RUNX2 (Homo sapiens)
Runt

TF Information

Pfam ID Interpro ID Gene ID CIS-BP ID Sequence source Animal TF db
PF00853 (Runt) IPR013524 ENSG00000124813 T319383_2.00 Ensembl (2018-Dec-8) Link out

Directly determined binding motifs

Name/Motif ID Species Forward Reverse Type/Study/Study ID SR
Score		 DBD
Identity
RUNX2
M03468_2.00		 Homo sapiens
HRACCGCAAACCRCRD
HYGYGGTTTGCGGTYD		 SELEX
Jolma et al.(2013)
RUNX2_1		 (Direct) (Direct)
RUNX2
M03469_2.00		 Homo sapiens
HRACCRCADWWACCRCAD
HTGYGGTWWHTGYGGTYD		 SELEX
Jolma et al.(2013)
RUNX2_2		 (Direct) (Direct)
RUNX2
M03470_2.00		 Homo sapiens
WAACCRCAR
YTGYGGTTW		 SELEX
Jolma et al.(2013)
RUNX2_3		 (Direct) (Direct)
RUNX2
M05733_2.00		 Homo sapiens
NHRACCRCADWAACCRCAVN
NBTGYGGTTWHTGYGGTYDN		 SELEX
Yin et al.(2017)
RUNX2_eDBD_HT-SELEX		 (Direct) (Direct)
RUNX2
M05734_2.00		 Homo sapiens
NWAACCACRAAAACCACRRN
NYYGTGGTTTTYGTGGTTWN		 SELEX
Yin et al.(2017)
RUNX2_eDBD_Methyl-HT-SELEX		 (Direct) (Direct)
RUNX2
M09370_2.00		 Homo sapiens
MMHAACCACAVVMH
DKBBTGTGGTTDKK		 Misc
Kulakovskiy et al.(2013)
RUNX2_HUMAN.H11MO.0.A		 (Direct) (Direct)
RUNX2
M09630_2.00		 Homo sapiens
NHVACCACANNN
NNNTGTGGTBDN		 Misc
Heinz et al.(2010)
PCa-RUNX2_GSE33889		 (Direct) (Direct)
RUNX2
M11255_2.00		 Homo sapiens Transfac license required
 Transfac license required
 Transfac
Matys et al.(2006)
V$AML3_Q3		 (Direct) (Direct)
RUNX2
M11256_2.00		 Homo sapiens Transfac license required
 Transfac license required
 Transfac
Matys et al.(2006)
V$AML3_Q6		 (Direct) (Direct)
RUNX2
M11257_2.00		 Homo sapiens Transfac license required
 Transfac license required
 Transfac
Matys et al.(2006)
V$OSF2_Q6		 (Direct) (Direct)

