CBF1 (Saccharomyces cerevisiae)
bHLH

TF Information

Pfam ID Interpro ID Gene ID CIS-BP ID Sequence source Animal TF db
PF00010 (HLH) IPR001092 YJR060W T046367_2.00 Ensembl (2018-Dec-8) Link out
NCBI Gene Info:
Enables DNA-binding transcription factor activity, RNA polymerase II-specific; RNA polymerase II-specific DNA-binding transcription factor binding activity; and sequence-specific double-stranded DNA binding activity. Involved in several processes, including chromatin remodeling; ncRNA transcription; and regulation of transcription by RNA polymerase II. Located in kinetochore. Part of Cbf1-Met4-Met28 complex. Human ortholog(s) of this gene implicated in cardiovascular system disease and type 2 diabetes mellitus. Orthologous to human USF1 (upstream transcription factor 1). [provided by Alliance of Genome Resources, Apr 2022]

Directly determined binding motifs

Name/Motif ID Species Forward Reverse Type/Study/Study ID SR
Score		 DBD
Identity
CBF1
M00010_2.00		 Saccharomyces cerevisiae
NDCACGTGANN
NNTCACGTGHN		 PBM
Badis et al.(2008)
CBF1_2160		 (Direct) (Direct)
CBF1
M00374_2.00		 Saccharomyces cerevisiae
NCACGTGAY
RTCACGTGN		 PBM
Berger et al.(2006)
Cbf1		 (Direct) (Direct)
CBF1
M01520_2.00		 Saccharomyces cerevisiae
CACGTGAYH
DRTCACGTG		 PBM
Zhu et al.(2009)
Cbf1		 (Direct) (Direct)
CBF1
M07440_2.00		 Saccharomyces cerevisiae
TCACGTGH
DCACGTGA		 PBM, CSA and or DIP-chip
Mathelier et al.(2014)
MA0281.1		 (Direct) (Direct)
CBF1
M08485_2.00		 Saccharomyces cerevisiae
NCAYRTGN
NCAYRTGN		 Misc
DeBoer et al.(2011)
YJR060W_1347		 (Direct) (Direct)
CBF1
M09483_2.00		 Saccharomyces cerevisiae
KCACGTGAYN
NRTCACGTGM		 Misc
Heinz et al.(2010)
Yeast-Cbf1_GSE29506		 (Direct) (Direct)
CBF1
M09897_2.00		 Saccharomyces cerevisiae Transfac license required
 Transfac license required
 Transfac
Matys et al.(2006)
F$CBF1_02		 (Direct) (Direct)
CBF1
M09898_2.00		 Saccharomyces cerevisiae Transfac license required
 Transfac license required
 Transfac
Matys et al.(2006)
F$CBF1_03		 (Direct) (Direct)
CBF1
M09899_2.00		 Saccharomyces cerevisiae Transfac license required
 Transfac license required
 Transfac
Matys et al.(2006)
F$CBF1_04		 (Direct) (Direct)
CBF1
M09900_2.00		 Saccharomyces cerevisiae Transfac license required
 Transfac license required
 Transfac
Matys et al.(2006)
F$CBF1_B		 (Direct) (Direct)
CBF1
M09901_2.00		 Saccharomyces cerevisiae Transfac license required
 Transfac license required
 Transfac
Matys et al.(2006)
F$CBF1_Q6		 (Direct) (Direct)

Motifs from related TFs

Name/Motif ID Species Forward Reverse Type/Study/Study ID SR
Score		 DBD
Identity
For this family, TFs with SR scores > 0.838 will likely have a similar motif

Experimental Constructs

Motif ID Domain From To Sequence
M00010_2.00 bHLH 51 99
M00374_2.00 bHLH 223 271
M01520_2.00 bHLH 223 271

DNA Binding Domains

Protein ID Domain From To Sequence
YJR060W bHLH 223 271

Links

Other bHLH family TFs
Other Saccharomyces cerevisiae TFs

23 Related TFs

Name Species Gene ID Motif Evidence SR
Score		 Action
12421_YJR060W Saccharomyces mikatae 12421_YJR060W I 0.893
SKUD_191104 Saccharomyces kudriavzevii SKUD_191104 I 0.893
13072_YJR060W Saccharomyces bayanus 13072_YJR060W I 0.893
12538_YJR060W Saccharomyces paradoxus 12538_YJR060W I 0.893
SAKL0D12650g Lachancea kluyveri SAKL0D12650g I 0.893
Kpol_1054p48 Vanderwaltozyma polyspora Kpol_1054p48 I 0.873
TBLA_0D03730 Tetrapisispora blattae TBLA_0D03730 I 0.873
ZBAI_06241 Zygosaccharomyces bailii ZBAI_06241 I 0.866
Kwal_9999 Kluyveromyces waltii Kwal_9999 I 0.866
ZBAI_00952 Zygosaccharomyces bailii ZBAI_00952 I 0.866
KLTH0C02640g Kluyveromyces thermotolerans KLTH0C02640g I 0.866
ZYRO0G04466g Zygosaccharomyces rouxii ZYRO0G04466g I 0.866
TDEL_0F00520 Torulaspora delbrueckii TDEL_0F00520 I 0.866
TPHA_0F03530 Tetrapisispora phaffii TPHA_0F03530 I 0.866
KLTH0C02640g Lachancea thermotolerans KLTH0C02640g I 0.866
KAFR_0D03630 Kazachstania africana KAFR_0D03630 I 0.863
KNAG_0B00250 Kazachstania naganishii KNAG_0B00250 I 0.861
Ecym_3159 Eremothecium cymbalariae Ecym_3159 I 0.855
AACERI_AaceriAFR414W Saccharomycetaceae sp ashbya aceri AACERI_AaceriAFR414W I 0.855
AGOS_AFR414W Ashbya gossypii AGOS_AFR414W I 0.855
LALA0_S07e03906g Lachancea lanzarotensis LALA0_S07e03906g I 0.842
NCAS_0A12210 Naumovozyma castellii NCAS_0A12210 I 0.839
Scas_Contig673.33 Saccharomyces castellii Scas_Contig673.33 I 0.839