ENSP00000189444 (Macaca fascicularis)
Rel

TF Information

Pfam ID Interpro ID Gene ID CIS-BP ID Sequence source
PF00554 (RHD_DNA_bind) IPR011539 ENSP00000189444 T317769_2.00 GigaDB (2015-Oct-22)
NCBI Gene Info:
This gene encodes a subunit of the transcription factor complex nuclear factor-kappa-B (NFkB). The NFkB complex is expressed in numerous cell types and functions as a central activator of genes involved in inflammation and immune function. The protein encoded by this gene can function as both a transcriptional activator or repressor depending on its dimerization partner. The p100 full-length protein is co-translationally processed into a p52 active form. Chromosomal rearrangements and translocations of this locus have been observed in B cell lymphomas, some of which may result in the formation of fusion proteins. There is a pseudogene for this gene on chromosome 18. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2013]

Directly determined binding motifs

Name/Motif ID Species Forward Reverse Type/Study/Study ID SR
Score
DBD
Identity
No direct experiments

Motifs from related TFs

Name/Motif ID Species Forward Reverse Type/Study/Study ID SR
Score
DBD
Identity
NFKB2
M03446_2.00
Homo sapiens
NGGGGAWTCCCCB

VGGGGAWTCCCCN
SELEX
Jolma et al.(2013)
NFKB2_1
0.988 0.988
NFKB2
M05699_2.00
Homo sapiens
HGGKRNWTCCCCN

NGGGGAWNYMCCD
SELEX
Yin et al.(2017)
NFKB2_eDBD_HT-SELEX
0.988 0.988
NFKB2
M09344_2.00
Homo sapiens
GGGRHTTYCCC

GGGRAADYCCC
Misc
Kulakovskiy et al.(2013)
NFKB2_HUMAN.H11MO.0.B
0.988 0.988
NFKB2
M05700_2.00
Homo sapiens
HGGKRNWTYCCCN

NGGGRAWNYMCCD
SELEX
Yin et al.(2017)
NFKB2_eDBD_Methyl-HT-SELEX
0.988 0.988
Nfkb2
M09356_2.00
Mus musculus
GGGRHTTYCCC

GGGRAADYCCC
Misc
Kulakovskiy et al.(2013)
NFKB2_MOUSE.H11MO.0.C
0.963 0.963
For this family, TFs with SR scores > 0.700 will likely have a similar motif

DNA Binding Domains

Protein ID Domain From To Sequence
ENSP00000189444 Rel 53 227

Links

Other Rel family TFs
Other Macaca fascicularis TFs

50 Related TFs

Name Species Gene ID Motif Evidence SR
Score
Action
NFKB2 Otolemur garnettii ENSOGAG00000016379 I 0.963
ENSOARG00000000483 Ovis aries ENSOARG00000000483 I 0.963
ENSMPUG00000016882 Mustela putorius furo ENSMPUG00000016882 I 0.963
NFKB2 Myotis lucifugus ENSMLUG00000006287 I 0.963
Nfkb2 Rattus norvegicus ENSRNOG00000019311 I 0.963
NFKB2 Sus scrofa ENSSSCG00000010580 I 0.963
Myotis_brandtii_NFKB2_10025917 Myotis brandtii Myotis_brandtii_NFKB2_10025917 I 0.963
ENSBTAP00000007904-D1 Bos grunniens ENSBTAP00000007904-D1 I 0.963
ENSSTOG00000002191 Ictidomys tridecemlineatus ENSSTOG00000002191 I 0.963
NFKB2 Felis catus ENSFCAG00000001242 I 0.963
Nfkb2 Mus musculus ENSMUSG00000025225 D 0.963
NFKB2 Canis familiaris ENSCAFG00000010155 I 0.963
NFKB2 Cavia porcellus ENSCPOG00000004847 I 0.963
NFKB2 Bos taurus ENSBTAG00000006017 I 0.963
NFKB2 Callithrix jacchus ENSCJAG00000017928 I 0.963
ENSAMEG00000017735 Ailuropoda melanoleuca ENSAMEG00000017735 I 0.963
NFKB2 Equus caballus ENSECAG00000019593 I 0.957
NFKB2 Dasypus novemcinctus ENSDNOG00000032784 I 0.957
NFKB2 Microcebus murinus ENSMICG00000011856 I 0.957
ENSNLEG00000015079 Nomascus leucogenys ENSNLEG00000015079 I 0.953
ENSCSAG00000005442 Chlorocebus sabaeus ENSCSAG00000005442 I 0.953
ENSPPYG00000002599 Pongo abelii ENSPPYG00000002599 I 0.953
NFKB2 Pan troglodytes ENSPTRG00000002888 I 0.953
ENSPANG00000021013 Papio anubis ENSPANG00000021013 I 0.953
NFKB2 Homo sapiens ENSG00000077150 D 0.953
NFKB2 Macaca mulatta ENSMMUG00000002990 I 0.953
NFKB2 Gorilla gorilla ENSGGOG00000006971 I 0.953
Nfkb2 Dipodomys ordii ENSDORG00000013409 I 0.951
NFKB2 Oryctolagus cuniculus ENSOCUG00000005735 I 0.929
NFKB2 Loxodonta africana ENSLAFG00000006805 I 0.905
NFKB2 Procavia capensis ENSPCAG00000011503 I 0.905
ENSMEUG00000011176 Macropus eugenii ENSMEUG00000011176 I 0.899
ENSSHAG00000018852 Sarcophilus harrisii ENSSHAG00000018852 I 0.899
ENSOANG00000030023 Ornithorhynchus anatinus ENSOANG00000030023 I 0.884
NFKB2 Echinops telfairi ENSETEG00000002347 I 0.869
NFKB2 Anolis carolinensis ENSACAG00000014215 I 0.798
Cmyd_10006544 Chelonia mydas Cmyd_10006544 I 0.798
Pvit_13855 Pogona vitticeps Pvit_13855 I 0.791
Brh_R009664 Buceros rhinoceros Brh_R009664 I 0.791
ENSMGAG00000007084 Meleagris gallopavo ENSMGAG00000007084 I 0.791
Gfo_R002459 Geospiza fortis Gfo_R002459 I 0.785
NFKB2 Taeniopygia guttata ENSTGUG00000007491 I 0.785
NFKB2 Tursiops truncatus ENSTTRG00000008357 I 0.780
Aan_R011824 Calypte anna Aan_R011824 I 0.779
Ogr18048 Ophisaurus gracilis Ogr18048 I 0.773
Alligator_sinensis_CCG009270.1 Alligator sinensis Alligator_sinensis_CCG009270.1 I 0.769
ENSFALG00000007271 Ficedula albicollis ENSFALG00000007271 I 0.763
NFKB2 Gallus gallus ENSGALG00000005653 I 0.757
ENSAPLG00000013409 Anas platyrhynchos ENSAPLG00000013409 I 0.757
Afo_R002575 Aptenodytes forsteri Afo_R002575 I 0.751