Zfx (Mus musculus)
C2H2 ZF

TF Information

Pfam ID Interpro ID Gene ID CIS-BP ID Sequence source Animal TF db
PF00096 (zf-C2H2) IPR007087 ENSMUSG00000079509 T101547_2.00 Ensembl (2018-Dec-8) Link out
NCBI Gene Info:
Predicted to enable chromatin insulator sequence binding activity. Acts upstream of or within several processes, including gamete generation; ovarian follicle development; and parental behavior. Predicted to be located in nucleolus and nucleoplasm. Predicted to be active in chromosome. Is expressed in several structures, including 4-cell stage embryo; genitourinary system; ileum; liver; and spleen. Orthologous to several human genes including ZFX (zinc finger protein X-linked). [provided by Alliance of Genome Resources, Apr 2022]

Directly determined binding motifs

Name/Motif ID Species Forward Reverse Type/Study/Study ID SR
Score		 DBD
Identity
Zfx
M00788_2.00		 Mus musculus
NRGGCCNNN
NNNGGCCYN		 PBM
Weirauch et al.(2013)
pTH2933		 (Direct) (Direct)
Zfx
M08100_2.00		 Mus musculus
BBVRSCBVGGCCTV
BAGGCCBVGSYBVV		 ChIP-seq
Mathelier et al.(2014)
MA0146.2		 (Direct) (Direct)
Zfx
M09017_2.00		 Mus musculus
VVSVSBNBBAGGCCBVGSH
DSCBVGGCCTVVNVSBSBB		 Misc
Kulakovskiy et al.(2013)
ZFX_MOUSE.H11MO.0.B		 (Direct) (Direct)
Zfx
M09517_2.00		 Mus musculus
BNAGGCCT
AGGCCTNV		 Misc
Heinz et al.(2010)
mES-Zfx_GSE11431		 (Direct) (Direct)

Motifs from related TFs

Name/Motif ID Species Forward Reverse Type/Study/Study ID SR
Score		 DBD
Identity
ZFX
M08850_2.00 		Homo sapiens
YBVGGCCTVS
SBAGGCCBVR		 Misc
Kulakovskiy et al.(2013)
ZFX_HUMAN.H11MO.0.A 		0.822 0.993
ZFX
M10098_2.00 		Homo sapiens Transfac license required
 Transfac license required
 Transfac
Matys et al.(2006)
V$ZFX_01 		0.822 0.993
For this family, TFs with SR scores > 0.755 will likely have a similar motif

Experimental Constructs

Motif ID Domain From To Sequence
M00788_2.00 C2H2 ZF 16 38
M00788_2.00 C2H2 ZF 47 69
M00788_2.00 C2H2 ZF 79 101
M00788_2.00 C2H2 ZF 110 133
M00788_2.00 C2H2 ZF 139 161
M00788_2.00 C2H2 ZF 167 190
M00788_2.00 C2H2 ZF 196 218
M00788_2.00 C2H2 ZF 224 247
M00788_2.00 C2H2 ZF 253 275
M00788_2.00 C2H2 ZF 281 304
M00788_2.00 C2H2 ZF 310 332
M00788_2.00 C2H2 ZF 338 361
M00788_2.00 C2H2 ZF 367 390

DNA Binding Domains

Protein ID Domain From To Sequence
ENSMUSP00000085423 C2H2 ZF 419 441
ENSMUSP00000085423 C2H2 ZF 450 472
ENSMUSP00000085423 C2H2 ZF 482 504
ENSMUSP00000085423 C2H2 ZF 513 536
ENSMUSP00000085423 C2H2 ZF 542 564
ENSMUSP00000085423 C2H2 ZF 570 593
ENSMUSP00000085423 C2H2 ZF 599 621
ENSMUSP00000085423 C2H2 ZF 627 650
ENSMUSP00000085423 C2H2 ZF 656 678
ENSMUSP00000085423 C2H2 ZF 684 707
ENSMUSP00000085423 C2H2 ZF 713 735
ENSMUSP00000085423 C2H2 ZF 741 764
ENSMUSP00000085423 C2H2 ZF 770 793
ENSMUSP00000109559 C2H2 ZF 419 441
ENSMUSP00000109559 C2H2 ZF 450 472
ENSMUSP00000109559 C2H2 ZF 482 504
ENSMUSP00000109559 C2H2 ZF 513 536
ENSMUSP00000109559 C2H2 ZF 542 564
ENSMUSP00000109559 C2H2 ZF 570 593
ENSMUSP00000109559 C2H2 ZF 599 621
ENSMUSP00000109559 C2H2 ZF 627 650
ENSMUSP00000109559 C2H2 ZF 656 678
ENSMUSP00000109559 C2H2 ZF 684 707
ENSMUSP00000109559 C2H2 ZF 713 735
ENSMUSP00000109559 C2H2 ZF 741 764
ENSMUSP00000109559 C2H2 ZF 770 793
ENSMUSP00000109560 C2H2 ZF 419 441
ENSMUSP00000109560 C2H2 ZF 450 472
ENSMUSP00000109560 C2H2 ZF 513 536
ENSMUSP00000109560 C2H2 ZF 542 564
ENSMUSP00000109560 C2H2 ZF 570 593
ENSMUSP00000109560 C2H2 ZF 599 621
ENSMUSP00000109560 C2H2 ZF 627 650
ENSMUSP00000109560 C2H2 ZF 656 678
ENSMUSP00000109560 C2H2 ZF 684 707
ENSMUSP00000109560 C2H2 ZF 713 735
ENSMUSP00000109560 C2H2 ZF 741 764
ENSMUSP00000109560 C2H2 ZF 770 793

