ENSPPYG00000013578 (Pongo abelii)
Sox

TF Information

Pfam ID Interpro ID Gene ID CIS-BP ID Sequence source Animal TF db
PF00505 (HMG_box) IPR000910 ENSPPYG00000013578 T328942_2.00 Ensembl (2018-Dec-8) Link out

Directly determined binding motifs

Name/Motif ID Species Forward Reverse Type/Study/Study ID SR
Score
DBD
Identity
No direct experiments

Motifs from related TFs

Name/Motif ID Species Forward Reverse Type/Study/Study ID SR
Score
DBD
Identity
BBX
M05763_2.00
Homo sapiens
TGAWCDNYGWTCA

TGAWCRNHGWTCA
SELEX
Yin et al.(2017)
BBX_eDBD_HT-SELEX
0.741 1.000
BBX
M05764_2.00
Homo sapiens
TGAACDNYGTTCA

TGAACRNHGTTCA
SELEX
Yin et al.(2017)
BBX_eDBD_Methyl-HT-SELEX
0.741 1.000
Bbx
M00196_2.00
Mus musculus
TTCATTGA

TCAATGAA
PBM
Badis et al.(2009)
Bbx_3753
0.708 0.986
bbx
M03975_2.00
Drosophila melanogaster
NAACAATDNCATTGTTN

NAACAATGNHATTGTTN
SELEX
Nitta et al.(2015)
bbx_1
0.519 0.609
Cic
M00195_2.00
Mus musculus
NNTGCTGABN

NVTCAGCANN
PBM
Badis et al.(2009)
Cic_3454
0.468 0.594
cic
M06452_2.00
Drosophila melanogaster
YYCATTSA

TSAATGRR
B1H
Zhu et al.(2011)
cic_SANGER_5_FBgn0028386
0.430 0.478
gei-3
M00711_2.00
Caenorhabditis elegans
NWNWMWDN

NHWKWNWN
PBM
Narasimhan et al.(2015)
pTH10038
0.429 0.493
For this family, TFs with SR scores > 0.415 will likely have a similar motif

DNA Binding Domains

Protein ID Domain From To Sequence
ENSPPYP00000015181 Sox 80 148
ENSPPYP00000024711 Sox 80 148

