NPAS2 (Homo sapiens)
bHLH

TF Information

Pfam ID Interpro ID Gene ID CIS-BP ID Sequence source Animal TF db
PF00010 (HLH) IPR001092 ENSG00000170485 T034312_2.00 Ensembl (2018-Dec-8) Link out
NCBI Gene Info:
The protein encoded by this gene is a member of the basic helix-loop-helix (bHLH)-PAS family of transcription factors. A similar mouse protein may play a regulatory role in the acquisition of specific types of memory. It also may function as a part of a molecular clock operative in the mammalian forebrain. [provided by RefSeq, Jul 2008]

Directly determined binding motifs

Name/Motif ID Species Forward Reverse Type/Study/Study ID SR
Score
DBD
Identity
NPAS2
M04158_2.00
Homo sapiens
NRCACGTGKH

DMCACGTGYN
SELEX
Yin et al.(2017)
NPAS2_eDBD_HT-SELEX
(Direct) (Direct)
NPAS2
M04159_2.00
Homo sapiens
DVCRCRTGKH

DMCAYGYGBH
SELEX
Yin et al.(2017)
NPAS2_eDBD_Methyl-HT-SELEX
(Direct) (Direct)

Motifs from related TFs

Name/Motif ID Species Forward Reverse Type/Study/Study ID SR
Score
DBD
Identity
Npas2
M01731_2.00
Mus musculus
NVCACGTGBN

NVCACGTGBN
PBM
Weirauch et al.(2014)
pTH5457
0.914 1.000
Npas2
M09468_2.00
Mus musculus
VKCACRTGKM

KMCAYGTGMB
Misc
Heinz et al.(2010)
Liver-NPAS2_GSE39860
0.777 1.000
For this family, TFs with SR scores > 0.838 will likely have a similar motif

DNA Binding Domains

Protein ID Domain From To Sequence
ENSP00000338283 bHLH 10 59
ENSP00000388528 bHLH 1 49
ENSP00000395265 bHLH 1 43
ENSP00000397595 bHLH 75 124

Links

Other bHLH family TFs
Other Homo sapiens TFs

55 Related TFs

Name Species Gene ID Motif Evidence SR
Score
Action
ENSPPYG00000012101 Pongo abelii ENSPPYG00000012101 I 0.914
NPAS2 Procavia capensis ENSPCAG00000004689 I 0.914
NPAS2 Pan troglodytes ENSPTRG00000012287 I 0.914
NPAS2 Pteropus vampyrus ENSPVAG00000011717 I 0.914
NPAS2 Sus scrofa ENSSSCG00000008171 I 0.914
ENSPANG00000000546 Papio anubis ENSPANG00000000546 I 0.914
NPAS2 Ochotona princeps ENSOPRG00000001179 N 0.914
Npas2 Mus musculus ENSMUSG00000026077 D 0.914
ENSOARG00000013285 Ovis aries ENSOARG00000013285 I 0.914
NPAS2 Oryctolagus cuniculus ENSOCUG00000002384 I 0.914
NPAS2 Otolemur garnettii ENSOGAG00000014490 I 0.914
ENSSTOG00000008934 Ictidomys tridecemlineatus ENSSTOG00000008934 I 0.914
NPAS2 Tupaia belangeri ENSTBEG00000012008 I 0.914
Tal_R012319 Tyto alba Tal_R012319 I 0.914
ENSMMUP00000012928 Macaca fascicularis ENSMMUP00000012928 I 0.914
ENSP00000338283-D1 Bos grunniens ENSP00000338283-D1 I 0.914
Gfo_R005610 Geospiza fortis Gfo_R005610 I 0.914
Afo_R015956 Aptenodytes forsteri Afo_R015956 I 0.914
Aan_R003197 Calypte anna Aan_R003197 I 0.914
NPAS2 Taeniopygia guttata ENSTGUG00000010003 I 0.914
ENSTSYG00000005382 Tarsius syrichta ENSTSYG00000005382 I 0.914
NPAS2 Tursiops truncatus ENSTTRG00000016446 I 0.914
NPAS2 Vicugna pacos ENSVPAG00000001242 I 0.914
ENSMPUG00000012117 Mustela putorius furo ENSMPUG00000012117 I 0.914
ENSNLEG00000014404 Nomascus leucogenys ENSNLEG00000014404 I 0.914
ENSFALG00000003827 Ficedula albicollis ENSFALG00000003827 I 0.914
NPAS2 Felis catus ENSFCAG00000005306 I 0.914
NPAS2 Callithrix jacchus ENSCJAG00000021202 I 0.914
NPAS2 Choloepus hoffmanni ENSCHOG00000008122 I 0.914
NPAS2 Echinops telfairi ENSETEG00000008221 I 0.914
NPAS2 Equus caballus ENSECAG00000000171 I 0.914
ENSCSAG00000017176 Chlorocebus sabaeus ENSCSAG00000017176 I 0.914
NPAS2 Dasypus novemcinctus ENSDNOG00000002520 I 0.914
ENSDORG00000015727 Dipodomys ordii ENSDORG00000015727 I 0.914
NPAS2 Gallus gallus ENSGALG00000016774 I 0.914
NPAS2 Microcebus murinus ENSMICG00000016027 I 0.914
NPAS2 Macaca mulatta ENSMMUG00000009871 I 0.914
NPAS2 Bos taurus ENSBTAG00000019697 I 0.914
ENSAPLG00000016315 Anas platyrhynchos ENSAPLG00000016315 I 0.914
NPAS2 Meleagris gallopavo ENSMGAG00000014799 I 0.914
NPAS2 Canis familiaris ENSCAFG00000002223 I 0.914
NPAS2 Gorilla gorilla ENSGGOG00000006420 I 0.914
ENSLACG00000011834 Latimeria chalumnae ENSLACG00000011834 I 0.914
NPAS2 Loxodonta africana ENSLAFG00000016336 I 0.914
ENSCPOG00000002470 Cavia porcellus ENSCPOG00000002470 I 0.914
ENSSHAG00000010526 Sarcophilus harrisii ENSSHAG00000010526 I 0.901
NPAS2 Monodelphis domestica ENSMODG00000001691 I 0.901
ENSMEUG00000000949 Macropus eugenii ENSMEUG00000000949 I 0.901
Npas2 Rattus norvegicus ENSRNOG00000013408 I 0.901
Ogr16001 Ophisaurus gracilis Ogr16001 I 0.894
NPAS2 Anolis carolinensis ENSACAG00000007946 I 0.894
Pvit_02251 Pogona vitticeps Pvit_02251 I 0.894
ENSOANG00000022558 Ornithorhynchus anatinus ENSOANG00000022558 I 0.890
Cmyd_10011837 Chelonia mydas Cmyd_10011837 I 0.882