CUX2 (Homo sapiens)
CUT,Homeodomain

TF Information

Pfam ID Interpro ID Gene ID CIS-BP ID Sequence source Animal TF db
PF02376 (CUT)
PF00046 (Homeobox)
IPR003350
IPR001356
ENSG00000111249 T167057_2.00 Ensembl (2018-Dec-8) Link out
NCBI Gene Info:
This gene encodes a protein which contains three CUT domains and a homeodomain; both domains are DNA-binding motifs. A similar gene, whose gene product possesses different DNA-binding activities, is located on chromosome on chromosome 7. Two pseudogenes of this gene have been identified on chromosomes 10 and 4. [provided by RefSeq, Jan 2013]

Directly determined binding motifs

Name/Motif ID Species Forward Reverse Type/Study/Study ID SR
Score
DBD
Identity
CUX2
M01499_2.00
Homo sapiens
NKATYRVNN

NNBYRATMN
PBM
Yin et al.(2017b)
CUX2_5mCG
(Direct) (Direct)
CUX2
M01500_2.00
Homo sapiens
NDATYRRHN

NDYYRATHN
PBM
Yin et al.(2017b)
CUX2_Cytosine
(Direct) (Direct)
CUX2
M02940_2.00
Homo sapiens
ATCRATAHNNDWATCGAT

ATCGATWHNNDTATYGAT
SELEX
Jolma et al.(2013)
CUX2_1
(Direct) (Direct)
CUX2
M02941_2.00
Homo sapiens
DDATYGATYA

TRATCRATHH
SELEX
Jolma et al.(2013)
CUX2_2
(Direct) (Direct)
CUX2
M04665_2.00
Homo sapiens
NTRATCGATYRN

NYRATCGATYAN
SELEX
Yin et al.(2017)
CUX2_eDBD_HT-SELEX
(Direct) (Direct)
CUX2
M04666_2.00
Homo sapiens
BYRATCGATYRB

VYRATCGATYRV
SELEX
Yin et al.(2017)
CUX2_eDBD_Methyl-HT-SELEX
(Direct) (Direct)

Motifs from related TFs

Name/Motif ID Species Forward Reverse Type/Study/Study ID SR
Score
DBD
Identity
Cux2
M09025_2.00
Mus musculus
NBBATTGATYD

HRATCAATVVN
Misc
Kulakovskiy et al.(2013)
CUX2_MOUSE.H11MO.0.C
0.986 0.986
CUX1
M02946_2.00
Homo sapiens
ATCRATHNNNDATCRAT

ATYGATHNNNDATYGAT
SELEX
Jolma et al.(2013)
CUX1_1
0.888 0.888
CUX1
M02947_2.00
Homo sapiens
ATCRATHNNNNDATCRAT

ATYGATHNNNNDATYGAT
SELEX
Jolma et al.(2013)
CUX1_2
0.888 0.888
CUX1
M02948_2.00
Homo sapiens
TDATCRATNN

NNATYGATHA
SELEX
Jolma et al.(2013)
CUX1_3
0.888 0.888
CUX1
M04679_2.00
Homo sapiens
NDATCRATNN

NNATYGATHN
SELEX
Yin et al.(2017)
CUX1_eDBD_HT-SELEX
0.888 0.888
CUX1
M09023_2.00
Homo sapiens
RBRVNDATYGRTBN

NVAYCRATHNBYVY
Misc
Kulakovskiy et al.(2013)
CUX1_HUMAN.H11MO.0.C
0.888 0.888
Cux1
M09024_2.00
Mus musculus
RBRVNDATYGRTBN

NVAYCRATHNBYVY
Misc
Kulakovskiy et al.(2013)
CUX1_MOUSE.H11MO.0.C
0.888 0.888
CUX1
M10422_2.00
Homo sapiens
CCAATAATCRAT

ATYGATTATTGG
Transfac
Matys et al.(2006)
V$CDP_01
0.888 0.888
CUX1
M10423_2.00
Homo sapiens
DWDATCGATYADHDH