Links

Other Sox family TFs
Other Pongo abelii TFs

285 Related TFs

Name Species Gene ID Motif Evidence SR
Score
Action
ENSAMEG00000002574 Ailuropoda melanoleuca ENSAMEG00000002574 I 0.741
ENSAPLG00000005336 Anas platyrhynchos ENSAPLG00000005336 I 0.741
BBX Bos taurus ENSBTAG00000006893 I 0.741
BBX Canis familiaris ENSCAFG00000009867 I 0.741
BBX Callithrix jacchus ENSCJAG00000004843 I 0.741
BBX Cavia porcellus ENSCPOG00000003575 I 0.741
ENSCSAG00000006313 Chlorocebus sabaeus ENSCSAG00000006313 I 0.741
bbx Danio rerio ENSDARG00000012699 I 0.741
BBX Dasypus novemcinctus ENSDNOG00000013923 I 0.741
Bbx Dipodomys ordii ENSDORG00000008169 I 0.741
BBX Equus caballus ENSECAG00000023413 I 0.741
BBX Erinaceus europaeus ENSEEUG00000014092 I 0.741
BBX Echinops telfairi ENSETEG00000005122 I 0.741
BBX Felis catus ENSFCAG00000007296 I 0.741
BBX Homo sapiens ENSG00000114439 D 0.741
BBX Gorilla gorilla ENSGGOG00000028441 I 0.741
ENSLACG00000001134 Latimeria chalumnae ENSLACG00000001134 I 0.741
BBX Meleagris gallopavo ENSMGAG00000014384 I 0.741
BBX Macaca mulatta ENSMMUG00000008787 I 0.741
BBX Monodelphis domestica ENSMODG00000001748 I 0.741
ENSMPUG00000009907 Mustela putorius furo ENSMPUG00000009907 I 0.741
ENSNLEG00000003524 Nomascus leucogenys ENSNLEG00000003524 I 0.741
BBX Ornithorhynchus anatinus ENSOANG00000007497 I 0.741
ENSOARG00000018829 Ovis aries ENSOARG00000018829 I 0.741
BBX Oryctolagus cuniculus ENSOCUG00000001686 I 0.741
BBX Otolemur garnettii ENSOGAG00000008056 I 0.741
BBX Ochotona princeps ENSOPRG00000017013 I 0.741
ENSPANG00000018335 Papio anubis ENSPANG00000018335 I 0.741
BBX Procavia capensis ENSPCAG00000013443 I 0.741
ENSPSIG00000015872 Pelodiscus sinensis ENSPSIG00000015872 I 0.741
BBX Pan troglodytes ENSPTRG00000015187 I 0.741
BBX Pteropus vampyrus ENSPVAG00000010534 I 0.741
ENSSHAG00000003009 Sarcophilus harrisii ENSSHAG00000003009 I 0.741
BBX Sus scrofa ENSSSCG00000011943 I 0.741
bbx Tetraodon nigroviridis ENSTNIG00000008596 I 0.741
ENSTSYG00000000857 Tarsius syrichta ENSTSYG00000000857 I 0.741
BBX Tursiops truncatus ENSTTRG00000013182 I 0.741
BBX Vicugna pacos ENSVPAG00000007818 I 0.741
Aan_R014485 Calypte anna Aan_R014485 I 0.741
Afo_R006638 Aptenodytes forsteri Afo_R006638 I 0.741
Alligator_sinensis_CCG019960.1 Alligator sinensis Alligator_sinensis_CCG019960.1 I 0.741
Cmyd_10015225 Chelonia mydas Cmyd_10015225 I 0.741
ENSBTAP00000009058-D1 Bos grunniens ENSBTAP00000009058-D1 I 0.741
ENSMMUP00000011518 Macaca fascicularis ENSMMUP00000011518 I 0.741
Tal_R013114 Tyto alba Tal_R013114 I 0.741
bbx.L Xenopus laevis XB-GENE-981431 I 0.741
XP_002932333 Xenopus tropicalis XP_002932333 I 0.741
BBX Anolis carolinensis ENSACAG00000006532 I 0.739
ENSFALG00000006478 Ficedula albicollis ENSFALG00000006478 I 0.739
ENSTGUG00000013611 Taeniopygia guttata ENSTGUG00000013611 I 0.739
Brh_R008020 Buceros rhinoceros Brh_R008020 I 0.739
Gfo_R002593 Geospiza fortis Gfo_R002593 I 0.739
Ogr11041 Ophisaurus gracilis Ogr11041 I 0.739
Pvit_02469 Pogona vitticeps Pvit_02469 I 0.739
BBX Myotis lucifugus ENSMLUG00000007351 I 0.737
Myotis_brandtii_BBX_10016000 Myotis brandtii Myotis_brandtii_BBX_10016000 I 0.737
