hlfa (Danio rerio)
bZIP

TF Information

Pfam ID Interpro ID Gene ID CIS-BP ID Sequence source Animal TF db
PF00170 (bZIP_1) IPR011616 ENSDARG00000074752 T059436_2.00 Ensembl (2018-Dec-8) Link out
NCBI Gene Info:
Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Predicted to be involved in regulation of transcription by RNA polymerase II. Predicted to act upstream of or within regulation of transcription, DNA-templated. Predicted to be active in nucleus. Is expressed in epiphysis; eye; and midbrain hindbrain boundary. Orthologous to human HLF (HLF transcription factor, PAR bZIP family member). [provided by Alliance of Genome Resources, Apr 2022]

Directly determined binding motifs

Name/Motif ID Species Forward Reverse Type/Study/Study ID SR
Score		 DBD
Identity
No direct experiments

Motifs from related TFs

Name/Motif ID Species Forward Reverse Type/Study/Study ID SR
Score		 DBD
Identity
HLF
M02831_2.00 		Homo sapiens
NRTTAYRTAABN
NVTTAYRTAAYN		 SELEX
Jolma et al.(2013)
HLF_1 		0.865 0.887
Hlf
M02860_2.00 		Mus musculus
KRTTACGTAAYN
NRTTACGTAAYM		 SELEX
Jolma et al.(2013)
Hlf_1 		0.865 0.887
HLF
M04245_2.00 		Homo sapiens
NVTTRCRYAABN
NVTTRYGYAABN		 SELEX
Yin et al.(2017)
HLF_FL_HT-SELEX 		0.865 0.887
HLF
M04016_2.00 		Homo sapiens
RTKAYRTAAB
VTTAYRTMAY		 SELEX
Rodriguez-Martinez et al.(2017)
HLF.1 		0.865 0.887
HLF
M08786_2.00 		Homo sapiens
NRTTRYGTAAYMS
SKRTTACRYAAYN		 Misc
Kulakovskiy et al.(2013)
HLF_HUMAN.H11MO.0.C 		0.865 0.887
Hlf
M08815_2.00 		Mus musculus
VTTRTGYAABH
DVTTRCAYAAB		 Misc
Kulakovskiy et al.(2013)
HLF_MOUSE.H11MO.0.C 		0.865 0.887
HLF
M09937_2.00 		Homo sapiens
ATKRYGTAAY
RTTACRYMAT		 Transfac
Matys et al.(2006)
V$HLF_01 		0.865 0.887
HLF
M04246_2.00 		Homo sapiens
NVTTRCRYAABN
NVTTRYGYAABN		 SELEX
Yin et al.(2017)
HLF_FL_Methyl-HT-SELEX 		0.865 0.887
Tef
M01803_2.00 		Mus musculus
NVTTRYVNNN
NNNBRYAABN		 PBM
Weirauch et al.(2014)
pTH5078 		0.842 0.758
TEF
M02849_2.00 		Homo sapiens
NRTTAYGTAAYN
NRTTACRTAAYN		 SELEX
Jolma et al.(2013)
TEF_1 		0.842 0.758
TEF
M02850_2.00 		Homo sapiens
NVTTAYGTAABN
NVTTACRTAABN		 SELEX
Jolma et al.(2013)
TEF_2 		0.842 0.758
TEF
M04325_2.00 		Homo sapiens
NRTTACGTAAYN
NRTTACGTAAYN		 SELEX
Yin et al.(2017)
TEF_eDBD_HT-SELEX 		0.842 0.758
TEF
M09983_2.00 		Homo sapiens Transfac license required
 Transfac license required
 Transfac
Matys et al.(2006)
V$TEF_05 		0.842 0.758
TEF
M09984_2.00 		Homo sapiens Transfac license required
 Transfac license required
 Transfac
Matys et al.(2006)
V$TEF_06 		0.842 0.758
TEF
M09985_2.00 		Homo sapiens Transfac license required
 Transfac license required
 Transfac
Matys et al.(2006)
V$TEF_Q6 		0.842 0.758
TEF
M09986_2.00 		Homo sapiens
MTKAYGTAAY
RTTACRTMAK		 Transfac
Matys et al.(2006)
V$VBP_01 		0.842 0.758
TEF
M04326_2.00 		Homo sapiens
NRTTACRTAAYN
NRTTAYGTAAYN		 SELEX
Yin et al.(2017)
TEF_eDBD_Methyl-HT-SELEX 		0.842 0.758
Pdp1
M03645_2.00 		Drosophila melanogaster
VTTACGTAAB
VTTACGTAAB		 SELEX
Nitta et al.(2015)
Pdp1_1 		0.797 0.694
Pdp1
M03646_2.00 		Drosophila melanogaster
RTTACGTAAY
RTTACGTAAY		 SELEX
Nitta et al.(2015)
Pdp1_2 		0.797 0.694
For this family, TFs with SR scores > 0.782 will likely have a similar motif

