CUX1 (Homo sapiens)
CUT,Homeodomain

TF Information

Pfam ID Interpro ID Gene ID CIS-BP ID Sequence source Animal TF db
PF02376 (CUT)
PF00046 (Homeobox) 		IPR003350
IPR001356 		ENSG00000257923 T167063_2.00 Ensembl (2018-Dec-8) Link out
NCBI Gene Info:
The protein encoded by this gene is a member of the homeodomain family of DNA binding proteins. It may regulate gene expression, morphogenesis, and differentiation and it may also play a role in the cell cycle progession. Several alternatively spliced transcript variants encoding different isoforms have been identified.[provided by RefSeq, Feb 2011]

Directly determined binding motifs

Name/Motif ID Species Forward Reverse Type/Study/Study ID SR
Score		 DBD
Identity
CUX1
M01501_2.00		 Homo sapiens
NDATYRRNN
NNYYRATHN		 PBM
Yin et al.(2017b)
CUX1_5mCG		 (Direct) (Direct)
CUX1
M01502_2.00		 Homo sapiens
NDATYGRHN
NDYCRATHN		 PBM
Yin et al.(2017b)
CUX1_Cytosine		 (Direct) (Direct)
CUX1
M02946_2.00		 Homo sapiens
ATCRATHNNNDATCRAT
ATYGATHNNNDATYGAT		 SELEX
Jolma et al.(2013)
CUX1_1		 (Direct) (Direct)
CUX1
M02947_2.00		 Homo sapiens
ATCRATHNNNNDATCRAT
ATYGATHNNNNDATYGAT		 SELEX
Jolma et al.(2013)
CUX1_2		 (Direct) (Direct)
CUX1
M02948_2.00		 Homo sapiens
TDATCRATNN
NNATYGATHA		 SELEX
Jolma et al.(2013)
CUX1_3		 (Direct) (Direct)
CUX1
M04679_2.00		 Homo sapiens
NDATCRATNN
NNATYGATHN		 SELEX
Yin et al.(2017)
CUX1_eDBD_HT-SELEX		 (Direct) (Direct)
CUX1
M04680_2.00		 Homo sapiens
NBATTGATHR
YDATCAATVN		 SELEX
Yin et al.(2017)
CUX1_eDBD_Methyl-HT-SELEX		 (Direct) (Direct)
CUX1
M09023_2.00		 Homo sapiens
RBRVNDATYGRTBN
NVAYCRATHNBYVY		 Misc
Kulakovskiy et al.(2013)
CUX1_HUMAN.H11MO.0.C		 (Direct) (Direct)
CUX1
M10422_2.00		 Homo sapiens
CCAATAATCRAT
ATYGATTATTGG		 Transfac
Matys et al.(2006)
V$CDP_01		 (Direct) (Direct)
CUX1
M10423_2.00		 Homo sapiens
DWDATCGATYADHDH
DHDHTRATCGATHWH		 Transfac
Matys et al.(2006)
V$CDP_02		 (Direct) (Direct)
CUX1
M10424_2.00		 Homo sapiens
SCVATCRATN
NATYGATBGS		 Transfac
Matys et al.(2006)
V$CDPCR1_01		 (Direct) (Direct)
CUX1
M10425_2.00		 Homo sapiens
CVATABNTATYKGTG
CACMRATANVTATBG		 Transfac
Matys et al.(2006)
V$CDPCR3_01		 (Direct) (Direct)
CUX1
M10426_2.00		 Homo sapiens
SVSATCRATB
VATYGATSBS		 Transfac
Matys et al.(2006)
V$CDPCR3HD_01		 (Direct) (Direct)
CUX1
M10427_2.00		 Homo sapiens Transfac license required
 Transfac license required
 Transfac
Matys et al.(2006)
V$CDP_Q6_01		 (Direct) (Direct)

