CIS-BP Database: Catalog of Inferred Sequence Binding Preferences
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Aire
(
Rattus norvegicus
)
SAND
TF Information
Pfam ID
Interpro ID
Gene ID
CIS-BP ID
Sequence source
Animal TF db
PF01342 (SAND)
IPR000770
ENSRNOG00000001213
T321897_2.00
Ensembl (2018-Dec-8)
Link out
NCBI Gene Info:
Predicted to enable several functions, including RNA polymerase II transcription regulatory region sequence-specific DNA binding activity; identical protein binding activity; and zinc ion binding activity. Predicted to be involved in several processes, including immune system development; positive regulation of macromolecule metabolic process; and regulation of thymocyte migration. Predicted to be located in cytoplasm and nuclear body. Predicted to be active in nucleus. Used to study autoimmune polyendocrine syndrome. Human ortholog(s) of this gene implicated in autoimmune polyendocrine syndrome and autoimmune polyendocrine syndrome type 1. Orthologous to human AIRE (autoimmune regulator). [provided by Alliance of Genome Resources, Apr 2022]
Directly determined binding motifs
Name/Motif ID
Species
Forward
Reverse
Type/Study/Study ID
SR
Score
DBD
Identity
No direct experiments
Motifs from related TFs
Name/Motif ID
Species
Forward
Reverse
Type/Study/Study ID
SR
Score
DBD
Identity
Aire
M09376_2.00
Mus musculus
DHVHCCWWHWNWWCCNND
HNNGGWWNWDWWGGDBDH
Misc
Kulakovskiy et al.(2013)
AIRE_MOUSE.H11MO.0.C
0.983
0.889
AIRE
M09375_2.00
Homo sapiens
DHVHCCWWHWNWWCCNND
HNNGGWWNWDWWGGDBDH
Misc
Kulakovskiy et al.(2013)
AIRE_HUMAN.H11MO.0.C
0.949
0.741
AIRE
M11264_2.00
Homo sapiens
Transfac license required
Transfac license required
Transfac
Matys et al.(2006)
V$AIRE_01
0.949
0.741
AIRE
M11265_2.00
Homo sapiens
Transfac license required
Transfac license required
Transfac
Matys et al.(2006)
V$AIRE_02
0.949
0.741
For this family, TFs with SR scores >
0.843
will likely have a similar motif
DNA Binding Domains
Protein ID
Domain
From
To
Sequence
ENSRNOP00000001611
SAND
196
249
SSGDVPGSRGAVEGILIQQVFESGGSKKCIQVGGEFYKPSKFEDPSGNLKNKTR
Links
Other
SAND
family TFs
Other
Rattus norvegicus
TFs
25 Related TFs
Name
Species
Gene ID
Motif Evidence
SR
Score
Action
Invalid Input OrderBy