STAT4 (Homo sapiens)
STAT

TF Information

Pfam ID Interpro ID Gene ID CIS-BP ID Sequence source Animal TF db
PF02864 (STAT_bind) IPR013801 ENSG00000138378 T337446_2.00 Ensembl (2018-Dec-8) Link out
NCBI Gene Info:
The protein encoded by this gene is a member of the STAT family of transcription factors. In response to cytokines and growth factors, STAT family members are phosphorylated by the receptor associated kinases, and then form homo- or heterodimers that translocate to the cell nucleus where they act as transcription activators. This protein is essential for mediating responses to IL12 in lymphocytes, and regulating the differentiation of T helper cells. Mutations in this gene may be associated with systemic lupus erythematosus and rheumatoid arthritis. Alternate splicing results in multiple transcript variants that encode the same protein. [provided by RefSeq, Aug 2011]

Directly determined binding motifs

Name/Motif ID Species Forward Reverse Type/Study/Study ID SR
Score		 DBD
Identity
STAT4
M09413_2.00		 Homo sapiens
YTTCYBDKMAN
NTKMHVRGAAR		 Misc
Kulakovskiy et al.(2013)
STAT4_HUMAN.H11MO.0.A		 (Direct) (Direct)
STAT4
M11361_2.00		 Homo sapiens
BNHTTCNN
NNGAADNV		 Transfac
Matys et al.(2006)
V$STAT4_01		 (Direct) (Direct)
STAT4
M11362_2.00		 Homo sapiens Transfac license required
 Transfac license required
 Transfac
Matys et al.(2006)
V$STAT4_Q4		 (Direct) (Direct)
STAT4
M11363_2.00		 Homo sapiens Transfac license required
 Transfac license required
 Transfac
Matys et al.(2006)
V$STAT4_Q5		 (Direct) (Direct)

Motifs from related TFs

Name/Motif ID Species Forward Reverse Type/Study/Study ID SR
Score		 DBD
Identity
Stat4
M08174_2.00 		Mus musculus
NNNYTTCYYRGAAV
BTTCYRRGAARNNN		 ChIP-seq
Mathelier et al.(2014)
MA0518.1 		0.936 0.936
Stat4
M09424_2.00 		Mus musculus
YTTCYHDKMA
TKMHDRGAAR		 Misc
Kulakovskiy et al.(2013)
STAT4_MOUSE.H11MO.0.A 		0.936 0.936
Stat4
M09646_2.00 		Mus musculus
NYTTCCNGGAAR
YTTCCNGGAARN		 Misc
Heinz et al.(2010)
CD4-Stat4_GSE22104 		0.936 0.936
For this family, TFs with SR scores > 0.700 will likely have a similar motif

DNA Binding Domains

Protein ID Domain From To Sequence
ENSP00000351255 STAT 316 562
ENSP00000376134 STAT 316 562

Links

Other STAT family TFs
Other Homo sapiens TFs

35 Related TFs

Name Species Gene ID Motif Evidence SR
Score		 Action
ENSPANG00000022795 Papio anubis ENSPANG00000022795 I 0.996
ENSPPYG00000013028 Pongo abelii ENSPPYG00000013028 I 0.996
ENSNLEG00000006726 Nomascus leucogenys ENSNLEG00000006726 I 0.996
STAT4 Macaca mulatta ENSMMUG00000005617 I 0.991
ENSCSAG00000012146 Chlorocebus sabaeus ENSCSAG00000012146 I 0.991
STAT4 Callithrix jacchus ENSCJAG00000005895 I 0.979
STAT4 Equus caballus ENSECAG00000023170 I 0.974
STAT4 Oryctolagus cuniculus ENSOCUG00000002466 I 0.974
STAT4 Otolemur garnettii ENSOGAG00000003042 I 0.974
STAT4 Ochotona princeps ENSOPRG00000008636 I 0.970
ENSCAFG00000009797 Canis familiaris ENSCAFG00000009797 I 0.970
STAT4 Choloepus hoffmanni ENSCHOG00000006838 I 0.970
ENSMPUG00000012539 Mustela putorius furo ENSMPUG00000012539 I 0.966
ENSP00000351255-D1 Bos grunniens ENSP00000351255-D1 I 0.966
STAT4 Pteropus vampyrus ENSPVAG00000004736 I 0.966
ENSOARG00000013903 Ovis aries ENSOARG00000013903 I 0.961
STAT4 Felis catus ENSFCAG00000018634 I 0.961
STAT4 Tursiops truncatus ENSTTRG00000001136 I 0.953
STAT4 Loxodonta africana ENSLAFG00000012299 I 0.949
STAT4 Erinaceus europaeus ENSEEUG00000002778 I 0.944
STAT4 Sus scrofa ENSSSCG00000016059 I 0.940
Stat1 Rattus norvegicus ENSRNOG00000014079 I 0.940
Stat4 Mus musculus ENSMUSG00000062939 D 0.936
STAT4 Monodelphis domestica ENSMODG00000011767 I 0.893
ENSGALG00000025974 Gallus gallus ENSGALG00000025974 I 0.863
Tal_R001379 Tyto alba Tal_R001379 I 0.863
STAT4 Meleagris gallopavo ENSMGAG00000016413 I 0.863
Brh_R001450 Buceros rhinoceros Brh_R001450 I 0.863
STAT1 Bos taurus ENSBTAG00000007867 I 0.854
Stat4 Dipodomys ordii ENSDORG00000011535 I 0.836
ENSPSIG00000010185 Pelodiscus sinensis ENSPSIG00000010185 I 0.833
STAT4 Vicugna pacos ENSVPAG00000011545 I 0.811
ENSTNIG00000019687 Tetraodon nigroviridis ENSTNIG00000019687 I 0.722
ENSOANG00000031223 Ornithorhynchus anatinus ENSOANG00000031223 I 0.700