XBP1 (Homo sapiens)
bZIP

TF Information

Pfam ID Interpro ID Gene ID CIS-BP ID Sequence source Animal TF db
PF00170 (bZIP_1) IPR011616 ENSG00000100219 T059725_2.00 Ensembl (2018-Dec-8) Link out
NCBI Gene Info:
This gene encodes a transcription factor that regulates MHC class II genes by binding to a promoter element referred to as an X box. This gene product is a bZIP protein, which was also identified as a cellular transcription factor that binds to an enhancer in the promoter of the T cell leukemia virus type 1 promoter. It may increase expression of viral proteins by acting as the DNA binding partner of a viral transactivator. It has been found that upon accumulation of unfolded proteins in the endoplasmic reticulum (ER), the mRNA of this gene is processed to an active form by an unconventional splicing mechanism that is mediated by the endonuclease inositol-requiring enzyme 1 (IRE1). The resulting loss of 26 nt from the spliced mRNA causes a frame-shift and an isoform XBP1(S), which is the functionally active transcription factor. The isoform encoded by the unspliced mRNA, XBP1(U), is constitutively expressed, and thought to function as a negative feedback regulator of XBP1(S), which shuts off transcription of target genes during the recovery phase of ER stress. A pseudogene of XBP1 has been identified and localized to chromosome 5. [provided by RefSeq, Jul 2008]

Directly determined binding motifs

Name/Motif ID Species Forward Reverse Type/Study/Study ID SR
Score
DBD
Identity
XBP1
M02730_2.00
Homo sapiens
GACGTGKCNNW

WNNGMCACGTC
SELEX
Jolma et al.(2010)
XBP1_monomer
(Direct) (Direct)
XBP1
M02825_2.00
Homo sapiens
GVTGACGTCABB

VVTGACGTCABC
SELEX
Jolma et al.(2013)
XBP1_1
(Direct) (Direct)
XBP1
M02826_2.00
Homo sapiens
GVTGACGTGKCVHW

WDBGMCACGTCABC
SELEX
Jolma et al.(2013)
XBP1_2
(Direct) (Direct)
XBP1
M04010_2.00
Homo sapiens
GRTGACGTGKCV

BGMCACGTCAYC
SELEX
Rodriguez-Martinez et al.(2017)
XBP1.1
(Direct) (Direct)
XBP1
M04011_2.00
Homo sapiens
GRTGACGTCAYS

SRTGACGTCAYC
SELEX
Rodriguez-Martinez et al.(2017)
XBP1.2
(Direct) (Direct)
XBP1
M04012_2.00
Homo sapiens
KGMCACGTGKMCH

DGKMCACGTGKCM
SELEX
Rodriguez-Martinez et al.(2017)
XBP1.3
(Direct) (Direct)
XBP1
M04231_2.00
Homo sapiens
NVTGACGTGKNN

NNMCACGTCABN
SELEX
Yin et al.(2017)
XBP1_FL_HT-SELEX_1
(Direct) (Direct)
XBP1
M04232_2.00
Homo sapiens
NVTKACGTMABV

BVTKACGTMABN
SELEX
Yin et al.(2017)
XBP1_FL_HT-SELEX_2
(Direct) (Direct)
XBP1
M04233_2.00
Homo sapiens
BKMCACRTCAYS

SRTGAYGTGKMV
SELEX
Yin et al.(2017)
XBP1_FL_Methyl-HT-SELEX_1
(Direct) (Direct)
XBP1
M04234_2.00
Homo sapiens
VVTGWCRTCAYS

SRTGAYGWCABB
SELEX
Yin et al.(2017)
XBP1_FL_Methyl-HT-SELEX_2
(Direct) (Direct)
XBP1
M09932_2.00
Homo sapiens
NHNWDHRVTGACGTGKHNHWDDHB

VDHHWDNDMCACGTCABYDHWNDN
Transfac
Matys et al.(2006)
V$HTF_01
(Direct) (Direct)
XBP1
M09933_2.00
Homo sapiens
DBRHTKACGTGKHNHWD

HWDNDMCACGTMADYVH
Transfac
Matys et al.(2006)
V$XBP1_01
(Direct) (Direct)

Motifs from related TFs

Name/Motif ID Species Forward Reverse Type/Study/Study ID SR
Score
DBD
Identity
Xbp1
M00757_2.00
Mus musculus
NNHBAYDNNN

NNNHRTVDNN
PBM
Weirauch et al.(2013)
pTH2852
0.831 0.857
Xbp1
M01802_2.00
Mus musculus
NHNACGYNN

NNRCGTNDN
PBM
Weirauch et al.(2014)
pTH5019
0.831 0.857
Xbp1
M08818_2.00
Mus musculus
GACGTGKCMHWD

HWDKGMCACGTC
Misc
Kulakovskiy et al.(2013)
XBP1_MOUSE.H11MO.0.C
0.831 0.857
For this family, TFs with SR scores > 0.782 will likely have a similar motif

DNA Binding Domains

Protein ID Domain From To Sequence
ENSP00000216037 bZIP 68 131
ENSP00000343155 bZIP 68 131
ENSP00000384295 bZIP 19 81
ENSP00000385162 bZIP 68 142
ENSP00000481170 bZIP 68 131

