CIS-BP Database: Catalog of Inferred Sequence Binding Preferences
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TFAP4
(
Homo sapiens
)
bHLH
TF Information
Pfam ID
Interpro ID
Gene ID
CIS-BP ID
Sequence source
Animal TF db
PF00010 (HLH)
IPR001092
ENSG00000090447
T034253_2.00
Ensembl (2018-Dec-8)
Link out
NCBI Gene Info:
Transcription factors of the basic helix-loop-helix-zipper (bHLH-ZIP) family contain a basic domain, which is used for DNA binding, and HLH and ZIP domains, which are used for oligomerization. Transcription factor AP4 activates both viral and cellular genes by binding to the symmetrical DNA sequence CAGCTG (Mermod et al., 1988 [PubMed 2833704]; Hu et al., 1990 [PubMed 2123466]).[supplied by OMIM, Jul 2009]
Directly determined binding motifs
Name/Motif ID
Species
Forward
Reverse
Type/Study/Study ID
SR
Score
DBD
Identity
TFAP4
M02776_2.00
Homo sapiens
AWCAGCTGWY
RWCAGCTGWT
SELEX
Jolma et al.(2013)
TFAP4_1
(Direct)
(Direct)
TFAP4
M02777_2.00
Homo sapiens
AWCAGCTGWT
AWCAGCTGWT
SELEX
Jolma et al.(2013)
TFAP4_2
(Direct)
(Direct)
TFAP4
M04066_2.00
Homo sapiens
VHCAKVTGDB
VHCABMTGDB
SELEX
Yin et al.(2017)
TFAP4_eDBD_HT-SELEX_1
(Direct)
(Direct)
TFAP4
M04067_2.00
Homo sapiens
VWCAGCTGWB
VWCAGCTGWB
SELEX
Yin et al.(2017)
TFAP4_eDBD_HT-SELEX_2
(Direct)
(Direct)
TFAP4
M04068_2.00
Homo sapiens
DHCABMTGDN
NHCAKVTGDH
SELEX
Yin et al.(2017)
TFAP4_eDBD_Methyl-HT-SELEX_1
(Direct)
(Direct)
TFAP4
M04069_2.00
Homo sapiens
AWCAGCTGWT
AWCAGCTGWT
SELEX
Yin et al.(2017)
TFAP4_eDBD_Methyl-HT-SELEX_2
(Direct)
(Direct)
TFAP4
M04070_2.00
Homo sapiens
RHCAYVTGDB
VHCABRTGDY
SELEX
Yin et al.(2017)
TFAP4_FL_HT-SELEX_1
(Direct)
(Direct)
TFAP4
M04071_2.00
Homo sapiens
VHCAGCTGDB
VHCAGCTGDB
SELEX
Yin et al.(2017)
TFAP4_FL_HT-SELEX_2
(Direct)
(Direct)
TFAP4
M04072_2.00
Homo sapiens
VHCABVTGDB
VHCABVTGDB
SELEX
Yin et al.(2017)
TFAP4_FL_Methyl-HT-SELEX_1
(Direct)
(Direct)
TFAP4
M04073_2.00
Homo sapiens
VHCAGCTGDB
VHCAGCTGDB
SELEX
Yin et al.(2017)
TFAP4_FL_Methyl-HT-SELEX_2
(Direct)
(Direct)
TFAP4
M08712_2.00
Homo sapiens
VMNCAGCTGR
YCAGCTGNKB
Misc
Kulakovskiy et al.(2013)
TFAP4_HUMAN.H11MO.0.A
(Direct)
(Direct)
TFAP4
M09453_2.00
Homo sapiens
NVHCAGCTGD
HCAGCTGDBN
Misc
Heinz et al.(2010)
AML-Tfap4_GSE45738
(Direct)
(Direct)
TFAP4
M09802_2.00
Homo sapiens
MNGNCHVCAGCTGDBBBW
WVVVHCAGCTGBDGNCNK
Transfac
Matys et al.(2006)
V$AP4_01
(Direct)
(Direct)
TFAP4
M09803_2.00
Homo sapiens
NNSAGCTGHB
VDCAGCTSNN
Transfac
Matys et al.(2006)
V$AP4_Q5
(Direct)
(Direct)
TFAP4
M09804_2.00
Homo sapiens
Transfac license required
Transfac license required
Transfac
Matys et al.(2006)
V$AP4_Q6_01
(Direct)
(Direct)
TFAP4
M09805_2.00
Homo sapiens
Transfac license required
Transfac license required
Transfac
Matys et al.(2006)
V$AP4_Q6_02
(Direct)
(Direct)
TFAP4
M09806_2.00
Homo sapiens
NVCAGCTGHB
VDCAGCTGBN
Transfac
Matys et al.(2006)
V$AP4_Q6
(Direct)
(Direct)
Motifs from related TFs
Name/Motif ID
Species
Forward
Reverse
Type/Study/Study ID
SR
Score
DBD
Identity
Tfap4
M01717_2.00
Mus musculus
VHCABVYGB
VCRBVTGDB
PBM
Weirauch et al.(2014)
pTH5067
0.724
1.000
crp
M03595_2.00
Drosophila melanogaster
AACAGCTGWT
AWCAGCTGTT
SELEX
Nitta et al.(2015)
crp_1
0.843
0.808
crp
