HHAL000695-PA (Halyomorpha halys)
bHLH

TF Information

Pfam ID Interpro ID Gene ID CIS-BP ID Sequence source
PF00010 (HLH) IPR001092 HHAL000695-PA T051396_2.00 Misc (2018-Jan-19)
NCBI Gene Info:
This gene encodes a tumor suppressor protein containing transcriptional activation, DNA binding, and oligomerization domains. The encoded protein responds to diverse cellular stresses to regulate expression of target genes, thereby inducing cell cycle arrest, apoptosis, senescence, DNA repair, or changes in metabolism. Mutations in this gene are associated with a variety of human cancers, including hereditary cancers such as Li-Fraumeni syndrome. Alternative splicing of this gene and the use of alternate promoters result in multiple transcript variants and isoforms. Additional isoforms have also been shown to result from the use of alternate translation initiation codons from identical transcript variants (PMIDs: 12032546, 20937277). [provided by RefSeq, Dec 2016]

Directly determined binding motifs

Name/Motif ID Species Forward Reverse Type/Study/Study ID SR
Score		 DBD
Identity
No direct experiments

Motifs from related TFs

Name/Motif ID Species Forward Reverse Type/Study/Study ID SR
Score		 DBD
Identity
Tcf21
M01746_2.00 		Mus musculus
RMCAKMTGK
MCAKMTGKY		 PBM
Weirauch et al.(2014)
pTH5087 		0.883 0.942
Tcf21
M02819_2.00 		Mus musculus
VNAACAGCTGTTVN
NBAACAGCTGTTNB		 SELEX
Jolma et al.(2013)
Tcf21_1 		0.883 0.942
TCF21
M04092_2.00 		Homo sapiens
BAACAGCTGBYN
NRVCAGCTGTTV		 SELEX
Yin et al.(2017)
TCF21_eDBD_HT-SELEX_1 		0.883 0.942
TCF21
M04093_2.00 		Homo sapiens
NRCCATATGKYV
BRMCATATGGYN		 SELEX
Yin et al.(2017)
TCF21_eDBD_HT-SELEX_2 		0.883 0.942
TCF21
M04094_2.00 		Homo sapiens
BAACAGCTGTYV
BRACAGCTGTTV		 SELEX
Yin et al.(2017)
TCF21_eDBD_Methyl-HT-SELEX_1 		0.883 0.942
TCF21
M04095_2.00 		Homo sapiens
BACCATATGKYV
BRMCATATGGTV		 SELEX
Yin et al.(2017)
TCF21_eDBD_Methyl-HT-SELEX_2 		0.883 0.942
Msc
M01730_2.00 		Mus musculus
NVCRKMYGBN
NVCRKMYGBN		 PBM
Weirauch et al.(2014)
pTH5112 		0.883 0.923
MSC
M02801_2.00 		Homo sapiens
AACAGCTGTT
AACAGCTGTT		 SELEX
Jolma et al.(2013)
MSC_1 		0.883 0.923
MSC
M04183_2.00 		Homo sapiens
NRMCAGMTGBYN
NRVCAKCTGKYN		 SELEX
Yin et al.(2017)
MSC_eDBD_HT-SELEX_1 		0.883 0.923
MSC
M04184_2.00 		Homo sapiens
NRVCAYVTGBYN
NRVCABRTGBYN		 SELEX
Yin et al.(2017)
MSC_eDBD_HT-SELEX_2 		0.883 0.923
MSC
M04187_2.00 		Homo sapiens
NRMCAGCTGBYV
BRVCAGCTGKYN		 SELEX
Yin et al.(2017)
MSC_FL_HT-SELEX_1 		0.883 0.923
MSC
M04188_2.00 		Homo sapiens
BRMCATATGKYN
NRMCATATGKYV		 SELEX
Yin et al.(2017)
MSC_FL_HT-SELEX_2 		0.883 0.923
MSC
M04185_2.00 		Homo sapiens
NRVCAGCTGBBN
NVVCAGCTGBYN		 SELEX
Yin et al.(2017)
MSC_eDBD_Methyl-HT-SELEX_1 		0.883 0.923
MSC
M04186_2.00 		Homo sapiens
BRMCATATGKYV
BRMCATATGKYV		 SELEX
Yin et al.(2017)
MSC_eDBD_Methyl-HT-SELEX_2 		0.883 0.923
MSC
M04189_2.00 		Homo sapiens
BRACAGCTGTYV
BRACAGCTGTYV		 SELEX
Yin et al.(2017)
MSC_FL_Methyl-HT-SELEX_1 		0.883 0.923
MSC
M04190_2.00 		Homo sapiens
BRMCATATGKYV
BRMCATATGKYV		 SELEX
Yin et al.(2017)
MSC_FL_Methyl-HT-SELEX_2 		0.883 0.923
For this family, TFs with SR scores > 0.838 will likely have a similar motif

