Aire (Mus musculus)
SAND

TF Information

Pfam ID Interpro ID Gene ID CIS-BP ID Sequence source Animal TF db
PF01342 (SAND) IPR000770 ENSMUSG00000000731 T321797_2.00 Ensembl (2018-Dec-8) Link out
NCBI Gene Info:
Enables identical protein binding activity. Involved in immune system development; positive regulation of chemokine production; and regulation of thymocyte migration. Acts upstream of or within humoral immune response; negative thymic T cell selection; and positive regulation of transcription by RNA polymerase II. Located in cytoplasm and nuclear body. Is expressed in several structures, including alimentary system; genitourinary system; hemolymphoid system; nervous system; and sensory organ. Used to study Guillain-Barre syndrome; Sjogren's syndrome; and autoimmune polyendocrine syndrome type 1. Human ortholog(s) of this gene implicated in autoimmune polyendocrine syndrome and autoimmune polyendocrine syndrome type 1. Orthologous to human AIRE (autoimmune regulator). [provided by Alliance of Genome Resources, Apr 2022]

Directly determined binding motifs

Name/Motif ID Species Forward Reverse Type/Study/Study ID SR
Score		 DBD
Identity
Aire
M09376_2.00		 Mus musculus
DHVHCCWWHWNWWCCNND
HNNGGWWNWDWWGGDBDH		 Misc
Kulakovskiy et al.(2013)
AIRE_MOUSE.H11MO.0.C		 (Direct) (Direct)

Motifs from related TFs

Name/Motif ID Species Forward Reverse Type/Study/Study ID SR
Score		 DBD
Identity
AIRE
M09375_2.00 		Homo sapiens
DHVHCCWWHWNWWCCNND
HNNGGWWNWDWWGGDBDH		 Misc
Kulakovskiy et al.(2013)
AIRE_HUMAN.H11MO.0.C 		0.912 0.696
AIRE
M11264_2.00 		Homo sapiens Transfac license required
 Transfac license required
 Transfac
Matys et al.(2006)
V$AIRE_01 		0.912 0.709
AIRE
M11265_2.00 		Homo sapiens Transfac license required
 Transfac license required
 Transfac
Matys et al.(2006)
V$AIRE_02 		0.912 0.709
For this family, TFs with SR scores > 0.843 will likely have a similar motif

DNA Binding Domains

Protein ID Domain From To Sequence
ENSMUSP00000019257 SAND 196 250
ENSMUSP00000101034 SAND 195 250
ENSMUSP00000101035 SAND 196 250
ENSMUSP00000114904 SAND 196 250
ENSMUSP00000115162 SAND 195 250
ENSMUSP00000117094 SAND 196 250
ENSMUSP00000118317 SAND 195 250
ENSMUSP00000120150 SAND 196 249
ENSMUSP00000121477 SAND 195 250
ENSMUSP00000122190 SAND 196 250
ENSMUSP00000122659 SAND 196 249
ENSMUSP00000123678 SAND 195 250

Links

Other SAND family TFs
Other Mus musculus TFs

24 Related TFs

Name Species Gene ID Motif Evidence SR
Score		 Action
Aire Rattus norvegicus ENSRNOG00000001213 I 0.986
ENSCSAG00000007836 Chlorocebus sabaeus ENSCSAG00000007836 I 0.961
ENSPANG00000020902 Papio anubis ENSPANG00000020902 I 0.954
ENSPPYG00000011482 Pongo abelii ENSPPYG00000011482 I 0.954
ENSMMUP00000005576 Macaca fascicularis ENSMMUP00000005576 I 0.954
ENSSTOG00000023870 Ictidomys tridecemlineatus ENSSTOG00000023870 I 0.951
AIRE Macaca mulatta ENSMMUG00000004168 I 0.948
AIRE Tupaia belangeri ENSTBEG00000016828 I 0.945
AIRE Gorilla gorilla ENSGGOG00000005672 I 0.944
AIRE Pan troglodytes ENSPTRG00000013974 I 0.944
Myotis_brandtii_Aire_10004050 Myotis brandtii Myotis_brandtii_Aire_10004050 I 0.940
ENSMPUG00000010031 Mustela putorius furo ENSMPUG00000010031 I 0.935
ENSMLUG00000010968 Myotis lucifugus ENSMLUG00000010968 I 0.928
AIRE Homo sapiens ENSG00000160224 D 0.926
Aire Dipodomys ordii ENSDORG00000004132 I 0.904
AIRE Loxodonta africana ENSLAFG00000008582 I 0.900
AIRE Pteropus vampyrus ENSPVAG00000011010 I 0.894
AIRE Tursiops truncatus ENSTTRG00000010417 I 0.893
AIRE Cavia porcellus ENSCPOG00000019868 I 0.889
AIRE Procavia capensis ENSPCAG00000007455 I 0.859
AIRE Monodelphis domestica ENSMODG00000011425 I 0.850
AIRE Canis familiaris ENSCAFG00000010724 I 0.850
AIRE Felis catus ENSFCAG00000007933 I 0.843