Motifs from related TFs

Name/Motif ID Species Forward Reverse Type/Study/Study ID SR
Score		 DBD
Identity
Runx2
M01307_2.00 		Mus musculus
NHDACCRCAN
NTGYGGTHDN		 PBM
Lambert et al.(2019)
pTH9764 		0.985 0.985
Runx2
M09373_2.00 		Mus musculus
VWRACCACARVV
BBYTGTGGTYWB		 Misc
Kulakovskiy et al.(2013)
RUNX2_MOUSE.H11MO.0.A 		1.000 1.000
RUNX3
M03464_2.00 		Homo sapiens
HRACCGCAAACCRCAN
NTGYGGTTTGCGGTYD		 SELEX
Jolma et al.(2013)
RUNX3_1 		0.946 0.946
RUNX3
M03465_2.00 		Homo sapiens
WAACCRCARN
NYTGYGGTTW		 SELEX
Jolma et al.(2013)
RUNX3_2 		0.946 0.946
RUNX3
M03466_2.00 		Homo sapiens
HDACCRCADWAACCRCRN
NYGYGGTTWHTGYGGTHD		 SELEX
Jolma et al.(2013)
RUNX3_3 		0.931 0.931
RUNX3
M03467_2.00 		Homo sapiens
HRACCRCAAH
DTTGYGGTYD		 SELEX
Jolma et al.(2013)
RUNX3_4 		0.931 0.931
RUNX3
M02751_2.00 		Homo sapiens
WACCRCAM
KTGYGGTW		 SELEX
Jolma et al.(2010)
RUNX3_monomer 		0.931 0.931
RUNX3
M05731_2.00 		Homo sapiens
YWAACCGCAAAAACCGCARV
BYTGCGGTTTTTGCGGTTWR		 SELEX
Yin et al.(2017)
RUNX3_FL_HT-SELEX 		0.931 0.931
RUNX3
M09369_2.00 		Homo sapiens
HAACCACARN
NYTGTGGTTD		 Misc
Kulakovskiy et al.(2013)
RUNX3_HUMAN.H11MO.0.A 		0.931 0.931
Runx3
M09374_2.00 		Mus musculus
NHRACCACARVN
NBYTGTGGTYDN		 Misc
Kulakovskiy et al.(2013)
RUNX3_MOUSE.H11MO.0.A 		0.931 0.931
RUNX3
M11252_2.00 		Homo sapiens Transfac license required
 Transfac license required
 Transfac
Matys et al.(2006)
V$AML2_Q3_01 		0.931 0.931
RUNX3
M11253_2.00 		Homo sapiens Transfac license required
 Transfac license required
 Transfac
Matys et al.(2006)
V$AML2_Q3 		0.946 0.946
RUNX3
M11254_2.00 		Homo sapiens Transfac license required
 Transfac license required
 Transfac
Matys et al.(2006)
V$AML2_Q4 		0.931 0.931
RUNX3
M05732_2.00 		Homo sapiens
HWAACCACRAAAACCACRARN
NYTYGTGGTTTTYGTGGTTWD		 SELEX
Yin et al.(2017)
RUNX3_FL_Methyl-HT-SELEX 		0.931 0.931
Runx1
M08163_2.00 		Mus musculus
HRRCCACARVN
NBYTGTGGYYD		 ChIP-seq
Mathelier et al.(2014)
MA0002.2 		0.908 0.908
RUNX1
M09371_2.00 		Homo sapiens
NWAACCACARV
BYTGTGGTTWN		 Misc
Kulakovskiy et al.(2013)
RUNX1_HUMAN.H11MO.0.A 		0.908 0.908
Runx1
M09372_2.00 		Mus musculus
VWRACCACARVV
BBYTGTGGTYWB		 Misc
Kulakovskiy et al.(2013)
RUNX1_MOUSE.H11MO.0.A 		0.908 0.908
RUNX1
M09632_2.00 		Homo sapiens
HAACCACADV
BHTGTGGTTD		 Misc
Heinz et al.(2010)
Jurkat-RUNX1_GSE29180 		0.908 0.908
RUNX1
M09631_2.00 		Homo sapiens
VCCACWTCCTBY
RVAGGAWGTGGB		 Misc
Heinz et al.(2010)
Jurkat-RUNX1_GSE17954 		0.923 0.923
Runx1
M09633_2.00 		Mus musculus
NWAACCACAR
YTGTGGTTWN		 Misc
Heinz et al.(2010)
HPC7-Runx1_GSE22178 		0.923 0.923
RUNX1
M11258_2.00 		Homo sapiens
ACCRCA
TGYGGT		 Transfac
Matys et al.(2006)
V$AML1_01 		0.908 0.908
RUNX1
M11259_2.00 		Homo sapiens Transfac license required
 Transfac license required
 Transfac
Matys et al.(2006)
V$AML1_Q4_01 		0.908 0.908
RUNX1
M11260_2.00 		Homo sapiens Transfac license required
 Transfac license required
 Transfac
Matys et al.(2006)
V$AML1_Q4_02 		0.908 0.908
RUNX1
M11261_2.00 		Homo sapiens Transfac license required
 Transfac license required
 Transfac
Matys et al.(2006)
V$AML1_Q4 		0.908 0.908
RUNX1
M11262_2.00 		Homo sapiens Transfac license required
 Transfac license required
 Transfac
Matys et al.(2006)
V$AML1_Q5 		0.908 0.908
RUNX1
M11263_2.00 		Homo sapiens Transfac license required
 Transfac license required
 Transfac
Matys et al.(2006)
V$AML1_Q6 		0.908 0.908
lz
M03964_2.00 		Drosophila melanogaster
HRACCGCAAHM
KDTTGCGGTYD		 SELEX
Nitta et al.(2015)
lz_1 		0.731 0.731
lz
M03965_2.00 		Drosophila melanogaster
HVACCRCARWAACCRCAV
BTGYGGTTWYTGYGGTBD		 SELEX
Nitta et al.(2015)
lz_2 		0.731 0.731
lz
M03966_2.00 		Drosophila melanogaster
WRACCRCAWTAACCRCAA
TTGYGGTTAWTGYGGTYW		 SELEX
Nitta et al.(2015)
lz_3 		0.731 0.731
lz
M03967_2.00 		Drosophila melanogaster
HRACCGCAAAACCRCAR
YTGYGGTTTTGCGGTYD		 SELEX
Nitta et al.(2015)
lz_4 		0.731 0.731
For this family, TFs with SR scores > 0.700 will likely have a similar motif

