ENSP00000356795 (Macaca fascicularis)
T-box

TF Information

Pfam ID Interpro ID Gene ID CIS-BP ID Sequence source
PF00907 (T-box) IPR001699 ENSP00000356795 T341064_2.00 GigaDB (2015-Oct-22)
NCBI Gene Info:
This gene is a member of a phylogenetically conserved family of genes that share a common DNA-binding domain, the T-box. T-box genes encode transcription factors involved in the regulation of developmental processes. Mutations in this gene were found in patients with isolated deficiency of pituitary POMC-derived ACTH, suggesting an essential role for this gene in differentiation of the pituitary POMC lineage. ACTH deficiency is characterized by adrenal insufficiency symptoms such as weight loss, lack of appetite (anorexia), weakness, nausea, vomiting, and low blood pressure. [provided by RefSeq, Jul 2008]

Directly determined binding motifs

Name/Motif ID Species Forward Reverse Type/Study/Study ID SR
Score		 DBD
Identity
No direct experiments

Motifs from related TFs

Name/Motif ID Species Forward Reverse Type/Study/Study ID SR
Score		 DBD
Identity
TBX19
M03562_2.00 		Homo sapiens
NDTVRCACVTANGTGYKANN
NNTMRCACNTABGTGYBAHN		 SELEX
Jolma et al.(2013)
TBX19_1 		0.920 1.000
TBX19
M05803_2.00 		Homo sapiens
NAGGTGYBAHWDTMRCACNTN
NANGTGYKAHWDTVRCACCTN		 SELEX
Yin et al.(2017)
TBX19_eDBD_HT-SELEX 		0.920 1.000
TBX19
M05804_2.00 		Homo sapiens
NANGTGYKAHWDTVRCACSTN
NASGTGYBAHWDTMRCACNTN		 SELEX
Yin et al.(2017)
TBX19_eDBD_Methyl-HT-SELEX 		0.920 1.000
T
M05809_2.00 		Homo sapiens
NANGTGYGAHWWNTVRCACCTN
NAGGTGYBANWWDTCRCACNTN		 SELEX
Yin et al.(2017)
T_eDBD_HT-SELEX_1 		0.876 0.835
T
M05810_2.00 		Homo sapiens
DTCRCAYVTABGTGYGAH
DTCRCACVTABRTGYGAH		 SELEX
Yin et al.(2017)
T_eDBD_HT-SELEX_2 		0.876 0.835
T
M09427_2.00 		Homo sapiens
BYNVCANNNVDGTGWKARDN
NHYTMWCACHBNNNTGBNRV		 Misc
Kulakovskiy et al.(2013)
BRAC_HUMAN.H11MO.0.A 		0.876 0.835
T
M09431_2.00 		Mus musculus
VVNRAWTTSACASNYHDVTGBNMAN
NTKNVCABHDRNSTGTSAAWTYNBB		 Misc
Kulakovskiy et al.(2013)
BRAC_MOUSE.H11MO.0.B 		0.876 0.835
T
M09651_2.00 		Mus musculus
NYTVDCASNNNNSTGHBARNN
NNYTVDCASNNNNSTGHBARN		 Misc
Heinz et al.(2010)
Mesoendoderm-Brachyury_GSE54963 		0.876 0.835
T
M11384_2.00 		Homo sapiens
MKHBTSACACSTAGGTGTGAAATK
MATTTCACACCTASGTGTSAVDMK		 Transfac
Matys et al.(2006)
V$BRACH_01 		0.876 0.835
T
M05811_2.00 		Homo sapiens
NABGTGYGAHWWNTVRCACSTN
NASGTGYBANWWDTCRCACVTN		 SELEX
Yin et al.(2017)
T_eDBD_Methyl-HT-SELEX_1 		0.876 0.835
T
M05812_2.00 		Homo sapiens
DTMRCAYVTABGTGYKAH
DTMRCACVTABRTGYKAH		 SELEX
Yin et al.(2017)
T_eDBD_Methyl-HT-SELEX_2 		0.876 0.835
byn
M03984_2.00 		Drosophila melanogaster
ABGTGYGADDD
HHHTCRCACVT		 SELEX
Nitta et al.(2015)
byn_1 		0.816 0.761
byn
M03985_2.00 		Drosophila melanogaster
DNGTGYBAHWWDTVRCACNH
DNGTGYBAHWWDTVRCACNH		 SELEX
Nitta et al.(2015)
byn_2 		0.816 0.761
byn
M03986_2.00 		Drosophila melanogaster
RDGTGYGADNDNDNNNNNNDRDGTGYGADD
HHTCRCACHYHNNNNNNHNHNHTCRCACHY		 SELEX
Nitta et al.(2015)
byn_3 		0.816 0.761
byn
M03987_2.00 		Drosophila melanogaster
NNTMRCAYNWWNRTGYKAHN
NDTMRCAYNWWNRTGYKANN		 SELEX
Nitta et al.(2015)
byn_4 		0.816 0.761
byn
M06453_2.00 		Drosophila melanogaster
ADGTGCDA
THGCACHT		 B1H
Zhu et al.(2011)
byn_FlyReg_FBgn0011723 		0.816 0.761
For this family, TFs with SR scores > 0.734 will likely have a similar motif

DNA Binding Domains

Protein ID Domain From To Sequence
ENSP00000356795 T-box 43 218

Links

Other T-box family TFs
Other Macaca fascicularis TFs

Invalid Input OrderBy

177 Related TFs

Name Species Gene ID Motif Evidence SR
Score		 Action