DNA Binding Domains

Protein ID Domain From To Sequence
ENSDARP00000106703 bZIP 223 284

Links

Other bZIP family TFs
Other Danio rerio TFs

217 Related TFs

Name Species Gene ID Motif Evidence SR
Score		 Action
ENSGMOG00000004830 Gadus morhua ENSGMOG00000004830 I 0.885
ENSXMAG00000012903 Xiphophorus maculatus ENSXMAG00000012903 I 0.884
Ogr00037 Ophisaurus gracilis Ogr00037 I 0.877
ENSONIG00000009563 Oreochromis niloticus ENSONIG00000009563 I 0.874
ENSPFOG00000018222 Poecilia formosa ENSPFOG00000018222 I 0.874
hlfa Oryzias latipes ENSORLG00000000969 I 0.874
ENSTNIG00000003545 Tetraodon nigroviridis ENSTNIG00000003545 I 0.872
ENSONIG00000019079 Oreochromis niloticus ENSONIG00000019079 I 0.869
ENSLACG00000012701 Latimeria chalumnae ENSLACG00000012701 I 0.869
HLF Taeniopygia guttata ENSTGUG00000009478 I 0.868
ENSFALG00000002265 Ficedula albicollis ENSFALG00000002265 I 0.868
HLF Gallus gallus ENSGALG00000003059 I 0.868
ENSLACG00000012726 Latimeria chalumnae ENSLACG00000012726 I 0.868
ENSAPLG00000004386 Anas platyrhynchos ENSAPLG00000004386 I 0.868
ENSPSIG00000016356 Pelodiscus sinensis ENSPSIG00000016356 I 0.868
HLF Anolis carolinensis ENSACAG00000017417 I 0.868
Gfo_R006518 Geospiza fortis Gfo_R006518 I 0.868
Pvit_00680 Pogona vitticeps Pvit_00680 I 0.868
Tal_R009182 Tyto alba Tal_R009182 I 0.868
Brh_R008067 Buceros rhinoceros Brh_R008067 I 0.868
Cmyd_10013489 Chelonia mydas Cmyd_10013489 I 0.868
Afo_R002997 Aptenodytes forsteri Afo_R002997 I 0.868
Aan_R004902 Calypte anna Aan_R004902 I 0.868
HLF Macaca mulatta ENSMMUG00000022627 I 0.865
ENSP00000226067 Macaca fascicularis ENSP00000226067 I 0.865
HLF Monodelphis domestica ENSMODG00000014851 I 0.865
ENSMPUG00000015400 Mustela putorius furo ENSMPUG00000015400 I 0.865
Hlf Mus musculus ENSMUSG00000003949 D 0.865
HLF Myotis lucifugus ENSMLUG00000007393 I 0.865
ENSMEUG00000016384 Macropus eugenii ENSMEUG00000016384 I 0.865
Myotis_brandtii_Hlf_10020713 Myotis brandtii Myotis_brandtii_Hlf_10020713 I 0.865
HLF Tursiops truncatus ENSTTRG00000007194 I 0.865
HLF Loxodonta africana ENSLAFG00000016475 I 0.865
ENSLOCG00000012233 Lepisosteus oculatus ENSLOCG00000012233 I 0.865
ENSNLEG00000007993 Nomascus leucogenys ENSNLEG00000007993 I 0.865
ENSMICG00000002860 Microcebus murinus ENSMICG00000002860 I 0.865
HLF Oryctolagus cuniculus ENSOCUG00000010547 I 0.865
ENSPPYG00000008257 Pongo abelii ENSPPYG00000008257 I 0.865
ENSSTOG00000029018 Ictidomys tridecemlineatus ENSSTOG00000029018 I 0.865
