klu (Drosophila melanogaster)
C2H2 ZF

TF Information

Pfam ID Interpro ID Gene ID CIS-BP ID Sequence source Animal TF db
PF00096 (zf-C2H2) IPR007087 FBgn0013469 T114435_2.00 Ensembl (2018-Dec-8) Link out
NCBI Gene Info:
Enables DNA-binding transcription repressor activity, RNA polymerase II-specific; RNA polymerase II transcription regulatory region sequence-specific DNA binding activity; and cis-regulatory region sequence-specific DNA binding activity. Involved in several processes, including generation of neurons; larval feeding behavior; and neuronal stem cell population maintenance. Located in nucleus. Is expressed in several structures, including anterior-posterior subdivision of organism; extended germ band embryo; imaginal disc; presumptive embryonic/larval system; and somatic precursor cell. Orthologous to human ZBTB7A (zinc finger and BTB domain containing 7A). [provided by Alliance of Genome Resources, Apr 2022]

Directly determined binding motifs

Name/Motif ID Species Forward Reverse Type/Study/Study ID SR
Score		 DBD
Identity
klu
M03680_2.00		 Drosophila melanogaster
HCCRCCCACGCAH
DTGCGTGGGYGGD		 SELEX
Nitta et al.(2015)
klu_1		 (Direct) (Direct)
klu
M03681_2.00		 Drosophila melanogaster
YMCGCCCMCGCAH
DTGCGKGGGCGKR		 SELEX
Nitta et al.(2015)
klu_2		 (Direct) (Direct)
klu
M06114_2.00		 Drosophila melanogaster
MCACCCMCRCA
TGYGKGGGTGK		 B1H
Zhu et al.(2011)
klu_SANGER_10_FBgn0013469		 (Direct) (Direct)
klu
M06115_2.00		 Drosophila melanogaster
NNNNMCACCCMCRCN
NGYGKGGGTGKNNNN		 B1H
Zhu et al.(2011)
klu_SOLEXA_5_FBgn0013469		 (Direct) (Direct)

Motifs from related TFs

Name/Motif ID Species Forward Reverse Type/Study/Study ID SR
Score		 DBD
Identity
For this family, TFs with SR scores > 0.755 will likely have a similar motif

DNA Binding Domains

Protein ID Domain From To Sequence
FBpp0075976 C2H2 ZF 590 613
FBpp0075976 C2H2 ZF 626 648
FBpp0075976 C2H2 ZF 654 676
FBpp0075976 C2H2 ZF 682 704
FBpp0303113 C2H2 ZF 590 613
FBpp0303113 C2H2 ZF 626 648
FBpp0303113 C2H2 ZF 654 676
FBpp0303113 C2H2 ZF 682 704
FBpp0305553 C2H2 ZF 590 613
FBpp0305553 C2H2 ZF 626 648
FBpp0305553 C2H2 ZF 654 676
FBpp0305553 C2H2 ZF 682 704
FBpp0311501 C2H2 ZF 590 613
FBpp0311501 C2H2 ZF 626 648
FBpp0311501 C2H2 ZF 654 676
FBpp0311501 C2H2 ZF 682 704

Links

Other C2H2 ZF family TFs
Other Drosophila melanogaster TFs

Invalid Input OrderBy

67 Related TFs

Name Species Gene ID Motif Evidence SR
Score		 Action