NKX2-2 (Myotis lucifugus)
Homeodomain

TF Information

Pfam ID Interpro ID Gene ID CIS-BP ID Sequence source Animal TF db
PF00046 (Homeobox) IPR001356 ENSMLUG00000009371 T211770_2.00 Ensembl (2018-Dec-8) Link out

Directly determined binding motifs

Name/Motif ID Species Forward Reverse Type/Study/Study ID SR
Score		 DBD
Identity
No direct experiments

Motifs from related TFs

Name/Motif ID Species Forward Reverse Type/Study/Study ID SR
Score		 DBD
Identity
Nkx2-2
M00438_2.00 		Mus musculus
NNNRAGDRN
NYHCTYNNN		 PBM
Berger et al.(2008)
Nkx2-2_2823 		0.867 1.000
Nkx2-2
M09190_2.00 		Mus musculus
NTBRAGWGBBN
NVVCWCTYVAN		 Misc
Kulakovskiy et al.(2013)
NKX22_MOUSE.H11MO.0.A 		0.867 1.000
NKX2-2
M10681_2.00 		Homo sapiens
WTAAGTRBTT
AAVYACTTAW		 Transfac
Matys et al.(2006)
V$NKX22_01 		0.867 1.000
NKX2-2
M10682_2.00 		Homo sapiens Transfac license required
 Transfac license required
 Transfac
Matys et al.(2006)
V$NKX2B_Q3_01 		0.867 1.000
NKX2-2
M10683_2.00 		Homo sapiens Transfac license required
 Transfac license required
 Transfac
Matys et al.(2006)
V$NKX2B_Q3 		0.867 1.000
vnd
M06551_2.00 		Drosophila melanogaster
WYTCAAGTR
YACTTGARW		 B1H
Mathelier et al.(2014)
MA0253.1 		0.850 0.965
vnd
M06377_2.00 		Drosophila melanogaster
WYTCAAGTR
YACTTGARW		 B1H
Zhu et al.(2011)
Vnd_Cell_FBgn0003986 		0.850 0.965
vnd
M06378_2.00 		Drosophila melanogaster
KYTSAAGWGY
RCWCTTSARM		 B1H
Zhu et al.(2011)
vnd_FlyReg_FBgn0003986 		0.850 0.965
vnd
M06379_2.00 		Drosophila melanogaster
BTBAAGTR
YACTTVAV		 B1H
Zhu et al.(2011)
Vnd_SOLEXA_FBgn0003986 		0.850 0.965
vnd
M09683_2.00 		Drosophila melanogaster
TCAAGTGB
VCACTTGA		 Misc
Kulakovskiy et al.(2009)
vnd 		0.850 0.965
Nkx2-9
M00520_2.00 		Mus musculus
NNNRAGDRBN
NVYHCTYNNN		 PBM
Berger et al.(2008)
Nkx2-9_3082 		0.843 0.912
Nkx2-9
M00800_2.00 		Mus musculus
NNRAGDRBNN
NNVYHCTYNN		 PBM
Weirauch et al.(2013)
pTH2842 		0.843 0.912
Nkx2-9
M09215_2.00 		Mus musculus
BTCAAGKRB
VYMCTTGAV		 Misc
Kulakovskiy et al.(2013)
NKX28_MOUSE.H11MO.0.C 		0.843 0.912
NKX2-8
M00302_2.00 		Homo sapiens
NNRAGDRB
VYHCTYNN		 PBM
Barrera et al.(2016)