DHDHTRATCGATHWH
Transfac
Matys et al.(2006)
V$CDP_02
0.888 0.888
CUX1
M10424_2.00
Homo sapiens
SCVATCRATN

NATYGATBGS
Transfac
Matys et al.(2006)
V$CDPCR1_01
0.888 0.888
CUX1
M10425_2.00
Homo sapiens
CVATABNTATYKGTG

CACMRATANVTATBG
Transfac
Matys et al.(2006)
V$CDPCR3_01
0.888 0.888
CUX1
M10426_2.00
Homo sapiens
SVSATCRATB

VATYGATSBS
Transfac
Matys et al.(2006)
V$CDPCR3HD_01
0.888 0.888
CUX1
M10427_2.00
Homo sapiens Transfac license required
Transfac license required
Transfac
Matys et al.(2006)
V$CDP_Q6_01
0.888 0.888
CUX1
M10416_2.00
Canis familiaris
DHDATYGATYADYDW

WHRHTRATCRATHDH
Transfac
Matys et al.(2006)
V$CLOX_01
0.888 0.888
CUX1
M04680_2.00
Homo sapiens
NBATTGATHR

YDATCAATVN
SELEX
Yin et al.(2017)
CUX1_eDBD_Methyl-HT-SELEX
0.888 0.888
For this family, TFs with SR scores > 0.700 will likely have a similar motif

Experimental Constructs

Motif ID Domain From To Sequence
M01499_2.00 CUT 25 103
M01499_2.00 CUT 368 443
M01499_2.00 CUT 519 596
M01499_2.00 Homeodomain 645 701
M01500_2.00 CUT 25 103
M01500_2.00 CUT 368 443
M01500_2.00 CUT 519 596
M01500_2.00 Homeodomain 645 701

DNA Binding Domains

Protein ID Domain From To Sequence
ENSP00000261726 CUT 549 627
ENSP00000261726 CUT 892 967
ENSP00000261726 CUT 1043 1120
ENSP00000261726 Homeodomain 1169 1225

