Stat4 (Mus musculus)
STAT

TF Information

Pfam ID Interpro ID Gene ID CIS-BP ID Sequence source Animal TF db
PF02864 (STAT_bind) IPR013801 ENSMUSG00000062939 T337547_2.00 Ensembl (2018-Dec-8) Link out
NCBI Gene Info:
The protein encoded by this gene is a member of the STAT family of transcription factors. In response to cytokines and growth factors, STAT family members are phosphorylated by the receptor associated kinases, and then form homo- or heterodimers that translocate to the cell nucleus where they act as transcription activators. Homozygous knockout mice for this gene exhibit reduced inflammation and cytokine production in response to immune challenge. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Apr 2015]

Directly determined binding motifs

Name/Motif ID Species Forward Reverse Type/Study/Study ID SR
Score
DBD
Identity
Stat4
M08174_2.00
Mus musculus
NNNYTTCYYRGAAV

BTTCYRRGAARNNN
ChIP-seq
Mathelier et al.(2014)
MA0518.1
(Direct) (Direct)
Stat4
M09424_2.00
Mus musculus
YTTCYHDKMA

TKMHDRGAAR
Misc
Kulakovskiy et al.(2013)
STAT4_MOUSE.H11MO.0.A
(Direct) (Direct)
Stat4
M09646_2.00
Mus musculus
NYTTCCNGGAAR

YTTCCNGGAARN
Misc
Heinz et al.(2010)
CD4-Stat4_GSE22104
(Direct) (Direct)

Motifs from related TFs

Name/Motif ID Species Forward Reverse Type/Study/Study ID SR
Score
DBD
Identity
STAT4
M09413_2.00
Homo sapiens
YTTCYBDKMAN

NTKMHVRGAAR
Misc
Kulakovskiy et al.(2013)
STAT4_HUMAN.H11MO.0.A
0.936 0.936
STAT4
M11361_2.00
Homo sapiens
BNHTTCNN

NNGAADNV
Transfac
Matys et al.(2006)
V$STAT4_01
0.936 0.936
STAT4
M11362_2.00
Homo sapiens Transfac license required
Transfac license required
Transfac
Matys et al.(2006)
V$STAT4_Q4
0.936 0.936
STAT4
M11363_2.00
Homo sapiens Transfac license required
Transfac license required
Transfac
Matys et al.(2006)
V$STAT4_Q5
0.936 0.936
For this family, TFs with SR scores > 0.700 will likely have a similar motif

DNA Binding Domains

Protein ID Domain From To Sequence
ENSMUSP00000027277 STAT 316 562
ENSMUSP00000130713 STAT 316 562

Links

Other STAT family TFs
Other Mus musculus TFs

33 Related TFs

Name Species Gene ID Motif Evidence SR
Score
Action
Brh_R001450 Buceros rhinoceros Brh_R001450 I 0.871
ENSCAFG00000009797 Canis familiaris ENSCAFG00000009797 I 0.957
ENSCSAG00000012146 Chlorocebus sabaeus ENSCSAG00000012146 I 0.936
ENSGALG00000025974 Gallus gallus ENSGALG00000025974 I 0.871
ENSMPUG00000012539 Mustela putorius furo ENSMPUG00000012539 I 0.944
ENSNLEG00000006726 Nomascus leucogenys ENSNLEG00000006726 I 0.940
ENSOARG00000013903 Ovis aries ENSOARG00000013903 I 0.940
ENSP00000351255-D1 Bos grunniens ENSP00000351255-D1 I 0.949
ENSPANG00000022795 Papio anubis ENSPANG00000022795 I 0.940
ENSPPYG00000013028 Pongo abelii ENSPPYG00000013028 I 0.940
ENSPSIG00000010185 Pelodiscus sinensis ENSPSIG00000010185 I 0.824
STAT1 Bos taurus ENSBTAG00000007867 I 0.833
Stat1 Rattus norvegicus ENSRNOG00000014079 I 0.987
STAT4 Sus scrofa ENSSSCG00000016059 I 0.914
STAT4 Ochotona princeps ENSOPRG00000008636 I 0.953
STAT4 Tursiops truncatus ENSTTRG00000001136 I 0.940
STAT4 Otolemur garnettii ENSOGAG00000003042 I 0.940
STAT4 Vicugna pacos ENSVPAG00000011545 I 0.807
STAT4 Pteropus vampyrus ENSPVAG00000004736 I 0.944
STAT4 Oryctolagus cuniculus ENSOCUG00000002466 I 0.953
STAT4 Choloepus hoffmanni ENSCHOG00000006838 I 0.957
STAT4 Callithrix jacchus ENSCJAG00000005895 I 0.923
Stat4 Dipodomys ordii ENSDORG00000011535 I 0.798
STAT4 Equus caballus ENSECAG00000023170 I 0.957
STAT4 Erinaceus europaeus ENSEEUG00000002778 I 0.923
STAT4 Felis catus ENSFCAG00000018634 I 0.949
STAT4 Homo sapiens ENSG00000138378 D 0.936
STAT4 Loxodonta africana ENSLAFG00000012299 I 0.936
STAT4 Meleagris gallopavo ENSMGAG00000016413 I 0.871
STAT4 Macaca mulatta ENSMMUG00000005617 I 0.940
STAT4 Monodelphis domestica ENSMODG00000011767 I 0.871
Tal_R001379 Tyto alba Tal_R001379 I 0.871