Motifs from related TFs

Name/Motif ID Species Forward Reverse Type/Study/Study ID SR
Score		 DBD
Identity
Cux1
M09024_2.00 		Mus musculus
RBRVNDATYGRTBN
NVAYCRATHNBYVY		 Misc
Kulakovskiy et al.(2013)
CUX1_MOUSE.H11MO.0.C 		0.993 0.993
CUX1
M10416_2.00 		Canis familiaris
DHDATYGATYADYDW
WHRHTRATCRATHDH		 Transfac
Matys et al.(2006)
V$CLOX_01 		0.993 0.993
CUX2
M02940_2.00 		Homo sapiens
ATCRATAHNNDWATCGAT
ATCGATWHNNDTATYGAT		 SELEX
Jolma et al.(2013)
CUX2_1 		0.885 0.885
CUX2
M02941_2.00 		Homo sapiens
DDATYGATYA
TRATCRATHH		 SELEX
Jolma et al.(2013)
CUX2_2 		0.885 0.885
CUX2
M04665_2.00 		Homo sapiens
NTRATCGATYRN
NYRATCGATYAN		 SELEX
Yin et al.(2017)
CUX2_eDBD_HT-SELEX 		0.885 0.885
CUX2
M04666_2.00 		Homo sapiens
BYRATCGATYRB
VYRATCGATYRV		 SELEX
Yin et al.(2017)
CUX2_eDBD_Methyl-HT-SELEX 		0.885 0.885
Cux2
M09025_2.00 		Mus musculus
NBBATTGATYD
HRATCAATVVN		 Misc
Kulakovskiy et al.(2013)
CUX2_MOUSE.H11MO.0.C 		0.878 0.878
For this family, TFs with SR scores > 0.700 will likely have a similar motif

Experimental Constructs

Motif ID Domain From To Sequence
M01501_2.00 CUT 39 116
M01501_2.00 CUT 431 507
M01501_2.00 CUT 614 692
M01501_2.00 Homeodomain 737 793
M01502_2.00 CUT 39 116
M01502_2.00 CUT 431 507
M01502_2.00 CUT 614 692
M01502_2.00 Homeodomain 737 793

DNA Binding Domains

Protein ID Domain From To Sequence
ENSP00000292535 CUT 547 624
ENSP00000292535 CUT 939 1015
ENSP00000292535 CUT 1122 1200
ENSP00000292535 Homeodomain 1245 1301
ENSP00000353401 CUT 558 635
ENSP00000353401 CUT 950 1026
ENSP00000353401 CUT 1133 1211
ENSP00000353401 Homeodomain 1256 1312
ENSP00000446630 CUT 547 624
ENSP00000446630 CUT 917 993
ENSP00000446630 CUT 1100 1178
ENSP00000446630 Homeodomain 1223 1279
ENSP00000447373 CUT 547 624
ENSP00000447373 CUT 883 959
ENSP00000447373 CUT 1066 1144
ENSP00000447373 Homeodomain 1189 1245
ENSP00000450125 CUT 445 522
ENSP00000450125 CUT 837 913
ENSP00000450125 CUT 1020 1098
ENSP00000450125 Homeodomain 1143 1199
ENSP00000451558 CUT 445 522
ENSP00000451558 CUT 781 857
ENSP00000451558 CUT 964 1042
ENSP00000451558 Homeodomain 1087 1143

