TP53 (Homo sapiens)
p53

TF Information

Pfam ID Interpro ID Gene ID CIS-BP ID Sequence source Animal TF db
PF00870 (P53) IPR011615 ENSG00000141510 T311040_2.00 Ensembl (2018-Dec-8) Link out
NCBI Gene Info:
This gene encodes a tumor suppressor protein containing transcriptional activation, DNA binding, and oligomerization domains. The encoded protein responds to diverse cellular stresses to regulate expression of target genes, thereby inducing cell cycle arrest, apoptosis, senescence, DNA repair, or changes in metabolism. Mutations in this gene are associated with a variety of human cancers, including hereditary cancers such as Li-Fraumeni syndrome. Alternative splicing of this gene and the use of alternate promoters result in multiple transcript variants and isoforms. Additional isoforms have also been shown to result from the use of alternate translation initiation codons from identical transcript variants (PMIDs: 12032546, 20937277). [provided by RefSeq, Dec 2016]

Directly determined binding motifs

Name/Motif ID Species Forward Reverse Type/Study/Study ID SR
Score
DBD
Identity
TP53
M09337_2.00
Homo sapiens
DRRCWTGYYCAGRCATGYYY

RRRCATGYCTGRRCAWGYYH
Misc
Kulakovskiy et al.(2013)
P53_HUMAN.H11MO.0.A
(Direct) (Direct)
TP53
M09621_2.00
Homo sapiens
NNDRCAWGYHNNDRCWWGYH

DRCWWGYHNNDRCWTGYHNN
Misc
Heinz et al.(2010)
Saos-p53
(Direct) (Direct)
TP53
M11197_2.00
Homo sapiens
RGACATGCCCGGGCATGTYC

GRACATGCCCGGGCATGTCY
Transfac
Matys et al.(2006)
V$P53_01
(Direct) (Direct)
TP53
M11198_2.00
Homo sapiens
NGRCWTGYYY

RRRCAWGYCN
Transfac
Matys et al.(2006)
V$P53_02
(Direct) (Direct)
TP53
M11199_2.00
Homo sapiens Transfac license required
Transfac license required
Transfac
Matys et al.(2006)
V$P53_03
(Direct) (Direct)
TP53
M11200_2.00
Homo sapiens Transfac license required
Transfac license required
Transfac
Matys et al.(2006)
V$P53_04
(Direct) (Direct)
TP53
M11201_2.00
Homo sapiens Transfac license required
Transfac license required
Transfac
Matys et al.(2006)
V$P53_05
(Direct) (Direct)
TP53
M11202_2.00
Homo sapiens Transfac license required
Transfac license required
Transfac
Matys et al.(2006)
V$P53_Q3_01
(Direct) (Direct)
TP53
M11203_2.00
Homo sapiens Transfac license required
Transfac license required
Transfac
Matys et al.(2006)
V$P53_Q3
(Direct) (Direct)

Motifs from related TFs

Name/Motif ID Species Forward Reverse Type/Study/Study ID SR
Score
DBD
Identity
Trp53
M03439_2.00
Mus musculus
ACWTGYYNHHDSACWTGT

ACAWGTSHDDNRRCAWGT
SELEX
Jolma et al.(2013)
Tp53_1
0.829 0.829
Trp53
M03440_2.00
Mus musculus
ACWTGTYHNNGACWTGT

ACAWGTCNNDRACAWGT
SELEX
Jolma et al.(2013)
Tp53_2
0.875 0.875
Trp53
M03441_2.00
Mus musculus
RACATGYCYRGRCATGTY

RACATGYCYRGRCATGTY
SELEX
Jolma et al.(2013)
Tp53_3
0.836 0.836
Trp53
M09340_2.00
Mus musculus
RRRCAWGYCCRGRCADGYMH

DKRCHTGYCYGGRCWTGYYY
Misc
Kulakovskiy et al.(2013)
P53_MOUSE.H11MO.0.A
0.836 0.836
For this family, TFs with SR scores > 0.700 will likely have a similar motif

DNA Binding Domains

Protein ID Domain From To Sequence
ENSP00000269305 p53 95 289
ENSP00000352610 p53 95 289
ENSP00000391127 p53 95 289
ENSP00000391478 p53 95 289
ENSP00000398846 p53 95 289
ENSP00000410739 p53 95 269
ENSP00000423862 p53 28 155
ENSP00000424104 p53 95 165
ENSP00000425104 p53 1 157
ENSP00000426252 p53 95 127
ENSP00000473895 p53 95 143
ENSP00000477531 p53 1 130
ENSP00000478219 p53 56 250
ENSP00000478499 p53 1 157
ENSP00000480868 p53 56 250
ENSP00000481179 p53 1 157
ENSP00000481401 p53 1 130
ENSP00000481638 p53 56 250
ENSP00000482222 p53 56 250
ENSP00000482258 p53 95 289
ENSP00000482537 p53 56 250
ENSP00000482903 p53 95 278
ENSP00000484375 p53 1 130
ENSP00000484409 p53 1 157