Links

Other bZIP family TFs
Other Homo sapiens TFs

59 Related TFs

Name Species Gene ID Motif Evidence SR
Score
Action
Xbp1 Mus musculus ENSMUSG00000020484 D 0.872
ENSNLEG00000002404 Nomascus leucogenys ENSNLEG00000002404 I 0.872
ENSMPUG00000013524 Mustela putorius furo ENSMPUG00000013524 I 0.872
XBP1 Macaca mulatta ENSMMUG00000007215 I 0.872
XBP1 Microcebus murinus ENSMICG00000004235 I 0.872
ENSMLUG00000001735 Myotis lucifugus ENSMLUG00000001735 I 0.872
ENSOPRG00000013983 Ochotona princeps ENSOPRG00000013983 I 0.872
ENSPANG00000000372 Papio anubis ENSPANG00000000372 I 0.872
Xbp1 Rattus norvegicus ENSRNOG00000010298 I 0.872
XBP1 Sorex araneus ENSSARG00000002418 I 0.872
ENSPVAG00000004528 Pteropus vampyrus ENSPVAG00000004528 I 0.872
XBP1 Pan troglodytes ENSPTRG00000014210 I 0.872
ENSPPYG00000011678 Pongo abelii ENSPPYG00000011678 I 0.872
XBP1 Gorilla gorilla ENSGGOG00000007154 I 0.872
ENSOARG00000002962 Ovis aries ENSOARG00000002962 I 0.872
ENSCAFG00000011954 Canis familiaris ENSCAFG00000011954 I 0.872
XBP1 Equus caballus ENSECAG00000014780 I 0.872
XBP1 Cavia porcellus ENSCPOG00000007796 I 0.872
ENSCSAG00000009947 Chlorocebus sabaeus ENSCSAG00000009947 I 0.872
XBP1 Bos taurus ENSBTAG00000005970 I 0.872
XBP1 Loxodonta africana ENSLAFG00000029029 I 0.868
ENSTSYG00000000515 Tarsius syrichta ENSTSYG00000000515 I 0.864
ENSLOCG00000003156 Lepisosteus oculatus ENSLOCG00000003156 I 0.863
ENSSHAG00000010795 Sarcophilus harrisii ENSSHAG00000010795 I 0.862
ENSGMOG00000000538 Gadus morhua ENSGMOG00000000538 I 0.861
xbp1.L Xenopus laevis XB-GENE-487128 I 0.857
xbp1 Xenopus tropicalis XB-GENE-487124 I 0.857
XBP1 Taeniopygia guttata ENSTGUG00000007938 I 0.853
Aan_R010399 Calypte anna Aan_R010399 I 0.853
ENSFALG00000008312 Ficedula albicollis ENSFALG00000008312 I 0.853
ENSXMAG00000002665 Xiphophorus maculatus ENSXMAG00000002665 I 0.849
xbp1 Takifugu rubripes ENSTRUG00000016185 I 0.849
XBP1 Tetraodon nigroviridis ENSTNIG00000015621 I 0.849
ENSPFOG00000014555 Poecilia formosa ENSPFOG00000014555 I 0.849
ENSONIG00000010547 Oreochromis niloticus ENSONIG00000010547 I 0.849
ENSMODG00000023331 Monodelphis domestica ENSMODG00000023331 I 0.848
ENSAMXG00000004136 Astyanax mexicanus ENSAMXG00000004136 I 0.848
xbp1 Gasterosteus aculeatus ENSGACG00000014266 I 0.848
xbp1 Danio rerio ENSDARG00000035622 I 0.847
AAI60967 Xenopus tropicalis AAI60967 I 0.847
ENSCHOG00000011608 Choloepus hoffmanni ENSCHOG00000011608 I 0.844
ENSPANG00000007517 Papio anubis ENSPANG00000007517 N 0.834
XBP1 Gallus gallus ENSGALG00000005796 I 0.832
ENSFCAG00000028366 Felis catus ENSFCAG00000028366 I 0.830
ENSP00000343155-D2 Bos grunniens ENSP00000343155-D2 I 0.830
Myotis_brandtii_XBP1_10027497 Myotis brandtii Myotis_brandtii_XBP1_10027497 I 0.830
ENSMMUP00000009460 Macaca fascicularis ENSMMUP00000009460 I 0.830
XBP1 Ornithorhynchus anatinus ENSOANG00000008817 I 0.830
ENSDNOG00000034497 Dasypus novemcinctus ENSDNOG00000034497 I 0.830
ENSAMEG00000008458 Ailuropoda melanoleuca ENSAMEG00000008458 I 0.830
ENSOCUG00000006928 Oryctolagus cuniculus ENSOCUG00000006928 I 0.830
ENSSTOG00000004168 Ictidomys tridecemlineatus ENSSTOG00000004168 I 0.830
NEMVEDRAFT_v1g211292 Nematostella vectensis NEMVEDRAFT_v1g211292 I 0.827
XBP1 Callithrix jacchus ENSCJAG00000020084 I 0.826
ENSTBEG00000000324 Tupaia belangeri ENSTBEG00000000324 I 0.815
Pvit_02423 Pogona vitticeps Pvit_02423 I 0.811
XBP1 Procavia capensis ENSPCAG00000004565 N 0.796
ENSMGAG00000007147 Meleagris gallopavo ENSMGAG00000007147 I 0.789