NKX2-8_REF 		0.811 0.912
NKX2-8
M05149_2.00 		Homo sapiens
BTSRAGTGBN
NVCACTYSAV		 SELEX
Yin et al.(2017)
NKX2-8_FL_HT-SELEX 		0.811 0.912
NKX2-8
M09145_2.00 		Homo sapiens
BTCAAGKRB
VYMCTTGAV		 Misc
Kulakovskiy et al.(2013)
NKX28_HUMAN.H11MO.0.C 		0.811 0.912
NKX2-8
M05150_2.00 		Homo sapiens
GCARTAACGACATC
GATGTCGTTAYTGC		 SELEX
Yin et al.(2017)
NKX2-8_FL_Methyl-HT-SELEX_1 		0.811 0.912
NKX2-8
M05151_2.00 		Homo sapiens
BTSAAGTGBN
NVCACTTSAV		 SELEX
Yin et al.(2017)
NKX2-8_FL_Methyl-HT-SELEX_2 		0.811 0.912
NKX2-8
M05152_2.00 		Homo sapiens
BTBAACGAB
VTCGTTVAV		 SELEX
Yin et al.(2017)
NKX2-8_FL_Methyl-HT-SELEX_3 		0.811 0.912
NKX2-8
M00301_2.00 		Homo sapiens
NNRAKDRB
VYHMTYNN		 PBM
Barrera et al.(2016)
NKX2-8_A94T 		0.811 0.895
ceh-22
M00376_2.00 		Caenorhabditis elegans
WBRAGTRBNN
NNVYACTYVW		 PBM
Berger et al.(2006)
Ceh-22 		0.807 0.860
scro
M03854_2.00 		Drosophila melanogaster
NNBRMGTGB
VCACKYVNN		 SELEX
Nitta et al.(2015)
scro_1 		0.799 0.895
Nkx2-1
M00385_2.00 		Mus musculus
NNRAGDRN
NYHCTYNN		 PBM
Berger et al.(2008)
Titf1_1722 		0.798 0.895
Nkx2-4
M00514_2.00 		Mus musculus
NNRAGDRBNN
NNVYHCTYNN		 PBM
Berger et al.(2008)
Nkx2-4_3074 		0.798 0.895
NKX2-1
M09146_2.00 		Homo sapiens
BTKGAGWGBN
NVCWCTCMAV		 Misc
Kulakovskiy et al.(2013)
NKX21_HUMAN.H11MO.0.A 		0.798 0.895
Nkx2-1
M09171_2.00 		Mus musculus
NBTKGAGWGB
VCWCTCMAVN		 Misc
Kulakovskiy et al.(2013)
NKX21_MOUSE.H11MO.0.A 		0.798 0.895
Nkx2-1
M09563_2.00 		Mus musculus
BTBRAGWGBH
DVCWCTYVAV		 Misc
Heinz et al.(2010)
LungAC-Nkx2.1_GSE43252 		0.798 0.895
NKX2-1
M10694_2.00 		Homo sapiens Transfac license required
 Transfac license required
 Transfac
Matys et al.(2006)
V$TITF1_Q3 		0.798 0.895
NKX2-1
M10695_2.00 		Homo sapiens Transfac license required
 Transfac license required
 Transfac
Matys et al.(2006)
V$TTF1_Q5_01 		0.798 0.895
NKX2-1
M10696_2.00 		Homo sapiens Transfac license required
 Transfac license required
 Transfac
Matys et al.(2006)
V$TTF1_Q5 		0.798 0.895
NKX2-1
M10697_2.00 		Homo sapiens Transfac license required
 Transfac license required
 Transfac
Matys et al.(2006)
