Nkx2-4 (Rattus norvegicus)
Homeodomain

TF Information

Pfam ID Interpro ID Gene ID CIS-BP ID Sequence source Animal TF db
PF00046 (Homeobox) IPR001356 ENSRNOG00000012647 T215397_2.00 Ensembl (2018-Dec-8) Link out

Directly determined binding motifs

Name/Motif ID Species Forward Reverse Type/Study/Study ID SR
Score		 DBD
Identity
No direct experiments

Motifs from related TFs

Name/Motif ID Species Forward Reverse Type/Study/Study ID SR
Score		 DBD
Identity
Nkx2-1
M00385_2.00 		Mus musculus
NNRAGDRN
NYHCTYNN		 PBM
Berger et al.(2008)
Titf1_1722 		0.867 1.000
Nkx2-4
M00514_2.00 		Mus musculus
NNRAGDRBNN
NNVYHCTYNN		 PBM
Berger et al.(2008)
Nkx2-4_3074 		0.867 1.000
NKX2-1
M09146_2.00 		Homo sapiens
BTKGAGWGBN
NVCWCTCMAV		 Misc
Kulakovskiy et al.(2013)
NKX21_HUMAN.H11MO.0.A 		0.867 1.000
Nkx2-1
M09171_2.00 		Mus musculus
NBTKGAGWGB
VCWCTCMAVN		 Misc
Kulakovskiy et al.(2013)
NKX21_MOUSE.H11MO.0.A 		0.867 1.000
Nkx2-1
M09563_2.00 		Mus musculus
BTBRAGWGBH
DVCWCTYVAV		 Misc
Heinz et al.(2010)
LungAC-Nkx2.1_GSE43252 		0.867 1.000
NKX2-1
M10694_2.00 		Homo sapiens Transfac license required
 Transfac license required
 Transfac
Matys et al.(2006)
V$TITF1_Q3 		0.867 1.000
NKX2-1
M10695_2.00 		Homo sapiens Transfac license required
 Transfac license required
 Transfac
Matys et al.(2006)
V$TTF1_Q5_01 		0.867 1.000
NKX2-1
M10696_2.00 		Homo sapiens Transfac license required
 Transfac license required
 Transfac
Matys et al.(2006)
V$TTF1_Q5 		0.867 1.000
NKX2-1
M10697_2.00 		Homo sapiens Transfac license required
 Transfac license required
 Transfac
Matys et al.(2006)
V$TTF1_Q6 		0.867 1.000
ceh-24
M02181_2.00 		Caenorhabditis elegans
NNRAKWRNN
NNYWMTYNN		 PBM
Weirauch et al.(2014)
pTH6327 		0.837 0.877
scro
M03854_2.00 		Drosophila melanogaster
NNBRMGTGB
VCACKYVNN		 SELEX
Nitta et al.(2015)
scro_1 		0.834 0.930
Nkx2-2
M00438_2.00 		Mus musculus
NNNRAGDRN
NYHCTYNNN		 PBM
Berger et al.(2008)
Nkx2-2_2823 		0.798 0.895
Nkx2-2
M09190_2.00 		Mus musculus
NTBRAGWGBBN
NVVCWCTYVAN		 Misc
Kulakovskiy et al.(2013)
NKX22_MOUSE.H11MO.0.A 		0.798 0.895
NKX2-2
M10681_2.00 		Homo sapiens
WTAAGTRBTT
AAVYACTTAW		 Transfac
Matys et al.(2006)
V$NKX22_01 		0.798 0.895
NKX2-2
M10682_2.00 		Homo sapiens Transfac license required
 Transfac license required
 Transfac
Matys et al.(2006)
V$NKX2B_Q3_01 		0.798 0.895
NKX2-2
M10683_2.00 		Homo sapiens Transfac license required
 Transfac license required
 Transfac
Matys et al.(2006)
V$NKX2B_Q3 		0.798 0.895
NKX2-5
M00323_2.00 		Homo sapiens
NWYAAGTGSNN
NNSCACTTRWN		 PBM
Barrera et al.(2016)
NKX2-5_REF 		0.787 0.825
Nkx2-5
M00404_2.00 		Mus musculus
NNNRAGDRBN
NVYHCTYNNN		 PBM
Berger et al.(2008)
Nkx2-5_3436 		0.787 0.825
NKX2-5
M05346_2.00 		Homo sapiens
BHYAAGTGBN
NVCACTTRDV		 SELEX
Yin et al.(2017)
NKX2-5_FL_HT-SELEX 		0.787 0.825
