
IPR011615
ENSDARG00000035559
T311017_2.00
Ensembl (2018-Dec-8)
Link out
NCBI Gene Info:
Enables DNA-binding transcription factor activity; identical protein binding activity; and sequence-specific DNA binding activity. Involved in intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator and regulation of transcription by RNA polymerase II. Acts upstream of or within with a positive effect on transforming growth factor beta receptor signaling pathway involved in endodermal cell fate specification and transforming growth factor beta receptor signaling pathway involved in mesodermal cell fate specification. Acts upstream of or within several processes, including hemopoiesis; intracellular signal transduction; and regulation of nucleobase-containing compound metabolic process. Located in chromatin. Is expressed in several structures, including digestive system; head; musculature system; nervous system; and reproductive system. Used to study Li-Fraumeni syndrome; aggressive NK-cell leukemia; angiosarcoma; cancer; and malignant peripheral nerve sheath tumor. Human ortholog(s) of this gene implicated in several diseases, including Li-Fraumeni syndrome (multiple); carcinoma (multiple); hematologic cancer (multiple); open-angle glaucoma (multiple); and pancreatic cancer (multiple). Orthologous to human TP53 (tumor protein p53). [provided by Alliance of Genome Resources, Apr 2022]
Directly determined binding motifs
Name/Motif ID
Species
Forward
Reverse
Type/Study/Study ID
SR
Score
DBD
Identity
No direct experiments
Motifs from related TFs
Name/Motif ID
Species
Forward
Reverse
Type/Study/Study ID
SR
Score
DBD
Identity
Trp53
M03439_2.00
Mus musculus
ACWTGYYNHHDSACWTGT
ACAWGTSHDDNRRCAWGT
SELEX
Jolma et al.(2013)
Tp53_1
0.723
0.723
Trp53
M03440_2.00
Mus musculus
ACWTGTYHNNGACWTGT
ACAWGTCNNDRACAWGT
SELEX
Jolma et al.(2013)
Tp53_2
0.723
0.723
Trp53
M03441_2.00
Mus musculus
RACATGYCYRGRCATGTY
RACATGYCYRGRCATGTY
SELEX
Jolma et al.(2013)
Tp53_3
0.723
0.723
Trp53
M09340_2.00
Mus musculus
RRRCAWGYCCRGRCADGYMH
DKRCHTGYCYGGRCWTGYYY
Misc
Kulakovskiy et al.(2013)
P53_MOUSE.H11MO.0.A
0.723
0.723
TP53
M09337_2.00
Homo sapiens
DRRCWTGYYCAGRCATGYYY
RRRCATGYCTGRRCAWGYYH
Misc
Kulakovskiy et al.(2013)
P53_HUMAN.H11MO.0.A
0.708
0.708
TP53
M09621_2.00
Homo sapiens
NNDRCAWGYHNNDRCWWGYH
DRCWWGYHNNDRCWTGYHNN
Misc
Heinz et al.(2010)
Saos-p53
0.708
0.708
TP53
M11197_2.00
Homo sapiens
RGACATGCCCGGGCATGTYC
GRACATGCCCGGGCATGTCY
Transfac
Matys et al.(2006)
V$P53_01
0.708
0.708
TP53
M11198_2.00
Homo sapiens
NGRCWTGYYY
RRRCAWGYCN
Transfac
Matys et al.(2006)
V$P53_02
0.708
0.708
TP53
M11199_2.00
Homo sapiens
Transfac license required
Transfac license required
Transfac
Matys et al.(2006)
V$P53_03
0.708
0.708
TP53
M11200_2.00
Homo sapiens
Transfac license required
Transfac license required
Transfac
Matys et al.(2006)
V$P53_04
0.708
0.708
TP53
M11201_2.00
Homo sapiens
Transfac license required
Transfac license required
Transfac
Matys et al.(2006)
V$P53_05
0.708
0.708
TP53
M11202_2.00
Homo sapiens
Transfac license required
Transfac license required
Transfac
Matys et al.(2006)
V$P53_Q3_01
0.708
0.708
TP53
M11203_2.00
Homo sapiens
Transfac license required
Transfac license required
Transfac
Matys et al.(2006)
V$P53_Q3
0.708
0.708
For this family, TFs with SR scores >
0.700
will likely have a similar motif
DNA Binding Domains
Protein ID
Domain
From
To
Sequence
ENSDARP00000051548
p53
64
258
STVPETSDYPGDHGFRLRFPQSGTAKSVTCTYSPDLNKLFCQLAKTCPVQMVVDVAPPQGSVVRATAIYKKSEHVAEVVRRCPHHERTPDGDNLAPAGHLIRVEGNQRANYREDNITLRHSVFVPYEAPQLGAEWTTVLLNYMCNSSCMGGMNRRPILTIITLETQEGQLLGRRSFEVRVCACPGRDRKTEESNF
ENSDARP00000116736
p53
63
257
STVPETSDYPGDHGFRLRFPQSGTAKSVTCTYSPDLNKLFCQLAKTCPVQMVVDVAPPQGSVVRATAIYKKSEHVAEVVRRCPHHERTPDGDNLAPAGHLIRVEGNQRANYREDNITLRHSVFVPYEAPQLGAEWTTVLLNYMCNSSCMGGMNRRPILTIITLETQEGQLLGRRSFEVRVCACPGRDRKTEESNF
Links
Other
p53
family TFs
Other
Danio rerio
TFs
47 Related TFs
Name
Species
Gene ID
Motif Evidence
SR
Score
Action
Invalid Input OrderBy