tbx-2 (Caenorhabditis elegans)
T-box

TF Information

Pfam ID Interpro ID Gene ID CIS-BP ID Sequence source Animal TF db
PF00907 (T-box) IPR001699 WBGene00006543 T340933_2.00 Ensembl (2018-Dec-8) Link out
NCBI Gene Info:
Enables DNA-binding transcription repressor activity; core promoter sequence-specific DNA binding activity; and enzyme binding activity. Involved in several processes, including muscle cell fate specification; olfactory behavior; and pharyngeal muscle development. Located in cytoplasm and nucleus. Is expressed in several structures, including amphid neurons; anal region; head; pharynx; and vulva. Human ortholog(s) of this gene implicated in ulnar-mammary syndrome and vertebral anomalies and variable endocrine and T-cell dysfunction. Orthologous to human TBX2 (T-box transcription factor 2) and TBX3 (T-box transcription factor 3). [provided by Alliance of Genome Resources, Apr 2022]

Directly determined binding motifs

Name/Motif ID Species Forward Reverse Type/Study/Study ID SR
Score		 DBD
Identity
No direct experiments

Motifs from related TFs

Name/Motif ID Species Forward Reverse Type/Study/Study ID SR
Score		 DBD
Identity
Tbx2
M00830_2.00 		Mus musculus
NYVDCACBHN
NDVGTGHBRN		 PBM
Weirauch et al.(2013)
pTH3751 		0.790 0.729
Tbx3
M00834_2.00 		Mus musculus
NHNDCACNHN
NDNGTGHNDN		 PBM
Weirauch et al.(2013)
pTH3998 		0.790 0.729
TBX2
M03556_2.00 		Homo sapiens
GGTGTKADDWNTVACACB
VGTGTBANWHHTMACACC		 SELEX
Jolma et al.(2013)
TBX2_1 		0.790 0.729
TBX2
M03557_2.00 		Homo sapiens
NAGGTGTBAWN
NWTVACACCTN		 SELEX
Jolma et al.(2013)
TBX2_2 		0.790 0.729
TBX2
M05799_2.00 		Homo sapiens
NNVRCRCNNN
NNNGYGYBNN		 SELEX
Yin et al.(2017)
TBX2_eDBD_HT-SELEX 		0.790 0.729
TBX3
M05801_2.00 		Homo sapiens
NDSGTGTBRN
NYVACACSHN		 SELEX
Yin et al.(2017)
TBX3_eDBD_HT-SELEX 		0.790 0.729
Tbx2
M08044_2.00 		Mus musculus
GCHYBCTGGGADHTGTAGTYH
DRACTACADHTCCCAGVRDGC		 ChIP-seq
Chen et al.(2011)
SRP001585_Tbx2 		0.790 0.729
TBX3
M09426_2.00 		Homo sapiens
DVDGGTGBNAR
YTNVCACCHBH		 Misc
Kulakovskiy et al.(2013)
TBX3_HUMAN.H11MO.0.C 		0.790 0.729
Tbx3
M09429_2.00 		Mus musculus
RRGGTGBBR
YVVCACCYY		 Misc
Kulakovskiy et al.(2013)
TBX3_MOUSE.H11MO.0.B 		0.790 0.729
TBX2
M11381_2.00 		Homo sapiens Transfac license required
 Transfac license required
 Transfac
Matys et al.(2006)
V$TBX2_Q2 		0.790 0.729
TBX2
M11382_2.00 		Homo sapiens Transfac license required
 Transfac license required
 Transfac
Matys et al.(2006)
V$TBX2_Q5 		0.790 0.729
TBX2
M05800_2.00 		Homo sapiens
NNVRCRCBNN
NNVGYGYBNN		 SELEX
Yin et al.(2017)
TBX2_eDBD_Methyl-HT-SELEX 		0.790 0.729
TBX3
M05802_2.00 		Homo sapiens
DAGGTGTKAN
NTMACACCTH		 SELEX
Yin et al.(2017)
TBX3_eDBD_Methyl-HT-SELEX 		0.790 0.729
TBX2
M02495_2.00 		Gasterosteus aculeatus
NNVDCACNHN
NDNGTGHBNN		 PBM
Weirauch et al.(2014)
pTH9182 		0.761 0.724
TBX2
M02496_2.00 		Takifugu rubripes
DAGGTGTBRN
NYVACACCTH		 PBM
Weirauch et al.(2014)
pTH9289 		0.761 0.718
XP_008203914.1
M01029_2.00 		Nasonia vitripennis
AGGTGTBA
TVACACCT		 PBM
SebePedros et al.(2013)
pTH9336 		0.752 0.696
Doc3
M03990_2.00 		Drosophila melanogaster
NRGGTGTBAD
HTVACACCYN		 SELEX
Nitta et al.(2015)
Doc3_1 		0.740 0.547
Doc3
M03991_2.00 		Drosophila melanogaster
DAGGTGTBAN
NTVACACCTH		 SELEX
Nitta et al.(2015)
Doc3_2 		0.740 0.547
For this family, TFs with SR scores > 0.734 will likely have a similar motif