ENSAMXG00000017656 Astyanax mexicanus ENSAMXG00000017656 I 0.735
bbx Gasterosteus aculeatus ENSGACG00000020111 I 0.735
ENSGMOG00000015829 Gadus morhua ENSGMOG00000015829 I 0.735
BBX Loxodonta africana ENSLAFG00000006362 I 0.735
bbx Oryzias latipes ENSORLG00000005486 I 0.735
ENSPFOG00000000813 Poecilia formosa ENSPFOG00000000813 I 0.735
ENSXMAG00000009457 Xiphophorus maculatus ENSXMAG00000009457 I 0.735
ENSONIG00000004775 Oreochromis niloticus ENSONIG00000004775 I 0.732
Bbx Mus musculus ENSMUSG00000022641 D 0.708
Bbx Rattus norvegicus ENSRNOG00000001971 I 0.708
bbx Takifugu rubripes ENSTRUG00000003077 I 0.701
Sakowv30039572m.g Saccoglossus kowalevskii Sakowv30039572m.g I 0.675
BGLB009093 Biomphalaria glabrata BGLB009093 I 0.656
CapteG223458 Capitella teleta CapteG223458 I 0.624
CapteG39110 Capitella teleta CapteG39110 I 0.624
CGI_10018417 Crassostrea gigas CGI_10018417 I 0.624
LotgiG89909 Lottia gigantea LotgiG89909 I 0.624
ENSLOCG00000005165 Lepisosteus oculatus ENSLOCG00000005165 I 0.606
Ocbimv22001036m.g Octopus bimaculoides Ocbimv22001036m.g I 0.575
CpipJ_CPIJ005582 Culex pipiens CpipJ_CPIJ005582 I 0.574
AAEL011161 Aedes aegypti AAEL011161 I 0.574
CPIJ005582 Culex quinquefasciatus CPIJ005582 I 0.574
ENSSSCG00000025539 Sus scrofa ENSSSCG00000025539 I 0.565
ISCW010061 Ixodes scapularis ISCW010061 I 0.559
BGIBMGA008274 Bombyx mori BGIBMGA008274 I 0.557
HMEL012996 Heliconius melpomene HMEL012996 I 0.557
L798_02329 Zootermopsis nevadensis L798_02329 I 0.546
tetur23g01950 Tetranychus urticae tetur23g01950 I 0.539
GB48450 Apis mellifera GB48450 I 0.538
SINV12425 Solenopsis invicta SINV12425 I 0.538
Cflo_04908--XP_624175.2_APIME Camponotus floridanus Cflo_04908--XP_624175.2_APIME I 0.538
Hsal_01854--XP_624175.2_APIME Harpegnathos saltator Hsal_01854--XP_624175.2_APIME I 0.538
TC007499 Tribolium castaneum TC007499 I 0.523
bbx Drosophila melanogaster FBgn0024251 D 0.519
GA16961 Drosophila pseudoobscura FBgn0076975 I 0.519
GF20922 Drosophila ananassae FBgn0097927 I 0.519
GG19727 Drosophila erecta FBgn0111928 I 0.519
GI21541 Drosophila mojavensis FBgn0144271 I 0.519
GM23082 Drosophila sechellia FBgn0177950 I 0.519
GJ16014 Drosophila virilis FBgn0203199 I 0.519
GK25081 Drosophila willistoni FBgn0227040 I 0.519
GE17925 Drosophila yakuba FBgn0235361 I 0.519
MDOA012813 Musca domestica MDOA012813 I 0.519
LCUP006498 Lucilia cuprina LCUP006498 I 0.512
KGM_16790 Danaus plexippus KGM_16790 I 0.489
SMAR012744 Strigamia maritima SMAR012744 I 0.484
YQE_06837 Dendroctonus ponderosae YQE_06837 I 0.483
LDEC000948 Leptinotarsa decemlineata LDEC000948 I 0.483
ACYPI004663 Acyrthosiphon pisum ACYPI004663 I 0.474
csin104163 Clonorchis sinensis csin104163 I 0.474
T265_01499 Opisthorchis viverrini T265_01499 I 0.474
ASTEI00827 Anopheles stephensi ASTEI00827 I 0.471
ASTEI11145 Anopheles stephensi ASTEI11145 I 0.471
SBAD_0000026401 Soboliphyme baturini SBAD_0000026401 I 0.471
ACEP13490 Atta cephalotes ACEP13490 I 0.469
CpipJ_CPIJ012202 Culex pipiens CpipJ_CPIJ012202 I 0.468
ACEP18843 Atta cephalotes ACEP18843 I 0.468
ADAC008993 Anopheles darlingi ADAC008993 I 0.468
