nhr-208 (Caenorhabditis elegans)
Nuclear receptor

TF Information

Pfam ID Interpro ID Gene ID CIS-BP ID Sequence source Animal TF db
PF00105 (zf-C4) IPR001628 WBGene00011099 T306284_2.00 Ensembl (2018-Dec-8) Link out
NCBI Gene Info:
Predicted to enable RNA polymerase II cis-regulatory region sequence-specific DNA binding activity and nuclear receptor activity. Involved in response to starvation. Predicted to be located in nucleus. Is expressed in several structures, including anal sphincter muscle; hyp12; pharynx; rectum; and tail hypodermis. Human ortholog(s) of this gene implicated in Fanconi renotubular syndrome 4; familial combined hyperlipidemia; hypoglycemia; maturity-onset diabetes of the young type 1; and type 2 diabetes mellitus. Orthologous to human HNF4A (hepatocyte nuclear factor 4 alpha) and HNF4G (hepatocyte nuclear factor 4 gamma). [provided by Alliance of Genome Resources, Apr 2022]

Directly determined binding motifs

Name/Motif ID Species Forward Reverse Type/Study/Study ID SR
Score		 DBD
Identity
No direct experiments

Motifs from related TFs

Name/Motif ID Species Forward Reverse Type/Study/Study ID SR
Score		 DBD
Identity
CBG23380
M01296_2.00 		Caenorhabditis briggsae
NDBDHHANWN
NWNTDDHVHN		 PBM
Lambert et al.(2019)
pTH11449 		0.916 0.629
nhr-154
M00698_2.00 		Caenorhabditis elegans
NRBRYCAHWD
HWDTGRYVYN		 PBM
Narasimhan et al.(2015)
pTH10650 		0.916 0.629
For this family, TFs with SR scores > 0.745 will likely have a similar motif

DNA Binding Domains

Protein ID Domain From To Sequence
R07B7.15 Nuclear receptor 41 112

Links

Other Nuclear receptor family TFs
Other Caenorhabditis elegans TFs

12 Related TFs

Name Species Gene ID Motif Evidence SR
Score		 Action
nhr-206 Caenorhabditis elegans WBGene00011097 I 0.984
nhr-154 Caenorhabditis elegans WBGene00007547 D 0.916
CBG23380 Caenorhabditis briggsae CBG23380 D 0.916
CRE27050 Caenorhabditis remanei CRE27050 I 0.916
CBN28497 Caenorhabditis brenneri CBN28497 I 0.916
CBG23381 Caenorhabditis briggsae CBG23381 I 0.916
nhr-153 Caenorhabditis elegans WBGene00007546 I 0.913
CJA03696 Caenorhabditis japonica CJA03696 I 0.912
CBN28791 Caenorhabditis brenneri CBN28791 I 0.909
CRE27052 Caenorhabditis remanei CRE27052 I 0.906
nhr-207 Caenorhabditis elegans WBGene00011098 I 0.856
CRE27051 Caenorhabditis remanei CRE27051 I 0.844