DNA Binding Domains

Protein ID Domain From To Sequence
ENSP00000352514 Runt 88 217
ENSP00000360486 Runt 102 231
ENSP00000360491 Runt 102 231
ENSP00000360493 Runt 102 231
ENSP00000420707 Runt 102 231
ENSP00000458178 Runt 102 231
ENSP00000460188 Runt 88 217
ENSP00000485863 Runt 88 217

Links

Other Runt family TFs
Other Homo sapiens TFs

364 Related TFs

Name Species Gene ID Motif Evidence SR
Score		 Action
SGR5 Arabidopsis thaliana AT2G01940 D
ORUFI03G10000 Oryza rufipogon ORUFI03G10000 I
mgf008235m Mimulus guttatus mgf008235m I
cassava1947.valid.m1 Manihot esculenta cassava1947.valid.m1 I
Pm005926 Prunus mume Pm005926 I
Cla005913 Citrullus lanatus Cla005913 I
Ca_22171 Cicer arietinum Ca_22171 I
Traes_4AS_2718699A7 Triticum aestivum Traes_4AS_2718699A7 I
Sb07g022700 Sorghum bicolor Sb07g022700 I
Sb02g026230 Sorghum bicolor Sb02g026230 I
PRUPE_ppa005331mg Prunus persica PRUPE_ppa005331mg I
OS08G0467100 Oryza sativa OS08G0467100 I
OS03G0237250 Oryza sativa OS03G0237250 I
ORUFI09G13180 Oryza rufipogon ORUFI09G13180 I
Bostr.15697s0010 Boechera stricta Bostr.15697s0010 I
ORGLA09G0169200 Oryza glaberrima ORGLA09G0169200 I
ORGLA09G0092400 Oryza glaberrima ORGLA09G0092400 I
ORGLA08G0153600 Oryza glaberrima ORGLA08G0153600 I
ORGLA03G0094200 Oryza glaberrima ORGLA03G0094200 I
OPUNC09G10740 Oryza punctata OPUNC09G10740 I
OPUNC08G15410 Oryza punctata OPUNC08G15410 I
OPUNC03G09440 Oryza punctata OPUNC03G09440 I
ONIVA09G13010 Oryza nivara ONIVA09G13010 I
ONIVA08G19430 Oryza nivara ONIVA08G19430 I
ONIVA03G10380 Oryza nivara ONIVA03G10380 I
gene00618-v1.0-hybrid Fragaria vesca gene00618-v1.0-hybrid I
chr4.CM0387.280.nc Lotus japonicus chr4.CM0387.280.nc I
PK17145.1 Cannabis sativa PK17145.1 I
Thhalv10018614m.g Eutrema salsugineum Thhalv10018614m.g I
Thhalv10009376m.g Eutrema salsugineum Thhalv10009376m.g I
Thhalv10004221m.g Eutrema salsugineum Thhalv10004221m.g I
SapurV1A.0074s0350 Salix purpurea SapurV1A.0074s0350 I
Pavir.J40191 Panicum virgatum Pavir.J40191 I
Pavir.J12350 Panicum virgatum Pavir.J12350 I
Pavir.Fb01741 Panicum virgatum Pavir.Fb01741 I
Pavir.Fa00691 Panicum virgatum Pavir.Fa00691 I
Pavir.Ba02057 Panicum virgatum Pavir.Ba02057 I
Bostr.0556s0022 Boechera stricta Bostr.0556s0022 I
Eucgr.K02292 Eucalyptus grandis Eucgr.K02292 I
Eucgr.H00574 Eucalyptus grandis Eucgr.H00574 I
Eucgr.G02066 Eucalyptus grandis Eucgr.G02066 I
Carubv10020337m.g Capsella rubella Carubv10020337m.g I
Carubv10017254m.g Capsella rubella Carubv10017254m.g I