AGAP013411 Anopheles gambiae AGAP013411 I 0.468
BGIBMGA010263 Bombyx mori BGIBMGA010263 I 0.468
CapteG39126 Capitella teleta CapteG39126 I 0.468
CGI_10015746 Crassostrea gigas CGI_10015746 I 0.468
CPIJ012202 Culex quinquefasciatus CPIJ012202 I 0.468
ENSAMXG00000018358 Astyanax mexicanus ENSAMXG00000018358 I 0.468
ENSBTAG00000019785 Bos taurus ENSBTAG00000019785 I 0.468
CIC Canis familiaris ENSCAFG00000004858 I 0.468
CIC Callithrix jacchus ENSCJAG00000012847 I 0.468
ENSCPOG00000004391 Cavia porcellus ENSCPOG00000004391 I 0.468
CIC Dasypus novemcinctus ENSDNOG00000047657 I 0.468
Cic Dipodomys ordii ENSDORG00000008822 I 0.468
CIC Equus caballus ENSECAG00000011342 I 0.468
CIC Echinops telfairi ENSETEG00000017271 I 0.468
ENSFCAG00000012737 Felis catus ENSFCAG00000012737 I 0.468
CIC Homo sapiens ENSG00000079432 I 0.468
cicb Gasterosteus aculeatus ENSGACG00000009452 I 0.468
CIC Gorilla gorilla ENSGGOG00000000192 I 0.468
ENSGMOG00000005167 Gadus morhua ENSGMOG00000005167 I 0.468
ENSLACG00000002764 Latimeria chalumnae ENSLACG00000002764 I 0.468
ENSMEUG00000016625 Macropus eugenii ENSMEUG00000016625 I 0.468
ENSMICG00000015176 Microcebus murinus ENSMICG00000015176 I 0.468
ENSMLUG00000016650 Myotis lucifugus ENSMLUG00000016650 I 0.468
ENSMMUG00000012174 Macaca mulatta ENSMMUG00000012174 I 0.468
ENSMPUG00000007557 Mustela putorius furo ENSMPUG00000007557 I 0.468
Cic Mus musculus ENSMUSG00000005442 D 0.468
ENSNLEG00000010614 Nomascus leucogenys ENSNLEG00000010614 I 0.468
ENSOARG00000007985 Ovis aries ENSOARG00000007985 I 0.468
ENSOCUG00000006458 Oryctolagus cuniculus ENSOCUG00000006458 I 0.468
CIC Otolemur garnettii ENSOGAG00000003964 I 0.468
ENSONIG00000013108 Oreochromis niloticus ENSONIG00000013108 I 0.468
cicb Oryzias latipes ENSORLG00000013259 I 0.468
ENSPANG00000009039 Papio anubis ENSPANG00000009039 I 0.468
ENSPFOG00000000116 Poecilia formosa ENSPFOG00000000116 I 0.468
ENSPFOG00000016231 Poecilia formosa ENSPFOG00000016231 I 0.468
ENSPPYG00000010041 Pongo abelii ENSPPYG00000010041 I 0.468
CIC Pan troglodytes ENSPTRG00000011051 I 0.468
CIC Pteropus vampyrus ENSPVAG00000016806 I 0.468
Cic Rattus norvegicus ENSRNOG00000056118 I 0.468
CIC Sus scrofa ENSSSCG00000003030 I 0.468
ENSSTOG00000000852 Ictidomys tridecemlineatus ENSSTOG00000000852 I 0.468
CIC Tupaia belangeri ENSTBEG00000009044 I 0.468
CIC Tetraodon nigroviridis ENSTNIG00000003521 I 0.468
CIC Takifugu rubripes ENSTRUG00000007193 I 0.468
CIC Tursiops truncatus ENSTTRG00000013873 I 0.468
GB43462 Apis mellifera GB43462 I 0.468
KGM_16941 Danaus plexippus KGM_16941 I 0.468
MCINX015089 Melitaea cinxia MCINX015089 I 0.468
NV10910 Nasonia vitripennis NV10910 I 0.468
PHUM079880 Pediculus humanus PHUM079880 I 0.468
SMAR009315 Strigamia maritima SMAR009315 I 0.468
SPU_025292 Strongylocentrotus purpuratus SPU_025292 I 0.468
TC004697 Tribolium castaneum TC004697 I 0.468
Alligator_sinensis_CCG005631.1 Alligator sinensis Alligator_sinensis_CCG005631.1 I 0.468
Cflo_01544--XP_624175.2_APIME Camponotus floridanus Cflo_01544--XP_624175.2_APIME I 0.468
Cmyd_10001800 Chelonia mydas Cmyd_10001800 I 0.468