V$TTF1_Q6 		0.798 0.895
ceh-24
M02181_2.00 		Caenorhabditis elegans
NNRAKWRNN
NNYWMTYNN		 PBM
Weirauch et al.(2014)
pTH6327 		0.784 0.825
NKX2-5
M00323_2.00 		Homo sapiens
NWYAAGTGSNN
NNSCACTTRWN		 PBM
Barrera et al.(2016)
NKX2-5_REF 		0.742 0.789
Nkx2-5
M00404_2.00 		Mus musculus
NNNRAGDRBN
NVYHCTYNNN		 PBM
Berger et al.(2008)
Nkx2-5_3436 		0.742 0.789
NKX2-5
M05346_2.00 		Homo sapiens
BHYAAGTGBN
NVCACTTRDV		 SELEX
Yin et al.(2017)
NKX2-5_FL_HT-SELEX 		0.742 0.789
Nkx2-5
M02686_2.00 		Mus musculus
WTAAKWK
MWMTTAW		 SELEX
Mathelier et al.(2014)
MA0063.1 		0.742 0.789
Nkx2-5
M08136_2.00 		Mus musculus
SYTGAGWGSYH
DRSCWCTCARS		 ChIP-seq
Mathelier et al.(2014)
MA0503.1 		0.742 0.789
NKX2-5
M09163_2.00 		Homo sapiens
BKRAGWGV
BCWCTYMV		 Misc
Kulakovskiy et al.(2013)
NKX25_HUMAN.H11MO.0.B 		0.742 0.789
Nkx2-5
M09177_2.00 		Mus musculus
NBYBRAGTGS
SCACTYVRVN		 Misc
Kulakovskiy et al.(2013)
NKX25_MOUSE.H11MO.0.A 		0.742 0.789
Nkx2-5
M09567_2.00 		Mus musculus
HBRAGWGBNN
NNVCWCTYVD		 Misc
Heinz et al.(2010)
HL1-Nkx2.5.biotin_GSE21529 		0.742 0.789
NKX2-5
M10742_2.00 		Homo sapiens
TYAAGTG
CACTTRA		 Transfac
Matys et al.(2006)
V$NKX25_01 		0.742 0.789
NKX2-5
M10743_2.00 		Homo sapiens
CWTAATTV
BAATTAWG		 Transfac
Matys et al.(2006)
V$NKX25_02 		0.742 0.789
NKX2-5
M10744_2.00 		Homo sapiens Transfac license required
 Transfac license required
 Transfac
Matys et al.(2006)
V$NKX25_Q5 		0.742 0.789
NKX2-5
M10745_2.00 		Homo sapiens Transfac license required
 Transfac license required
 Transfac
Matys et al.(2006)
V$NKX25_Q6 		0.742 0.789
NKX2-5
M05347_2.00 		Homo sapiens
BTYAAGTGGN
NCCACTTRAV		 SELEX
Yin et al.(2017)
NKX2-5_FL_Methyl-HT-SELEX_1 		0.742 0.789
NKX2-5
M05348_2.00 		Homo sapiens
BTYAACGAB
VTCGTTRAV		 SELEX
Yin et al.(2017)
NKX2-5_FL_Methyl-HT-SELEX_2 		0.742 0.789
NKX2-5
M00322_2.00 		Homo sapiens
NNNRNNN
NNNYNNN		 PBM
Barrera et al.(2016)
NKX2-5_R190C 		0.742 0.772
NKX2-5
M00324_2.00 		Homo sapiens
NHNNNNN
NNNNNDN		 PBM
Barrera et al.(2016)
NKX2-5_T178M 		0.742 0.772
Nkx2-3
M00497_2.00 		Mus musculus
NNRAGDRNN
NNYHCTYNN		 PBM
Berger et al.(2008)
