ENSP00000384406 (Macaca fascicularis)
IRF

TF Information

Pfam ID Interpro ID Gene ID CIS-BP ID Sequence source
PF00605 (IRF) IPR001346 ENSP00000384406 T244547_2.00 GigaDB (2015-Oct-22)
NCBI Gene Info:
The protein encoded by this gene is a transcriptional regulator and tumor suppressor, serving as an activator of genes involved in both innate and acquired immune responses. The encoded protein activates the transcription of genes involved in the body's response to viruses and bacteria, playing a role in cell proliferation, apoptosis, the immune response, and DNA damage response. This protein represses the transcription of several other genes. As a tumor suppressor, it both suppresses tumor cell growth and stimulates an immune response against tumor cells. Defects in this gene have been associated with gastric cancer, myelogenous leukemia, and lung cancer. [provided by RefSeq, Aug 2017]

Directly determined binding motifs

Name/Motif ID Species Forward Reverse Type/Study/Study ID SR
Score
DBD
Identity
No direct experiments

Motifs from related TFs

Name/Motif ID Species Forward Reverse Type/Study/Study ID SR
Score
DBD
Identity
IRF1
M08142_2.00
Homo sapiens
RWANNGAAASYGAAASYRNNN

NNNYRSTTTCRSTTTCNNTWY
ChIP-seq
Mathelier et al.(2014)
MA0050.2
1.000 1.000
IRF1
M09233_2.00
Homo sapiens
NRAANNGAAASWGAAASHRN

NYDSTTTCWSTTTCNNTTYN
Misc
Kulakovskiy et al.(2013)
IRF1_HUMAN.H11MO.0.A
1.000 1.000
Irf1
M09242_2.00
Mus musculus
VRAANNGAAASYGAAASYVN

NBRSTTTCRSTTTCNNTTYB
Misc
Kulakovskiy et al.(2013)
IRF1_MOUSE.H11MO.0.A
1.000 1.000
IRF1
M09594_2.00
Homo sapiens
GAAASTGAAASY

RSTTTCASTTTC
Misc
Heinz et al.(2010)
PBMC-IRF1_GSE43036
1.000 1.000
IRF1
M10879_2.00
Homo sapiens
SAAAASYGAAASY

RSTTTCRSTTTTS
Transfac
Matys et al.(2006)
V$IRF1_01
1.000 1.000
IRF1
M10880_2.00
Homo sapiens Transfac license required
Transfac license required
Transfac
Matys et al.(2006)
V$IRF1_03
1.000 1.000
IRF1
M10881_2.00
Homo sapiens Transfac license required
Transfac license required
Transfac
Matys et al.(2006)
V$IRF1_Q5
1.000 1.000
IRF1
M10882_2.00
Homo sapiens Transfac license required
Transfac license required
Transfac
Matys et al.(2006)
V$IRF1_Q6
1.000 1.000
Irf2
M00805_2.00
Mus musculus
NDWNHGAAAV

BTTTCDNWHN
PBM
Weirauch et al.(2013)
pTH2835
0.771 0.771
IRF2
M05545_2.00
Homo sapiens
NGAAAVYGAAAS

STTTCRBTTTCN
SELEX
Yin et al.(2017)
IRF2_FL_HT-SELEX
0.771 0.771
IRF2
M02691_2.00
Homo sapiens
SGAAAGYGAAASYNWWHH

DDWWNRSTTTCRCTTTCS
SELEX
Mathelier et al.(2014)
MA0051.1
0.771 0.771
IRF2
M09237_2.00
Homo sapiens
NRAANNGAAASYGAAASYRV

BYRSTTTCRSTTTCNNTTYN
Misc
Kulakovskiy et al.(2013)
IRF2_HUMAN.H11MO.0.A
0.771 0.771
Irf2
M09245_2.00
Mus musculus
NRAANNGAAASYGAAASYRV

BYRSTTTCRSTTTCNNTTYN
Misc
Kulakovskiy et al.(2013)
IRF2_MOUSE.H11MO.0.B
0.771 0.771
IRF2
M09596_2.00
Homo sapiens
NRAAVNRRAASB