Links

Other CUT,Homeodomain family TFs
Other Homo sapiens TFs

110 Related TFs

Name Species Gene ID Motif Evidence SR
Score		 Action
ENSNLEG00000008310 Nomascus leucogenys ENSNLEG00000008310 I 1.000
ENSOGAG00000009038 Otolemur garnettii ENSOGAG00000009038 I 1.000
ENSP00000353401 Macaca fascicularis ENSP00000353401 I 1.000
ENSCSAG00000018062 Chlorocebus sabaeus ENSCSAG00000018062 I 1.000
ENSPANG00000016879 Papio anubis ENSPANG00000016879 I 1.000
CUX1 Pan troglodytes ENSPTRG00000019531 I 1.000
CUX1 Macaca mulatta ENSMMUG00000021461 I 1.000
CUX1 Microcebus murinus ENSMICG00000010274 I 1.000
CUX1 Callithrix jacchus ENSCJAG00000016076 I 0.997
Cux1 Rattus norvegicus ENSRNOG00000001424 I 0.993
ENSP00000353401-D1 Bos grunniens ENSP00000353401-D1 I 0.993
Pvit_01819 Pogona vitticeps Pvit_01819 I 0.993
CUX1 Myotis lucifugus ENSMLUG00000007264 I 0.993
CUX1 Canis familiaris ENSCAFG00000013749 D 0.993
Cux1 Mus musculus ENSMUSG00000029705 D 0.993
CUX1 Bos taurus ENSBTAG00000010659 I 0.993
CUX1 Erinaceus europaeus ENSEEUG00000005128 I 0.990
CUX1 Anolis carolinensis ENSACAG00000015088 I 0.986
ENSSHAG00000007801 Sarcophilus harrisii ENSSHAG00000007801 I 0.986
CUX1 Monodelphis domestica ENSMODG00000013581 I 0.986
ENSGALG00000001807 Gallus gallus ENSGALG00000001807 I 0.983
Aan_R003487 Calypte anna Aan_R003487 I 0.983
ENSAPLG00000002588 Anas platyrhynchos ENSAPLG00000002588 I 0.983
Ogr05066 Ophisaurus gracilis Ogr05066 I 0.983
Gfo_R011360 Geospiza fortis Gfo_R011360 I 0.983
Alligator_sinensis_CCG004936.1 Alligator sinensis Alligator_sinensis_CCG004936.1 I 0.983
ENSFALG00000009409 Ficedula albicollis ENSFALG00000009409 I 0.983
CUX1 Taeniopygia guttata ENSTGUG00000004386 I 0.983
Afo_R009437 Aptenodytes forsteri Afo_R009437 I 0.983
ENSLACG00000017710 Latimeria chalumnae ENSLACG00000017710 I 0.979
Tal_R013483 Tyto alba Tal_R013483 I 0.979
ENSSTOG00000010390 Ictidomys tridecemlineatus ENSSTOG00000010390 I 0.979
Cmyd_10006308 Chelonia mydas Cmyd_10006308 I 0.979
ENSPSIG00000008210 Pelodiscus sinensis ENSPSIG00000008210 I 0.979
CUX1 Tursiops truncatus ENSTTRG00000014625 I 0.976
XP_002942311 Xenopus tropicalis XP_002942311 I 0.976
ENSOARG00000014629 Ovis aries ENSOARG00000014629 I 0.976
ENSAMEG00000015392 Ailuropoda melanoleuca ENSAMEG00000015392 I 0.976
CUX1 Loxodonta africana ENSLAFG00000002555 I 0.976
CUX1 Felis catus ENSFCAG00000008074 I 0.976
CUX1 Ochotona princeps ENSOPRG00000000165 I 0.972
Myotis_brandtii_CUX1_10015212 Myotis brandtii Myotis_brandtii_CUX1_10015212 I 0.972
ENSLOCG00000001531 Lepisosteus oculatus ENSLOCG00000001531 I 0.969
CUX1 Meleagris gallopavo ENSMGAG00000003398 I 0.958
cux1a Danio rerio ENSDARG00000078459 I 0.937
ENSAMXG00000008817 Astyanax mexicanus ENSAMXG00000008817 I 0.910
Gfo_R003142 Geospiza fortis Gfo_R003142 I 0.890
ENSLOCG00000007417 Lepisosteus oculatus ENSLOCG00000007417 I 0.889
ENSAMXG00000006105 Astyanax mexicanus ENSAMXG00000006105 I 0.889
CUX2 Oryctolagus cuniculus ENSOCUG00000021923 I 0.888
CUX2 Dasypus novemcinctus ENSDNOG00000039959 I 0.885
CUX2 Felis catus ENSFCAG00000003176 I 0.885
CUX2 Homo sapiens ENSG00000111249 D 0.885
CUX2 Tursiops truncatus ENSTTRG00000000945 I 0.885
