|
HHAL002953-PA
(Halyomorpha halys)
C2H2 ZF
|
TF Information |
Pfam ID |
Interpro ID |
Gene ID |
CIS-BP ID |
Sequence source |
PF00096 (zf-C2H2) |
IPR007087 |
HHAL002953-PA |
T144035_2.00 |
Misc (2018-Jan-19) |
NCBI Gene Info:This gene encodes a tumor suppressor protein containing transcriptional activation, DNA binding, and oligomerization domains. The encoded protein responds to diverse cellular stresses to regulate expression of target genes, thereby inducing cell cycle arrest, apoptosis, senescence, DNA repair, or changes in metabolism. Mutations in this gene are associated with a variety of human cancers, including hereditary cancers such as Li-Fraumeni syndrome. Alternative splicing of this gene and the use of alternate promoters result in multiple transcript variants and isoforms. Additional isoforms have also been shown to result from the use of alternate translation initiation codons from identical transcript variants (PMIDs: 12032546, 20937277). [provided by RefSeq, Dec 2016] |
Directly determined binding motifs |
Name/Motif ID |
Species |
Forward |
Reverse |
Type/Study/Study ID |
SR Score |
DBD Identity |
No direct experiments |
|
|
|
|
|
Motifs from related TFs |
Name/Motif ID |
Species |
Forward |
Reverse |
Type/Study/Study ID |
SR Score |
DBD Identity |
Sp4
M01862_2.00 |
Mus musculus |
NMCGCCCMY |
RKGGGCGKN |
PBM
Weirauch et al.(2014)
pTH4998
|
0.800
|
0.870
|
Sp4
M00133_2.00 |
Mus musculus |
HMCGCCCMYN |
NRKGGGCGKD |
PBM
Badis et al.(2009)
Sp4_1011
|
0.800
|
0.870
|
Sp4
M05859_2.00 |
Mus musculus |
DGNYMCGCCCHNN |
NNDGGGCGKRNCH |
SMiLE-seq
Isakova et al.(2017)
SP4
|
0.800
|
0.870
|
Sp4
M08975_2.00 |
Mus musculus |
BYHDKCYCCGCCYYYHBSBB |
VVSVDRRRGGCGGRGMHDRV |
Misc
Kulakovskiy et al.(2013)
SP4_MOUSE.H11MO.0.B
|
0.800
|
0.870
|
SP4
M02879_2.00 |
Homo sapiens |
NWRGCCACGCCCMCHYN |
NRDGKGGGCGTGGCYWN |
SELEX
Jolma et al.(2013)
SP4_1
|
0.784
|
0.855
|
SP4
M08296_2.00 |
Homo sapiens |
NNVGCYCCKCCYMYH |
DRKRGGMGGRGCBNN |
ChIP-seq
Schmitges et al.(2016)
Q02446.MEME
|
0.784
|
0.855
|
SP4
M08873_2.00 |
Homo sapiens |
BYHDKCYCCGCCYYYHBSBB |
VVSVDRRRGGCGGRGMHDRV |
Misc
Kulakovskiy et al.(2013)
SP4_HUMAN.H11MO.0.A
|
0.784
|
0.855
|
SP4
M10165_2.00 |
Homo sapiens |
Transfac license required
|
Transfac license required
|
Transfac
Matys et al.(2006)
V$SP4_Q3
|
0.784
|
0.855
|
SP4
M10166_2.00 |
Homo sapiens |
Transfac license required
|
Transfac license required
|
Transfac
Matys et al.(2006)
V$SP4_Q5
|
0.784
|
0.855
|
Spps
M06159_2.00 |
Drosophila melanogaster |
KWDRCCMCGCCCMBH |
DVKGGGCGKGGYHWM |
B1H
Zhu et al.(2011)
CG5669_SANGER_10_FBgn0039169
|
0.772
|
0.884
|
Spps
M06160_2.00 |