DNA Binding Domains

Protein ID Domain From To Sequence
HHAL000695-PA bHLH 18 70

Links

Other bHLH family TFs
Other Halyomorpha halys TFs

151 Related TFs

Name Species Gene ID Motif Evidence SR
Score		 Action
RPRC001590 Rhodnius prolixus RPRC001590 I 0.914
ENSLACG00000014348 Latimeria chalumnae ENSLACG00000014348 I 0.903
ENSAMXG00000000487 Astyanax mexicanus ENSAMXG00000000487 I 0.903
CLEC012607 Cimex lectularius CLEC012607 I 0.886
DAPPUDRAFT_37461 Daphnia pulex DAPPUDRAFT_37461 I 0.886
ENSPFOG00000010821 Poecilia formosa ENSPFOG00000010821 I 0.883
ENSPPYG00000017022 Pongo abelii ENSPPYG00000017022 I 0.883
ENSPSIG00000003604 Pelodiscus sinensis ENSPSIG00000003604 I 0.883
ENSPPYG00000018665 Pongo abelii ENSPPYG00000018665 I 0.883
TCF21 Pan troglodytes ENSPTRG00000018622 I 0.883
MSC Pteropus vampyrus ENSPVAG00000009083 I 0.883
ENSSHAG00000002801 Sarcophilus harrisii ENSSHAG00000002801 I 0.883
ENSSHAG00000004870 Sarcophilus harrisii ENSSHAG00000004870 I 0.883
Tcf21 Rattus norvegicus ENSRNOG00000016700 I 0.883
Msc Rattus norvegicus ENSRNOG00000007540 I 0.883
TCF21 Pteropus vampyrus ENSPVAG00000009085 I 0.883
MSC Pan troglodytes ENSPTRG00000020339 I 0.883
ENSPANG00000022301 Papio anubis ENSPANG00000022301 I 0.883
ENSOARG00000014623 Ovis aries ENSOARG00000014623 I 0.883
MSC Oryctolagus cuniculus ENSOCUG00000007208 I 0.883
ENSOARG00000004844 Ovis aries ENSOARG00000004844 I 0.883
TCF21 Ornithorhynchus anatinus ENSOANG00000013098 I 0.883
ENSNLEG00000011452 Nomascus leucogenys ENSNLEG00000011452 I 0.883
ENSNLEG00000014647 Nomascus leucogenys ENSNLEG00000014647 I 0.883
TCF21 Oryctolagus cuniculus ENSOCUG00000017761 I 0.883
MSC Otolemur garnettii ENSOGAG00000013827 I 0.883
ENSSSCG00000004174 Sus scrofa ENSSSCG00000004174 I 0.883
MSC Procavia capensis ENSPCAG00000004330 I 0.883
tcf21 Oryzias latipes ENSORLG00000016491 I 0.883
ENSONIG00000000446 Oreochromis niloticus ENSONIG00000000446 I 0.883
TCF21 Otolemur garnettii ENSOGAG00000034073 I 0.883
ENSPCAG00000006459 Procavia capensis ENSPCAG00000006459 I 0.883
ENSSTOG00000024832 Ictidomys tridecemlineatus ENSSTOG00000024832 I 0.883
ENSBTAP00000052463-D1 Bos grunniens ENSBTAP00000052463-D1 I 0.883
ENSP00000321445 Macaca fascicularis ENSP00000321445 I 0.883
ENSBTAP00000044112-D1 Bos grunniens ENSBTAP00000044112-D1 I 0.883
Brh_R005605 Buceros rhinoceros Brh_R005605 I 0.883
Alligator_sinensis_CCG001917.1 Alligator sinensis Alligator_sinensis_CCG001917.1 I 0.883
ENSP00000356857 Macaca fascicularis ENSP00000356857 I 0.883
Gfo_R006439 Geospiza fortis Gfo_R006439 I 0.883
tcf21.L Xenopus laevis XB-GENE-484809 I 0.883
msc Xenopus tropicalis XB-GENE-978233 I 0.883
tcf21 Xenopus tropicalis XB-GENE-484805 I 0.883
Ogr02938 Ophisaurus gracilis Ogr02938 I 0.883
Myotis_brandtii_TCF21_10035690 Myotis brandtii Myotis_brandtii_TCF21_10035690 I 0.883
Afo_R014913 Aptenodytes forsteri Afo_R014913 I 0.883
Aan_R009769 Calypte anna Aan_R009769 I 0.883
