CIS-BP Database: Catalog of Inferred Sequence Binding Preferences
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ENSP00000332973
(
Macaca fascicularis
)
SMAD
TF Information
Pfam ID
Interpro ID
Gene ID
CIS-BP ID
Sequence source
PF03165 (MH1)
IPR003619
ENSP00000332973
T325295_2.00
GigaDB (2015-Oct-22)
NCBI Gene Info:
The SMAD family of proteins are a group of intracellular signal transducer proteins similar to the gene products of the Drosophila gene 'mothers against decapentaplegic' (Mad) and the C. elegans gene Sma. The SMAD3 protein functions in the transforming growth factor-beta signaling pathway, and transmits signals from the cell surface to the nucleus, regulating gene activity and cell proliferation. This protein forms a complex with other SMAD proteins and binds DNA, functioning both as a transcription factor and tumor suppressor. Mutations in this gene are associated with aneurysms-osteoarthritis syndrome and Loeys-Dietz Syndrome 3. [provided by RefSeq, May 2022]
Directly determined binding motifs
Name/Motif ID
Species
Forward
Reverse
Type/Study/Study ID
SR
Score
DBD
Identity
No direct experiments
Motifs from related TFs
Name/Motif ID
Species
Forward
Reverse
Type/Study/Study ID
SR
Score
DBD
Identity
Smad3
M00192_2.00
Mus musculus
NNNNNMGMCN
NGKCKNNNNN
PBM
Badis et al.(2009)
Smad3_3805
0.950
0.950
SMAD3
M03482_2.00
Homo sapiens
YGTCTAGACA
TGTCTAGACR
SELEX
Jolma et al.(2013)
SMAD3_1
0.950
0.950
SMAD3
M09380_2.00
Homo sapiens
NBCTSHCWSCWB
VWGSWGDSAGVN
Misc
Kulakovskiy et al.(2013)
SMAD3_HUMAN.H11MO.0.B
0.950
0.950
Smad3
M09384_2.00
Mus musculus
NBCTSHCWSCWB
VWGSWGDSAGVN
Misc
Kulakovskiy et al.(2013)
SMAD3_MOUSE.H11MO.0.B
0.950
0.950
Smad3
M09637_2.00
Mus musculus
BYAGMCWN
NWGKCTRV
Misc
Heinz et al.(2010)
NPC-Smad3_GSE36673
0.950
0.950
SMAD3
M11283_2.00
Homo sapiens
Transfac license required
Transfac license required
Transfac
Matys et al.(2006)
V$SMAD3_Q6_01
0.950
0.950
SMAD3
M11284_2.00
Homo sapiens
Transfac license required
Transfac license required
Transfac
Matys et al.(2006)
V$SMAD3_Q6_02
0.950
0.950
SMAD3
M11285_2.00
Homo sapiens
Transfac license required
Transfac license required
Transfac
Matys et al.(2006)
V$SMAD3_Q6
0.950
0.950
For this family, TFs with SR scores >
0.700
will likely have a similar motif
DNA Binding Domains
Protein ID
Domain
From
To
Sequence
ENSP00000332973
SMAD
31
130
CEKAVKSLVKKLKKTGQLDELEKAITTQNANTKCITIPRSLDGRLQVSHRKGLPHVIYCRLWRWPDLHSHHELRAMELCEFAFNMKKDEVCVNPYHPEGL
Links
Other
SMAD
family TFs
Other
Macaca fascicularis
TFs
114 Related TFs
Name
Species
Gene ID
Motif Evidence
SR
Score
Action
Invalid Input OrderBy