Drosophila melanogaster |
BDDGCCMCGCCCMYN |
NRKGGGCGKGGCHHV |
B1H
Zhu et al.(2011)
CG5669_SOLEXA_5_FBgn0039169
|
0.772
|
0.884
|
Sp3
M08978_2.00 |
Mus musculus |
NBBNVSCCCCKCCCMBBBNN |
NNVVVKGGGMGGGGSBNVVN |
Misc
Kulakovskiy et al.(2013)
SP3_MOUSE.H11MO.0.B
|
0.771
|
0.855
|
Sp1
M00765_2.00 |
Mus musculus |
NMCGCCCMY |
RKGGGCGKN |
PBM
Weirauch et al.(2013)
pTH0978
|
0.764
|
0.826
|
SP1
M02921_2.00 |
Homo sapiens |
RCCMCDCCCMH |
DKGGGHGKGGY |
SELEX
Jolma et al.(2013)
SP1_1
|
0.764
|
0.826
|
SP1
M04605_2.00 |
Homo sapiens |
NWRRCCACGCCCMCH |
DGKGGGCGTGGYYWN |
SELEX
Yin et al.(2017)
SP1_eDBD_HT-SELEX
|
0.764
|
0.826
|
SP1
M08096_2.00 |
Homo sapiens |
BYCCCKCCCCY |
RGGGGMGGGRV |
ChIP-seq
Mathelier et al.(2014)
MA0079.3
|
0.764
|
0.826
|
SP1
M08363_2.00 |
Homo sapiens |
CCCHNBCYCCDCCCY |
RGGGHGGRGVNDGGG |
ChIP-seq
Schmitges et al.(2016)
P08047.MEME
|
0.764
|
0.826
|
SP1
M08938_2.00 |
Homo sapiens |
BCSSSBCCHVGCCCCGCCCCYN |
NRGGGGCGGGGCBDGGVSSSGV |
Misc
Kulakovskiy et al.(2013)
SP1_HUMAN.H11MO.0.A
|
0.764
|
0.826
|
Sp1
M08963_2.00 |
Mus musculus |
CCCBKCYCCKCCCCCNBCYCSBSC |
GSVSGRGVNGGGGGMGGRGMVGGG |
Misc
Kulakovskiy et al.(2013)
SP1_MOUSE.H11MO.0.A
|
0.764
|
0.826
|
SP1
M10294_2.00 |
Homo sapiens |
DSCMHGCCYH |
DRGGCDKGSH |
Transfac
Matys et al.(2006)
V$SP1_01
|
0.764
|
0.826
|
SP1
M10295_2.00 |
Homo sapiens |
Transfac license required
|
Transfac license required
|
Transfac
Matys et al.(2006)
V$SP1_02
|
0.764
|
0.826
|
SP1
M10296_2.00 |
Homo sapiens |
Transfac license required
|
Transfac license required
|
Transfac
Matys et al.(2006)
V$SP1_07
|
0.764
|
0.826
|
SP1
M10297_2.00 |
Homo sapiens |
Transfac license required
|
Transfac license required
|
Transfac
Matys et al.(2006)
V$SP1_08
|
0.764
|
0.826
|
SP1
M10298_2.00 |
Homo sapiens |
Transfac license required
|
Transfac license required
|
Transfac
Matys et al.(2006)
V$SP1_Q2_02
|
0.764
|
0.826
|
SP1
M10299_2.00 |
Homo sapiens |
Transfac license required
|
Transfac license required
|
Transfac
Matys et al.(2006)
V$SP1_Q3
|
0.764
|
0.826
|
SP1
M10300_2.00 |
Homo sapiens |
VVCCCCGCCCMBN |
NVKGGGCGGGGBB |
Transfac
Matys et al.(2006)
V$SP1_Q6
|
0.764
|
0.826
|
SP1
M04606_2.00 |
Homo sapiens |
NWRGCCMCGCCCMYH |
DRKGGGCGKGGCYWN |
SELEX
Yin et al.(2017)
SP1_eDBD_Methyl-HT-SELEX
|
0.764
|
0.826
|
Sp5
M09016_2.00 |
Mus musculus |
CYCCKCCYHYHBCYYHBYYYHYHB |
VDRDRRRVDRRGVDRDRGGMGGRG |
Misc
Kulakovskiy et al.(2013)
SP5_MOUSE.H11MO.0.C
|
0.758
|
0.812
|
SP5
M10319_2.00 |
Homo sapiens |
Transfac license required
|
Transfac license required
|
Transfac
Matys et al.(2006)
V$SP5_Q2
|
0.758
|
0.812
|
For this family, TFs with SR scores > 0.755 will likely have a similar motif |