HLF Gorilla gorilla ENSGGOG00000006075 I 0.865
HLF Pteropus vampyrus ENSPVAG00000007461 I 0.865
ENSSARG00000013841 Sorex araneus ENSSARG00000013841 I 0.865
Hlf Rattus norvegicus ENSRNOG00000002456 I 0.865
ENSPFOG00000004560 Poecilia formosa ENSPFOG00000004560 I 0.865
ENSPANG00000022360 Papio anubis ENSPANG00000022360 I 0.865
ENSBTAP00000008682-D1 Bos grunniens ENSBTAP00000008682-D1 I 0.865
HLF Otolemur garnettii ENSOGAG00000007056 I 0.865
ENSTSYG00000009210 Tarsius syrichta ENSTSYG00000009210 I 0.865
HLF Ochotona princeps ENSOPRG00000004195 I 0.865
HLF Tupaia belangeri ENSTBEG00000006958 I 0.865
ENSSHAG00000015304 Sarcophilus harrisii ENSSHAG00000015304 I 0.865
HLF Pan troglodytes ENSPTRG00000009424 I 0.865
HLF Canis familiaris ENSCAFG00000030851 I 0.865
ENSAMEG00000014714 Ailuropoda melanoleuca ENSAMEG00000014714 I 0.865
HLF Felis catus ENSFCAG00000022556 I 0.865
HLF Bos taurus ENSBTAG00000006618 I 0.865
HLF Echinops telfairi ENSETEG00000017670 I 0.865
HLF Erinaceus europaeus ENSEEUG00000010964 I 0.865
HLF Callithrix jacchus ENSCJAG00000011298 I 0.865
HLF Equus caballus ENSECAG00000016953 I 0.865
HLF Homo sapiens ENSG00000108924 D 0.865
ENSCPOG00000011000 Cavia porcellus ENSCPOG00000011000 I 0.865
ENSCSAG00000005557 Chlorocebus sabaeus ENSCSAG00000005557 I 0.865
ENSDORG00000012644 Dipodomys ordii ENSDORG00000012644 I 0.865
ENSCHOG00000001396 Choloepus hoffmanni ENSCHOG00000001396 I 0.865
Alligator_sinensis_CCG020587.1 Alligator sinensis Alligator_sinensis_CCG020587.1 I 0.856
ENSXMAG00000016939 Xiphophorus maculatus ENSXMAG00000016939 I 0.856
HLF Ornithorhynchus anatinus ENSOANG00000010288 I 0.856
hlfb Takifugu rubripes ENSTRUG00000003909 I 0.854
tefb Gasterosteus aculeatus ENSGACG00000007628 I 0.853
tefb Takifugu rubripes ENSTRUG00000003565 I 0.853
ENSONIG00000019694 Oreochromis niloticus ENSONIG00000019694 I 0.852
ENSONIG00000008480 Oreochromis niloticus ENSONIG00000008480 I 0.852
ENSLOCG00000011595 Lepisosteus oculatus ENSLOCG00000011595 I 0.850
ENSPFOG00000013950 Poecilia formosa ENSPFOG00000013950 I 0.849
tefb Oryzias latipes ENSORLG00000014144 I 0.849
ENSAMXG00000008798 Astyanax mexicanus ENSAMXG00000008798 I 0.847
tefa Oryzias latipes ENSORLG00000002582 I 0.844
TEF Callithrix jacchus ENSCJAG00000004977 I 0.842
ENSAMEG00000002146 Ailuropoda melanoleuca ENSAMEG00000002146 I 0.842
TEF Pteropus vampyrus ENSPVAG00000001160 I 0.842
