nhr-154 (Caenorhabditis elegans)
Nuclear receptor

TF Information

Pfam ID Interpro ID Gene ID CIS-BP ID Sequence source Animal TF db
PF00105 (zf-C4) IPR001628 WBGene00007547 T306257_2.00 Ensembl (2018-Dec-8) Link out
NCBI Gene Info:
Predicted to enable RNA polymerase II cis-regulatory region sequence-specific DNA binding activity and nuclear receptor activity. Involved in response to starvation. Predicted to be located in nucleus. Is expressed in alimentary muscle; head neurons; intestine; pharynx; and rectal valve cell. Human ortholog(s) of this gene implicated in Fanconi renotubular syndrome 4; familial combined hyperlipidemia; hypoglycemia; maturity-onset diabetes of the young type 1; and type 2 diabetes mellitus. Orthologous to human HNF4A (hepatocyte nuclear factor 4 alpha) and HNF4G (hepatocyte nuclear factor 4 gamma). [provided by Alliance of Genome Resources, Apr 2022]

Directly determined binding motifs

Name/Motif ID Species Forward Reverse Type/Study/Study ID SR
Score		 DBD
Identity
nhr-154
M00698_2.00		 Caenorhabditis elegans
NRBRYCAHWD
HWDTGRYVYN		 PBM
Narasimhan et al.(2015)
pTH10650		 (Direct) (Direct)

Motifs from related TFs

Name/Motif ID Species Forward Reverse Type/Study/Study ID SR
Score		 DBD
Identity
CBG23380
M01296_2.00 		Caenorhabditis briggsae
NDBDHHANWN
NWNTDDHVHN		 PBM
Lambert et al.(2019)
pTH11449 		0.990 0.928
For this family, TFs with SR scores > 0.745 will likely have a similar motif