ENSP00000160740-D1 Bos grunniens ENSP00000160740-D1 I 0.468
ENSP00000160740 Macaca fascicularis ENSP00000160740 I 0.468
Hsal_08911--XP_624175.2_APIME Harpegnathos saltator Hsal_08911--XP_624175.2_APIME I 0.468
Myotis_brandtii_Cic_10007129 Myotis brandtii Myotis_brandtii_Cic_10007129 I 0.468
Ogr10275 Ophisaurus gracilis Ogr10275 I 0.468
Pvit_02876 Pogona vitticeps Pvit_02876 I 0.468
gw.448.64.1 Branchiostoma floridae gw.448.64.1 I 0.468
gw.46.292.1 Branchiostoma floridae gw.46.292.1 I 0.468
Ocbimv22037932m.g Octopus bimaculoides Ocbimv22037932m.g I 0.468
Sakowv30042695m.g Saccoglossus kowalevskii Sakowv30042695m.g I 0.468
CLEC003268 Cimex lectularius CLEC003268 I 0.468
cic Xenopus tropicalis XB-GENE-6467430 I 0.468
AALB003439 Anopheles albimanus AALB003439 I 0.468
AARA001217 Anopheles arabiensis AARA001217 I 0.468
ACHR006446 Anopheles christyi ACHR006446 I 0.468
ACUA015009 Anopheles culicifacies ACUA015009 I 0.468
ADIR003322 Anopheles dirus ADIR003322 I 0.468
AEPI005675 Anopheles epiroticus AEPI005675 I 0.468
AFAF009600 Anopheles farauti AFAF009600 I 0.468
AFUN006011 Anopheles funestus AFUN006011 I 0.468
AMAM017484 Anopheles maculatus AMAM017484 I 0.468
AMEC010127 Anopheles melas AMEC010127 I 0.468
AMEM005678 Anopheles merus AMEM005678 I 0.468
AMIN003810 Anopheles minimus AMIN003810 I 0.468
AQUA008168 Anopheles quadriannulatus AQUA008168 I 0.468
ASTEI00261 Anopheles stephensi ASTEI00261 I 0.468
LLOJ007756 Lutzomyia longipalpis LLOJ007756 I 0.468
CRE24068 Caenorhabditis remanei CRE24068 I 0.462
cica Oryzias latipes ENSORLG00000007091 I 0.462
CIC Procavia capensis ENSPCAG00000017001 I 0.462
L798_08623 Zootermopsis nevadensis L798_08623 I 0.462
RPRC001090 Rhodnius prolixus RPRC001090 I 0.462
HHAL000065-PA Halyomorpha halys HHAL000065-PA I 0.462
BGLB001462 Biomphalaria glabrata BGLB001462 I 0.462
D917_02434 Trichinella nativa D917_02434 I 0.462
D918_06270 Trichuris suis D918_06270 I 0.462
TMUE_s0223001200 Trichuris muris TMUE_s0223001200 I 0.462
TTRE_0000098801 Trichuris trichiura TTRE_0000098801 I 0.462
CY34DRAFT_798812 Suillus luteus CY34DRAFT_798812 I 0.461
PAXRUDRAFT_130978 Paxillus rubicundulus PAXRUDRAFT_130978 I 0.461
SCLCIDRAFT_120630 Scleroderma citrinum SCLCIDRAFT_120630 I 0.461
AAEL004381 Aedes aegypti AAEL004381 I 0.459
ENSAMXG00000014362 Astyanax mexicanus ENSAMXG00000014362 I 0.459
cica Danio rerio ENSDARG00000071150 I 0.459
tetur21g00740 Tetranychus urticae tetur21g00740 I 0.459
YQE_03282 Dendroctonus ponderosae YQE_03282 I 0.459
TVAG_344020 Trichomonas vaginalis TVAG_344020 I 0.459
ENSONIG00000004979 Oreochromis niloticus ENSONIG00000004979 I 0.453
Sjc_0093980 Schistosoma japonicum Sjc_0093980 I 0.450
B_00914 Schistosoma haematobium B_00914 I 0.450
SCUD_0001673101 Schistosoma curassoni SCUD_0001673101 I 0.450
Smp_142600 Schistosoma mansoni Smp_142600 I 0.443
ECPE_0001539401 Echinostoma caproni ECPE_0001539401 I 0.443
CBG00068 Caenorhabditis briggsae CBG00068 I 0.440
ENSCING00000007655 Ciona intestinalis ENSCING00000007655 I 0.439
PHUM230960 Pediculus humanus PHUM230960 I 0.439
AMIN000258 Anopheles minimus AMIN000258 I 0.436