TEF Cavia porcellus ENSCPOG00000020591 I 0.842
ENSPPYG00000011867 Pongo abelii ENSPPYG00000011867 I 0.842
TEF Pan troglodytes ENSPTRG00000014425 I 0.842
ENSPSIG00000006835 Pelodiscus sinensis ENSPSIG00000006835 I 0.842
ENSSTOG00000019642 Ictidomys tridecemlineatus ENSSTOG00000019642 I 0.842
Aan_R013230 Calypte anna Aan_R013230 I 0.842
ENSAPLG00000005838 Anas platyrhynchos ENSAPLG00000005838 I 0.842
TEF Gorilla gorilla ENSGGOG00000016460 I 0.842
ENSTSYG00000008965 Tarsius syrichta ENSTSYG00000008965 I 0.842
TEF Vicugna pacos ENSVPAG00000002612 I 0.842
TEF Tursiops truncatus ENSTTRG00000003365 I 0.842
Afo_R007951 Aptenodytes forsteri Afo_R007951 I 0.842
TEF Taeniopygia guttata ENSTGUG00000009944 I 0.842
TEF Sorex araneus ENSSARG00000003323 I 0.842
Tef Rattus norvegicus ENSRNOG00000019383 I 0.842
ENSSHAG00000009361 Sarcophilus harrisii ENSSHAG00000009361 I 0.842
TEF Canis familiaris ENSCAFG00000001095 I 0.842
TEF Tupaia belangeri ENSTBEG00000010576 I 0.842
TEF Bos taurus ENSBTAG00000016580 I 0.842
Alligator_sinensis_CCG007983.1 Alligator sinensis Alligator_sinensis_CCG007983.1 I 0.842
TEF Anolis carolinensis ENSACAG00000004810 I 0.842
TEF Felis catus ENSFCAG00000003674 I 0.842
TEF Myotis lucifugus ENSMLUG00000002459 I 0.842
ENSMICG00000013518 Microcebus murinus ENSMICG00000013518 I 0.842
TEF Macaca mulatta ENSMMUG00000005221 I 0.842
ENSFALG00000011967 Ficedula albicollis ENSFALG00000011967 I 0.842
Brh_R010854 Buceros rhinoceros Brh_R010854 I 0.842
TEF Monodelphis domestica ENSMODG00000016547 I 0.842
TEF Meleagris gallopavo ENSMGAG00000012262 I 0.842
ENSMEUG00000013604 Macropus eugenii ENSMEUG00000013604 I 0.842
Pvit_18616 Pogona vitticeps Pvit_18616 I 0.842
Tal_R002658 Tyto alba Tal_R002658 I 0.842
TEF Gallus gallus ENSGALG00000011958 I 0.842
Ogr14443 Ophisaurus gracilis Ogr14443 I 0.842
TEF Loxodonta africana ENSLAFG00000013151 I 0.842
TEF Homo sapiens ENSG00000167074 D 0.842
Myotis_brandtii_Tef_10013968 Myotis brandtii Myotis_brandtii_Tef_10013968 I 0.842
TEF Equus caballus ENSECAG00000018137 I 0.842
ENSMPUG00000016407 Mustela putorius furo ENSMPUG00000016407 I 0.842
Tef Mus musculus ENSMUSG00000022389 D 0.842
ENSPANG00000024579 Papio anubis ENSPANG00000024579 I 0.842
Gfo_R004744 Geospiza fortis Gfo_R004744 I 0.842
ENSCSAG00000005816 Chlorocebus sabaeus ENSCSAG00000005816 I 0.842
ENSBTAP00000022056-D1 Bos grunniens ENSBTAP00000022056-D1 I 0.842
ENSP00000403078 Macaca fascicularis ENSP00000403078 I 0.842