Nkx2-5
M02686_2.00 		Mus musculus
WTAAKWK
MWMTTAW		 SELEX
Mathelier et al.(2014)
MA0063.1 		0.787 0.825
Nkx2-5
M08136_2.00 		Mus musculus
SYTGAGWGSYH
DRSCWCTCARS		 ChIP-seq
Mathelier et al.(2014)
MA0503.1 		0.787 0.825
NKX2-5
M09163_2.00 		Homo sapiens
BKRAGWGV
BCWCTYMV		 Misc
Kulakovskiy et al.(2013)
NKX25_HUMAN.H11MO.0.B 		0.787 0.825
Nkx2-5
M09177_2.00 		Mus musculus
NBYBRAGTGS
SCACTYVRVN		 Misc
Kulakovskiy et al.(2013)
NKX25_MOUSE.H11MO.0.A 		0.787 0.825
Nkx2-5
M09567_2.00 		Mus musculus
HBRAGWGBNN
NNVCWCTYVD		 Misc
Heinz et al.(2010)
HL1-Nkx2.5.biotin_GSE21529 		0.787 0.825
NKX2-5
M10742_2.00 		Homo sapiens
TYAAGTG
CACTTRA		 Transfac
Matys et al.(2006)
V$NKX25_01 		0.787 0.825
NKX2-5
M10743_2.00 		Homo sapiens
CWTAATTV
BAATTAWG		 Transfac
Matys et al.(2006)
V$NKX25_02 		0.787 0.825
NKX2-5
M10744_2.00 		Homo sapiens Transfac license required
 Transfac license required
 Transfac
Matys et al.(2006)
V$NKX25_Q5 		0.787 0.825
NKX2-5
M10745_2.00 		Homo sapiens Transfac license required
 Transfac license required
 Transfac
Matys et al.(2006)
V$NKX25_Q6 		0.787 0.825
NKX2-5
M00321_2.00 		Homo sapiens
HNAAGTRBNN
NNVYACTTND		 PBM
Barrera et al.(2016)
NKX2-5_R161P 		0.787 0.825
NKX2-5
M05347_2.00 		Homo sapiens
BTYAAGTGGN
NCCACTTRAV		 SELEX
Yin et al.(2017)
NKX2-5_FL_Methyl-HT-SELEX_1 		0.787 0.825
NKX2-5
M05348_2.00 		Homo sapiens
BTYAACGAB
VTCGTTRAV		 SELEX
Yin et al.(2017)
NKX2-5_FL_Methyl-HT-SELEX_2 		0.787 0.825
NKX2-5
M00322_2.00 		Homo sapiens
NNNRNNN
NNNYNNN		 PBM
Barrera et al.(2016)
NKX2-5_R190C 		0.787 0.807
NKX2-5
M00324_2.00 		Homo sapiens
NHNNNNN
NNNNNDN		 PBM
Barrera et al.(2016)
NKX2-5_T178M 		0.787 0.807
Nkx2-3
M00497_2.00 		Mus musculus
NNRAGDRNN
NNYHCTYNN		 PBM
Berger et al.(2008)
Nkx2-3_3435 		0.785 0.842
NKX2-3
M05042_2.00 		Homo sapiens
NNBAAGTGBN
NVCACTTVNN		 SELEX
Yin et al.(2017)
NKX2-3_eDBD_HT-SELEX 		0.785 0.842
NKX2-3
M05045_2.00 		Homo sapiens
BNBAAGTGBN
NVCACTTVNV		 SELEX
Yin et al.(2017)
NKX2-3_FL_HT-SELEX 		0.785 0.842
NKX2-3
M05043_2.00 		Homo sapiens
BNBAAGTGBN
NVCACTTVNV		 SELEX
Yin et al.(2017)
NKX2-3_eDBD_Methyl-HT-SELEX_1 		0.785 0.842
NKX2-3
M05044_2.00 		Homo sapiens
SDYAACGHB
VDCGTTRHS		 SELEX
Yin et al.(2017)
NKX2-3_eDBD_Methyl-HT-SELEX_2 		0.785 0.842
NKX2-3
M05046_2.00 		Homo sapiens
BNBAAGTGBN
NVCACTTVNV		 SELEX
Yin et al.(2017)
NKX2-3_FL_Methyl-HT-SELEX_1 		0.785 0.842
NKX2-3
M05047_2.00 		Homo sapiens
SWYAACSHB
VDSGTTRWS		 SELEX
Yin et al.(2017)
NKX2-3_FL_Methyl-HT-SELEX_2 		0.785 0.842
vnd
M06551_2.00 		Drosophila melanogaster
WYTCAAGTR
YACTTGARW		 B1H
Mathelier et al.(2014)
MA0253.1 		0.782 0.860
vnd
M06377_2.00 		Drosophila melanogaster
WYTCAAGTR
YACTTGARW		 B1H
Zhu et al.(2011)
Vnd_Cell_FBgn0003986 		0.782 0.860
vnd
M06378_2.00 		Drosophila melanogaster
KYTSAAGWGY
RCWCTTSARM		 B1H