Nkx2-3_3435 		0.741 0.807
NKX2-3
M05042_2.00 		Homo sapiens
NNBAAGTGBN
NVCACTTVNN		 SELEX
Yin et al.(2017)
NKX2-3_eDBD_HT-SELEX 		0.741 0.807
NKX2-3
M05045_2.00 		Homo sapiens
BNBAAGTGBN
NVCACTTVNV		 SELEX
Yin et al.(2017)
NKX2-3_FL_HT-SELEX 		0.741 0.807
NKX2-3
M05043_2.00 		Homo sapiens
BNBAAGTGBN
NVCACTTVNV		 SELEX
Yin et al.(2017)
NKX2-3_eDBD_Methyl-HT-SELEX_1 		0.741 0.807
NKX2-3
M05044_2.00 		Homo sapiens
SDYAACGHB
VDCGTTRHS		 SELEX
Yin et al.(2017)
NKX2-3_eDBD_Methyl-HT-SELEX_2 		0.741 0.807
NKX2-3
M05046_2.00 		Homo sapiens
BNBAAGTGBN
NVCACTTVNV		 SELEX
Yin et al.(2017)
NKX2-3_FL_Methyl-HT-SELEX_1 		0.741 0.807
NKX2-3
M05047_2.00 		Homo sapiens
SWYAACSHB
VDSGTTRWS		 SELEX
Yin et al.(2017)
NKX2-3_FL_Methyl-HT-SELEX_2 		0.741 0.807
NKX2-5
M00321_2.00 		Homo sapiens
HNAAGTRBNN
NNVYACTTND		 PBM
Barrera et al.(2016)
NKX2-5_R161P 		0.737 0.772
ceh-28
M08210_2.00 		Caenorhabditis elegans
AATCGATW
WATCGATT		 ChIP-seq
Contrino et al.(2012)
Mw138 		0.736 0.649
Nkx2-6
M00496_2.00 		Mus musculus
HYAAGTRBNN
NNVYACTTRD		 PBM
Berger et al.(2008)
Nkx2-6_3437 		0.718 0.754
tin
M00559_2.00 		Drosophila melanogaster
NWYAAGTGGNN
NNCCACTTRWN		 PBM
Busser et al.(2012a)
Tin 		0.718 0.632
tin
M03809_2.00 		Drosophila melanogaster
BTYAAGTGSN
NSCACTTRAV		 SELEX
Nitta et al.(2015)
tin_1 		0.718 0.632
tin
M06284_2.00 		Drosophila melanogaster
BTYAAGTG
CACTTRAV		 B1H
Zhu et al.(2011)
Tin_Cell_FBgn0004110 		0.718 0.632
tin
M06285_2.00 		Drosophila melanogaster
BCTCAAGTGSVN
NBSCACTTGAGV		 B1H
Zhu et al.(2011)
tin_FlyReg_FBgn0004110 		0.718 0.632
tin
M06286_2.00 		Drosophila melanogaster
BWYAAGTR
YACTTRWV		 B1H
Zhu et al.(2011)
Tin_SOLEXA_FBgn0004110 		0.718 0.632
tin
M08421_2.00 		Drosophila melanogaster
DBTCRAGTGS
SCACTYGAVH		 ChIP-chip
Mathelier et al.(2014)
MA0247.2 		0.718 0.632
NKX2-5
M00320_2.00 		Homo sapiens
NHBAAKWRN
NYWMTTVDN		 PBM
Barrera et al.(2016)
NKX2-5_K183E 		0.709 0.772
Q24782_9CNID
M02206_2.00 		Eleutheria dichotoma
TTAATTAA
TTAATTAA		 PBM
Weirauch et al.(2014)
pTH5486 		0.613 0.491
For this family, TFs with SR scores > 0.599 will likely have a similar motif