TEF Dasypus novemcinctus ENSDNOG00000035257 I 0.842
TEF Otolemur garnettii ENSOGAG00000025997 I 0.842
TEF Ornithorhynchus anatinus ENSOANG00000011535 I 0.842
ENSNLEG00000015473 Nomascus leucogenys ENSNLEG00000015473 I 0.842
ENSOARG00000018238 Ovis aries ENSOARG00000018238 I 0.842
Tef Dipodomys ordii ENSDORG00000014982 I 0.842
TEF Oryctolagus cuniculus ENSOCUG00000012866 I 0.842
TEF Ochotona princeps ENSOPRG00000013592 I 0.841
tefa Tetraodon nigroviridis ENSTNIG00000012940 I 0.840
ENSAMXG00000015442 Astyanax mexicanus ENSAMXG00000015442 I 0.839
hlfa Tetraodon nigroviridis ENSTNIG00000011274 I 0.837
hlfa Takifugu rubripes ENSTRUG00000003731 I 0.837
hlfb Danio rerio ENSDARG00000061011 I 0.837
ENSXMAG00000000678 Xiphophorus maculatus ENSXMAG00000000678 I 0.836
tefa Takifugu rubripes ENSTRUG00000017028 I 0.836
ENSPFOG00000016821 Poecilia formosa ENSPFOG00000016821 I 0.836
ENSAMXG00000017639 Astyanax mexicanus ENSAMXG00000017639 I 0.836
tefa Danio rerio ENSDARG00000039117 I 0.832
SMAR002779 Strigamia maritima SMAR002779 I 0.832
SPU_004414 Strongylocentrotus purpuratus SPU_004414 I 0.829
tefb Danio rerio ENSDARG00000098103 I 0.826
hlfb Gasterosteus aculeatus ENSGACG00000010103 I 0.823
tefa Gasterosteus aculeatus ENSGACG00000004793 I 0.823
ENSTNIG00000002167 Tetraodon nigroviridis ENSTNIG00000002167 I 0.821
AATE006511 Anopheles atroparvus AATE006511 I 0.818
hlf Xenopus tropicalis XB-GENE-955698 I 0.813
XP_002937859 Xenopus tropicalis XP_002937859 I 0.813
KGM_21614 Danaus plexippus KGM_21614 I 0.808
BGIBMGA003874 Bombyx mori BGIBMGA003874 I 0.808
MCINX004280 Melitaea cinxia MCINX004280 I 0.808
HMEL011029 Heliconius melpomene HMEL011029 I 0.808
YQE_01842 Dendroctonus ponderosae YQE_01842 I 0.807
Cflo_03674--XP_391997.2_APIME Camponotus floridanus Cflo_03674--XP_391997.2_APIME I 0.805
NV13265 Nasonia vitripennis NV13265 I 0.805
GB43643 Apis mellifera GB43643 I 0.805
Hsal_12188--XP_391997.2_APIME Harpegnathos saltator Hsal_12188--XP_391997.2_APIME I 0.805
ACEP27179 Atta cephalotes ACEP27179 I 0.805
PPAI002842 Phlebotomus papatasi PPAI002842 I 0.801
TEF Choloepus hoffmanni ENSCHOG00000009442 I 0.801
ENSTRUG00000003893 Takifugu rubripes ENSTRUG00000003893 I 0.801
ENSORLG00000011412 Oryzias latipes ENSORLG00000011412 I 0.801
LLOJ006612 Lutzomyia longipalpis LLOJ006612 I 0.801
ENSTNIG00000008098 Tetraodon nigroviridis ENSTNIG00000008098 I 0.801
ENSONIG00000012778 Oreochromis niloticus ENSONIG00000012778 I 0.801
