CIS-BP Database: Catalog of Inferred Sequence Binding Preferences
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Stat4
(
Mus musculus
)
STAT
TF Information
Pfam ID
Interpro ID
Gene ID
CIS-BP ID
Sequence source
Animal TF db
PF02864 (STAT_bind)
IPR013801
ENSMUSG00000062939
T337547_2.00
Ensembl (2018-Dec-8)
Link out
NCBI Gene Info:
The protein encoded by this gene is a member of the STAT family of transcription factors. In response to cytokines and growth factors, STAT family members are phosphorylated by the receptor associated kinases, and then form homo- or heterodimers that translocate to the cell nucleus where they act as transcription activators. Homozygous knockout mice for this gene exhibit reduced inflammation and cytokine production in response to immune challenge. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Apr 2015]
Directly determined binding motifs
Name/Motif ID
Species
Forward
Reverse
Type/Study/Study ID
SR
Score
DBD
Identity
Stat4
M08174_2.00
Mus musculus
NNNYTTCYYRGAAV
BTTCYRRGAARNNN
ChIP-seq
Mathelier et al.(2014)
MA0518.1
(Direct)
(Direct)
Stat4
M09424_2.00
Mus musculus
YTTCYHDKMA
TKMHDRGAAR
Misc
Kulakovskiy et al.(2013)
STAT4_MOUSE.H11MO.0.A
(Direct)
(Direct)
Stat4
M09646_2.00
Mus musculus
NYTTCCNGGAAR
YTTCCNGGAARN
Misc
Heinz et al.(2010)
CD4-Stat4_GSE22104
(Direct)
(Direct)
Motifs from related TFs
Name/Motif ID
Species
Forward
Reverse
Type/Study/Study ID
SR
Score
DBD
Identity
STAT4
M09413_2.00
Homo sapiens
YTTCYBDKMAN
NTKMHVRGAAR
Misc
Kulakovskiy et al.(2013)
STAT4_HUMAN.H11MO.0.A
0.936
0.936
STAT4
M11361_2.00
Homo sapiens
BNHTTCNN
NNGAADNV
Transfac
Matys et al.(2006)
V$STAT4_01
0.936
0.936
STAT4
M11362_2.00
Homo sapiens
Transfac license required
Transfac license required
Transfac
Matys et al.(2006)
V$STAT4_Q4
0.936
0.936
STAT4
M11363_2.00
Homo sapiens
Transfac license required
Transfac license required
Transfac
Matys et al.(2006)
V$STAT4_Q5
0.936
0.936
For this family, TFs with SR scores >
0.700
will likely have a similar motif
DNA Binding Domains
Protein ID
Domain
From
To
Sequence
ENSMUSP00000027277
STAT
316
562
FVVERQPCMPTHPQRPMVLKTLIQFTVKLRLLIKLPELNYQVKVKASIDKNVSTLSNRRFVLCGTHVKAMSSEESSNGSLSVEFRHLQPKEMKCSTGSKGNEGCHMVTEELHSITFETQICLYGLTINLETSSLPVVMISNVSQLPNAWASIIWYNVSTNDSQNLVFFNNPPSVTLGQLLEVMSWQFSSYVGRGLNSEQLNMLAEKLTVQSNYNDGHLTWAKFCKEHLPGKTFTFWTWLEAILDLIK
ENSMUSP00000130713
STAT
316
562
FVVERQPCMPTHPQRPMVLKTLIQFTVKLRLLIKLPELNYQVKVKASIDKNVSTLSNRRFVLCGTHVKAMSSEESSNGSLSVEFRHLQPKEMKCSTGSKGNEGCHMVTEELHSITFETQICLYGLTINLETSSLPVVMISNVSQLPNAWASIIWYNVSTNDSQNLVFFNNPPSVTLGQLLEVMSWQFSSYVGRGLNSEQLNMLAEKLTVQSNYNDGHLTWAKFCKEHLPGKTFTFWTWLEAILDLIK
Links
Other
STAT
family TFs
Other
Mus musculus
TFs
33 Related TFs
Name
Species
Gene ID
Motif Evidence
SR
Score
Action
Invalid Input OrderBy