DNA Binding Domains

Protein ID Domain From To Sequence
ENSMLUP00000008537 Homeodomain 129 185

Links

Other Homeodomain family TFs
Other Myotis lucifugus TFs

821 Related TFs

Name Species Gene ID Motif Evidence SR
Score		 Action
AACERI_AaceriAAR026W Saccharomycetaceae sp ashbya aceri AACERI_AaceriAAR026W I
Aan_R000440 Calypte anna Aan_R000440 I
Afo_R001715 Aptenodytes forsteri Afo_R001715 I
AGOS_AAR026W Ashbya gossypii AGOS_AAR026W I
Alligator_sinensis_CCG000124.1 Alligator sinensis Alligator_sinensis_CCG000124.1 I
Brh_R002687 Buceros rhinoceros Brh_R002687 I
CANTEDRAFT_136140 Candida tenuis CANTEDRAFT_136140 I
CGI_10003963 Crassostrea gigas CGI_10003963 I
Cmyd_10005373 Chelonia mydas Cmyd_10005373 I
csin104163 Clonorchis sinensis csin104163 I
D915_09544 Fasciola hepatica D915_09544 I
DAPPUDRAFT_313324 Daphnia pulex DAPPUDRAFT_313324 I
DICSQDRAFT_40774 Dichomitus squalens DICSQDRAFT_40774 I
ECPE_0001539401 Echinostoma caproni ECPE_0001539401 I
Ecym_1257 Eremothecium cymbalariae Ecym_1257 I
ENSAMEG00000013492 Ailuropoda melanoleuca ENSAMEG00000013492 I
ENSAMXG00000017678 Astyanax mexicanus ENSAMXG00000017678 I
ENSAPLG00000007110 Anas platyrhynchos ENSAPLG00000007110 I
ENSBTAP00000044156-D1 Bos grunniens ENSBTAP00000044156-D1 I
ENSCSAG00000011395 Chlorocebus sabaeus ENSCSAG00000011395 I
ENSFALG00000010259 Ficedula albicollis ENSFALG00000010259 I
ENSGACG00000019192 Gasterosteus aculeatus ENSGACG00000019192 I
ENSGMOG00000013782 Gadus morhua ENSGMOG00000013782 I
ENSLACG00000009119 Latimeria chalumnae ENSLACG00000009119 I
ENSLOCG00000015822 Lepisosteus oculatus ENSLOCG00000015822 I
ENSMEUG00000011116 Macropus eugenii ENSMEUG00000011116 I
ENSMPUG00000018249 Mustela putorius furo ENSMPUG00000018249 I
ENSNLEG00000008761 Nomascus leucogenys ENSNLEG00000008761 I
ENSOARG00000005055 Ovis aries ENSOARG00000005055 I
ENSONIG00000008523 Oreochromis niloticus ENSONIG00000008523 I
ENSONIG00000011868 Oreochromis niloticus ENSONIG00000011868 I
ENSORLG00000009474 Oryzias latipes ENSORLG00000009474 I
ENSP00000420500 Macaca fascicularis ENSP00000420500 I
ENSPANG00000024385 Papio anubis ENSPANG00000024385 I
ENSPFOG00000003951 Poecilia formosa ENSPFOG00000003951 I
ENSPFOG00000012271 Poecilia formosa ENSPFOG00000012271 I
ENSPMAG00000002631 Petromyzon marinus ENSPMAG00000002631 I
ENSPPYG00000017898 Pongo abelii ENSPPYG00000017898 I
ENSPSIG00000012478 Pelodiscus sinensis ENSPSIG00000012478 I
ENSSHAG00000010948 Sarcophilus harrisii ENSSHAG00000010948 I
ENSSTOG00000013846 Ictidomys tridecemlineatus ENSSTOG00000013846 I
ENSTNIG00000002023 Tetraodon nigroviridis ENSTNIG00000002023 I
ENSTRUG00000011881 Takifugu rubripes ENSTRUG00000011881 I
ENSTSYG00000010057 Tarsius syrichta ENSTSYG00000010057 I
ENSXMAG00000007586 Xiphophorus maculatus ENSXMAG00000007586 I
ENSXMAG00000016455 Xiphophorus maculatus ENSXMAG00000016455 I
e_gw.61.169.1 Branchiostoma floridae e_gw.61.169.1 I