DNA Binding Domains

Protein ID Domain From To Sequence
F21H11.3 T-box 63 243

Links

Other T-box family TFs
Other Caenorhabditis elegans TFs

185 Related TFs

Name Species Gene ID Motif Evidence SR
Score		 Action
CBG21316 Caenorhabditis briggsae CBG21316 I 0.872
CRE29327 Caenorhabditis remanei CRE29327 I 0.869
CBN26017 Caenorhabditis brenneri CBN26017 I 0.863
CJA11793 Caenorhabditis japonica CJA11793 I 0.859
PTRK_0001005500 Parastrongyloides trichosuri PTRK_0001005500 I 0.833
SSTP_0000270400 Strongyloides stercoralis SSTP_0000270400 I 0.826
SPAL_0001704100 Strongyloides papillosus SPAL_0001704100 I 0.826
SVE_1909900 Strongyloides venezuelensis SVE_1909900 I 0.826
WBGene00245873 Onchocerca volvulus WBGene00245873 I 0.823
Bm3498 Brugia malayi Bm3498 I 0.813
ASU_08095 Ascaris suum ASU_08095 I 0.813
ENSONIG00000011959 Oreochromis niloticus ENSONIG00000011959 I 0.813
ACAC_0001257201 Angiostrongylus cantonensis ACAC_0001257201 I 0.809
DICVIV_03029 Dictyocaulus viviparus DICVIV_03029 I 0.809
ACOC_0000095801 Angiostrongylus costaricensis ACOC_0000095801 I 0.809
HPLM_0000823101 Haemonchus placei HPLM_0000823101 I 0.809
TELCIR_02934 Teladorsagia circumcincta TELCIR_02934 I 0.809
HCOI00950300 Haemonchus contortus HCOI00950300 I 0.809
Hba_14542 Heterorhabditis bacteriophora Hba_14542 I 0.808
ANCCAN_17341 Ancylostoma caninum ANCCAN_17341 I 0.807
ANCCEY_07585 Ancylostoma ceylanicum ANCCEY_07585 I 0.807
ENSLOCG00000007598 Lepisosteus oculatus ENSLOCG00000007598 I 0.801
TTRE_0000604401 Trichuris trichiura TTRE_0000604401 I 0.797
D918_00588 Trichuris suis D918_00588 I 0.797
TMUE_s0121001900 Trichuris muris TMUE_s0121001900 I 0.797
tbx3.S Xenopus laevis XB-GENE-1018237 I 0.792
TBX2 Pan troglodytes ENSPTRG00000009489 I 0.790
TBX3 Pan troglodytes ENSPTRG00000023749 I 0.790
TBX3 Ochotona princeps ENSOPRG00000004462 I 0.790
ENSPSIG00000017536 Pelodiscus sinensis ENSPSIG00000017536 I 0.790
ENSPANG00000008730 Papio anubis ENSPANG00000008730 I 0.790
TBX2 Ochotona princeps ENSOPRG00000012183 I 0.790
ENSPPYG00000004995 Pongo abelii ENSPPYG00000004995 I 0.790
TBX3 Ornithorhynchus anatinus ENSOANG00000007095 I 0.790
Tbx3 Mus musculus ENSMUSG00000018604 D 0.790
Tbx2 Mus musculus ENSMUSG00000000093 D 0.790
ENSMPUG00000015118 Mustela putorius furo ENSMPUG00000015118 I 0.790
ENSSHAG00000004253 Sarcophilus harrisii ENSSHAG00000004253 I 0.790
ENSNLEG00000000224 Nomascus leucogenys ENSNLEG00000000224 I 0.790
ENSNLEG00000000423 Nomascus leucogenys ENSNLEG00000000423 I 0.790
TBX2 Otolemur garnettii ENSOGAG00000014815 I 0.790
TBX3 Oryctolagus cuniculus ENSOCUG00000014595 I 0.790
ENSOARG00000006249 Ovis aries ENSOARG00000006249 I 0.790