VSTTYYNBTTYN
Misc
Heinz et al.(2010)
Erythroblas-IRF2_GSE36985
0.771 0.771
IRF2
M10892_2.00
Homo sapiens
GAAAAGYGAAASY

RSTTTCRCTTTTC
Transfac
Matys et al.(2006)
V$IRF2_01
0.771 0.771
IRF2
M10893_2.00
Homo sapiens Transfac license required
Transfac license required
Transfac
Matys et al.(2006)
V$IRF2_Q6
0.771 0.771
IRF2
M05546_2.00
Homo sapiens
NGAAASYGAAAS

STTTCRSTTTCN
SELEX
Yin et al.(2017)
IRF2_FL_Methyl-HT-SELEX
0.771 0.771
For this family, TFs with SR scores > 0.700 will likely have a similar motif

DNA Binding Domains

Protein ID Domain From To Sequence
ENSP00000384406 IRF 7 112

Links

Other IRF family TFs
Other Macaca fascicularis TFs

127 Related TFs

Name Species Gene ID Motif Evidence SR
Score
Action
IRF1 Gorilla gorilla ENSGGOG00000013927 I 1.000
IRF1 Microcebus murinus ENSMICG00000008190 I 1.000
IRF1 Macaca mulatta ENSMMUG00000008100 I 1.000
IRF1 Sorex araneus ENSSARG00000006226 I 1.000
ENSSTOG00000009857 Ictidomys tridecemlineatus ENSSTOG00000009857 I 1.000
IRF1 Homo sapiens ENSG00000125347 D 1.000
IRF1 Equus caballus ENSECAG00000017794 I 1.000
IRF1 Erinaceus europaeus ENSEEUG00000013362 I 1.000
IRF1 Felis catus ENSFCAG00000013318 I 1.000
ENSMPUG00000010522 Mustela putorius furo ENSMPUG00000010522 I 1.000
Irf1 Mus musculus ENSMUSG00000018899 D 1.000
ENSP00000384406-D1 Bos grunniens ENSP00000384406-D1 I 1.000
ENSPPYG00000015762 Pongo abelii ENSPPYG00000015762 I 1.000
ENSPANG00000014875 Papio anubis ENSPANG00000014875 I 1.000
IRF1 Pan troglodytes ENSPTRG00000017216 I 1.000
IRF1 Oryctolagus cuniculus ENSOCUG00000004165 I 1.000
IRF1 Pteropus vampyrus ENSPVAG00000000430 I 1.000
ENSNLEG00000012720 Nomascus leucogenys ENSNLEG00000012720 I 1.000
ENSOARG00000015078 Ovis aries ENSOARG00000015078 I 1.000
IRF1 Dasypus novemcinctus ENSDNOG00000035479 I 1.000
IRF1 Sus scrofa ENSSSCG00000014277 I 1.000
IRF1 Bos taurus ENSBTAG00000031231 I 1.000
IRF1 Callithrix jacchus ENSCJAG00000013013 I 1.000
ENSAMEG00000017694 Ailuropoda melanoleuca ENSAMEG00000017694 I 1.000
IRF1 Canis familiaris ENSCAFG00000000851 I 1.000
ENSTSYG00000001107 Tarsius syrichta ENSTSYG00000001107 I 1.000
IRF1 Tursiops truncatus ENSTTRG00000002597 I 0.990
Irf1 Rattus norvegicus ENSRNOG00000008144 I 0.990
IRF1 Cavia porcellus ENSCPOG00000004848 I 0.990
IRF1 Otolemur garnettii ENSOGAG00000015489 I 0.990
ENSDORG00000003799 Dipodomys ordii ENSDORG00000003799 I 0.990
IRF1 Myotis lucifugus ENSMLUG00000016545 I 0.981
IRF1 Loxodonta africana ENSLAFG00000007502 I 0.981
Myotis_brandtii_IRF1_10032556 Myotis brandtii Myotis_brandtii_IRF1_10032556 I 0.981
