TF Information

Trp63 *(Mus musculus)* p53
Pfam ID	Interpro ID	Gene ID	CIS-BP ID	Sequence source	Animal TF db
PF00870 (P53)	IPR011615	ENSMUSG00000022510	T311091_2.00	Ensembl (2018-Dec-8)	Link out
NCBI Gene Info: This gene encodes tumor protein p63, a member of the p53 family of transcription factors involved in cellular responses to stress and development. The family members include tumor proteins p53, p63, and p73, which have high sequence similarity to one another. This similarity allows p63 and p73 to transactivate p53-responsive genes causing cell cycle arrest and apoptosis. The family members can interact with each other in many ways, including direct and indirect protein interactions. This results in mutual regulation of target gene promoters. Tumor protein p63 -/- mice have several developmental defects which include the lack of limbs and other tissues, such as teeth and mammary glands, which develop as a result of interactions between mesenchyme and epithelium. Both alternative splicing and the use of alternative promoters result in multiple transcript variants encoding different protein isoforms.[provided by RefSeq, Dec 2009]
Directly determined binding motifs
Name/Motif ID	Species	Forward	Reverse	Type/Study/Study ID	SR Score	DBD Identity
Trp63 M09338_2.00	Mus musculus	DRCAWGYHCHRRCHTGYHN	NDRCADGYYDGDRCWTGYH	Misc Kulakovskiy et al.(2013) P63_MOUSE.H11MO.0.B	(Direct)	(Direct)
Motifs from related TFs
Name/Motif ID	Species	Forward	Reverse	Type/Study/Study ID	SR Score	DBD Identity
Trp73 M03438_2.00	Mus musculus	DRCAWGTYNNRACAYGYH	DRCRTGTYNNRACWTGYH	SELEX Jolma et al.(2013) Tp73_1	0.857	0.857
TP73 M08035_2.00	Homo sapiens	RCADGYHSDGRCWDG	CHWGYCHSDRCHTGY	ChIP-seq Chen et al.(2011) GSE15704_TP73_rapamycin	0.857	0.857
TP73 M08036_2.00	Homo sapiens	DRRCAWGYHCWGRCWTGYH	DRCAWGYCWGDRCWTGYYH	ChIP-seq Chen et al.(2011) GSE15704_TP73_vehicle	0.857	0.857
TP73 M08037_2.00	Homo sapiens	RCMDGYBCHNDCHKG	CMDGHNDGVRCHKGY	ChIP-seq Chen et al.(2011) GSE18650_TP73	0.857	0.857
TP73 M09336_2.00	Homo sapiens	NDDCHWGYYCMRRCHTGYH	DRCADGYYKGRRCWDGHHN	Misc Kulakovskiy et al.(2013) P73_HUMAN.H11MO.0.A	0.857	0.857
Trp73 M09339_2.00	Mus musculus	NDDCHWGYYCMRRCHTGYH	DRCADGYYKGRRCWDGHHN	Misc Kulakovskiy et al.(2013) P73_MOUSE.H11MO.0.B	0.857	0.857
TP73 M11196_2.00	Homo sapiens	Transfac license required	Transfac license required	Transfac Matys et al.(2006) V$P73_Q6	0.857	0.857
For this family, TFs with SR scores > 0.700* will likely have a similar motif*

DNA Binding Domains

Protein ID	Domain	From	To	Sequence
ENSMUSP00000038117	p53	69	265	PAIPSNTDYPGPHSFDVSFQQSSTAKSATWTYSTELKKLYCQIAKTCPIQIKVMTPPPQGAVIRAMPVYKKAEHVTEVVKRCPNHELSREFNEGQIAPPSHLIRVEGNSHAQYVEDPITGRQSVLVPYEPPQVGTEFTTVLYNFMCNSSCVGGMNRRPILIIVTLETRDGQVLGRRCFEARICACPGRDRKADEDSI
ENSMUSP00000067005	p53	163	359	PAIPSNTDYPGPHSFDVSFQQSSTAKSATWTYSTELKKLYCQIAKTCPIQIKVMTPPPQGAVIRAMPVYKKAEHVTEVVKRCPNHELSREFNEGQIAPPSHLIRVEGNSHAQYVEDPITGRQSVLVPYEPPQVGTEFTTVLYNFMCNSSCVGGMNRRPILIIVTLETRDGQVLGRRCFEARICACPGRDRKADEDSI
ENSMUSP00000110959	p53	69	265	PAIPSNTDYPGPHSFDVSFQQSSTAKSATWTYSTELKKLYCQIAKTCPIQIKVMTPPPQGAVIRAMPVYKKAEHVTEVVKRCPNHELSREFNEGQIAPPSHLIRVEGNSHAQYVEDPITGRQSVLVPYEPPQVGTEFTTVLYNFMCNSSCVGGMNRRPILIIVTLETRDGQVLGRRCFEARICACPGRDRKADEDSI
ENSMUSP00000110960	p53	69	265	PAIPSNTDYPGPHSFDVSFQQSSTAKSATWTYSTELKKLYCQIAKTCPIQIKVMTPPPQGAVIRAMPVYKKAEHVTEVVKRCPNHELSREFNEGQIAPPSHLIRVEGNSHAQYVEDPITGRQSVLVPYEPPQVGTEFTTVLYNFMCNSSCVGGMNRRPILIIVTLETRDGQVLGRRCFEARICACPGRDRKADEDSI
ENSMUSP00000110961	p53	69	265	PAIPSNTDYPGPHSFDVSFQQSSTAKSATWTYSTELKKLYCQIAKTCPIQIKVMTPPPQGAVIRAMPVYKKAEHVTEVVKRCPNHELSREFNEGQIAPPSHLIRVEGNSHAQYVEDPITGRQSVLVPYEPPQVGTEFTTVLYNFMCNSSCVGGMNRRPILIIVTLETRDGQVLGRRCFEARICACPGRDRKADEDSI
ENSMUSP00000110962	p53	163	200	PAIPSNTDYPGPHSFDVSFQQSSTAKSATWTVRESDSE
ENSMUSP00000110963	p53	163	359	PAIPSNTDYPGPHSFDVSFQQSSTAKSATWTYSTELKKLYCQIAKTCPIQIKVMTPPPQGAVIRAMPVYKKAEHVTEVVKRCPNHELSREFNEGQIAPPSHLIRVEGNSHAQYVEDPITGRQSVLVPYEPPQVGTEFTTVLYNFMCNSSCVGGMNRRPILIIVTLETRDGQVLGRRCFEARICACPGRDRKADEDSI
ENSMUSP00000110965	p53	163	359	PAIPSNTDYPGPHSFDVSFQQSSTAKSATWTYSTELKKLYCQIAKTCPIQIKVMTPPPQGAVIRAMPVYKKAEHVTEVVKRCPNHELSREFNEGQIAPPSHLIRVEGNSHAQYVEDPITGRQSVLVPYEPPQVGTEFTTVLYNFMCNSSCVGGMNRRPILIIVTLETRDGQVLGRRCFEARICACPGRDRKADEDSI

Links
Other p53 family TFs
Other *Mus musculus* TFs

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125 Related TFs

Name	Species	Gene ID	Motif Evidence	SR Score	Action