TBX3 Otolemur garnettii ENSOGAG00000016212 I 0.790
Cmyd_10018098 Chelonia mydas Cmyd_10018098 I 0.790
Myotis_brandtii_Tbx3_10028216 Myotis brandtii Myotis_brandtii_Tbx3_10028216 I 0.790
ENSP00000257566 Macaca fascicularis ENSP00000257566 I 0.790
ENSBTAP00000028930-D1 Bos grunniens ENSBTAP00000028930-D1 I 0.790
ENSMPUG00000002720 Mustela putorius furo ENSMPUG00000002720 I 0.790
Ogr02099 Ophisaurus gracilis Ogr02099 I 0.790
Ogr11256 Ophisaurus gracilis Ogr11256 I 0.790
tbx2.L Xenopus laevis XB-GENE-1018122 I 0.790
tbx2 Xenopus tropicalis XB-GENE-1018115 I 0.790
Pvit_16429 Pogona vitticeps Pvit_16429 I 0.790
Alligator_sinensis_CCG008095.1 Alligator sinensis Alligator_sinensis_CCG008095.1 I 0.790
Alligator_sinensis_CCG002051.1 Alligator sinensis Alligator_sinensis_CCG002051.1 I 0.790
ENSSTOG00000009350 Ictidomys tridecemlineatus ENSSTOG00000009350 I 0.790
TBX2 Sus scrofa ENSSSCG00000027060 I 0.790
TBX3 Sus scrofa ENSSSCG00000009865 I 0.790
ENSSTOG00000009817 Ictidomys tridecemlineatus ENSSTOG00000009817 I 0.790
TBX3 Tupaia belangeri ENSTBEG00000014612 I 0.790
Afo_R010397 Aptenodytes forsteri Afo_R010397 I 0.790
TBX2 Tursiops truncatus ENSTTRG00000004541 I 0.790
ENSTSYG00000008994 Tarsius syrichta ENSTSYG00000008994 I 0.790
ENSSHAG00000012290 Sarcophilus harrisii ENSSHAG00000012290 I 0.790
Tbx3 Rattus norvegicus ENSRNOG00000008706 I 0.790
ENSCSAG00000002344 Chlorocebus sabaeus ENSCSAG00000002344 I 0.790
TBX3 Cavia porcellus ENSCPOG00000003952 I 0.790
ENSAMEG00000001090 Ailuropoda melanoleuca ENSAMEG00000001090 I 0.790
ENSLACG00000006293 Latimeria chalumnae ENSLACG00000006293 I 0.790
TBX2 Monodelphis domestica ENSMODG00000014204 I 0.790
TBX3 Loxodonta africana ENSLAFG00000002948 I 0.790
TBX2 Bos taurus ENSBTAG00000014278 I 0.790
TBX3 Gorilla gorilla ENSGGOG00000004238 I 0.790
ENSGALG00000023577 Gallus gallus ENSGALG00000023577 I 0.790
ENSCPOG00000001042 Cavia porcellus ENSCPOG00000001042 I 0.790
TBX2 Homo sapiens ENSG00000121068 D 0.790
TBX3 Callithrix jacchus ENSCJAG00000009716 I 0.790
TBX3 Bos taurus ENSBTAG00000021706 I 0.790
ENSAMXG00000007070 Astyanax mexicanus ENSAMXG00000007070 I 0.790
ENSGALG00000008250 Gallus gallus ENSGALG00000008250 I 0.790
ENSAMEG00000008826 Ailuropoda melanoleuca ENSAMEG00000008826 I 0.790
TBX3 Homo sapiens ENSG00000135111 D 0.790
ENSFALG00000007792 Ficedula albicollis ENSFALG00000007792 I 0.790
TBX3 Microcebus murinus ENSMICG00000010947 I 0.790
ENSMGAG00000010084 Meleagris gallopavo ENSMGAG00000010084 I 0.790
ENSECAG00000012861 Equus caballus ENSECAG00000012861 I 0.790
TBX2 Microcebus murinus ENSMICG00000016649 I 0.790
