|
TP53
(Homo sapiens)
p53
|
TF Information |
Pfam ID |
Interpro ID |
Gene ID |
CIS-BP ID |
Sequence source |
Animal TF db |
PF00870 (P53) |
IPR011615 |
ENSG00000141510 |
T311040_2.00 |
Ensembl (2018-Dec-8) |
Link out |
NCBI Gene Info:This gene encodes a tumor suppressor protein containing transcriptional activation, DNA binding, and oligomerization domains. The encoded protein responds to diverse cellular stresses to regulate expression of target genes, thereby inducing cell cycle arrest, apoptosis, senescence, DNA repair, or changes in metabolism. Mutations in this gene are associated with a variety of human cancers, including hereditary cancers such as Li-Fraumeni syndrome. Alternative splicing of this gene and the use of alternate promoters result in multiple transcript variants and isoforms. Additional isoforms have also been shown to result from the use of alternate translation initiation codons from identical transcript variants (PMIDs: 12032546, 20937277). [provided by RefSeq, Dec 2016] |
Directly determined binding motifs |
Name/Motif ID |
Species |
Forward |
Reverse |
Type/Study/Study ID |
SR Score |
DBD Identity |
TP53 M09337_2.00 |
Homo sapiens |
DRRCWTGYYCAGRCATGYYY |
RRRCATGYCTGRRCAWGYYH |
Misc
Kulakovskiy et al.(2013)
P53_HUMAN.H11MO.0.A |
(Direct) |
(Direct) |
TP53 M09621_2.00 |
Homo sapiens |
NNDRCAWGYHNNDRCWWGYH |
DRCWWGYHNNDRCWTGYHNN |
Misc
Heinz et al.(2010)
Saos-p53 |
(Direct) |
(Direct) |
TP53 M11197_2.00 |
Homo sapiens |
RGACATGCCCGGGCATGTYC |
GRACATGCCCGGGCATGTCY |
Transfac
Matys et al.(2006)
V$P53_01 |
(Direct) |
(Direct) |
TP53 M11198_2.00 |
Homo sapiens |
NGRCWTGYYY |
RRRCAWGYCN |
Transfac
Matys et al.(2006)
V$P53_02 |
(Direct) |
(Direct) |
TP53 M11199_2.00 |
Homo sapiens |
Transfac license required
|
Transfac license required
|
Transfac
Matys et al.(2006)
V$P53_03 |
(Direct) |
(Direct) |
TP53 M11200_2.00 |
Homo sapiens |
Transfac license required
|
Transfac license required
|
Transfac
Matys et al.(2006)
V$P53_04 |
(Direct) |
(Direct) |
TP53 M11201_2.00 |
Homo sapiens |
Transfac license required
|
Transfac license required
|
Transfac
Matys et al.(2006)
V$P53_05 |
(Direct) |
(Direct) |
TP53 M11202_2.00 |
Homo sapiens |
Transfac license required
|
Transfac license required
|
Transfac
Matys et al.(2006)
V$P53_Q3_01 |
(Direct) |
(Direct) |
TP53 M11203_2.00 |
Homo sapiens |
Transfac license required
|
Transfac license required
|
Transfac
Matys et al.(2006)
V$P53_Q3 |
(Direct) |
(Direct) |
Motifs from related TFs |
Name/Motif ID |
Species |
Forward |
Reverse |
Type/Study/Study ID |
SR Score |
DBD Identity |
Trp53
M03439_2.00 |
Mus musculus |
ACWTGYYNHHDSACWTGT |
ACAWGTSHDDNRRCAWGT |
SELEX
Jolma et al.(2013)
Tp53_1
|
0.831
|
0.831
|
Trp53
M03440_2.00 |
Mus musculus |
ACWTGTYHNNGACWTGT |
ACAWGTCNNDRACAWGT |
SELEX
Jolma et al.(2013)
Tp53_2
|
0.829
|
0.829
|
Trp53
M03441_2.00 |
Mus musculus |
RACATGYCYRGRCATGTY |
RACATGYCYRGRCATGTY |
SELEX
Jolma et al.(2013)
Tp53_3
|
0.829
|
0.829
|
Trp53
M09340_2.00 |
Mus musculus |
RRRCAWGYCCRGRCADGYMH |
DKRCHTGYCYGGRCWTGYYY |
Misc
Kulakovskiy et al.(2013)
P53_MOUSE.H11MO.0.A
|
0.875
|
0.875
|
For this family, TFs with SR scores > 0.700 will likely have a similar motif |