STAT1 (Homo sapiens)
STAT

TF Information

Pfam ID Interpro ID Gene ID CIS-BP ID Sequence source Animal TF db
PF02864 (STAT_bind) IPR013801 ENSG00000115415 T337444_2.00 Ensembl (2018-Dec-8) Link out
NCBI Gene Info:
The protein encoded by this gene is a member of the STAT protein family. In response to cytokines and growth factors, STAT family members are phosphorylated by the receptor associated kinases, and then form homo- or heterodimers that translocate to the cell nucleus where they act as transcription activators. This protein can be activated by various ligands including interferon-alpha, interferon-gamma, EGF, PDGF and IL6. This protein mediates the expression of a variety of genes, which is thought to be important for cell viability in response to different cell stimuli and pathogens. Two alternatively spliced transcript variants encoding distinct isoforms have been described. [provided by RefSeq, Jul 2008]

Directly determined binding motifs

Name/Motif ID Species Forward Reverse Type/Study/Study ID SR
Score
DBD
Identity
STAT1
M08013_2.00
Homo sapiens
NBBNBTTCCHRGAADNSHNNN

NNNDSNHTTCYDGGAAVNVVN
ChIP-seq
Gerstein et al.(2012)
HeLa-S3_STAT1_Stanford
(Direct) (Direct)
STAT1
M08014_2.00
Homo sapiens
YTTCCYRGAAR

YTTCYRGGAAR
ChIP-seq
Gerstein et al.(2012)
K562_STAT1_Stanford
(Direct) (Direct)
STAT1
M08171_2.00
Homo sapiens
HTTCCYRGAAV

BTTCYRGGAAD
ChIP-seq
Mathelier et al.(2014)
MA0137.3
(Direct) (Direct)
STAT1
M08229_2.00
Homo sapiens
NTTCYNRGAA

TTCYNRGAAN
ChIP-seq
Contrino et al.(2012)
Mv124
(Direct) (Direct)
STAT1
M08230_2.00
Homo sapiens
RGTTTCRBTT

AAVYGAAACY
ChIP-seq
Contrino et al.(2012)
Mv125
(Direct) (Direct)
STAT1
M09411_2.00
Homo sapiens
HBHNYTTCCNRGAARHSHN

NDSDYTTCYNGGAARNDVD
Misc
Kulakovskiy et al.(2013)
STAT1_HUMAN.H11MO.0.A
(Direct) (Direct)
STAT1
M09642_2.00
Homo sapiens
NHTTCYNRGAADNN

NNHTTCYNRGAADN
Misc
Heinz et al.(2010)
HelaS3-STAT1_GSE12782
(Direct) (Direct)
STAT1
M11348_2.00
Homo sapiens
NSNYAHTTCCSGGAADBBNHV

BDNVVHTTCCSGGAADTRNSN
Transfac
Matys et al.(2006)
V$STAT1_01
(Direct) (Direct)
STAT1
M11349_2.00
Homo sapiens Transfac license required
Transfac license required
Transfac
Matys et al.(2006)
V$STAT1_02
(Direct) (Direct)
STAT1
M11350_2.00
Homo sapiens
VNHTTMBN

NVKAADNB
Transfac
Matys et al.(2006)
V$STAT1_03
(Direct) (Direct)
STAT1
M11351_2.00
Homo sapiens Transfac license required
Transfac license required
Transfac
Matys et al.(2006)
V$STAT1_05
(Direct) (Direct)
STAT1
M11352_2.00
Homo sapiens Transfac license required
Transfac license required
Transfac
Matys et al.(2006)
V$STAT1_07
(Direct) (Direct)
STAT1
M11353_2.00
Homo sapiens Transfac license required
Transfac license required
Transfac
Matys et al.(2006)
V$STAT1_Q4
(Direct) (Direct)
STAT1
M11354_2.00
Homo sapiens Transfac license required
Transfac license required
Transfac
Matys et al.(2006)
V$STAT1_Q6
(Direct) (Direct)

Motifs from related TFs

Name/Motif ID Species Forward Reverse Type/Study/Study ID SR
Score
DBD
Identity
Stat1
M09422_2.00
Mus musculus
HNDBYNTNDBTTTCHNTTYYYY