Links

Other p53 family TFs
Other Homo sapiens TFs

58 Related TFs

Name Species Gene ID Motif Evidence SR
Score
Action
TP53 Pan troglodytes ENSPTRG00000008703 I 1.000
ENSPPYG00000007934 Pongo abelii ENSPPYG00000007934 I 1.000
LOC100910954 Rattus norvegicus ENSRNOG00000046657 I 1.000
TP53 Gorilla gorilla ENSGGOG00000009786 I 1.000
ENSPANG00000024061 Papio anubis ENSPANG00000024061 I 0.981
ENSCSAG00000011345 Chlorocebus sabaeus ENSCSAG00000011345 I 0.981
TP53 Macaca mulatta ENSMMUG00000008639 I 0.981
ENSP00000269305 Macaca fascicularis ENSP00000269305 I 0.981
ENSOCUG00000001138 Oryctolagus cuniculus ENSOCUG00000001138 I 0.977
TP53 Callithrix jacchus ENSCJAG00000014978 I 0.975
ENSSTOG00000022774 Ictidomys tridecemlineatus ENSSTOG00000022774 I 0.968
ENSNLEG00000009730 Nomascus leucogenys ENSNLEG00000009730 I 0.962
TP53 Equus caballus ENSECAG00000008126 I 0.954
TP53 Otolemur garnettii ENSOGAG00000016871 I 0.944
TP53 Microcebus murinus ENSMICG00000014853 I 0.944
TP53 Sus scrofa ENSSSCG00000017950 I 0.938
Tp53 Rattus norvegicus ENSRNOG00000010756 I 0.924
TP53 Tursiops truncatus ENSTTRG00000010250 I 0.924
ENSAMEG00000016851 Ailuropoda melanoleuca ENSAMEG00000016851 I 0.923
TP53 Bos taurus ENSBTAG00000001069 I 0.917
ENSBTAP00000001420-D1 Bos grunniens ENSBTAP00000001420-D1 I 0.917
TP53 Ochotona princeps ENSOPRG00000006441 I 0.917
TP53 Cavia porcellus ENSCPOG00000014252 I 0.917
ENSMLUG00000006411 Myotis lucifugus ENSMLUG00000006411 I 0.915
TP53 Canis familiaris ENSCAFG00000016714 I 0.911
ENSOARG00000015571 Ovis aries ENSOARG00000015571 I 0.909
ENSMPUG00000009017 Mustela putorius furo ENSMPUG00000009017 I 0.898
TP53 Felis catus ENSFCAG00000009623 I 0.898
Trp53 Mus musculus ENSMUSG00000059552 D 0.892
Myotis_brandtii_TP53_10021059 Myotis brandtii Myotis_brandtii_TP53_10021059 I 0.885
TP53 Sorex araneus ENSSARG00000006206 I 0.885
TP53 Dasypus novemcinctus ENSDNOG00000005252 I 0.879
TP53 Procavia capensis ENSPCAG00000012725 I 0.879
ENSOCUG00000022109 Oryctolagus cuniculus ENSOCUG00000022109 I 0.869
ENSLAFG00000007483 Loxodonta africana ENSLAFG00000007483 I 0.852
ENSSHAG00000015510 Sarcophilus harrisii ENSSHAG00000015510 I 0.848
ENSLAFG00000027474 Loxodonta africana ENSLAFG00000027474 I 0.848
ENSMEUG00000013135 Macropus eugenii ENSMEUG00000013135 I 0.846
TP53 Erinaceus europaeus ENSEEUG00000014573 I 0.841
ENSETEG00000008987 Echinops telfairi ENSETEG00000008987 I 0.828
ENSLAFG00000027669 Loxodonta africana ENSLAFG00000027669 N 0.818
ENSMLUG00000025140 Myotis lucifugus ENSMLUG00000025140 I 0.817
ENSLAFG00000028692 Loxodonta africana ENSLAFG00000028692 I 0.816
ENSLAFG00000030880 Loxodonta africana ENSLAFG00000030880 I 0.816
ENSLAFG00000026238 Loxodonta africana ENSLAFG00000026238 N 0.746
ENSLAFG00000032042 Loxodonta africana ENSLAFG00000032042 I 0.746
ENSACAG00000022533 Anolis carolinensis ENSACAG00000022533 I 0.738
ENSLAFG00000028299 Loxodonta africana ENSLAFG00000028299 I 0.732
ENSPSIG00000013302 Pelodiscus sinensis ENSPSIG00000013302 I 0.732
Cmyd_10000491 Chelonia mydas Cmyd_10000491 I 0.732
ENSLACG00000014014 Latimeria chalumnae ENSLACG00000014014 N 0.720
ENSMODG00000007271 Monodelphis domestica ENSMODG00000007271 I 0.718
tp53 Danio rerio ENSDARG00000035559 I 0.713
ENSLAFG00000027365 Loxodonta africana ENSLAFG00000027365 I 0.707
ENSLAFG00000030555 Loxodonta africana ENSLAFG00000030555 I 0.706
Alligator_sinensis_CCG007355.2 Alligator sinensis Alligator_sinensis_CCG007355.2 N 0.701
tp53.L Xenopus laevis XB-GENE-6252168 N 0.700