Links

Other CUT,Homeodomain family TFs
Other Homo sapiens TFs

111 Related TFs

Name Species Gene ID Motif Evidence SR
Score
Action
Aan_R003487 Calypte anna Aan_R003487 I 0.885
Aan_R010335 Calypte anna Aan_R010335 I 0.965
Afo_R009437 Aptenodytes forsteri Afo_R009437 I 0.885
Alligator_sinensis_CCG004936.1 Alligator sinensis Alligator_sinensis_CCG004936.1 I 0.885
Alligator_sinensis_CCG016555.1 Alligator sinensis Alligator_sinensis_CCG016555.1 I 0.976
Cmyd_10006308 Chelonia mydas Cmyd_10006308 I 0.882
Cmyd_10015658 Chelonia mydas Cmyd_10015658 I 0.979
CUX1 Pteropus vampyrus ENSPVAG00000017756 I 0.718
CUX1 Monodelphis domestica ENSMODG00000013581 I 0.888
CUX1 Felis catus ENSFCAG00000008074 I 0.875
CUX1 Homo sapiens ENSG00000257923 D 0.885
CUX1 Ochotona princeps ENSOPRG00000000165 I 0.868
CUX1 Microcebus murinus ENSMICG00000010274 I 0.885
CUX1 Loxodonta africana ENSLAFG00000002555 I 0.875
Cux1 Mus musculus ENSMUSG00000029705 D 0.885
CUX1 Macaca mulatta ENSMMUG00000021461 I 0.885
CUX1 Meleagris gallopavo ENSMGAG00000003398 I 0.864
CUX1 Myotis lucifugus ENSMLUG00000007264 I 0.885
Cux1 Rattus norvegicus ENSRNOG00000001424 I 0.885
CUX1 Erinaceus europaeus ENSEEUG00000005128 I 0.892
CUX1 Tursiops truncatus ENSTTRG00000014625 I 0.871
CUX1 Canis familiaris ENSCAFG00000013749 D 0.885
CUX1 Callithrix jacchus ENSCJAG00000016076 I 0.888
CUX1 Bos taurus ENSBTAG00000010659 I 0.885
CUX1 Takifugu rubripes ENSTRUG00000008546 I 0.741
CUX1 Anolis carolinensis ENSACAG00000015088 I 0.881
CUX1 Pan troglodytes ENSPTRG00000019531 I 0.885
CUX1 Taeniopygia guttata ENSTGUG00000004386 I 0.885
cux1a Danio rerio ENSDARG00000078459 I 0.868
cux2 Xenopus tropicalis XB-GENE-487236 I 0.944
CUX2 Monodelphis domestica ENSMODG00000012254 I 0.979
Cux2 Mus musculus ENSMUSG00000042589 D 0.986
CUX2 Ornithorhynchus anatinus ENSOANG00000004793 I 0.969
CUX2 Sus scrofa ENSSSCG00000009831 I 1.000
CUX2 Otolemur garnettii ENSOGAG00000029919 I 1.000
CUX2 Tursiops truncatus ENSTTRG00000000945 I 0.997
CUX2 Ochotona princeps ENSOPRG00000006461 I 0.993
CUX2 Pan troglodytes ENSPTRG00000005455 I 0.857
Cux2 Rattus norvegicus ENSRNOG00000001259 I 0.972
CUX2 Pteropus vampyrus ENSPVAG00000013176 I 0.997
CUX2 Taeniopygia guttata ENSTGUG00000006470 I 0.954
CUX2 Oryctolagus cuniculus ENSOCUG00000021923 I 0.990
CUX2 Myotis lucifugus ENSMLUG00000003239 I 0.997
CUX2 Meleagris gallopavo ENSMGAG00000005225 I 0.976
CUX2 Bos taurus ENSBTAG00000008571 I 1.000
CUX2 Canis familiaris ENSCAFG00000008575 I 0.993
CUX2 Callithrix jacchus ENSCJAG00000011694 I 1.000
CUX2 Gallus gallus ENSGALG00000004598 I 0.976
CUX2 Anolis carolinensis ENSACAG00000002281 I 0.958
CUX2 Felis catus ENSFCAG00000003176 I 0.993
CUX2 Cavia porcellus ENSCPOG00000020483 I 0.997
CUX2 Dasypus novemcinctus ENSDNOG00000039959 I 0.983
CUX2 Gorilla gorilla ENSGGOG00000012173 I 0.728
CUX2 Loxodonta africana ENSLAFG00000001145 I 0.997
cux2b Tetraodon nigroviridis ENSTNIG00000011453 I 0.920
cux2b Gasterosteus aculeatus ENSGACG00000013522 I 0.917
cux2b Takifugu rubripes ENSTRUG00000015853 I 0.923
cux2b Danio rerio ENSDARG00000086345 I 0.937
cux2b Oryzias latipes ENSORLG00000015973 I 0.927
ENSAMEG00000013799 Ailuropoda melanoleuca ENSAMEG00000013799 I 0.990