L596_g5739 Steinernema carpocapsae L596_g5739 I 0.435
L889_g11174 Steinernema feltiae L889_g11174 I 0.435
L893_g26751 Steinernema glaseri L893_g26751 I 0.435
L898_g8837 Steinernema monticolum L898_g8837 I 0.435
GF17645 Drosophila ananassae FBgn0094663 I 0.430
GG23823 Drosophila erecta FBgn0115962 I 0.430
GM23104 Drosophila sechellia FBgn0177972 I 0.430
GD19345 Drosophila simulans FBgn0190847 I 0.430
GK10919 Drosophila willistoni FBgn0212930 I 0.430
GE25659 Drosophila yakuba FBgn0242721 I 0.430
cic Drosophila melanogaster FBgn0262582 D 0.430
LCUP009387 Lucilia cuprina LCUP009387 I 0.430
MDOA004531 Musca domestica MDOA004531 I 0.430
CBN17413 Caenorhabditis brenneri CBN17413 I 0.429
CJA07419 Caenorhabditis japonica CJA07419 I 0.429
GH23608 Drosophila grimshawi FBgn0131065 I 0.429
GJ23448 Drosophila virilis FBgn0210547 I 0.429
gei-3 Caenorhabditis elegans WBGene00001560 D 0.429
ANCCAN_00149 Ancylostoma caninum ANCCAN_00149 I 0.429
ANCCEY_04123 Ancylostoma ceylanicum ANCCEY_04123 I 0.429
ANCDUO_05529 Ancylostoma duodenale ANCDUO_05529 I 0.429
Hba_18941 Heterorhabditis bacteriophora Hba_18941 I 0.429
OESDEN_00065 Oesophagostomum dentatum OESDEN_00065 I 0.429
SVUK_0000932601 Strongylus vulgaris SVUK_0000932601 I 0.429
AFAF016820 Anopheles farauti AFAF016820 I 0.428
AMAM016153 Anopheles maculatus AMAM016153 I 0.428
WUBG_04884 Wuchereria bancrofti WUBG_04884 I 0.427
Bm5934 Brugia malayi Bm5934 I 0.427
LOAG_17202 Loa loa LOAG_17202 I 0.427
M404DRAFT_998162 Pisolithus tinctorius M404DRAFT_998162 I 0.427
PISMIDRAFT_61363 Pisolithus microcarpus PISMIDRAFT_61363 I 0.427
WBGene00241539 Onchocerca volvulus WBGene00241539 I 0.427
ASIM_0000334601 Anisakis simplex ASIM_0000334601 I 0.427
ASU_10300 Ascaris suum ASU_10300 I 0.427
EVEC_0000011601 Enterobius vermicularis EVEC_0000011601 I 0.427
L892_g3879 Steinernema scapterisci L892_g3879 I 0.427
nAv.1.0.1.g00032 Acanthocheilonema viteae nAv.1.0.1.g00032 I 0.427
nDi.2.2.2.g01012 Dirofilaria immitis nDi.2.2.2.g01012 I 0.427
nLs.2.1.2.g07996 Litomosoides sigmodontis nLs.2.1.2.g07996 I 0.427
nOo.2.0.1.g00287 Onchocerca ochengi nOo.2.0.1.g00287 I 0.427
OFLC_0001331401 Onchocerca flexuosa OFLC_0001331401 I 0.427
SMUV_0001072601 Syphacia muris SMUV_0001072601 I 0.427
TCLT_0000608401 Thelazia callipaeda TCLT_0000608401 I 0.427
AFUN003674 Anopheles funestus AFUN003674 I 0.426
POSPLDRAFT_104619 Postia placenta POSPLDRAFT_104619 I 0.421
POSPLDRAFT_98507 Postia placenta POSPLDRAFT_98507 I 0.421
DEHA2E09460g Debaryomyces hansenii DEHA2E09460g I 0.419
GNLVRS01_PISO0K11912g Millerozyma farinosa GNLVRS01_PISO0K11912g I 0.419
GNLVRS01_PISO0L11913g Millerozyma farinosa GNLVRS01_PISO0L11913g I 0.419
TVAG_010230 Trichomonas vaginalis TVAG_010230 I 0.419
SMU15002098 Schmidtea mediterranea SMU15002098 I 0.419
PTRK_0000169700 Parastrongyloides trichosuri PTRK_0000169700 I 0.419
SPAL_0001296500 Strongyloides papillosus SPAL_0001296500 I 0.419
SSTP_0000494800 Strongyloides stercoralis SSTP_0000494800 I 0.419
SVE_0052600 Strongyloides venezuelensis SVE_0052600 I 0.419
CGI_10003963 Crassostrea gigas CGI_10003963 I 0.416
D915_09544 Fasciola hepatica D915_09544 I 0.416