Zhu et al.(2011)
vnd_FlyReg_FBgn0003986 		0.782 0.860
vnd
M06379_2.00 		Drosophila melanogaster
BTBAAGTR
YACTTVAV		 B1H
Zhu et al.(2011)
Vnd_SOLEXA_FBgn0003986 		0.782 0.860
vnd
M09683_2.00 		Drosophila melanogaster
TCAAGTGB
VCACTTGA		 Misc
Kulakovskiy et al.(2009)
vnd 		0.782 0.860
ceh-28
M08210_2.00 		Caenorhabditis elegans
AATCGATW
WATCGATT		 ChIP-seq
Contrino et al.(2012)
Mw138 		0.781 0.684
Nkx2-9
M00520_2.00 		Mus musculus
NNNRAGDRBN
NVYHCTYNNN		 PBM
Berger et al.(2008)
Nkx2-9_3082 		0.775 0.807
Nkx2-9
M00800_2.00 		Mus musculus
NNRAGDRBNN
NNVYHCTYNN		 PBM
Weirauch et al.(2013)
pTH2842 		0.775 0.807
Nkx2-9
M09215_2.00 		Mus musculus
BTCAAGKRB
VYMCTTGAV		 Misc
Kulakovskiy et al.(2013)
NKX28_MOUSE.H11MO.0.C 		0.775 0.807
tin
M00559_2.00 		Drosophila melanogaster
NWYAAGTGGNN
NNCCACTTRWN		 PBM
Busser et al.(2012a)
Tin 		0.771 0.667
tin
M03809_2.00 		Drosophila melanogaster
BTYAAGTGSN
NSCACTTRAV		 SELEX
Nitta et al.(2015)
tin_1 		0.771 0.667
tin
M06284_2.00 		Drosophila melanogaster
BTYAAGTG
CACTTRAV		 B1H
Zhu et al.(2011)
Tin_Cell_FBgn0004110 		0.771 0.667
tin
M06285_2.00 		Drosophila melanogaster
BCTCAAGTGSVN
NBSCACTTGAGV		 B1H
Zhu et al.(2011)
tin_FlyReg_FBgn0004110 		0.771 0.667
tin
M06286_2.00 		Drosophila melanogaster
BWYAAGTR
YACTTRWV		 B1H
Zhu et al.(2011)
Tin_SOLEXA_FBgn0004110 		0.771 0.667
tin
M08421_2.00 		Drosophila melanogaster
DBTCRAGTGS
SCACTYGAVH		 ChIP-chip
Mathelier et al.(2014)
MA0247.2 		0.771 0.667
Nkx2-6
M00496_2.00 		Mus musculus
HYAAGTRBNN
NNVYACTTRD		 PBM
Berger et al.(2008)
Nkx2-6_3437 		0.763 0.789
ceh-22
M00376_2.00 		Caenorhabditis elegans
WBRAGTRBNN
NNVYACTYVW		 PBM
Berger et al.(2006)
Ceh-22 		0.761 0.807
NKX2-5
M00320_2.00 		Homo sapiens
NHBAAKWRN
NYWMTTVDN		 PBM
Barrera et al.(2016)
NKX2-5_K183E 		0.754 0.807
NKX2-8
M00302_2.00 		Homo sapiens
NNRAGDRB
VYHCTYNN		 PBM
Barrera et al.(2016)
NKX2-8_REF 		0.743 0.807
NKX2-8
M05149_2.00 		Homo sapiens
BTSRAGTGBN
NVCACTYSAV		 SELEX
Yin et al.(2017)
NKX2-8_FL_HT-SELEX 		0.743 0.807
NKX2-8
M09145_2.00 		Homo sapiens
BTCAAGKRB
VYMCTTGAV		 Misc
Kulakovskiy et al.(2013)
NKX28_HUMAN.H11MO.0.C 		0.743 0.807
NKX2-8
M05150_2.00 		Homo sapiens
GCARTAACGACATC
GATGTCGTTAYTGC		 SELEX
Yin et al.(2017)
NKX2-8_FL_Methyl-HT-SELEX_1 		0.743 0.807
NKX2-8
M05151_2.00 		Homo sapiens
BTSAAGTGBN
NVCACTTSAV		 SELEX
Yin et al.(2017)
NKX2-8_FL_Methyl-HT-SELEX_2 		0.743 0.807
NKX2-8
M05152_2.00 		Homo sapiens
BTBAACGAB
VTCGTTVAV		 SELEX
Yin et al.(2017)
NKX2-8_FL_Methyl-HT-SELEX_3 		0.743 0.807
NKX2-8
M00301_2.00 		Homo sapiens
NNRAKDRB
VYHMTYNN		 PBM
Barrera et al.(2016)
NKX2-8_A94T 		0.743 0.789
Q24782_9CNID
M02206_2.00 		Eleutheria dichotoma
TTAATTAA
TTAATTAA		 PBM
Weirauch et al.(2014)
pTH5486 		0.600 0.474
For this family, TFs with SR scores > 0.599 will likely have a similar motif