ENSAMEG00000015392 Ailuropoda melanoleuca ENSAMEG00000015392 I 0.875
ENSAMXG00000006105 Astyanax mexicanus ENSAMXG00000006105 I 0.927
ENSAMXG00000008817 Astyanax mexicanus ENSAMXG00000008817 I 0.843
ENSAPLG00000002588 Anas platyrhynchos ENSAPLG00000002588 I 0.885
ENSAPLG00000004382 Anas platyrhynchos ENSAPLG00000004382 I 0.941
ENSCSAG00000018062 Chlorocebus sabaeus ENSCSAG00000018062 I 0.885
ENSFALG00000009019 Ficedula albicollis ENSFALG00000009019 I 0.976
ENSFALG00000009409 Ficedula albicollis ENSFALG00000009409 I 0.885
ENSGALG00000001807 Gallus gallus ENSGALG00000001807 I 0.885
ENSGMOG00000008990 Gadus morhua ENSGMOG00000008990 I 0.714
ENSGMOG00000017485 Gadus morhua ENSGMOG00000017485 I 0.930
ENSLACG00000014413 Latimeria chalumnae ENSLACG00000014413 I 0.944
ENSLACG00000017710 Latimeria chalumnae ENSLACG00000017710 I 0.885
ENSLOCG00000001531 Lepisosteus oculatus ENSLOCG00000001531 I 0.878
ENSLOCG00000007417 Lepisosteus oculatus ENSLOCG00000007417 I 0.951
ENSMEUG00000004239 Macropus eugenii ENSMEUG00000004239 I 0.779
ENSMEUG00000013552 Macropus eugenii ENSMEUG00000013552 I 0.721
ENSMPUG00000002207 Mustela putorius furo ENSMPUG00000002207 I 0.986
ENSNLEG00000000470 Nomascus leucogenys ENSNLEG00000000470 I 1.000
ENSNLEG00000008310 Nomascus leucogenys ENSNLEG00000008310 I 0.885
ENSOARG00000014629 Ovis aries ENSOARG00000014629 I 0.875
ENSOARG00000017879 Ovis aries ENSOARG00000017879 I 0.997
ENSOGAG00000009038 Otolemur garnettii ENSOGAG00000009038 I 0.892
ENSONIG00000003797 Oreochromis niloticus ENSONIG00000003797 I 0.700
ENSONIG00000015972 Oreochromis niloticus ENSONIG00000015972 I 0.930
ENSP00000261726 Macaca fascicularis ENSP00000261726 I 1.000
ENSP00000261726-D1 Bos grunniens ENSP00000261726-D1 I 1.000
ENSP00000353401 Macaca fascicularis ENSP00000353401 I 0.885
ENSP00000353401-D1 Bos grunniens ENSP00000353401-D1 I 0.885
ENSPANG00000011477 Papio anubis ENSPANG00000011477 I 0.728
ENSPANG00000016879 Papio anubis ENSPANG00000016879 I 0.885
ENSPFOG00000005210 Poecilia formosa ENSPFOG00000005210 I 0.927
ENSPSIG00000003536 Pelodiscus sinensis ENSPSIG00000003536 I 0.704
ENSPSIG00000008210 Pelodiscus sinensis ENSPSIG00000008210 I 0.882
ENSSHAG00000007801 Sarcophilus harrisii ENSSHAG00000007801 I 0.888
ENSSHAG00000009458 Sarcophilus harrisii ENSSHAG00000009458 I 0.979
ENSSTOG00000002242 Ictidomys tridecemlineatus ENSSTOG00000002242 I 0.990
ENSSTOG00000010390 Ictidomys tridecemlineatus ENSSTOG00000010390 I 0.878
ENSTNIG00000007722 Tetraodon nigroviridis ENSTNIG00000007722 I 0.770
ENSXMAG00000004131 Xiphophorus maculatus ENSXMAG00000004131 I 0.937
ENSXMAG00000018520 Xiphophorus maculatus ENSXMAG00000018520 I 0.759
Gfo_R003142 Geospiza fortis Gfo_R003142 I 0.979
Gfo_R011360 Geospiza fortis Gfo_R011360 I 0.885
Myotis_brandtii_CUX1_10015212 Myotis brandtii Myotis_brandtii_CUX1_10015212 I 0.871
Myotis_brandtii_CUX2_10011523 Myotis brandtii Myotis_brandtii_CUX2_10011523 I 0.993
Ogr05066 Ophisaurus gracilis Ogr05066 I 0.882
Ogr05872 Ophisaurus gracilis Ogr05872 I 0.955
Pvit_01819 Pogona vitticeps Pvit_01819 I 0.888
Pvit_05599 Pogona vitticeps Pvit_05599 I 0.965
Tal_R013483 Tyto alba Tal_R013483 I 0.880
XP_002942311 Xenopus tropicalis XP_002942311 I 0.882