RRRRAANDGAAAVHNANRVHND
Misc
Kulakovskiy et al.(2013)
STAT1_MOUSE.H11MO.0.A
0.945 0.945
For this family, TFs with SR scores > 0.700 will likely have a similar motif

DNA Binding Domains

Protein ID Domain From To Sequence
ENSP00000354394 STAT 317 566
ENSP00000376136 STAT 317 566
ENSP00000376137 STAT 319 568
ENSP00000386244 STAT 317 566

Links

Other STAT family TFs
Other Homo sapiens TFs

44 Related TFs

Name Species Gene ID Motif Evidence SR
Score
Action
ENSAPLG00000013226 Anas platyrhynchos ENSAPLG00000013226 I 0.907
STAT1 Bos taurus ENSBTAG00000007867 I 0.987
ENSBTAP00000010351-D1 Bos grunniens ENSBTAP00000010351-D1 I 0.987
ENSCAFG00000009797 Canis familiaris ENSCAFG00000009797 I 0.983
STAT1 Callithrix jacchus ENSCJAG00000005819 I 1.000
ENSCSAG00000012191 Chlorocebus sabaeus ENSCSAG00000012191 I 1.000
STAT1 Dasypus novemcinctus ENSDNOG00000007325 I 0.979
STAT1 Equus caballus ENSECAG00000009039 I 0.987
STAT1 Echinops telfairi ENSETEG00000017040 I 0.958
ENSFALG00000004349 Ficedula albicollis ENSFALG00000004349 I 0.903
STAT1 Felis catus ENSFCAG00000013725 I 0.983
STAT1 Gallus gallus ENSGALG00000007651 I 0.908
STAT1 Gorilla gorilla ENSGGOG00000000611 I 1.000
ENSGMOG00000012431 Gadus morhua ENSGMOG00000012431 I 0.713
ENSLACG00000006815 Latimeria chalumnae ENSLACG00000006815 I 0.882
STAT1 Loxodonta africana ENSLAFG00000001475 I 0.975
ENSLOCG00000009965 Lepisosteus oculatus ENSLOCG00000009965 I 0.869
STAT1 Meleagris gallopavo ENSMGAG00000006382 I 0.899
STAT1 Microcebus murinus ENSMICG00000002941 I 0.975
STAT1 Macaca mulatta ENSMMUG00000005613 I 1.000
STAT1 Monodelphis domestica ENSMODG00000011747 I 0.945
ENSMPUG00000012530 Mustela putorius furo ENSMPUG00000012530 I 0.987
Stat1 Mus musculus ENSMUSG00000026104 D 0.945
ENSNLEG00000006694 Nomascus leucogenys ENSNLEG00000006694 I 1.000
ENSOARG00000013903 Ovis aries ENSOARG00000013903 I 0.987
STAT1 Oryctolagus cuniculus ENSOCUG00000002455 I 0.958
STAT1 Otolemur garnettii ENSOGAG00000003038 I 0.966
ENSONIG00000012194 Oreochromis niloticus ENSONIG00000012194 I 0.717
STAT1 Ochotona princeps ENSOPRG00000008589 I 0.949
ENSPANG00000017818 Papio anubis ENSPANG00000017818 I 1.000
ENSPMAG00000002770 Petromyzon marinus ENSPMAG00000002770 I 0.743
ENSPPYG00000013027 Pongo abelii ENSPPYG00000013027 I 1.000
ENSPSIG00000010185 Pelodiscus sinensis ENSPSIG00000010185 I 0.911
STAT1 Pan troglodytes ENSPTRG00000012749 I 1.000
STAT1 Pteropus vampyrus ENSPVAG00000004735 I 0.792
Stat1 Rattus norvegicus ENSRNOG00000014079 I 0.945
ENSSHAG00000016913 Sarcophilus harrisii ENSSHAG00000016913 I 0.932
STAT1 Sus scrofa ENSSSCG00000016057 I 0.979
ENSSTOG00000008620 Ictidomys tridecemlineatus ENSSTOG00000008620 I 0.962
STAT1 Tursiops truncatus ENSTTRG00000001134 I 0.890
ENSXMAG00000001594 Xiphophorus maculatus ENSXMAG00000001594 I 0.700
stat1 Xenopus tropicalis XB-GENE-482166 I 0.886
stat1.L Xenopus laevis XB-GENE-864837 I 0.869