M05937_2.00
Drosophila melanogaster
VAHCAGCTGAY
RTCAGCTGDWB
B1H
Zhu et al.(2011)
crp_SANGER_10_FBgn0001994
0.843
0.808
For this family, TFs with SR scores >
0.838
will likely have a similar motif
DNA Binding Domains
Protein ID
Domain
From
To
Sequence
ENSP00000204517
bHLH
49
100
RREIANSNERRRMQSINAGFQSLKTLIPHTDGEKLSKAAILQQTAEYIFSLE
ENSP00000459390
bHLH
1
40
MQSINAGFQSLKTLIPHTDGEKLSKAAILQQTAEYIFSLE
Links
Other
bHLH
family TFs
Other
Homo sapiens
TFs
105 Related TFs
Name
Species
Gene ID
Motif Evidence
SR
Score
Action
TFAP4
Procavia capensis
ENSPCAG00000011134
I
0.914
ENSPANG00000010499
Papio anubis
ENSPANG00000010499
I
0.914
tfap4
Oryzias latipes
ENSORLG00000008286
I
0.914
ENSPPYG00000007054
Pongo abelii
ENSPPYG00000007054
I
0.914
ENSPSIG00000009002
Pelodiscus sinensis
ENSPSIG00000009002
I
0.914
Tfap4
Rattus norvegicus
ENSRNOG00000005227
I
0.914
ENSPVAG00000005418
Pteropus vampyrus
ENSPVAG00000005418
I
0.914
TFAP4
Pan troglodytes
ENSPTRG00000007713
I
0.914
ENSOPRG00000001061
Ochotona princeps
ENSOPRG00000001061
I
0.914
ENSONIG00000005196
Oreochromis niloticus
ENSONIG00000005196
I
0.914
ENSNLEG00000009797
Nomascus leucogenys
ENSNLEG00000009797
I
0.914
Tfap4
Mus musculus
ENSMUSG00000005718
D
0.914
ENSMPUG00000015023
Mustela putorius furo
ENSMPUG00000015023
I
0.914
TFAP4
Ornithorhynchus anatinus
ENSOANG00000019858
I
0.914
ENSOARG00000003120
Ovis aries
ENSOARG00000003120
I
0.914
TFAP4
Otolemur garnettii
ENSOGAG00000008955
I
0.914
TFAP4
Oryctolagus cuniculus
ENSOCUG00000024550
I
0.914
ENSSHAG00000011487
Sarcophilus harrisii
ENSSHAG00000011487
I
0.914
ENSSTOG00000028040
Ictidomys tridecemlineatus
ENSSTOG00000028040
I
0.914
Ogr05167
Ophisaurus gracilis
Ogr05167
I
0.914
Myotis_brandtii_TFAP4_10028039
Myotis brandtii
Myotis_brandtii_TFAP4_10028039
I
0.914
ENSP00000204517
Macaca fascicularis
ENSP00000204517
I
0.914
Pvit_18996
Pogona vitticeps
Pvit_18996
I
0.914
estExt_fgenesh2_pg.C_3260041
Branchiostoma floridae
estExt_fgenesh2_pg.C_3260041
I
0.914
tfap4
Xenopus tropicalis
XB-GENE-999265
I
0.914
fgenesh2_pg.scaffold_326000054
Branchiostoma floridae
fgenesh2_pg.scaffold_326000054
I
0.914
ENSP00000204517-D1
Bos grunniens
ENSP00000204517-D1
I
0.914
Cmyd_10017689
Chelonia mydas
Cmyd_10017689
I
0.914
tfap4
Takifugu rubripes
ENSTRUG00000006111
I
0.914
tfap4
Tetraodon nigroviridis
ENSTNIG00000009740
I
0.914
TFAP4
Tupaia belangeri
ENSTBEG00000014089
I
0.914
TFAP4
Tursiops truncatus
ENSTTRG00000002710
I
0.914
TFAP4
Vicugna pacos
ENSVPAG00000008001
I
0.914
Alligator_sinensis_CCG004455.1
Alligator sinensis
Alligator_sinensis_CCG004455.1
I
0.914
ENSXMAG00000004632
Xiphophorus maculatus
ENSXMAG00000004632
I
0.914
TFAP4
Monodelphis domestica
ENSMODG00000016377
I
0.914
ENSPFOG00000011355
Poecilia formosa
ENSPFOG00000011355
I
0.914
ENSFALG00000004331
Ficedula albicollis
ENSFALG00000004331
I
0.914
TFAP4
Felis catus
ENSFCAG00000011227
I
0.914
ENSCSAG00000009620
Chlorocebus sabaeus
ENSCSAG00000009620
I
0.914
TFAP4
Cavia porcellus
ENSCPOG00000004174
I
0.914
TFAP4
Echinops telfairi
ENSETEG00000008634
I
0.914
TFAP4
Erinaceus europaeus
ENSEEUG00000006004
I
0.914
tfap4
Danio rerio
ENSDARG00000103923
I
0.914
TFAP4
Dasypus novemcinctus
ENSDNOG00000039193
I
0.914
Tfap4
