CIS-BP Database: Catalog of Inferred Sequence Binding Preferences
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Stat3
(
Rattus norvegicus
)
STAT
TF Information
Pfam ID
Interpro ID
Gene ID
CIS-BP ID
Sequence source
Animal TF db
PF02864 (STAT_bind)
IPR013801
ENSRNOG00000019742
T337654_2.00
Ensembl (2018-Dec-8)
Link out
NCBI Gene Info:
Enables CCR5 chemokine receptor binding activity; glucocorticoid receptor binding activity; and sequence-specific DNA binding activity. Involved in several processes, including positive regulation of growth factor dependent skeletal muscle satellite cell proliferation; positive regulation of interleukin-6 production; and regulation of cellular biosynthetic process. Acts upstream of or within cellular response to cytokine stimulus and cellular response to organic cyclic compound. Located in mitochondrial inner membrane and nucleus. Is active in Schaffer collateral - CA1 synapse; glutamatergic synapse; and postsynaptic density. Used to study several diseases, including duodenal ulcer; hyperuricemia; non-alcoholic fatty liver disease; obesity; and transient cerebral ischemia. Biomarker of colon cancer; colorectal carcinoma; heart disease; and pre-malignant neoplasm. Human ortholog(s) of this gene implicated in several diseases, including autoimmune disease (multiple); carcinoma (multiple); hyper IgE recurrent infection syndrome 1; reproductive organ cancer (multiple); and type 2 diabetes mellitus. Orthologous to human STAT3 (signal transducer and activator of transcription 3). [provided by Alliance of Genome Resources, Apr 2022]
Directly determined binding motifs
Name/Motif ID
Species
Forward
Reverse
Type/Study/Study ID
SR
Score
DBD
Identity
No direct experiments
Motifs from related TFs
Name/Motif ID
Species
Forward
Reverse
Type/Study/Study ID
SR
Score
DBD
Identity
STAT3
M08172_2.00
Homo sapiens
HTTCCHRGMAV
BTKCYDGGAAD
ChIP-seq
Mathelier et al.(2014)
MA0144.2
1.000
1.000
STAT3
M08015_2.00
Homo sapiens
YDTTTMYYRGAARHSABVDB
VHBVTSDYTTCYRRKAAAHR
ChIP-seq
Gerstein et al.(2012)
GM12878_STAT3_Stanford
1.000
1.000
STAT3
M08016_2.00
Homo sapiens
NNNTTCCHRKAAN
NTTMYDGGAANNN
ChIP-seq
Gerstein et al.(2012)
HeLa-S3_STAT3_Stanford
1.000
1.000
STAT3
M08017_2.00
Homo sapiens
NNHTTCCYRKMANNN
NNNTKMYRGGAADNN
ChIP-seq
Gerstein et al.(2012)
MCF10A-Er-Src_STAT3_Harvard#Weissman
1.000
1.000
STAT3
M08018_2.00
Homo sapiens
NNHTTCCYRKMANNN
NNNTKMYRGGAADNN
ChIP-seq
Gerstein et al.(2012)
MCF10A-Er-Src_STAT3_Stanford
1.000
1.000
Stat3
M08043_2.00
Mus musculus
BTTCCYRGMAD
HTKCYRGGAAV
ChIP-seq
Chen et al.(2011)
SRP000217_Stat3
1.000
1.000
STAT3
M09415_2.00
Homo sapiens
NNYTTCCMRGAA
TTCYKGGAARNN
Misc
Kulakovskiy et al.(2013)
STAT3_HUMAN.H11MO.0.A
1.000
1.000
Stat3
M09419_2.00
Mus musculus
NNYTTMCHRKMA
TKMYDGKAARNN
Misc
Kulakovskiy et al.(2013)
STAT3_MOUSE.H11MO.0.A
1.000
1.000
Stat3
M09645_2.00
Mus musculus
NNBTTCCNGGAAVN
NBTTCCNGGAAVNN
Misc
Heinz et al.(2010)
CD4-Stat3_GSE19198
1.000
1.000
STAT3
M11367_2.00
Homo sapiens
NBBBATTTCCSGGAARTGNNN
NNNCAYTTCCSGGAAATVVVN
Transfac
Matys et al.(2006)
V$STAT3_01
1.000
1.000
STAT3
M11368_2.00
Homo sapiens
NNNTTCCN
NGGAANNN
Transfac
Matys et al.(2006)
V$STAT3_02
1.000
1.000
STAT3
M11369_2.00
Homo sapiens
Transfac license required
Transfac license required
Transfac
Matys et al.(2006)
V$STAT3_03
1.000
1.000
STAT3
M11370_2.00
Homo sapiens
Transfac license required
Transfac license required
Transfac
Matys et al.(2006)
V$STAT3_Q4
1.000
1.000
For this family, TFs with SR scores >
0.700
will likely have a similar motif
DNA Binding Domains
Protein ID
Domain
From
To
Sequence
ENSRNOP00000026760
STAT
321
573
FVVERQPCMPMHPDRPLVIKTGVQFTTKVRLLVKFPELNYQLKIKVCIDKDSGDVAALRGSRKFNILGTNTKVMNMEESNNGSLSAEFKHLTLREQRCGNGGRANCDASLIVTEELHLITFETEVYHQGLKIDLETHSLPVVVISNICQMPNAWASILWYNMLTNNPKNVNFFTKPPIGTWDQVAEVLSWQFSSTTKRGLSIEQLTTLAEKLLGPGVNYSGCQITWAKFCKENMAGKGFSFWVWLDNIIDLVK
Links
Other
STAT
family TFs
Other
Rattus norvegicus
TFs
65 Related TFs
Name
Species
Gene ID
Motif Evidence
SR
Score
Action
Invalid Input OrderBy