AIRE (Homo sapiens)
SAND

TF Information

Pfam ID Interpro ID Gene ID CIS-BP ID Sequence source Animal TF db
PF01342 (SAND) IPR000770 ENSG00000160224 T321713_2.00 Ensembl (2018-Dec-8) Link out
NCBI Gene Info:
This gene encodes a transcriptional regulator that forms nuclear bodies and interacts with the transcriptional coactivator CREB binding protein. The encoded protein plays an important role in immunity by regulating the expression of autoantigens and negative selection of autoreactive T-cells in the thymus. Mutations in this gene cause the rare autosomal-recessive systemic autoimmune disease termed autoimmune polyendocrinopathy with candidiasis and ectodermal dystrophy (APECED). [provided by RefSeq, Jun 2012]

Directly determined binding motifs

Name/Motif ID Species Forward Reverse Type/Study/Study ID SR
Score
DBD
Identity
AIRE
M09375_2.00
Homo sapiens
DHVHCCWWHWNWWCCNND

HNNGGWWNWDWWGGDBDH
Misc
Kulakovskiy et al.(2013)
AIRE_HUMAN.H11MO.0.C
(Direct) (Direct)
AIRE
M11264_2.00
Homo sapiens Transfac license required
Transfac license required
Transfac
Matys et al.(2006)
V$AIRE_01
(Direct) (Direct)
AIRE
M11265_2.00
Homo sapiens Transfac license required
Transfac license required
Transfac
Matys et al.(2006)
V$AIRE_02
(Direct) (Direct)

Motifs from related TFs

Name/Motif ID Species Forward Reverse Type/Study/Study ID SR
Score
DBD
Identity
Aire
M09376_2.00
Mus musculus
DHVHCCWWHWNWWCCNND

HNNGGWWNWDWWGGDBDH
Misc
Kulakovskiy et al.(2013)
AIRE_MOUSE.H11MO.0.C
0.912 0.780
For this family, TFs with SR scores > 0.843 will likely have a similar motif

DNA Binding Domains

Protein ID Domain From To Sequence
ENSP00000291582 SAND 197 249

Links

Other SAND family TFs
Other Homo sapiens TFs

29 Related TFs

Name Species Gene ID Motif Evidence SR
Score
Action
AIRE Pan troglodytes ENSPTRG00000013974 I 0.992
AIRE Gorilla gorilla ENSGGOG00000005672 I 0.990
AIRE Tupaia belangeri ENSTBEG00000016828 I 0.983
AIRE Macaca mulatta ENSMMUG00000004168 I 0.982
AIRE Pteropus vampyrus ENSPVAG00000011010 I 0.980
ENSMMUP00000005576 Macaca fascicularis ENSMMUP00000005576 I 0.979
ENSPANG00000020902 Papio anubis ENSPANG00000020902 I 0.979
ENSCSAG00000007836 Chlorocebus sabaeus ENSCSAG00000007836 I 0.975
ENSPPYG00000011482 Pongo abelii ENSPPYG00000011482 I 0.968
ENSMLUG00000010968 Myotis lucifugus ENSMLUG00000010968 I 0.968
AIRE Felis catus ENSFCAG00000007933 I 0.965
Myotis_brandtii_Aire_10004050 Myotis brandtii Myotis_brandtii_Aire_10004050 I 0.961
ENSSTOG00000023870 Ictidomys tridecemlineatus ENSSTOG00000023870 I 0.959
Aire Dipodomys ordii ENSDORG00000004132 I 0.956
Aire Rattus norvegicus ENSRNOG00000001213 I 0.949
AIRE Procavia capensis ENSPCAG00000007455 I 0.943
AIRE Loxodonta africana ENSLAFG00000008582 I 0.943
AIRE Equus caballus ENSECAG00000012924 I 0.933
AIRE Ochotona princeps ENSOPRG00000000050 I 0.931
Aire Mus musculus ENSMUSG00000000731 D 0.926
AIRE Cavia porcellus ENSCPOG00000019868 I 0.922
ENSMPUG00000010031 Mustela putorius furo ENSMPUG00000010031 I 0.916
ENSAMEG00000010859 Ailuropoda melanoleuca ENSAMEG00000010859 I 0.906
AIRE Canis familiaris ENSCAFG00000010724 I 0.893
ENSBTAP00000031798-D1 Bos grunniens ENSBTAP00000031798-D1 I 0.888
ENSOARG00000011819 Ovis aries ENSOARG00000011819 I 0.888
AIRE Bos taurus ENSBTAG00000023393 I 0.888
AIRE Tursiops truncatus ENSTTRG00000010417 I 0.885
AIRE Otolemur garnettii ENSOGAG00000010769 I 0.869