ENSCSAG00000013810 Chlorocebus sabaeus ENSCSAG00000013810 I 0.981
IRF1 Procavia capensis ENSPCAG00000017088 I 0.981
ENSMEUG00000011152 Macropus eugenii ENSMEUG00000011152 I 0.976
IRF1 Monodelphis domestica ENSMODG00000013963 I 0.962
IRF1 Ornithorhynchus anatinus ENSOANG00000010695 I 0.962
ENSSHAG00000009209 Sarcophilus harrisii ENSSHAG00000009209 I 0.962
IRF1 Meleagris gallopavo ENSMGAG00000008932 I 0.933
IRF1 Gallus gallus ENSGALG00000006785 I 0.933
Tal_R004238 Tyto alba Tal_R004238 I 0.924
Aan_R011063 Calypte anna Aan_R011063 I 0.924
Afo_R012154 Aptenodytes forsteri Afo_R012154 I 0.924
ENSAPLG00000009708 Anas platyrhynchos ENSAPLG00000009708 I 0.924
IRF1 Taeniopygia guttata ENSTGUG00000001375 I 0.914
Gfo_R013143 Geospiza fortis Gfo_R013143 I 0.914
ENSFALG00000013442 Ficedula albicollis ENSFALG00000013442 I 0.914
Alligator_sinensis_CCG004039.1 Alligator sinensis Alligator_sinensis_CCG004039.1 I 0.914
Brh_R004433 Buceros rhinoceros Brh_R004433 I 0.905
ENSPSIG00000010399 Pelodiscus sinensis ENSPSIG00000010399 I 0.895
irf1 Xenopus tropicalis XB-GENE-942994 I 0.867
ENSLACG00000001546 Latimeria chalumnae ENSLACG00000001546 I 0.857
irf1.S Xenopus laevis XB-GENE-17345840 I 0.857
irf1.L Xenopus laevis XB-GENE-6255163 I 0.848
ENSLOCG00000010331 Lepisosteus oculatus ENSLOCG00000010331 I 0.838
Pvit_14395 Pogona vitticeps Pvit_14395 I 0.829
IRF1 Anolis carolinensis ENSACAG00000012699 I 0.819
ENSTSYG00000003453 Tarsius syrichta ENSTSYG00000003453 I 0.800
ENSAPLG00000015442 Anas platyrhynchos ENSAPLG00000015442 I 0.790
Tal_R005926 Tyto alba Tal_R005926 I 0.790
IRF2 Gallus gallus ENSGALG00000010642 I 0.790
IRF2 Taeniopygia guttata ENSTGUG00000006662 I 0.781
Brh_R001640 Buceros rhinoceros Brh_R001640 I 0.781
ENSFALG00000011727 Ficedula albicollis ENSFALG00000011727 I 0.781
IRF2 Cavia porcellus ENSCPOG00000013097 I 0.781
IRF2 Meleagris gallopavo ENSMGAG00000006359 I 0.781
Gfo_R010481 Geospiza fortis Gfo_R010481 I 0.781
Aan_R004209 Calypte anna Aan_R004209 I 0.781
Afo_R013359 Aptenodytes forsteri Afo_R013359 I 0.781
IRF2 Tursiops truncatus ENSTTRG00000009391 I 0.771
Irf2 Rattus norvegicus ENSRNOG00000009824 I 0.771
IRF2 Sus scrofa ENSSSCG00000015782 I 0.771
IRF2 Pteropus vampyrus ENSPVAG00000007078 I 0.771
IRF2 Microcebus murinus ENSMICG00000015506 I 0.771
IRF2 Equus caballus ENSECAG00000007508 I 0.771
IRF2 Felis catus ENSFCAG00000030144 I 0.771
IRF2 Homo sapiens ENSG00000168310 D 0.771
IRF2 Gorilla gorilla ENSGGOG00000016559 I 0.771
txndc15 Danio rerio ENSDARG00000043249 I 0.771
irf2 Danio rerio ENSDARG00000040465 I 0.771
