nhr-218 (Caenorhabditis elegans)
Nuclear receptor

TF Information

Pfam ID Interpro ID Gene ID CIS-BP ID Sequence source Animal TF db
PF00105 (zf-C4) IPR001628 WBGene00011750 T306294_2.00 Ensembl (2018-Dec-8) Link out
NCBI Gene Info:
Predicted to enable DNA-binding transcription factor activity; sequence-specific DNA binding activity; and zinc ion binding activity. Predicted to be involved in regulation of transcription, DNA-templated. Predicted to be located in nucleus. Human ortholog(s) of this gene implicated in Alzheimer's disease; coronary artery disease; hepatocellular carcinoma; lipid metabolism disorder; and myocardial infarction. Orthologous to human PPARA (peroxisome proliferator activated receptor alpha). [provided by Alliance of Genome Resources, Apr 2022]

Directly determined binding motifs

Name/Motif ID Species Forward Reverse Type/Study/Study ID SR
Score		 DBD
Identity
No direct experiments

Motifs from related TFs

Name/Motif ID Species Forward Reverse Type/Study/Study ID SR
Score		 DBD
Identity
nhr-142
M00703_2.00 		Caenorhabditis elegans
RGTCACAR
YTGTGACY		 PBM
Narasimhan et al.(2015)
pTH10714 		0.865 0.557
For this family, TFs with SR scores > 0.745 will likely have a similar motif

DNA Binding Domains

Protein ID Domain From To Sequence
T13F3.2a Nuclear receptor 18 88

Links

Other Nuclear receptor family TFs
Other Caenorhabditis elegans TFs

25 Related TFs

Name Species Gene ID Motif Evidence SR
Score		 Action
CBG15881 Caenorhabditis briggsae CBG15881 I 0.915
CRE31070 Caenorhabditis remanei CRE31070 I 0.886
CBG09320 Caenorhabditis briggsae CBG09320 I 0.886
CJA28065 Caenorhabditis japonica CJA28065 I 0.880
CRE05044 Caenorhabditis remanei CRE05044 I 0.879
CBN21486 Caenorhabditis brenneri CBN21486 I 0.875
CBN28290 Caenorhabditis brenneri CBN28290 I 0.875
nhr-142 Caenorhabditis elegans WBGene00018430 D 0.865
L898_g12799 Steinernema monticolum L898_g12799 I 0.817
PEQ_0000560101 Parascaris equorum PEQ_0000560101 I 0.808
CBG04928 Caenorhabditis briggsae CBG04928 I 0.786
L898_g19021 Steinernema monticolum L898_g19021 I 0.780
SVUK_0002058501 Strongylus vulgaris SVUK_0002058501 I 0.779
CBG22870 Caenorhabditis briggsae CBG22870 I 0.778
HPBE_0001646201 Heligmosomoides bakeri HPBE_0001646201 I 0.769
nhr-213 Caenorhabditis elegans WBGene00011520 I 0.767
HPLM_0000974301 Haemonchus placei HPLM_0000974301 I 0.765
HCOI01190000 Haemonchus contortus HCOI01190000 I 0.765
ACOC_0000492601 Angiostrongylus costaricensis ACOC_0000492601 I 0.764
L893_g18993 Steinernema glaseri L893_g18993 I 0.762
CJA09697 Caenorhabditis japonica CJA09697 I 0.761
L892_g10843 Steinernema scapterisci L892_g10843 I 0.750
CRE08691 Caenorhabditis remanei CRE08691 I 0.749
scaffold31-EXSNAP2012.20 Pristionchus exspectatus scaffold31-EXSNAP2012.20 I 0.748
HPLM_0000974401 Haemonchus placei HPLM_0000974401 I 0.747