Links

Other C2H2 ZF family TFs
Other Mus musculus TFs

41 Related TFs

Name Species Gene ID Motif Evidence SR
Score		 Action
Zfx Rattus norvegicus ENSRNOG00000005624 I 0.826
ZFX Gorilla gorilla ENSGGOG00000004053 I 0.822
ZFX Pan troglodytes ENSPTRG00000021747 I 0.822
ZFX Homo sapiens ENSG00000005889 D 0.822
ENSPPYG00000020195 Pongo abelii ENSPPYG00000020195 I 0.822
ENSPANG00000000982 Papio anubis ENSPANG00000000982 I 0.804
ENSOARG00000017137 Ovis aries ENSOARG00000017137 I 0.804
ZFX Oryctolagus cuniculus ENSOCUG00000003815 I 0.804
ZFX Pteropus vampyrus ENSPVAG00000002534 I 0.804
ENSP00000304985 Macaca fascicularis ENSP00000304985 I 0.804
Myotis_brandtii_ZFX_10010226 Myotis brandtii Myotis_brandtii_ZFX_10010226 I 0.804
ENSBTAP00000010165-D1 Bos grunniens ENSBTAP00000010165-D1 I 0.804
ZFX Tursiops truncatus ENSTTRG00000012488 I 0.804
ENSSSCG00000021322 Sus scrofa ENSSSCG00000021322 I 0.804
ENSSTOG00000007158 Ictidomys tridecemlineatus ENSSTOG00000007158 I 0.804
ENSMPUG00000000105 Mustela putorius furo ENSMPUG00000000105 I 0.804
ENSNLEG00000010044 Nomascus leucogenys ENSNLEG00000010044 I 0.804
ENSCPOG00000011739 Cavia porcellus ENSCPOG00000011739 I 0.804
ZFX Equus caballus ENSECAG00000025018 I 0.804
ZFX Callithrix jacchus ENSCJAG00000004841 I 0.804
ZFX Canis familiaris ENSCAFG00000013408 I 0.804
ENSAMEG00000012681 Ailuropoda melanoleuca ENSAMEG00000012681 I 0.804
ZFY Bos taurus ENSBTAG00000007730 I 0.804
ZFX Felis catus ENSFCAG00000010544 I 0.804
ZFX Dasypus novemcinctus ENSDNOG00000034569 I 0.804
ZFX Macaca mulatta ENSMMUG00000009801 I 0.804
ZFY Myotis lucifugus ENSMLUG00000003962 I 0.804
ZFX Microcebus murinus ENSMICG00000009517 I 0.804
ENSSSCG00000012179 Sus scrofa ENSSSCG00000012179 I 0.803
ZFX Monodelphis domestica ENSMODG00000007512 I 0.803
ENSSHAG00000004983 Sarcophilus harrisii ENSSHAG00000004983 I 0.803
ENSCSAG00000018321 Chlorocebus sabaeus ENSCSAG00000018321 I 0.801
ZFY Pan troglodytes ENSPTRG00000022471 I 0.800
ZFX Loxodonta africana ENSLAFG00000006691 I 0.798
ZFY Homo sapiens ENSG00000067646 I 0.797
Pvit_09540 Pogona vitticeps Pvit_09540 I 0.784
Ogr18022 Ophisaurus gracilis Ogr18022 I 0.781
ENSACAG00000007227 Anolis carolinensis ENSACAG00000007227 I 0.781
ZFX Ornithorhynchus anatinus ENSOANG00000011502 I 0.768
ENSTSYG00000005088 Tarsius syrichta ENSTSYG00000005088 I 0.765