Dipodomys ordii
ENSDORG00000004656
I
0.914
TFAP4
Equus caballus
ENSECAG00000022311
I
0.914
TFAP4
Callithrix jacchus
ENSCJAG00000019756
I
0.914
TFAP4
Myotis lucifugus
ENSMLUG00000005725
I
0.914
TFAP4
Loxodonta africana
ENSLAFG00000022341
I
0.914
ENSLACG00000000328
Latimeria chalumnae
ENSLACG00000000328
I
0.914
ENSLOCG00000002626
Lepisosteus oculatus
ENSLOCG00000002626
I
0.914
ENSMEUG00000000888
Macropus eugenii
ENSMEUG00000000888
I
0.914
TFAP4
Meleagris gallopavo
ENSMGAG00000009411
I
0.914
TFAP4
Canis familiaris
ENSCAFG00000019231
I
0.914
TFAP4
Bos taurus
ENSBTAG00000033174
I
0.914
TFAP4
Anolis carolinensis
ENSACAG00000016352
I
0.914
TFAP4
Gorilla gorilla
ENSGGOG00000000451
I
0.914
ENSGALG00000027823
Gallus gallus
ENSGALG00000027823
I
0.914
ENSAMEG00000002016
Ailuropoda melanoleuca
ENSAMEG00000002016
I
0.914
ENSXMAG00000011968
Xiphophorus maculatus
ENSXMAG00000011968
I
0.912
tfap4
Takifugu rubripes
ENSTRUG00000013344
I
0.912
ENSCSAVG00000000333
Ciona savignyi
ENSCSAVG00000000333
I
0.912
tfap4
Tetraodon nigroviridis
ENSTNIG00000014095
I
0.912
ENSCING00000014406
Ciona intestinalis
ENSCING00000014406
I
0.912
ENSONIG00000016338
Oreochromis niloticus
ENSONIG00000016338
I
0.912
tfap4
Oryzias latipes
ENSORLG00000015050
I
0.912
ENSPFOG00000000836
Poecilia formosa
ENSPFOG00000000836
I
0.912
tfap4
Tetraodon nigroviridis
ENSTNIG00000002015
I
0.912
ENSGMOG00000014930
Gadus morhua
ENSGMOG00000014930
I
0.903
CGI_10026909
Crassostrea gigas
CGI_10026909
I
0.903
CapteG45346
Capitella teleta
CapteG45346
I
0.903
ENSGMOG00000015232
Gadus morhua
ENSGMOG00000015232
I
0.901
tfap4
Gasterosteus aculeatus
ENSGACG00000011329
I
0.894
ENSAPLG00000013446
Anas platyrhynchos
ENSAPLG00000013446
I
0.890
GB48999
Apis mellifera
GB48999
I
0.884
AGAP010201
Anopheles gambiae
AGAP010201
I
0.884
L798_07621
Zootermopsis nevadensis
L798_07621
I
0.884
LLOJ009485
Lutzomyia longipalpis
LLOJ009485
I
0.884
Sakowv30040946m.g
Saccoglossus kowalevskii
Sakowv30040946m.g
I
0.880
Ocbimv22002701m.g
Octopus bimaculoides
Ocbimv22002701m.g
N
0.873
tfap4
Gasterosteus aculeatus
ENSGACG00000018768
I
0.870
ACYPI003006
Acyrthosiphon pisum
ACYPI003006
I
0.865
tetur30g00270
Tetranychus urticae
tetur30g00270
I
0.860
BGIBMGA010353
Bombyx mori
BGIBMGA010353
I
0.854
KGM_15765
Danaus plexippus
KGM_15765
I
0.854
HMEL008759
Heliconius melpomene
HMEL008759
I
0.854
SPU_003179
Strongylocentrotus purpuratus
SPU_003179
I
0.852
TCLT_0000678201
Thelazia callipaeda
TCLT_0000678201
I
0.846
MDOA012071
Musca domestica
MDOA012071
I
0.843
crp
Drosophila melanogaster
FBgn0001994
D
0.843
GH10096
Drosophila grimshawi
FBgn0117577
I
0.843
GI14377
Drosophila mojavensis
FBgn0137129
I
0.843
GG24179
Drosophila erecta
FBgn0116312
I
0.843
GF21721
Drosophila ananassae
FBgn0098721
I
0.843
GA20511
Drosophila pseudoobscura
FBgn0080505
I
0.843
GL14101
Drosophila persimilis
FBgn0151706
I
0.843
GM17917
Drosophila sechellia
FBgn0172824
I
0.843
GE19372
Drosophila yakuba
FBgn0236717
I
0.843
GJ16254
Drosophila virilis
FBgn0203439
I
0.843
GK24289
Drosophila willistoni
FBgn0226250
I
0.843
GD21926
Drosophila simulans
FBgn0193342
I
0.843
Aan_R014038
Calypte anna
Aan_R014038
I
0.623
Afo_R007145
Aptenodytes forsteri
Afo_R007145
I
0.623