MSC Taeniopygia guttata ENSTGUG00000011502 I 0.883
TCF21 Taeniopygia guttata ENSTGUG00000011548 I 0.883
MSC Tupaia belangeri ENSTBEG00000014659 I 0.883
Tcf21 Mus musculus ENSMUSG00000045680 D 0.883
ENSSTOG00000023733 Ictidomys tridecemlineatus ENSSTOG00000023733 I 0.883
tcf21 Tetraodon nigroviridis ENSTNIG00000016326 I 0.883
tcf21 Takifugu rubripes ENSTRUG00000003919 I 0.883
TCF21 Vicugna pacos ENSVPAG00000006271 I 0.883
ENSXMAG00000004322 Xiphophorus maculatus ENSXMAG00000004322 I 0.883
MSC Vicugna pacos ENSVPAG00000000378 I 0.883
MSC Tursiops truncatus ENSTTRG00000017260 I 0.883
TCF21 Tursiops truncatus ENSTTRG00000009645 I 0.883
MSC Sus scrofa ENSSSCG00000006187 I 0.883
ENSPANG00000024238 Papio anubis ENSPANG00000024238 I 0.883
TCF21 Dasypus novemcinctus ENSDNOG00000042846 I 0.883
MSC Equus caballus ENSECAG00000008333 I 0.883
MSC Dasypus novemcinctus ENSDNOG00000019019 I 0.883
tcf21 Danio rerio ENSDARG00000036869 I 0.883
Msc Mus musculus ENSMUSG00000025930 D 0.883
TCF21 Equus caballus ENSECAG00000019197 I 0.883
MSC Erinaceus europaeus ENSEEUG00000005021 I 0.883
TCF21 Felis catus ENSFCAG00000031261 I 0.883
TCF21 Homo sapiens ENSG00000118526 D 0.883
ENSFALG00000011861 Ficedula albicollis ENSFALG00000011861 I 0.883
ENSFALG00000008455 Ficedula albicollis ENSFALG00000008455 I 0.883
TCF21 Echinops telfairi ENSETEG00000012492 I 0.883
ENSCSAG00000013709 Chlorocebus sabaeus ENSCSAG00000013709 I 0.883
TCF21 Cavia porcellus ENSCPOG00000024201 I 0.883
ENSAMEG00000015953 Ailuropoda melanoleuca ENSAMEG00000015953 I 0.883
ENSAPLG00000008024 Anas platyrhynchos ENSAPLG00000008024 I 0.883
ENSAMEG00000005942 Ailuropoda melanoleuca ENSAMEG00000005942 I 0.883
MSC Anolis carolinensis ENSACAG00000014585 I 0.883
TCF21 Anolis carolinensis ENSACAG00000010325 I 0.883
MSC Bos taurus ENSBTAG00000005404 I 0.883
TCF21 Bos taurus ENSBTAG00000021827 I 0.883
MSC Callithrix jacchus ENSCJAG00000007766 I 0.883
ENSCPOG00000004726 Cavia porcellus ENSCPOG00000004726 I 0.883
TCF21 Callithrix jacchus ENSCJAG00000002811 I 0.883
MSC Canis familiaris ENSCAFG00000007923 I 0.883
TCF21 Canis familiaris ENSCAFG00000000205 I 0.883
MSC Homo sapiens ENSG00000178860 D 0.883
ENSCSAG00000016705 Chlorocebus sabaeus ENSCSAG00000016705 I 0.883
ENSLOCG00000016232 Lepisosteus oculatus ENSLOCG00000016232 I 0.883
ENSLOCG00000003912 Lepisosteus oculatus ENSLOCG00000003912 I 0.883
MSC Macaca mulatta ENSMMUG00000000947 I 0.883
TCF21 Loxodonta africana ENSLAFG00000009507 I 0.883
TCF21 Myotis lucifugus ENSMLUG00000009194 I 0.883
ENSMEUG00000005491 Macropus eugenii ENSMEUG00000005491 I 0.883
ENSMICG00000014144 Microcebus murinus ENSMICG00000014144 I 0.883
TCF21 Meleagris gallopavo ENSMGAG00000013117 I 0.883
MSC Myotis lucifugus ENSMLUG00000008572 I 0.883
ENSMPUG00000014798 Mustela putorius furo ENSMPUG00000014798 I 0.883
TCF21 Macaca mulatta ENSMMUG00000002871 I 0.883
MSC Monodelphis domestica ENSMODG00000007225 I 0.883