ENSGMOG00000014488 Gadus morhua ENSGMOG00000014488 I 0.800
e_gw.24.282.1 Branchiostoma floridae e_gw.24.282.1 I 0.800
CGI_10003797 Crassostrea gigas CGI_10003797 N 0.800
tetur19g00770 Tetranychus urticae tetur19g00770 I 0.799
GM24985 Drosophila sechellia FBgn0179846 I 0.797
GD13032 Drosophila simulans FBgn0184754 I 0.797
GJ11425 Drosophila virilis FBgn0198683 I 0.797
GF24150 Drosophila ananassae FBgn0101144 I 0.797
LCUP014933 Lucilia cuprina LCUP014933 I 0.797
GG14935 Drosophila erecta FBgn0107189 I 0.797
GH23565 Drosophila grimshawi FBgn0131022 I 0.797
GI12193 Drosophila mojavensis FBgn0134950 I 0.797
GK10510 Drosophila willistoni FBgn0212525 I 0.797
GL17823 Drosophila persimilis FBgn0155426 I 0.797
Pdp1 Drosophila melanogaster FBgn0016694 D 0.797
GA28498 Drosophila pseudoobscura FBgn0249858 I 0.797
GE20386 Drosophila yakuba FBgn0237702 I 0.797
MDOA003519 Musca domestica MDOA003519 I 0.797
AEPI005427 Anopheles epiroticus AEPI005427 I 0.795
ADIR007438 Anopheles dirus ADIR007438 I 0.795
ACOM039838 Anopheles coluzzii ACOM039838 I 0.795
CpipJ_CPIJ014920 Culex pipiens CpipJ_CPIJ014920 I 0.795
ACUA004794 Anopheles culicifacies ACUA004794 I 0.795
AFAF017409 Anopheles farauti AFAF017409 I 0.795
AQUA000938 Anopheles quadriannulatus AQUA000938 I 0.795
AMIN007990 Anopheles minimus AMIN007990 I 0.795
AMEM018156 Anopheles merus AMEM018156 I 0.795
AFUN000141 Anopheles funestus AFUN000141 I 0.795
AARA000887 Anopheles arabiensis AARA000887 I 0.795
tef.S Xenopus laevis XB-GENE-962737 I 0.795
PDP1 Aedes aegypti AAEL005255 I 0.795
ENSGMOG00000013327 Gadus morhua ENSGMOG00000013327 I 0.795
ISCW004978 Ixodes scapularis ISCW004978 I 0.795
ADAC004162 Anopheles darlingi ADAC004162 I 0.795
ASIS001542 Anopheles sinensis ASIS001542 I 0.795
ASTEI09431 Anopheles stephensi ASTEI09431 I 0.795
ENSAMXG00000016053 Astyanax mexicanus ENSAMXG00000016053 I 0.795
PDP1 Anopheles gambiae AGAP006376 I 0.795
PDP1 Culex quinquefasciatus CPIJ014920 I 0.795
AALB004300 Anopheles albimanus AALB004300 I 0.795
dbp.L Xenopus laevis XB-GENE-6256610 I 0.791
ENSXMAG00000012054 Xiphophorus maculatus ENSXMAG00000012054 I 0.788
ENSPFOG00000010189 Poecilia formosa ENSPFOG00000010189 I 0.788
ENSTNIG00000004400 Tetraodon nigroviridis ENSTNIG00000004400 I 0.787
ENSTRUG00000007098 Takifugu rubripes ENSTRUG00000007098 I 0.787
BGLB012411 Biomphalaria glabrata BGLB012411 N 0.783
Ocbimv22024947m.g Octopus bimaculoides Ocbimv22024947m.g I 0.782