ENSP00000261726 Macaca fascicularis ENSP00000261726 I 0.885
CUX2 Bos taurus ENSBTAG00000008571 I 0.885
ENSAMEG00000013799 Ailuropoda melanoleuca ENSAMEG00000013799 I 0.885
CUX2 Canis familiaris ENSCAFG00000008575 I 0.885
CUX2 Pteropus vampyrus ENSPVAG00000013176 I 0.885
Cmyd_10015658 Chelonia mydas Cmyd_10015658 I 0.885
ENSP00000261726-D1 Bos grunniens ENSP00000261726-D1 I 0.885
CUX2 Callithrix jacchus ENSCJAG00000011694 I 0.885
CUX2 Sus scrofa ENSSSCG00000009831 I 0.885
ENSNLEG00000000470 Nomascus leucogenys ENSNLEG00000000470 I 0.885
ENSMPUG00000002207 Mustela putorius furo ENSMPUG00000002207 I 0.885
ENSOARG00000017879 Ovis aries ENSOARG00000017879 I 0.885
CUX2 Otolemur garnettii ENSOGAG00000029919 I 0.885
ENSFALG00000009019 Ficedula albicollis ENSFALG00000009019 I 0.882
CUX2 Cavia porcellus ENSCPOG00000020483 I 0.882
ENSSTOG00000002242 Ictidomys tridecemlineatus ENSSTOG00000002242 I 0.882
Alligator_sinensis_CCG016555.1 Alligator sinensis Alligator_sinensis_CCG016555.1 I 0.882
ENSSHAG00000009458 Sarcophilus harrisii ENSSHAG00000009458 I 0.882
ENSLACG00000014413 Latimeria chalumnae ENSLACG00000014413 I 0.882
CUX2 Ochotona princeps ENSOPRG00000006461 I 0.882
CUX2 Loxodonta africana ENSLAFG00000001145 I 0.882
CUX2 Myotis lucifugus ENSMLUG00000003239 I 0.882
CUX2 Monodelphis domestica ENSMODG00000012254 I 0.878
Myotis_brandtii_CUX2_10011523 Myotis brandtii Myotis_brandtii_CUX2_10011523 I 0.878
CUX2 Gallus gallus ENSGALG00000004598 I 0.878
CUX2 Meleagris gallopavo ENSMGAG00000005225 I 0.878
Cux2 Mus musculus ENSMUSG00000042589 D 0.878
cux2b Danio rerio ENSDARG00000086345 I 0.875
Pvit_05599 Pogona vitticeps Pvit_05599 I 0.875
CUX2 Ornithorhynchus anatinus ENSOANG00000004793 I 0.875
ENSXMAG00000004131 Xiphophorus maculatus ENSXMAG00000004131 I 0.875
ENSPFOG00000005210 Poecilia formosa ENSPFOG00000005210 I 0.875
Aan_R010335 Calypte anna Aan_R010335 I 0.872
CUX2 Anolis carolinensis ENSACAG00000002281 I 0.872
Cux2 Rattus norvegicus ENSRNOG00000001259 I 0.872
cux2b Oryzias latipes ENSORLG00000015973 I 0.868
ENSONIG00000015972 Oreochromis niloticus ENSONIG00000015972 I 0.868
cux2b Takifugu rubripes ENSTRUG00000015853 I 0.868
ENSMEUG00000004239 Macropus eugenii ENSMEUG00000004239 I 0.867
CUX2 Taeniopygia guttata ENSTGUG00000006470 I 0.865
Ogr05872 Ophisaurus gracilis Ogr05872 I 0.861
cux2b Gasterosteus aculeatus ENSGACG00000013522 I 0.861
cux2 Xenopus tropicalis XB-GENE-487236 I 0.861
cux2b Tetraodon nigroviridis ENSTNIG00000011453 I 0.861
ENSGMOG00000017485 Gadus morhua ENSGMOG00000017485 I 0.858
ENSAPLG00000004382 Anas platyrhynchos ENSAPLG00000004382 I 0.851
ENSTNIG00000007722 Tetraodon nigroviridis ENSTNIG00000007722 I 0.842
CUX1 Takifugu rubripes ENSTRUG00000008546 I 0.807
CUX1 Pteropus vampyrus ENSPVAG00000017756 I 0.802
ENSGMOG00000008990 Gadus morhua ENSGMOG00000008990 I 0.778
ENSXMAG00000018520 Xiphophorus maculatus ENSXMAG00000018520 I 0.764
ENSGACG00000009915 Gasterosteus aculeatus ENSGACG00000009915 I 0.764
ENSONIG00000003797 Oreochromis niloticus ENSONIG00000003797 I 0.760
CUX2 Pan troglodytes ENSPTRG00000005455 I 0.757
ENSGGOG00000016960 Gorilla gorilla ENSGGOG00000016960 I 0.733