DNA Binding Domains

Protein ID Domain From To Sequence
ENSRNOP00000016915 Homeodomain 188 244

Links

Other Homeodomain family TFs
Other Rattus norvegicus TFs

832 Related TFs

Name Species Gene ID Motif Evidence SR
Score		 Action
29820.m001008 Ricinus communis 29820.m001008 I
Bo2g006960 Brassica oleracea Bo2g006960 I
Bostr.13129s0423 Boechera stricta Bostr.13129s0423 I
Bostr.19424s1037 Boechera stricta Bostr.19424s1037 I
Bra005852 Brassica rapa Bra005852 I
Bra028759 Brassica rapa Bra028759 I
Cagra.1504s0045 Capsella grandiflora Cagra.1504s0045 I
Cagra.1655s0066 Capsella grandiflora Cagra.1655s0066 I
Cagra.7053s0020 Capsella grandiflora Cagra.7053s0020 I
Carubv10001099m.g Capsella rubella Carubv10001099m.g I
Carubv10013771m.g Capsella rubella Carubv10013771m.g I
Carubv10023556m.g Capsella rubella Carubv10023556m.g I
chr1.LjT01D01.90.nd Lotus japonicus chr1.LjT01D01.90.nd I
DREB2A Arabidopsis lyrata fgenesh2_kg.6__469__AT5G05410.1 I
DREB2A Arabidopsis thaliana AT5G05410 D
DREB2B Arabidopsis lyrata fgenesh2_kg.3__1148__AT3G11020.1 I
GLYMA07G19221 Glycine max GLYMA07G19221 I
GLYMA18G43750 Glycine max GLYMA18G43750 I
MTR_7g070220 Medicago truncatula MTR_7g070220 I
PGSC0003DMG401023951 Solanum tuberosum PGSC0003DMG401023951 I
Solyc06g050520.1 Solanum lycopersicum Solyc06g050520.1 I
TCM_021596 Theobroma cacao TCM_021596 I
Thhalv10021161m.g Eutrema salsugineum Thhalv10021161m.g I