TBX3 Myotis lucifugus ENSMLUG00000007567 I 0.790
ENSMMUG00000009859 Macaca mulatta ENSMMUG00000009859 I 0.790
TBX2 Myotis lucifugus ENSMLUG00000011673 I 0.790
tbx2a Danio rerio ENSDARG00000018025 I 0.790
TBX3 Canis familiaris ENSCAFG00000009216 I 0.790
TBX2 Loxodonta africana ENSLAFG00000006596 I 0.790
TBX3 Dasypus novemcinctus ENSDNOG00000044358 I 0.790
ENSFALG00000005458 Ficedula albicollis ENSFALG00000005458 I 0.790
ENSLOCG00000005074 Lepisosteus oculatus ENSLOCG00000005074 I 0.790
ENSMEUG00000010232 Macropus eugenii ENSMEUG00000010232 I 0.790
TBX3 Macaca mulatta ENSMMUG00000015070 I 0.790
TBX3 Erinaceus europaeus ENSEEUG00000008506 I 0.790
ENSGMOG00000012645 Gadus morhua ENSGMOG00000012645 I 0.789
Gfo_R010838 Geospiza fortis Gfo_R010838 I 0.787
AAI57537 Xenopus tropicalis AAI57537 I 0.784
tbx2.S Xenopus laevis XB-GENE-6255176 I 0.784
tbx2b Danio rerio ENSDARG00000006120 I 0.783
ENSAMXG00000001528 Astyanax mexicanus ENSAMXG00000001528 I 0.783
TBX4 Meleagris gallopavo ENSMGAG00000007617 I 0.783
tbx3 Xenopus tropicalis XB-GENE-1018231 I 0.781
tbx3.L Xenopus laevis XB-GENE-6252891 I 0.781
Pvit_13524 Pogona vitticeps Pvit_13524 I 0.781
ENSLACG00000015364 Latimeria chalumnae ENSLACG00000015364 I 0.781
NECAME_13239 Necator americanus NECAME_13239 I 0.780
HelroG63904 Helobdella robusta HelroG63904 I 0.780
RSKR_0000042800 Rhabditophanes kr3021 RSKR_0000042800 I 0.780
D917_09589 Trichinella nativa D917_09589 I 0.779
EFV62265 Trichinella spiralis EFV62265 I 0.779
TBX2 Equus caballus ENSECAG00000024480 I 0.778
fgenesh2_pg.scaffold_89000016 Branchiostoma floridae fgenesh2_pg.scaffold_89000016 I 0.777
TBX3 Monodelphis domestica ENSMODG00000012059 I 0.777
TBX2 Taeniopygia guttata ENSTGUG00000007813 I 0.776
RSKR_0001075800 Rhabditophanes kr3021 RSKR_0001075800 I 0.774
tbx3b Danio rerio ENSDARG00000061509 I 0.772
tbx3a Oryzias latipes ENSORLG00000007316 I 0.769
tbx3a Danio rerio ENSDARG00000002216 I 0.769
ENSPFOG00000024759 Poecilia formosa ENSPFOG00000024759 I 0.769
tbx3a Takifugu rubripes ENSTRUG00000015097 I 0.769
ENSGMOG00000011728 Gadus morhua ENSGMOG00000011728 I 0.769
ENSAMXG00000009197 Astyanax mexicanus ENSAMXG00000009197 I 0.769
ENSONIG00000000187 Oreochromis niloticus ENSONIG00000000187 I 0.769
ENSXMAG00000005372 Xiphophorus maculatus ENSXMAG00000005372 I 0.769
tbx3a Gasterosteus aculeatus ENSGACG00000016783 I 0.769
tbx3a Tetraodon nigroviridis ENSTNIG00000009035 I 0.769
tbx2b Oryzias latipes ENSORLG00000010011 I 0.766
ENSCING00000008678 Ciona intestinalis ENSCING00000008678 I 0.766
ENSCSAVG00000009650 Ciona savignyi ENSCSAVG00000009650 I 0.766
TBX2 Gasterosteus aculeatus ENSGACG00000013575 D 0.761
