Irf3 (Rattus norvegicus)
IRF

TF Information

Pfam ID Interpro ID Gene ID CIS-BP ID Sequence source Animal TF db
PF00605 (IRF) IPR001346 ENSRNOG00000043388 T244371_2.00 Ensembl (2018-Dec-8) Link out
NCBI Gene Info:
Predicted to enable several functions, including DNA-binding transcription activator activity, RNA polymerase II-specific; promoter-specific chromatin binding activity; and protein homodimerization activity. Involved in cellular response to exogenous dsRNA; positive regulation of I-kappaB kinase/NF-kappaB signaling; and positive regulation of cytokine production. Predicted to be located in cytosol and mitochondrion. Predicted to be active in nucleus. Human ortholog(s) of this gene implicated in brain disease. Orthologous to human IRF3 (interferon regulatory factor 3). [provided by Alliance of Genome Resources, Apr 2022]

Directly determined binding motifs

Name/Motif ID Species Forward Reverse Type/Study/Study ID SR
Score		 DBD
Identity
No direct experiments

Motifs from related TFs

Name/Motif ID Species Forward Reverse Type/Study/Study ID SR
Score		 DBD
Identity
Irf3
M00174_2.00 		Mus musculus
RDWNBGMAAS
STTKCVNWHY		 PBM
Badis et al.(2009)
Irf3_3985 		0.933 0.933
Irf3
M09241_2.00 		Mus musculus
RRRARDGAAAVDGRAASNRA
TYNSTTYCHBTTTCHYTYYY		 Misc
Kulakovskiy et al.(2013)
IRF3_MOUSE.H11MO.0.A 		0.933 0.933
IRF3
M03331_2.00 		Homo sapiens
NNRRAANGGAAACCGAAACYR
YRGTTTCGGTTTCCNTTYYNN		 SELEX
Jolma et al.(2013)
IRF3_1 		0.856 0.856
IRF3
M05531_2.00 		Homo sapiens
DCVGTTTCSNSGAAACCGMAASN
NSTTKCGGTTTCSNSGAAACBGH		 SELEX
Yin et al.(2017)
IRF3_eDBD_HT-SELEX 		0.856 0.856
IRF3
M05533_2.00 		Homo sapiens
HSGAAAVBGAAACYGAAACN
NGTTTCRGTTTCVBTTTCSD		 SELEX
Yin et al.(2017)
IRF3_FL_HT-SELEX 		0.856 0.856
IRF3
M09234_2.00 		Homo sapiens
RRRARDGAAAVDGRAASNRA
TYNSTTYCHBTTTCHYTYYY		 Misc
Kulakovskiy et al.(2013)
IRF3_HUMAN.H11MO.0.B 		0.856 0.856
IRF3
M10883_2.00 		Homo sapiens Transfac license required
 Transfac license required
 Transfac
Matys et al.(2006)
V$IRF3_Q3 		0.856 0.856
IRF3
M05532_2.00 		Homo sapiens
KCDSTTTCCHGGAAAMNRAWAV
BTWTYNKTTTCCDGGAAASHGM		 SELEX
Yin et al.(2017)
IRF3_eDBD_Methyl-HT-SELEX 		0.856 0.856
IRF3
M05534_2.00 		Homo sapiens
HGGAAABBGAAASBGAAASN
NSTTTCVSTTTCVVTTTCCD		 SELEX
Yin et al.(2017)
IRF3_FL_Methyl-HT-SELEX 		0.856 0.856
For this family, TFs with SR scores > 0.700 will likely have a similar motif

DNA Binding Domains

Protein ID Domain From To Sequence
ENSRNOP00000027786 IRF 7 110

Links

Other IRF family TFs
Other Rattus norvegicus TFs

Invalid Input OrderBy

34 Related TFs

Name Species Gene ID Motif Evidence SR
Score		 Action