Experimental Constructs

Motif ID Domain From To Sequence
M00698_2.00 Nuclear receptor 51 124

DNA Binding Domains

Protein ID Domain From To Sequence
C13C4.2 Nuclear receptor 81 154

Links

Other Nuclear receptor family TFs
Other Caenorhabditis elegans TFs

70 Related TFs

Name Species Gene ID Motif Evidence SR
Score		 Action
CBN28497 Caenorhabditis brenneri CBN28497 I 0.990
CRE27050 Caenorhabditis remanei CRE27050 I 0.990
CBG23380 Caenorhabditis briggsae CBG23380 D 0.990
nhr-153 Caenorhabditis elegans WBGene00007546 I 0.974
CBN28791 Caenorhabditis brenneri CBN28791 I 0.973
CBG23381 Caenorhabditis briggsae CBG23381 I 0.972
CRE27052 Caenorhabditis remanei CRE27052 I 0.972
CJA03696 Caenorhabditis japonica CJA03696 I 0.954
nhr-208 Caenorhabditis elegans WBGene00011099 I 0.916
CRE27051 Caenorhabditis remanei CRE27051 I 0.908
nhr-206 Caenorhabditis elegans WBGene00011097 I 0.898
L893_g28857 Steinernema glaseri L893_g28857 I 0.892
L889_g1557 Steinernema feltiae L889_g1557 I 0.886
L898_g9866 Steinernema monticolum L898_g9866 I 0.886
HCOI01292200 Haemonchus contortus HCOI01292200 I 0.885
HPLM_0000769401 Haemonchus placei HPLM_0000769401 I 0.884
L892_g4169 Steinernema scapterisci L892_g4169 I 0.883
scaffold43-EXSNAP2012.41 Pristionchus exspectatus scaffold43-EXSNAP2012.41 I 0.869
NECAME_08394 Necator americanus NECAME_08394 I 0.866
CBN29725 Caenorhabditis brenneri CBN29725 I 0.861
CRE27053 Caenorhabditis remanei CRE27053 I 0.861
L596_g27472 Steinernema carpocapsae L596_g27472 I 0.860
PPA21777 Pristionchus pacificus PPA21777 I 0.856
HPBE_0000704501 Heligmosomoides bakeri HPBE_0000704501 I 0.851
Hba_12763 Heterorhabditis bacteriophora Hba_12763 I 0.847
CBN24827 Caenorhabditis brenneri CBN24827 I 0.847
CJA08896 Caenorhabditis japonica CJA08896 I 0.845
CRE00149 Caenorhabditis remanei CRE00149 I 0.845
CBG10855 Caenorhabditis briggsae CBG10855 I 0.845
nhr-120 Caenorhabditis elegans WBGene00003710 I 0.845
PEQ_0000722401 Parascaris equorum PEQ_0000722401 I 0.839
ASU_03657 Ascaris suum ASU_03657 I 0.839
CJA41479 Caenorhabditis japonica CJA41479 I 0.831
nhr-207 Caenorhabditis elegans WBGene00011098 I 0.828
PPA29597 Pristionchus pacificus PPA29597 I 0.826
scaffold426-EXSNAP2012.35 Pristionchus exspectatus scaffold426-EXSNAP2012.35 I 0.826
ASIM_0001569801 Anisakis simplex ASIM_0001569801 I 0.824
L892_g17612 Steinernema scapterisci L892_g17612 I 0.822
L893_g3565 Steinernema glaseri L893_g3565 I 0.821
ASU_02755 Ascaris suum ASU_02755 I 0.817
nhr-209 Caenorhabditis elegans WBGene00011100 I 0.815
scaffold552-EXSNAP2012.18 Pristionchus exspectatus scaffold552-EXSNAP2012.18 I 0.814
CBG23379 Caenorhabditis briggsae CBG23379 I 0.814
ANCCEY_01254 Ancylostoma ceylanicum ANCCEY_01254 I 0.810
PPA24481 Pristionchus pacificus PPA24481 I 0.804
scaffold552-EXSNAP2012.17 Pristionchus exspectatus scaffold552-EXSNAP2012.17 I 0.804
L889_g1891 Steinernema feltiae L889_g1891 I 0.803
NECAME_01944 Necator americanus NECAME_01944 I 0.799
ANCCAN_09880 Ancylostoma caninum ANCCAN_09880 I 0.799
HPBE_0001246601 Heligmosomoides bakeri HPBE_0001246601 I 0.799
BTMF_0000941401 Brugia timori BTMF_0000941401 I 0.794
LOAG_16377 Loa loa LOAG_16377 I 0.794
HCOI01525900 Haemonchus contortus HCOI01525900 I 0.794
scaffold572-EXSNAP2012.7 Pristionchus exspectatus scaffold572-EXSNAP2012.7 I 0.793
Ppa-nhr-120 Pristionchus pacificus PPA00183 I 0.793
scaffold384-EXSNAP2012.4 Pristionchus exspectatus scaffold384-EXSNAP2012.4 I 0.793
EEL_0000989101 Elaeophora elaphi EEL_0000989101 I 0.791
L893_g7217 Steinernema glaseri L893_g7217 I 0.775
nhr-136 Caenorhabditis elegans WBGene00003726 I 0.773
L889_g27850 Steinernema feltiae L889_g27850 I 0.771
WBGene00240403 Onchocerca volvulus WBGene00240403 I 0.770
CJA00680 Caenorhabditis japonica CJA00680 I 0.769
L892_g17994 Steinernema scapterisci L892_g17994 I 0.764
L596_g27485 Steinernema carpocapsae L596_g27485 I 0.764
Minc11307 Meloidogyne incognita Minc11307 I 0.762
MhA1_Contig691.frz3.gene13 Meloidogyne hapla MhA1_Contig691.frz3.gene13 I 0.757
nhr-173 Caenorhabditis elegans WBGene00016975 I 0.750
CBG10857 Caenorhabditis briggsae CBG10857 I 0.750
CRE00606 Caenorhabditis remanei CRE00606 I 0.750
scaffold488-EXSNAP2012.17 Pristionchus exspectatus scaffold488-EXSNAP2012.17 I 0.746