CIS-BP Database: Catalog of Inferred Sequence Binding Preferences
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SMAD5
(
Homo sapiens
)
SMAD
TF Information
Pfam ID
Interpro ID
Gene ID
CIS-BP ID
Sequence source
Animal TF db
PF03165 (MH1)
IPR003619
ENSG00000113658
T324623_2.00
Ensembl (2018-Dec-8)
Link out
NCBI Gene Info:
The protein encoded by this gene is involved in the transforming growth factor beta signaling pathway that results in an inhibition of the proliferation of hematopoietic progenitor cells. The encoded protein is activated by bone morphogenetic proteins type 1 receptor kinase, and may be involved in cancer. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Feb 2014]
Directly determined binding motifs
Name/Motif ID
Species
Forward
Reverse
Type/Study/Study ID
SR
Score
DBD
Identity
SMAD5
M05743_2.00
Homo sapiens
YGTCTAGACW
WGTCTAGACR
SELEX
Yin et al.(2017)
SMAD5_eDBD_HT-SELEX
(Direct)
(Direct)
SMAD5
M05744_2.00
Homo sapiens
CGTCTAGACR
YGTCTAGACG
SELEX
Yin et al.(2017)
SMAD5_eDBD_Methyl-HT-SELEX
(Direct)
(Direct)
SMAD5
M11271_2.00
Homo sapiens
Transfac license required
Transfac license required
Transfac
Matys et al.(2006)
V$SMAD5_02
(Direct)
(Direct)
SMAD5
M11272_2.00
Homo sapiens
Transfac license required
Transfac license required
Transfac
Matys et al.(2006)
V$SMAD5_Q5_01
(Direct)
(Direct)
SMAD5
M11273_2.00
Homo sapiens
Transfac license required
Transfac license required
Transfac
Matys et al.(2006)
V$SMAD5_Q5
(Direct)
(Direct)
Motifs from related TFs
Name/Motif ID
Species
Forward
Reverse
Type/Study/Study ID
SR
Score
DBD
Identity
Smad5
M11288_2.00
Mus musculus
Transfac license required
Transfac license required
Transfac
Matys et al.(2006)
V$SMAD5_01
1.000
1.000
Smad5
M11292_2.00
Rattus norvegicus
Transfac license required
Transfac license required
Transfac
Matys et al.(2006)
V$SMAD5_03
1.000
1.000
SMAD1
M11286_2.00
Homo sapiens
Transfac license required
Transfac license required
Transfac
Matys et al.(2006)
V$SMAD1_01
0.961
0.961
SMAD1
M11287_2.00
Homo sapiens
Transfac license required
Transfac license required
Transfac
Matys et al.(2006)
V$SMAD1_Q6
0.961
0.961
SMAD9
M11274_2.00
Homo sapiens
Transfac license required
Transfac license required
Transfac
Matys et al.(2006)
V$SMAD8_01
0.931
0.931
Smad9
M11290_2.00
Rattus norvegicus
Transfac license required
Transfac license required
Transfac
Matys et al.(2006)
V$SMAD8_02
0.931
0.931
Smad9
M11289_2.00
Mus musculus
Transfac license required
Transfac license required
Transfac
Matys et al.(2006)
V$SMAD8_03
0.931
0.931
Mad
M06446_2.00
Drosophila melanogaster
GYGHCGBCVS
SBGVCGDCRC
B1H
Zhu et al.(2011)
Mad_FlyReg_FBgn0011648
0.888
0.888
Mad
M08427_2.00
Drosophila melanogaster
SNGRCGMSRVSRBNS
SNVYSBYSKCGYCNS
ChIP-chip
Mathelier et al.(2014)
MA0535.1
0.892
0.892
Mad
M09692_2.00
Drosophila melanogaster
KCBGSHGKCGCSNC
GNSGCGMCDSCVGM
Misc
Kulakovskiy et al.(2009)
Mad
0.892
0.892
Mad
M11293_2.00
Drosophila melanogaster
Transfac license required
Transfac license required
Transfac
Matys et al.(2006)
I$MAD_Q6
0.892
0.892
For this family, TFs with SR scores >
0.700
will likely have a similar motif
DNA Binding Domains
Protein ID
Domain
From
To
Sequence
ENSP00000422954
SMAD
31
80
AEKAVDALVKKLKKKKGAMEELEKALSSPGQPSKCVTIPRSLDGRLQVSH
ENSP00000424279
SMAD
31
132
AEKAVDALVKKLKKKKGAMEELEKALSSPGQPSKCVTIPRSLDGRLQVSHRKGLPHVIYCRVWRWPDLQSHHELKPLDICEFPFGSKQKEVCINPYHYKRVE
ENSP00000425749
SMAD
31
128
AEKAVDALVKKLKKKKGAMEELEKALSSPGQPSKCVTIPRSLDGRLQVSHRKGLPHVIYCRVWRWPDLQSHHELKPLDICEFPFGSKQKEVCINPYHY
ENSP00000441954
SMAD
31
132
AEKAVDALVKKLKKKKGAMEELEKALSSPGQPSKCVTIPRSLDGRLQVSHRKGLPHVIYCRVWRWPDLQSHHELKPLDICEFPFGSKQKEVCINPYHYKRVE
ENSP00000446474
SMAD
31
132
AEKAVDALVKKLKKKKGAMEELEKALSSPGQPSKCVTIPRSLDGRLQVSHRKGLPHVIYCRVWRWPDLQSHHELKPLDICEFPFGSKQKEVCINPYHYKRVE
Links
Other
SMAD
family TFs
Other
Homo sapiens
TFs
427 Related TFs
Name
Species
Gene ID
Motif Evidence
SR
Score
Action
Invalid Input OrderBy