e_gw.633.29.1 Branchiostoma floridae e_gw.633.29.1 I
GA30228 Drosophila pseudoobscura FBgn0263363 I
GB51010 Apis mellifera GB51010 I
Gfo_R011321 Geospiza fortis Gfo_R011321 I
GI22721 Drosophila mojavensis FBgn0145448 I
GL12097 Drosophila persimilis FBgn0149705 I
HBP1 Anolis carolinensis ENSACAG00000015023 I
HBP1 Bos taurus ENSBTAG00000005524 I
HBP1 Canis familiaris ENSCAFG00000003939 I
HBP1 Callithrix jacchus ENSCJAG00000016260 I
HBP1 Cavia porcellus ENSCPOG00000002375 I
hbp1 Danio rerio ENSDARG00000028517 I
HBP1 Dasypus novemcinctus ENSDNOG00000004405 I
Hbp1 Dipodomys ordii ENSDORG00000010576 I
HBP1 Equus caballus ENSECAG00000020969 I
HBP1 Echinops telfairi ENSETEG00000018542 I
HBP1 Homo sapiens ENSG00000105856 D
hbp1 Gasterosteus aculeatus ENSGACG00000010054 I
HBP1 Gallus gallus ENSGALG00000008050 I
HBP1 Gorilla gorilla ENSGGOG00000007788 I
HBP1 Loxodonta africana ENSLAFG00000005317 I
HBP1 Meleagris gallopavo ENSMGAG00000006880 I
HBP1 Microcebus murinus ENSMICG00000012858 I
HBP1 Myotis lucifugus ENSMLUG00000012425 I
HBP1 Macaca mulatta ENSMMUG00000015409 I
HBP1 Monodelphis domestica ENSMODG00000016376 I
Hbp1 Mus musculus ENSMUSG00000002996 D
HBP1 Ornithorhynchus anatinus ENSOANG00000003174 I
HBP1 Oryctolagus cuniculus ENSOCUG00000012758 I
HBP1 Otolemur garnettii ENSOGAG00000013102 I
hbp1 Oryzias latipes ENSORLG00000004396 I
HBP1 Procavia capensis ENSPCAG00000014060 I
HBP1 Pan troglodytes ENSPTRG00000019575 I
HBP1 Pteropus vampyrus ENSPVAG00000014543 I
Hbp1 Rattus norvegicus ENSRNOG00000008927 I
HBP1 Sorex araneus ENSSARG00000007731 I
HBP1 Tupaia belangeri ENSTBEG00000007793 I
HBP1 Taeniopygia guttata ENSTGUG00000003100 I
hbp1 Tetraodon nigroviridis ENSTNIG00000016027 I
hbp1 Takifugu rubripes ENSTRUG00000016990 I
HBP1 Tursiops truncatus ENSTTRG00000006826 I
HBP1 Vicugna pacos ENSVPAG00000008629 I
hbp1 Xenopus tropicalis XB-GENE-950343 I
hbp1.L Xenopus laevis XB-GENE-950348 I
hbp1.S Xenopus laevis XB-GENE-17342930 I
HelroG148167 Helobdella robusta HelroG148167 I
ISCW021979 Ixodes scapularis ISCW021979 I
L798_09303 Zootermopsis nevadensis L798_09303 I
ML040423a Mnemiopsis leidyi ML040423a I
Myotis_brandtii_HBP1_10033916 Myotis brandtii Myotis_brandtii_HBP1_10033916 I
NEMVEDRAFT_v1g120503 Nematostella vectensis NEMVEDRAFT_v1g120503 I
PHUM534240 Pediculus humanus PHUM534240 I
Pvit_03004 Pogona vitticeps Pvit_03004 I
SMAR013235 Strigamia maritima SMAR013235 I
Smp_148110 Schistosoma mansoni Smp_148110 I
SNAPOd2T00000335001 Oikopleura dioica SNAPOd2T00000335001 I
T265_01499 Opisthorchis viverrini T265_01499 I
Tal_R010197 Tyto alba Tal_R010197 I
tetur23g00840 Tetranychus urticae tetur23g00840 I
TriadG55419 Trichoplax adhaerens TriadG55419 I
XP_002155149.1 Hydra magnipapillata XP_002155149.1 I
ZBAI_00389 Zygosaccharomyces bailii ZBAI_00389 I
ZBAI_05541 Zygosaccharomyces bailii ZBAI_05541 I
ZYRO0C16214g Zygosaccharomyces rouxii ZYRO0C16214g I