TCF21 Gallus gallus ENSGALG00000029024 I 0.883
ENSGALG00000019470 Gallus gallus ENSGALG00000019470 I 0.883
ENSMPUG00000010593 Mustela putorius furo ENSMPUG00000010593 I 0.883
MSC Gorilla gorilla ENSGGOG00000009955 I 0.883
TCF21 Gorilla gorilla ENSGGOG00000005460 I 0.883
MSC Loxodonta africana ENSLAFG00000002649 I 0.883
ENSLACG00000005024 Latimeria chalumnae ENSLACG00000005024 I 0.883
TCF21 Monodelphis domestica ENSMODG00000017516 I 0.883
HelroG188977 Helobdella robusta HelroG188977 I 0.879
TC002349 Tribolium castaneum TC002349 I 0.866
L798_06836 Zootermopsis nevadensis L798_06836 I 0.866
LDEC005027 Leptinotarsa decemlineata LDEC005027 I 0.866
fgenesh2_pg.scaffold_201000027 Branchiostoma floridae fgenesh2_pg.scaffold_201000027 I 0.862
fgenesh2_pg.scaffold_201000026 Branchiostoma floridae fgenesh2_pg.scaffold_201000026 I 0.862
SPU_012008 Strongylocentrotus purpuratus SPU_012008 I 0.859
LLOJ001927 Lutzomyia longipalpis LLOJ001927 I 0.859
BGLB011346 Biomphalaria glabrata BGLB011346 I 0.859
PPAI008462 Phlebotomus papatasi PPAI008462 I 0.859
SCUD_0001558401 Schistosoma curassoni SCUD_0001558401 I 0.855
SMRZ_0001749101 Schistosoma margrebowiei SMRZ_0001749101 I 0.855
SMTD_0000660301 Schistosoma mattheei SMTD_0000660301 I 0.855
TRE_0000636201 Trichobilharzia regenti TRE_0000636201 I 0.855
T265_00953 Opisthorchis viverrini T265_00953 I 0.855
D915_08809 Fasciola hepatica D915_08809 I 0.855
A_02746 Schistosoma haematobium A_02746 I 0.855
CGI_10026944 Crassostrea gigas CGI_10026944 I 0.855
Sjc_0073180 Schistosoma japonicum Sjc_0073180 I 0.855
BGIBMGA012033 Bombyx mori BGIBMGA012033 I 0.855
CapteG80741 Capitella teleta CapteG80741 I 0.855
csin111822 Clonorchis sinensis csin111822 I 0.855
ENSONIG00000014278 Oreochromis niloticus ENSONIG00000014278 I 0.855
msc Takifugu rubripes ENSTRUG00000012425 I 0.855
msc Danio rerio ENSDARG00000045353 I 0.855
ENSXMAG00000010332 Xiphophorus maculatus ENSXMAG00000010332 I 0.855
ENSPFOG00000020725 Poecilia formosa ENSPFOG00000020725 I 0.855
msc Tetraodon nigroviridis ENSTNIG00000008188 I 0.855
tcf21 Gasterosteus aculeatus ENSGACG00000010957 I 0.855
ENSGMOG00000019481 Gadus morhua ENSGMOG00000019481 I 0.855
ENSPMAG00000000379 Petromyzon marinus ENSPMAG00000000379 I 0.855
Hsal_01862--XP_001122645.1_APIME Harpegnathos saltator Hsal_01862--XP_001122645.1_APIME I 0.855
GB42177 Apis mellifera GB42177 I 0.855
msc Gasterosteus aculeatus ENSGACG00000002802 I 0.855
Cflo_04912--XP_001121050.1_APIME Camponotus floridanus Cflo_04912--XP_001121050.1_APIME I 0.855
ENSAMXG00000004351 Astyanax mexicanus ENSAMXG00000004351 I 0.855
KGM_20305 Danaus plexippus KGM_20305 I 0.855
msc Oryzias latipes ENSORLG00000008030 I 0.855
Smp_022610 Schistosoma mansoni Smp_022610 I 0.855
SMAR006929 Strigamia maritima SMAR006929 I 0.855
fgenesh2_pg.scaffold_201000029 Branchiostoma floridae fgenesh2_pg.scaffold_201000029 I 0.846
ACYPI002601 Acyrthosiphon pisum ACYPI002601 I 0.842