Carubv10009424m.g Capsella rubella Carubv10009424m.g I
Cagra.3834s0006 Capsella grandiflora Cagra.3834s0006 I
Cagra.2231s0014 Capsella grandiflora Cagra.2231s0014 I
Cagra.1111s0006 Capsella grandiflora Cagra.1111s0006 I
Bostr.26959s0085 Boechera stricta Bostr.26959s0085 I
OMERI09G13410 Oryza meridionalis OMERI09G13410 I
Bra004283 Brassica rapa Bra004283 I
GLYMA05G33590 Glycine max GLYMA05G33590 I
SGR5 Arabidopsis lyrata fgenesh2_kg.5__108__AT2G01940.1 I
AtIDD14 Arabidopsis lyrata fgenesh2_kg.2__1036__AT1G68130.1 I
F775_43255 Aegilops tauschii F775_43255 I
BRADI4G31770 Brachypodium distachyon BRADI4G31770 I
BRADI3G37890 Brachypodium distachyon BRADI3G37890 I
BRADI1G68730 Brachypodium distachyon BRADI1G68730 I
Bra026624 Brassica rapa Bra026624 I
Bra024771 Brassica rapa Bra024771 I
Bra017432 Brassica rapa Bra017432 I
Bra010981 Brassica rapa Bra010981 I
GLYMA07G12170 Glycine max GLYMA07G12170 I
Bra004050 Brassica rapa Bra004050 I
Bo9g070370 Brassica oleracea Bo9g070370 I
Bo6g106560 Brassica oleracea Bo6g106560 I
Bo6g097320 Brassica oleracea Bo6g097320 I
Bo5g043540 Brassica oleracea Bo5g043540 I
Bo3g139880 Brassica oleracea Bo3g139880 I
Bo2g134790 Brassica oleracea Bo2g134790 I
BGIOSGA030871 Oryza indica BGIOSGA030871 I
BGIOSGA011151 Oryza indica BGIOSGA011151 I
IDD14 Arabidopsis thaliana AT1G68130 I
AtIDD16 Arabidopsis thaliana AT1G25250 I
LPERR03G08760 Leersia perrieri LPERR03G08760 I
OMERI08G14120 Oryza meridionalis OMERI08G14120 I
OMERI03G09110 Oryza meridionalis OMERI03G09110 I
OGLUM09G12720 Oryza glumaepatula OGLUM09G12720 I
OGLUM08G18370 Oryza glumaepatula OGLUM08G18370 I
OGLUM03G09920 Oryza glumaepatula OGLUM03G09920 I
OBART09G12250 Oryza barthii OBART09G12250 I
OBART08G17550 Oryza barthii OBART08G17550 I
OB09G18760 Oryza brachyantha OB09G18760 I
MLOC_57613 Hordeum vulgare MLOC_57613 I
LPERR09G08790 Leersia perrieri LPERR09G08790 I
LPERR08G14510 Leersia perrieri LPERR08G14510 I
AMTR_s00024p00098860 Amborella trichopoda AMTR_s00024p00098860 I
GSMUA_Achr7G18610_001 Musa acuminata GSMUA_Achr7G18610_001 I
GSMUA_Achr6G02490_001 Musa acuminata GSMUA_Achr6G02490_001 I
GSMUA_Achr5G23130_001 Musa acuminata GSMUA_Achr5G23130_001 I
GRMZM2G465595 Zea mays GRMZM2G465595 I
GRMZM2G141031 Zea mays GRMZM2G141031 I
GRMZM2G123094 Zea mays GRMZM2G123094 I
GRMZM2G110107 Zea mays GRMZM2G110107 I
GRMZM2G074032 Zea mays GRMZM2G074032 I
GLYMA09G30030 Glycine max GLYMA09G30030 I
GLYMA08G06130 Glycine max GLYMA08G06130 I