ENSXMAG00000005715 Xiphophorus maculatus ENSXMAG00000005715 I 0.761
ENSGMOG00000002896 Gadus morhua ENSGMOG00000002896 I 0.761
ENSONIG00000010454 Oreochromis niloticus ENSONIG00000010454 I 0.761
ENSPFOG00000016384 Poecilia formosa ENSPFOG00000016384 I 0.761
TBX2 Oryzias latipes ENSORLG00000014792 I 0.761
TBX2 Takifugu rubripes ENSTRUG00000008297 D 0.761
CGI_10016325 Crassostrea gigas CGI_10016325 I 0.757
CapteG163410 Capitella teleta CapteG163410 I 0.756
L893_g17881 Steinernema glaseri L893_g17881 I 0.756
L889_g18009 Steinernema feltiae L889_g18009 I 0.756
L898_g10464 Steinernema monticolum L898_g10464 I 0.754
ACYPI000143 Acyrthosiphon pisum ACYPI000143 I 0.754
tetur33g01070 Tetranychus urticae tetur33g01070 I 0.754
GB49684 Apis mellifera GB49684 I 0.752
AAEL018223 Aedes aegypti AAEL018223 I 0.752
XP_008203914.1 Nasonia vitripennis XP_008203914.1 D 0.752
SMU15026199 Schmidtea mediterranea SMU15026199 I 0.751
LotgiG116991 Lottia gigantea LotgiG116991 I 0.750
tbx2b Tetraodon nigroviridis ENSTNIG00000010765 I 0.748
L892_g3119 Steinernema scapterisci L892_g3119 I 0.747
L596_g26549 Steinernema carpocapsae L596_g26549 I 0.747
TBX2 Tetraodon nigroviridis ENSTNIG00000014395 I 0.747
ENSAPLG00000010653 Anas platyrhynchos ENSAPLG00000010653 I 0.744
NEMVEDRAFT_v1g102530 Nematostella vectensis NEMVEDRAFT_v1g102530 I 0.744
HNAJ_0001193901 Hymenolepis nana HNAJ_0001193901 I 0.743
GL14298 Drosophila persimilis FBgn0151903 I 0.743
bi Drosophila virilis FBgn0020983 I 0.743
bi Drosophila melanogaster FBgn0000179 I 0.743
DAPPUDRAFT_13272 Daphnia pulex DAPPUDRAFT_13272 I 0.743
GM12345 Drosophila sechellia FBgn0167282 I 0.743
GE16345 Drosophila yakuba FBgn0233875 I 0.743
GK15734 Drosophila willistoni FBgn0217737 I 0.743
GA22741 Drosophila pseudoobscura FBgn0244144 I 0.743
tbx2b Gasterosteus aculeatus ENSGACG00000020309 I 0.741
GE20799 Drosophila yakuba FBgn0238093 I 0.740
GG14368 Drosophila erecta FBgn0106627 I 0.740
GF24374 Drosophila ananassae FBgn0101368 I 0.740
GA18655 Drosophila pseudoobscura FBgn0078655 I 0.740
Doc3 Drosophila melanogaster FBgn0035954 D 0.740
GM25112 Drosophila sechellia FBgn0179973 I 0.740
GL15033 Drosophila persimilis FBgn0152637 I 0.740
SPU_023386 Strongylocentrotus purpuratus SPU_023386 I 0.740
GK12352 Drosophila willistoni FBgn0214362 I 0.740
GD14148 Drosophila simulans FBgn0185836 I 0.740
ENSXMAG00000000486 Xiphophorus maculatus ENSXMAG00000000486 I 0.738
CGI_10016324 Crassostrea gigas CGI_10016324 I 0.736
Cmyd_10016207 Chelonia mydas Cmyd_10016207 I 0.736
ENSONIG00000001919 Oreochromis niloticus ENSONIG00000001919 I 0.736
HelroG71638 Helobdella robusta HelroG71638 I 0.734