ENSAMEG00000008380 Ailuropoda melanoleuca ENSAMEG00000008380 I 0.771
IRF2 Canis familiaris ENSCAFG00000007761 I 0.771
IRF2 Callithrix jacchus ENSCJAG00000005731 I 0.771
ENSCSAG00000003010 Chlorocebus sabaeus ENSCSAG00000003010 I 0.771
Myotis_brandtii_IRF2_10027054 Myotis brandtii Myotis_brandtii_IRF2_10027054 I 0.771
IRF2 Loxodonta africana ENSLAFG00000000088 I 0.771
ENSNLEG00000010848 Nomascus leucogenys ENSNLEG00000010848 I 0.771
IRF2 Oryctolagus cuniculus ENSOCUG00000009229 I 0.771
IRF2 Otolemur garnettii ENSOGAG00000010966 I 0.771
ENSP00000377218 Macaca fascicularis ENSP00000377218 I 0.771
Cmyd_10017697 Chelonia mydas Cmyd_10017697 I 0.771
Irf2 Mus musculus ENSMUSG00000031627 D 0.771
IRF2 Myotis lucifugus ENSMLUG00000014246 I 0.771
ENSMPUG00000011075 Mustela putorius furo ENSMPUG00000011075 I 0.771
IRF2 Macaca mulatta ENSMMUG00000015087 I 0.771
IRF2 Monodelphis domestica ENSMODG00000004393 I 0.771
ENSBTAP00000013193-D1 Bos grunniens ENSBTAP00000013193-D1 I 0.762
ENSOARG00000007443 Ovis aries ENSOARG00000007443 I 0.762
ENSPSIG00000016830 Pelodiscus sinensis ENSPSIG00000016830 I 0.762
IRF2 Ochotona princeps ENSOPRG00000005398 I 0.762
IRF2 Bos taurus ENSBTAG00000010002 I 0.762
ENSLACG00000004013 Latimeria chalumnae ENSLACG00000004013 I 0.762
IRF2 Pan troglodytes ENSPTRG00000016639 I 0.762
ENSPFOG00000006505 Poecilia formosa ENSPFOG00000006505 I 0.762
ENSSHAG00000002124 Sarcophilus harrisii ENSSHAG00000002124 I 0.762
irf2 Takifugu rubripes ENSTRUG00000001842 I 0.762
ENSXMAG00000004071 Xiphophorus maculatus ENSXMAG00000004071 I 0.762
irf2 Gasterosteus aculeatus ENSGACG00000018763 I 0.752
Pvit_12337 Pogona vitticeps Pvit_12337 I 0.752
irf2a Danio rerio ENSDARG00000007387 I 0.752
ENSAMXG00000005897 Astyanax mexicanus ENSAMXG00000005897 I 0.752
Ogr17358 Ophisaurus gracilis Ogr17358 I 0.752
irf2 Xenopus tropicalis XB-GENE-942910 I 0.752
irf2.S Xenopus laevis XB-GENE-17339545 I 0.752
ENSLOCG00000013738 Lepisosteus oculatus ENSLOCG00000013738 I 0.752
irf2 Oryzias latipes ENSORLG00000008574 I 0.752
IRF2 Vicugna pacos ENSVPAG00000011297 I 0.752
ENSAMXG00000010595 Astyanax mexicanus ENSAMXG00000010595 I 0.743
ENSONIG00000015919 Oreochromis niloticus ENSONIG00000015919 I 0.743
IRF2 Choloepus hoffmanni ENSCHOG00000012067 I 0.738
irf2.L Xenopus laevis XB-GENE-942916 I 0.733
ENSGMOG00000016692 Gadus morhua ENSGMOG00000016692 I 0.733
ENSONIG00000017217 Oreochromis niloticus ENSONIG00000017217 I 0.714
ENSMEUG00000003128 Macropus eugenii ENSMEUG00000003128 I 0.708
ENSXMAG00000011087 Xiphophorus maculatus ENSXMAG00000011087 I 0.705